Recombinant Poxviruses provides a comprehensive examination of poxviruses with an emphasis on the potential of these viruses as new vaccines. The book considers a wide range of issues involved in producing new genetically engineered live vaccines, such as efficacy, safety, stability, cost, host range, immune response, immunization route, use of multivalent vaccines, and need for revaccination. The opening chapter describes the origin of vaccinia virus, its use to eradicate smallpox, and the pathogenesis of poxvirus infections. Subsequent chapters examine the molecular biology of poxviruses, methods of constructing vaccinia virus recombinants, and applications; the use and immune responses induced by poxvirus recombinants as live vaccines; and the important issues of the safety and immunogenicity of vaccinia virus. The book's final two chapters report the progress that has been made developing avipoxviruses and parapoxviruses as candidate recombinant vaccines. Recombinant Poxviruses will be a welcome addition to the bookshelves of virologists, microbiologists, infectious disease specialists, and veterinarians.
Strange as it sounds, during the 1870s and 1880s, America's most popular spectator sport wasn't baseball, football, or horseracing-it was competitive walking. Inside sold-out arenas, competitors walked around dirt tracks almost nonstop for six straight days (never on Sunday), risking their health and sanity to see who could walk the farthest-500 miles, then 520 miles, and 565 miles! These walking matches were as talked about as the weather, the details reported in newspapers and telegraphed to fans from coast to coast. This long-forgotten sport, known as pedestrianism, spawned America's first celebrity athletes. The top pedestrians earned a fortune in prize money and endorsement deals. The sport also opened doors for immigrants, African Americans, and women. But along with the excitement came the inevitable scandals, charges of doping-coca leaves!-and insider gambling. It even spawned a riot in 1879 when too many fans showed up at New York's Gilmore's Gardens, later renamed Madison Square Gardens, and were denied entry to a widely publicized showdown. Pedestrianism: When Watching People Walk Was America's Favorite Spectator Sport chronicles competitive walking's peculiar appeal and popularity, its rapid demise, and its enduring influence. In many ways, pedestrianism marked the beginning of modern spectator sports in the United States. Matthew Algeo is the author of Harry Truman's Excellent Adventure, The President Is a Sick Man, and Last Team Standing. An award-winning journalist, Algeo has reported from three continents for public radio's All Things Considered, Marketplace, and Morning Edition.
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