This comprehensive book is the first of its kind to take scientists and engineers beyond simply getting a patent granted. Through the author's extensive technical background and experience in intellectual property licensing, it ties the many technical, legal and business aspects of patent enforcement to the innovation and patenting stage in the patent value chain, with the objective of helping inventors to create valuable patents that can be capitalized. In easy-to-understand language, this book covers various aspects, including basic concepts of patent laws and rules, innovation protection, patenting, patents post-granting and patent licensing. With over 40 tables, 70 figures, nearly 100 cases and examples, and a comprehensive index table, it serves as a practical handbook for inventors and patent practitioners. This second edition incorporates the latest changes in the America Invents Act (AIA), with additional case studies and illustrations throughout the book. For inventors who want to file patents by themselves, this new edition provides guidelines and step-by-step instructions on preparing and filing a US provisional patent application, while avoiding the pitfalls that commonly occur in do-it-yourself patenting."--
The phenomenal growth of the Internet has resulted in huge amounts of online information, a situation that is overwhelming to the end users. To overcome this problem, personalization technologies have been extensively employed. The book is the first of its kind, representing research efforts in the diversity of personalization and recommendation techniques. These include user modeling, content, collaborative, hybrid and knowledge-based recommender systems. It presents theoretic research in the context of various applications from mobile information access, marketing and sales and web services, to library and personalized TV recommendation systems. This volume will serve as a basis to researchers who wish to learn more in the field of recommender systems, and also to those intending to deploy advanced personalization techniques in their systems. Sample Chapter(s). Personalization-Privacy Tradeoffs in Adaptive Information Access (865 KB). Contents: User Modeling and Profiling: Personalization-Privacy Tradeoffs in Adaptive Information Access (B Smyth); A Deep Evaluation of Two Cognitive User Models for Personalized Search (F Gasparetti & A Micarelli); Unobtrusive User Modeling for Adaptive Hypermedia (H J Holz et al.); User Modelling Sharing for Adaptive e-Learning and Intelligent Help (K Kabassi et al.); Collaborative Filtering: Experimental Analysis of Multiattribute Utility Collaborative Filtering on a Synthetic Data Set (N Manouselis & C Costopoulou); Efficient Collaborative Filtering in Content-Addressable Spaces (S Berkovsky et al.); Identifying and Analyzing User Model Information from Collaborative Filtering Datasets (J Griffith et al.); Content-Based Systems, Hybrid Systems and Machine Learning Methods: Personalization Strategies and Semantic Reasoning: Working in Tandem in Advanced Recommender Systems (Y Blanco-Fernindez et al.); Content Classification and Recommendation Techniques for Viewing Electronic Programming Guide on a Portable Device (J Zhu et al.); User Acceptance of Knowledge-Based Recommenders (A Felfernig et al.); Using Restricted Random Walks for Library Recommendations and Knowledge Space Exploration (M Franke & A Geyer-Schulz); An Experimental Study of Feature Selection Methods for Text Classification (G Uchyigit & K Clark). Readership: Researchers and graduate students in machine learning and databases/information science.
The last half century has witnessed two landmark events in medical history. The 1970s saw euphoria about the defeat of one of humankind's oldest disease scourges with the global eradication of smallpox. To set against this, the 2020s are experiencing the pandemic ravages of new viral diseases, of which COVID-19 is currently the most potent. But it is only the latest of a succession of threats. A Geography of Infection explores the distinctive spatial patterns and processes by which such infectious diseases spread from place to place and can grow from local and regional epidemics into global pandemics. This resource focuses initially on the local scale of doctors' practices and small islands where epidemic outbreaks are slight in the numbers infected and in geographical extent. Such local area studies raise two questions. First, how and where do epidemic diseases emerge and second, why do more diseases appear to be emerging now? To approach such questions implies a shift in spatial gear from painting epidemics with a fine-tipped local brush to an expanded palette on which doctors' practices and small islands are replaced by regional and global populations. Simultaneously, time bands are extended backwards to the origins of civilization and forwards into the twenty-first century. It eventually leads to a consideration of global pandemics - both historical (for example, plague, cholera and influenza) and contemporary (HIV/AIDS and COVID-19) and examines the ways the spread of infection can be prevented. All chapters are extensively illustrated with full-colour diagrams and maps - some of which are in colour for the first time. Bringing together the authors' collective 150 years of experience in research, mapping, and writing on spatial aspects of medical history, this is an invaluable resource for anyone interested in the spread, control, and eradication of epidemic and pandemic diseases.
