Published by Sinauer Associates, an imprint of Oxford University Press. Provides descriptions of the methods and tools used in molecular population genetics, which has combined advances in molecular biology and genomics with mathematical and empirical findings to uncover the history of natural selection and demographic shifts in many organisms.
Where did SARS come from? Have we inherited genes from Neanderthals? How do plants use their internal clock? The genomic revolution in biology enables us to answer such questions. But the revolution would have been impossible without the support of powerful computational and statistical methods that enable us to exploit genomic data. Many universities are introducing courses to train the next generation of bioinformaticians: biologists fluent in mathematics and computer science, and data analysts familiar with biology. This readable and entertaining book, based on successful taught courses, provides a roadmap to navigate entry to this field. It guides the reader through key achievements of bioinformatics, using a hands-on approach. Statistical sequence analysis, sequence alignment, hidden Markov models, gene and motif finding and more, are introduced in a rigorous yet accessible way. A companion website provides the reader with Matlab-related software tools for reproducing the steps demonstrated in the book.
During the Apartheid years in South Africa, a copy of The Complete Works of William Shakespeare was smuggled around the prison on Robben Island. The book's significance resides in the fact that the book's owner, Sonny Venkatratham, passed it to a number of his fellow political prisoners in the single cells, including Nelson Mandela, asking them to mark their favourite passages with a signature and date. Informally known as "the Robben Island Bible", numerous prisoners selected the speeches that meant the most to them and their experience as political prisoners. In 2008 and 2010, playwright and scholar Matthew Hahn conducted interviews with eight former political prisoners in South Africa. Offering a vivid and startling account of the experience of these political prisoners during Apartheid, this extraordinary verbatim play weaves Shakespeare's words together with first-hand accounts from these men. They offer their reflections on their time as Liberation activists and, twenty years later, on the costs, consequences and whether or not it was all worth it. The play is published alongside a preface by Sonny Venkatrathnam and an introduction by South African actor, director , playwright and cultural activist John Kani.
Are we related to Neanderthals? Where did SARS come from? Which part of our genome is evolving the fastest? These are some of the questions that can be answered by statistical and computational analysis of genetic data. This text presents an introduction to computational genomics.
Where did SARS come from? Have we inherited genes from Neanderthals? How do plants use their internal clock? The genomic revolution in biology enables us to answer such questions. But the revolution would have been impossible without the support of powerful computational and statistical methods that enable us to exploit genomic data. Many universities are introducing courses to train the next generation of bioinformaticians: biologists fluent in mathematics and computer science, and data analysts familiar with biology. This readable and entertaining book, based on successful taught courses, provides a roadmap to navigate entry to this field. It guides the reader through key achievements of bioinformatics, using a hands-on approach. Statistical sequence analysis, sequence alignment, hidden Markov models, gene and motif finding and more, are introduced in a rigorous yet accessible way. A companion website provides the reader with Matlab-related software tools for reproducing the steps demonstrated in the book.
The TRIPS Agreement was implemented in the WTO to gain access to a functioning dispute settlement mechanism that could authorize trade sanctions. Yet TRIPS and the WTO Dispute Settlement Understanding are based on systems that developed independently in WIPO and GATT. In this book, Matthew Kennedy exposes the challenges created by the integration and independence of TRIPS within the WTO by examining how this trade organization comes to grips with intellectual property disputes. He contrasts the way intellectual property disputes between governments have been handled before and after the establishment of the WTO. Based on practical experience, this book provides a comprehensive review of the issues that arise under the DSU, TRIPS, GATT 1994 and other WTO agreements in intellectual property matters. These range from procedural pitfalls to substantive treaty interpretation and conflicts as well as remedies, including cross-retaliation.
Love Become Incarnate is a Festschrift in honor of Bruce D. Marshall, Lehman Professor of Christian Doctrine at Southern Methodist University’s Perkins School of Theology. Marshall is one of the most significant Catholic theologians in the English-speaking world. His work exemplifies an intentionally Catholic theology that makes fearless use of the fullness of truth—wherever it may be found—in conscious service to the Church. Marshall has made significant contributions to the doctrine of the Trinity, Christology, Pneumatology, ecclesiology, ecumenism, Jewish-Christian dialogue, and fundamental theology. St. Thomas Aquinas has been his most constant theological companion, although he has also advanced our understanding of Saints Augustine and Anselm, John Duns Scotus, Martin Luther, Matthias Joseph Scheeben, Karl Barth, and other major figures. Marshall has carefully developed a unique, powerful, and wide-ranging theology of the primacy of Christ over all things. It is this same Christ who is the love of God become incarnate. This series of essays by Marcia Colish, J. Augustine Di Noia, Paul Griffiths, Reinhard Hütter, Matthew Levering, and others engage and advance Marshall’s ranging contributions to historical and systematic theology.
