The fungi have been major players in the molecular revolution that has transformed biology. Because they can be manipulated as microorganisms, yeast and Neurospora provide information that is difficult to acquire with plants and animals, and experimental findings with fungi often throw light on corresponding processes in plants and animals. The filamentous fungus Neurospora crassa has become a valuable model organism because of its favorable features for genetic analysis and because of the vast store of information that has been acquired during 75 years of research. This compendium provides researchers and students with a concise account of current knowledge about the genes and genome of Neurospora, setting the stage for research that will follow completion of the genome sequence.This book, which is fully documented and abundantly illustrated, will be an indispensable tool in any laboratory that uses fungi for research in molecular genetics, classical genetics, developmental genetics, or cell biology. - Molecular, genetic, and phenotypic information for over 1000 nuclear genes - Genetic maps - Linkage group assignments for 1000 loci - 2300 references, 68 figures - Guide to electronic and other sources of information - Summary information on the mitochondrial genome - cDNAs identified from different stages of life - Classical, cytogenetic, and molecular data, anticipating completion of the genome sequence
A concise review of the epidemiology, pathogenesis, and management of common respiratory conditions seen in a primary care setting. Using an illuminating case-based approach, Dr. Mintz assesses the key clinical questions that a primary care physician would ask and applies the most up-to-date research and guidelines to offer the practitioner evidence-based solutions. The author covers the range of knowledge needed to provide excellent care for patients with respiratory disease, from the basics of pulmonary function testing to understanding and caring for common respiratory illnesses, including chronic obstructive pulmonary disease, asthma, allergic rhinitis, and pneumonia. For each disorder, Dr. Mintz explains the key points regarding the epidemiology of the disease, its pathophysiology, the differential diagnosis and diagnosis, and its recommended treatment. A special PDA version of Disorders of the Respiratory Tract: Common Challenges in Primary Care is also available.
Relativism, or the claim that it is possible that the appearances and opinions of each of us are correct for each of us, and hence that any view is as true as any other, has remained a continuing problem for philosophy and science for 2,500 years. Today, because of the widespread acceptance of relativism, the problem is greater than ever before. This book argues that Plato in fact solved this problem. In the first two chapters, by means of a study of Husserl and Locke, Davis shows that it is possible to return to and take seriously Plato’s treatment of this problem. The third chapter presents Plato’s solution to it. This book is distinctive in that it shows that a problem that has been thought to be present throughout the history of Western thought was in fact solved by Plato, and in that it shows that we can, beginning from our contemporary situation, return to Plato’s solution.
In Joyce's Grand Operoar, two internationally respected Joyce scholars join forces to present over 3,000 of Joyce's opera allusions as they appear in Finnegans Wake. Ruth Bauerle's long, richly detailed, and often amusing introduction critically interprets Joyce's life and work in terms of its operatic and literary interconnections. The resulting volume will delight both opera lovers and Joyceans.
For more than 100 years, Henry's Clinical Diagnosis and Management by Laboratory Methods has been recognized as the premier text in clinical laboratory medicine, widely used by both clinical pathologists and laboratory technicians. Leading experts in each testing discipline clearly explain procedures and how they are used both to formulate clinical diagnoses and to plan patient medical care and long-term management. Employing a multidisciplinary approach, it provides cutting-edge coverage of automation, informatics, molecular diagnostics, proteomics, laboratory management, and quality control, emphasizing new testing methodologies throughout. - Remains the most comprehensive and authoritative text on every aspect of the clinical laboratory and the scientific foundation and clinical application of today's complete range of laboratory tests. - Updates include current hot topics and advances in clinical laboratory practices, including new and extended applications to diagnosis and management. New content covers next generation mass spectroscopy (MS), coagulation testing, next generation sequencing (NGS), transfusion medicine, genetics and cell-free DNA, therapeutic antibodies targeted to tumors, and new regulations such as ICD-10 coding for billing and reimbursement. - Emphasizes the clinical interpretation of laboratory data to assist the clinician in patient management. - Organizes chapters by organ system for quick access, and highlights information with full-color illustrations, tables, and diagrams. - Provides guidance on error detection, correction, and prevention, as well as cost-effective test selection. - Includes a chapter on Toxicology and Therapeutic Drug Monitoring that discusses the necessity of testing for therapeutic drugs that are more frequently being abused by users. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Covering three fantasitic regions for lovers of the "great outdoors" - the Rockies, Alberta and the Yukon - this guide introduces British Columbia including Vancouver and Vancouver Island. Eco-tourism, sport-based holidays and wildlife viewing are all available in this region of Canada and are all covered in this handbook. It features detailed information on hiking trails, canoe routes, ski hills, rock climbing, mountain biking and more, as well as routes that leave the beaten track to discover the secrets locals usually keep to themselves, including viewpoints, free hot springs and special beaches. The guide also offers a selection of accommodation concentrating on interesting hotels, B&Bs and campsites.
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