Few areas of biomedical research provide greater opportunities to capitalize upon the revolution in genomics and molecular biology than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. Gene Therapy in the Brain: From Bench to Bedside represents the definitive volume on this subject. Edited by two pioneers of neurological gene therapy, this volume contains contributions by leaders who helped to create the field as well as those who are expanding the promise of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides clear and informative reviews on a variety of subjects which would be of interest to anyone who is currently using or contemplating exploring gene therapy for neurobiological applications. Basic gene transfer technologies are discussed, with particular emphases upon novel vehicles, immunological issues and the role of gene therapy in stem cells. Numerous research applications are reviewed, particularly in complex fields such as behavioral neurobiology. Several preclinical areas are also covered which are likely to translate into clinical studies in the near future, including epilepsy, pain and amyotrophic lateral sclerosis. Among the most exciting advances in recent years has been the use of neurological gene therapy in human clinical trials, including Parkinson's disease, Canavan disease and Batten disease. Finally, readers will find "insider" information on technological and regulatory issues which can often limit effective translation of even the most promising idea into clinical use. This work provides up-to-date information and key insights into those gene therapy issues which are important to both scientists and clinicians focusing upon the brain and central nervous system.
Written by world renowned experts in surgical oncology, this book examines various types of cancer and their treatment options based on 'Level of Evidence' tables. The text provides an up-to-date review of the knowledge required by surgical oncologists, from basic biology, to the application of regional chemotherapy, minimally invasive surgery and palliative care.
The field of oncology is changing more rapidly than any other speciality and new biology as well as new therapies are constantly being tested. This entire text keeps the reader updated with these important advances in a comprehensive but readable format. This outstanding book has been authored by the world renowned experts in surgical oncology, practicing in a rising center of excellence in the field. It introduces 'Level of Evidence' tables to list the various options available for the treatment of each cancer and the strength of evidence available to support it. The text has been developed as.
For more than 100 years, Henry's Clinical Diagnosis and Management by Laboratory Methods has been recognized as the premier text in clinical laboratory medicine, widely used by both clinical pathologists and laboratory technicians. Leading experts in each testing discipline clearly explain procedures and how they are used both to formulate clinical diagnoses and to plan patient medical care and long-term management. Employing a multidisciplinary approach, it provides cutting-edge coverage of automation, informatics, molecular diagnostics, proteomics, laboratory management, and quality control, emphasizing new testing methodologies throughout. - Remains the most comprehensive and authoritative text on every aspect of the clinical laboratory and the scientific foundation and clinical application of today's complete range of laboratory tests. - Updates include current hot topics and advances in clinical laboratory practices, including new and extended applications to diagnosis and management. New content covers next generation mass spectroscopy (MS), coagulation testing, next generation sequencing (NGS), transfusion medicine, genetics and cell-free DNA, therapeutic antibodies targeted to tumors, and new regulations such as ICD-10 coding for billing and reimbursement. - Emphasizes the clinical interpretation of laboratory data to assist the clinician in patient management. - Organizes chapters by organ system for quick access, and highlights information with full-color illustrations, tables, and diagrams. - Provides guidance on error detection, correction, and prevention, as well as cost-effective test selection. - Includes a chapter on Toxicology and Therapeutic Drug Monitoring that discusses the necessity of testing for therapeutic drugs that are more frequently being abused by users. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
The Friar and the Maya offers a full study and new translation of the Relación de las Cosas de Yucatán (Account of the Things of Yucatan) by a unique set of eminent scholars, created by them over more than a decade from the original manuscript held by the Real Academia de la Historia in Madrid. This critical and careful reading of the Account is long overdue in Maya studies and will forever change how this seminal text is understood and used. For generations, scholars used (and misused) the Account as the sole eyewitness insight into an ancient civilization. It is credited to the sixteenth-century Spanish Franciscan, monastic inquisitor, and bishop Diego de Landa, whose legacy is complex and contested. His extensive writings on Maya culture and history were lost in the seventeenth century, save for the fragment that is the Account, discovered in the nineteenth century, and accorded near-biblical status in the twentieth as the first “ethnography” of the Maya. However, the Account is not authored by Landa alone; it is a compilation of excerpts, many from writings by other Spaniards—a significant revelation made here for the first time. This new translation accurately reflects the style and vocabulary of the original manuscript. It is augmented by a monograph—comprising an introductory chapter, seven essays, and hundreds of notes—that describes, explains, and analyzes the life and times of Diego de Landa, the Account, and the role it has played in the development of modern Maya studies. The Friar and the Maya is an innovative presentation on an important and previously misunderstood primary source.