In Signs of Light, Matthew Lauzon traces the development of very different French and British ideas about language over the course of the late seventeenth and eighteenth centuries and demonstrates how important these ideas were to emerging notions of national character. Drawing examples from a variety of French and English language works in a wide range of areas, including language theory, philosophy, rhetoric, psychology, missionary tracts, and literary texts, Lauzon explores how French and British thinkers of the day developed arguments that certain kinds of languages are superior to others. The nature of animal language and British and French understandings of the languages of North American Indians were vigorously debated. Theories of animal language juxtaposed the apparent virtues of transparency and wit; considerations of savage language resulted in eloquence being regarded as an even higher accomplishment. Eventually, the French language came to be prized for its wit and sociability and English for its simple clarity and vigor. Lauzon shows that, besides concerns about establishing the clarity of introspective representations, questions about the energetic communication of sincere emotion and about the sociable communication of wit were crucial to language theories during this period. A richly interdisciplinary work, Signs of Light is a compelling account of a formative period in language theory.
Paul and the Gentile Problem provides a new explanation for the apostle Paul's statements about the Jewish law in his letters to the Romans and Galatians. Paul's arguments against circumcision and the law in Romans 2 and his reading of Genesis 15-21 in Galatians 4:21-31 belong within a stream of Jewish thinking which rejected the possibility that gentiles could undergo circumcision and adopt the Jewish law, thereby becoming Jews. Paul opposes this solution to the gentile problem because he thinks it misunderstands how essentially hopeless the gentile situation remains outside of Christ. The second part of the book moves from Paul's arguments against a gospel that requires gentiles to undergo circumcision and adoption of the Jewish law to his own positive account, based on his reading of the Abraham Narrative, of the way in which Israel's God relates to gentiles. Having received the Spirit (pneuma) of Christ, gentiles are incorporated into Christ, who is the singular seed of Abraham, and, therefore, become materially related to Abraham. But this solution raises a question: Why is it so important for Paul that gentiles become seed of Abraham? The argument of this book is that Paul believes that God had made certain promises to Abraham that only those who are his seed could enjoy and that these promises can be summarized as being empowered to live a moral life, inheriting the cosmos, and having the hope of an indestructible life.
In Aquinas’s Eschatological Ethics and the Virtue of Temperance, Matthew Levering argues that Catholic ethics make sense only in light of the biblical worldview that Jesus has inaugurated the kingdom of God by pouring out his spirit. Jesus has made it possible for us to know and obey God’s law for human flourishing as individuals and communities. He has reoriented our lives toward the goal of beatific communion with him in charity, which affects the exercise of the moral virtues that pertain to human flourishing. Without the context of the inaugurated kingdom, Catholic ethics as traditionally conceived will seem like an effort to find a middle ground between legalistic rigorism and relativistic laxism, which is especially the case with the virtue of temperance, the focus of Levering’s book. After an opening chapter on the eschatological/biblical character of Catholic ethics, the ensuing chapters engage Aquinas’s theology of temperance in the Summa theologiae, which identifies and examines a number of virtues associated with temperance. Levering demonstrates that the theology of temperance is profoundly biblical, and that Aquinas’s theology of temperance relies for its intelligibility upon Christ’s inauguration of the kingdom of God as the graced fulfillment of our created nature. The book develops new vistas for scholars and students interested in moral theology.
In Gwinnett County’s two hundred years, the area has been western, southern, rural, suburban, and now increasingly urban. Its stories include the displacement of Native peoples, white settlement, legal battles over Indian Removal, slavery and cotton, the Civil War and the Lost Cause, New South railroad and town development, Reconstruction and Jim Crow, business development and finance in a national economy, a Populist uprising and Black outmigration, the entrance of women into the political arena, the evolution of cotton culture, the development of modern infrastructure, and the transformation from rural to suburban to a multicultural urbanizing place. Gwinnett, as its chamber of commerce likes to say, has it all. However, Gwinnett has yet to be the focus of a major historical exploration—until now. Through a compilation of essays written by professional historians with expertise in a diverse array of eras and fields, Michael Gagnon and Matthew Hild’s collection finally tells these stories in a systematic way—avoiding the pitfalls of nonprofessional local histories that tend to ignore issues of race, class, or gender. While not claiming to be comprehensive, this book provides general readers and scholars alike with a glimpse at Gwinnett through the ages.
Mathematics of Bioinformatics: Theory, Methods, and Applications provides a comprehensive format for connecting and integrating information derived from mathematical methods and applying it to the understanding of biological sequences, structures, and networks. Each chapter is divided into a number of sections based on the bioinformatics topics and related mathematical theory and methods. Each topic of the section is comprised of the following three parts: an introduction to the biological problems in bioinformatics; a presentation of relevant topics of mathematical theory and methods to the bioinformatics problems introduced in the first part; an integrative overview that draws the connections and interfaces between bioinformatics problems/issues and mathematical theory/methods/applications.
For more than 100 years, Henry's Clinical Diagnosis and Management by Laboratory Methods has been recognized as the premier text in clinical laboratory medicine, widely used by both clinical pathologists and laboratory technicians. Leading experts in each testing discipline clearly explain procedures and how they are used both to formulate clinical diagnoses and to plan patient medical care and long-term management. Employing a multidisciplinary approach, it provides cutting-edge coverage of automation, informatics, molecular diagnostics, proteomics, laboratory management, and quality control, emphasizing new testing methodologies throughout. Remains the most comprehensive and authoritative text on every aspect of the clinical laboratory and the scientific foundation and clinical application of today's complete range of laboratory tests. Updates include current hot topics and advances in clinical laboratory practices, including new and extended applications to diagnosis and management. New content covers next generation mass spectroscopy (MS), coagulation testing, next generation sequencing (NGS), transfusion medicine, genetics and cell-free DNA, therapeutic antibodies targeted to tumors, and new regulations such as ICD-10 coding for billing and reimbursement. Emphasizes the clinical interpretation of laboratory data to assist the clinician in patient management. Organizes chapters by organ system for quick access, and highlights information with full-color illustrations, tables, and diagrams. Provides guidance on error detection, correction, and prevention, as well as cost-effective test selection. Includes a chapter on Toxicology and Therapeutic Drug Monitoring that discusses the necessity of testing for therapeutic drugs that are more frequently being abused by users.
This undergraduate textbook provides a broad overview of the ways in which ‘adventurous practices’ influence, and are influenced by, the world around them. The concept of adventure is one that is too often tackled within subject silos of philosophy, education, tourism, or leisure. While much of the analysis is strong, there is little cross-pollination between disciplines. Adventure & Society pulls together the threads of these discourses into one coherent treatment of the term ‘adventure’ and the role that it plays in human social life of the 21st century. It explores how these practices can be considered more deeply through theoretical discourses of capitalism, identity construction, technology and social media, risk-taking, personal development, equalities, and sustainability. As such, the book speaks to a broad audience of undergraduate and postgraduate students across diverse subject areas, and aims to be an accessible starting point for deeper inquiry.
In this book, Novenson gives a revisionist account of messianism in antiquity. He shows that, for the ancient Jews and Christians who used the term, a messiah was not an article of faith but a manner of speaking: a scriptural figure of speech useful for thinking kinds of political order.