Since the second edition of this book appeared in 1954, two major discoveries in the field of Aramaic studies—the Qumran texts and the Neofiti Targum—have been made available to scholars. These, along with some important publications on the subject, have made this third edition necessary. The book has been completely revised and reset and the supplementary notes of the second edition incorporated in the text; a new chapter has been added to take account of the implications of the new discoveries for previous views about the language of Jesus. Those parts of the book dealing with Acts have been revised and supplemented in the light of Dr. Max Wilcox’s important book on the Semitisms of Acts; and an Appendix by Dr. Geza Vermes, Reader in Jewish Studies in Oxford, has been added containing fresh evidence for the use of the expression “son of man” in Palestinian Aramaic.
This textbook provides everything you need to get through a basic physics course. It guides students through all the essentials with a concise review of the concept, simple illustrations to demonstrate it, worked problems to showcase how to apply it, and a short quiz for self-testing. Whereas other standard books can be overwhelming to students, the author shares what has worked with his own students, trimming back unnecessary detail and focusing on the core basic physical concepts required to gain solid footing. The full range of topics are addressed in a manner that facilitates understanding and will encourage students to continue forward with their learning.
The hereditary retinopathy, retinitis pigmentosa (RP), which affects 1 in 3,500 people worldwide, is the most common cause of registered visual handicap among those of the working age in developed countries. RP is a highly variable disorder where patients may develop symptomatic visual loss in early childhood, while others may remain asymptomatic until mid-adulthood. Most cases of RP segregate in autosomal dominant, recessive or X-linked recessive modes, with approximately 41 genes being implicated in disease pathology to date (RetNet). The extensive genetic heterogeneity associated with autosomal dominant RP (adRP) is an undisputed hindrance to the development of genetically based therapeutics.
Sustainable Cassava: Production, Processing, Trade, Consumption and Waste Management Strategies presents viable approaches to promote sustainability in this globally important crop, enabling future generations to benefit. Providing key insights to enhance production while limiting environmental impact, this book provides readers with foundational understanding of growing and utilizing Cassava. Cassava (Manihot Mill. species Euphorbiaceae) is a staple crop in tropical and subtropical regions of the world with diverse food and non-food value. It is a principal energy source but may be fortified to provide improved nutritional status for consumers as well as for the production of value-added products. With the growing human population, there is a need to increase global production and efficiency in trade, diversify and ensure safe consumption, maximize utilization of all cassava processing wastes, and add value to the cassava production chain through sustainable practices Presented in three parts, the first addresses cassava diversity and distribution, sustainable production and cultivation practices, and root processing innovations of the crop. Cassava trade policies and economic value chains, food safety and use of cassava, and agro-industrial cassava products are addressed in the second part. The third part focuses on bioeconomy aspects, cassava waste quality assessment, toxicology, sanitary practices, environmental risk assessment as well as sustainable management strategies for cassava waste using biotechnological and industrial advances. Addressing the need for a unified and standardized approach for the trade, management, and utilization of cassava genetic resources, finished products, and cassava processing wastes, the book also explores policy and governance structure for addressing environmental and economic issues emanating from their use. In the lens of globalization, climate change adaptation and mitigation, and sustainable development, the contents of this book will promote the adoption of novel and advanced practices in cassava cultivation and production, harvest, use, and waste recovery or reduction and contribute to global cooling efforts. - Presents best practices and ideas from around the world, including technological advances for Cassava production and use - Focuses on sustainability throughout the lifecycle - Provides insights translatable to other tuber crops for further enhanced sustainable food security
YOU NEED THIS UPDATED EDITION OF FIRST AID TO EXCEL ON THE REVISED USMLE® STEP 1! First AidTM remains the most trusted name in USMLE® review—just ask any medical student! A complete framework for USMLE Step 1 preparation, annually updated with crowdsourced contributions from thousands of students Updated exam preparation advice for USMLE Step 1 pass/fail, Step 1 blueprint changes, and COVID-19 impacts New section on communication skills reflects the latest Step 1 content New focus on diversity, equity and inclusion incorporates race and ethnic considerations, as well as gender neutral terminology Nearly 1,400 must-know topics with mnemonics to focus your study 1,200+ color photos and illustration—170+ new or revised—help you visualize processes, disorders, and clinic findings Rapid Review section for efficient last-minute preparation Bonus material and real-time updates exclusively at FirstAidTeam.com
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