Inside Campaigns: Elections Through the Eyes of Political Professionals is essential reading not only for students interested in running campaigns and for journalism students who want to cover politics, but for campaign operatives generally and journalists who want to raise the level of their game. In fact, it’s good reading for everybody." —Thomas B. Edsall, Columbia Graduate School of Journalism "Much of our useful knowledge sits at the intersection of disciplines. Inside Campaigns demonstrates that through a skillful combination of political science with management in a highly readable and practical format. A first for this field!" —Leonard A. Schlesinger, Baker Foundation Professor-Harvard Business School, President Emeritus-Babson College Inside Campaigns, Second Edition takes readers on a journey into the world of campaign managers. Powered by scores of interviews and surveys of political professionals, the book considers the purpose, potency, and poetry of modern political campaigns in the US. The expert author team draw from years of scholarly research and professional campaign experience to guide readers on a behind-the-scenes tour of the ways campaigns are managed, the strategies that are employed, the roles played by both staff and the candidates, and the affects election outcomes have on American democracy. Readers will develop an understanding of what campaigns do and why they matter, as well as gain practical skills for working in a campaign or advocating for a cause. New to the Second Edition: A case study created from an in-depth interview with Bernie Sanders’ top digital decision-makers describes how the Sanders’ campaign used digital media to harness the energy of their highly motivated base supporters. This case shows students a real-life campaign decision-making situation, and demonstrates how campaigns use new digital media to drive traditional news media coverage. A unique joint interview with the top media buyers from the Clinton and Trump campaigns reveals how each campaign tracked the other’s advertising and adjusted their own advertising based on competitive tracking information. This interview illustrates to students how modern campaigns use media tracking technologies to monitor their opposition and spend tens of millions of dollars at the presidential level. A top Trump digital manager shares inside details of how the Republican National Committee moved quickly to help build out the Trump digital operations after it was clear that Trump would be the party’s presidential nominee. This insight helps students understand how the Trump campaign answered, "What do we tell them?" by testing messages online, including recycling Trump’s personal tweets in instant messages and emails. The differences between how the Clinton and Trump campaigns managed the news media are highlighted in a case study of one journalist’s experiences covering both campaigns. This case study helps the student build skills for becoming a "spinmeister" who handles day-to-day relationships with the news media. The authors’ research surprisingly reveals that, behind the scenes, Trump was much more available to reporters than Clinton, despite Trump’s continuous public attacks on the "fake news media.
J. Matthew Ward’s Garden of Ruins serves as an insightful social and military history of Civil War–era Louisiana. Partially occupied by Union forces starting in the spring of 1862, the Confederate state experienced the initial attempts of the U.S. Army to create a comprehensive occupation structure through military actions, social regulations, the destabilization of slavery, and the formation of a complex bureaucracy. Skirmishes between Union soldiers and white civilians supportive of the Confederate cause multiplied throughout this period, eventually turning occupation into a war on local households and culture. In unoccupied regions of the state, Confederate forces and their noncombatant allies likewise sought to patrol allegiance, leading to widespread conflict with those they deemed disloyal. Ward suggests that social stability during wartime, and ultimately victory itself, emerged from the capacity of military officials to secure their territory, governing powers, and nonmilitary populations. Garden of Ruins reveals the Civil War, state-building efforts, and democracy itself as contingent processes through which Louisianans shaped the world around them. It also illustrates how military forces and civilians discovered unique ways to wield and hold power during and immediately after the conflict.
It is a commonly held belief that medieval Catholics were focussed on the 'bells and whistles' of religious practices, the smoke, images, sights and sounds that dazzled pre-modern churchgoers. Protestantism, in contrast, has been cast as Catholicism's austere, intellective and less sensual rival sibling. With iis white-washed walls, lack of incense (and often music) Protestantism worship emphasised preaching and scripture, making the new religion a drab and disengaged sensual experience. In order to challenge such entrenched assumptions, this book examines Tudor views on the senses to create a new lens through which to explore the English Reformation. Divided into two sections, the book begins with an examination of pre-Reformation beliefs and practices, establishing intellectual views on the senses in fifteenth-century England, and situating them within their contemporary philosophical and cultural tensions. Having established the parameters for the role of sense before the Reformation, the second half of the book mirrors these concerns in the post-1520 world, looking at how, and to what degree, the relationship between religious practices and sensation changed as a result of the Reformation. By taking this long-term, binary approach, the study is able to tackle fundamental questions regarding the role of the senses in late-medieval and early modern English Christianity. By looking at what English men and women thought about sight, hearing, smell, taste and touch, the stereotype that Protestantism was not sensual, and that Catholicism was overly sensualised is wholly undermined. Through this examination of how worship was transformed in its textual and liturgical forms, the book illustrates how English religion sought to reflect changing ideas surrounding the senses and their place in religious life. Worship had to be 'sensible', and following how reformers and their opponents built liturgy around experience of the sacred through the physical allows us to tease out the tensions and pressures which shaped religious reform.
The goal of this memoir is to provide the foundations for the locally analytic representation theory that is required in three of the author's other papers on this topic. In the course of writing those papers the author found it useful to adopt a particular point of view on locally analytic representation theory: namely, regarding a locally analytic representation as being the inductive limit of its subspaces of analytic vectors (of various “radii of analyticity”). The author uses the analysis of these subspaces as one of the basic tools in his study of such representations. Thus in this memoir he presents a development of locally analytic representation theory built around this point of view. The author has made a deliberate effort to keep the exposition reasonably self-contained and hopes that this will be of some benefit to the reader.
In this book, the authors reconceptualize cost-benefit analysis, arguing that its objective should be overall well-being rather than economic efficiency. This book not only places cost-benefit analysis on a firmer theoretical foundation, but also has many practical implications for how government agencies should undertake cost-benefit studies.
This book is a comprehensive account of trends in Russian public opinion over the period 1988-94. Analysing data from Russian polling organizations, it covers the development of a professional polling industry and looks at changing popular moods; the depth of democratic values; attitudes towards political institutions; the attempt to introduce a free market economy and views about the loss of empire. Concluding sections consider attitudinal differences between social groups, and the impact of public opinion on postcommunist politics.
This book offers a comprehensive, biography-led examination of queenship in England between 850 and 1000, tracing the development of the queen’s role from bed companion to institutional office. The period 850–1000 is critical to the development of English queenship. In the aftermath of viking invasion, the kings of Wessex expanded their hegemony over neighbouring regions, gradually establishing themselves as the kings of England. Parallel to this broad narrative of political change is the lesser-known story, told in this book, of the royal women who took part in it. The lives of three remarkable women – Æthelflæd, Lady of the Mercians, and the West Saxon consorts Eadgifu and Ælfthryth – are central to the story, here retold through the careful analysis and reappraisal of source documents. These biographies set the stage for detailed study of the agency and advocacy of all women who held queenly office in England between 850 and 1000, as well as their legacies and reception by later generations. Early English Queens, 850–1000 gives important insights into the role women played in the first 150 years of the West Saxon dynasty, offering a compelling narrative that will appeal to students and scholars of early medieval England and royal studies.
Reckoning with Matter" tells the story of early modern European calculating machines, from the early attempts of Blaise Pascal in the 1640s through Charles Babbage s efforts of the 1820s to 40s. All failed spectacularly. By exploring these failed technologies, Matthew L. Jones tracks diverse forms of technical life different social arrangements of practitioners, different legal conceptions of the ownership of work and ideas, and different philosophical conceptions of knowledge and skill. Philosophers, engineers, and craftspeople wrote about their distinctive competencies, about technical novelty, and about the best way to coordinate their efforts, and drawing on these remarkably well-preserved records, Jones reveals the concrete processes of imagining, elaborating, testing, and building key components for calculating machines. By highlighting the makers and their conceptions of invention right up to the instauration of modern patent regimes and the solidification of the concept of Romantic genius, Jones argues that these conceptions of creativity and of making are often more incisive and more honest than those still dominating our own legal, political, and aesthetic culture. Ultimately, "Reckoning with Matter "uses the fascinating history of calculating machines to explore major contingencies of European early modernity, from its economic history to its vision of creative activity itself.
This book is the dogmatic sequel to Levering's Engaging the Doctrine of Marriage, in which he argued that God's purpose in creating the cosmos is the eschatological marriage of God and his people.. God sets this marriage into motion through his covenantal election of a particular people, the people of Israel. Central to this people's relationship with the Creator God are their Scriptures, exodus, Torah, Temple, land, and Davidic kingship. As a Christian Israelology, this book devotes a chapter to each of these topics, investigating their theological significance both in light of ongoing Judaism and in light of Christian Scripture (Old and New Testaments) and Christian theology. The book makes a significant contribution to charting a path forward for Jewish-Christian dialogue from the perspective of post-Vatican II Catholicism.
In Mission Manifest, Matthew Shannon argues that American evangelicals were central to American-Iranian relations during the decades leading up to the 1979 revolution. These Presbyterian missionaries and other Americans with ideals worked with US government officials, nongovernmental organizations, and their Iranian counterparts as cultural and political brokers—the living sinews of a binational relationship during the Second World War and early Cold War. As US global hegemony peaked between the 1940s and the 1960s, the religious authority of the Presbyterian Mission merged with the material power of the American state to infuse US foreign relations with the messianic ideals of Christian evangelicalism. In Tehran, the missions of American evangelicals became manifest in the realms of religion, development programs, international education, and cultural associations. Americans who lived in Iran also returned to the United States to inform the growth of the national security state, higher education, and evangelical culture. The literal and figurative missions of American evangelicals in late Pahlavi Iran had consequences for the binational relationship, the global evangelical movement, and individual Americans and Iranians. Mission Manifest offers a history of living, breathing people who shared personal, professional, and political aims in Iran at the height of American global power.
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