When a power-hungry computer magnate plots to take over the world, a motley band of rock stars, misfits, and a mysterious blues musician with superhuman technical skills may become Earth's only defense.
A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.” —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.
Recombinant Poxviruses provides a comprehensive examination of poxviruses with an emphasis on the potential of these viruses as new vaccines. The book considers a wide range of issues involved in producing new genetically engineered live vaccines, such as efficacy, safety, stability, cost, host range, immune response, immunization route, use of multivalent vaccines, and need for revaccination. The opening chapter describes the origin of vaccinia virus, its use to eradicate smallpox, and the pathogenesis of poxvirus infections. Subsequent chapters examine the molecular biology of poxviruses, methods of constructing vaccinia virus recombinants, and applications; the use and immune responses induced by poxvirus recombinants as live vaccines; and the important issues of the safety and immunogenicity of vaccinia virus. The book's final two chapters report the progress that has been made developing avipoxviruses and parapoxviruses as candidate recombinant vaccines. Recombinant Poxviruses will be a welcome addition to the bookshelves of virologists, microbiologists, infectious disease specialists, and veterinarians.
Northern Australia is one of few tropical places left on Earth in which biodiversity—and the ecological processes underpinning that biodiversity—is still relatively intact. However, scientific knowledge of that biodiversity is still in its infancy and the region remains a frontier for biological discovery. The butterfly and diurnal moth assemblages of the area, and their intimate associations with vascular plants (and sometimes ants), exemplify these points. However, the opportunity to fill knowledge gaps is quickly closing: proposals for substantial development and exploitation of Australia’s north will inevitably repeat the ecological devastation that has occurred in temperate southern Australia—loss of species, loss of ecological communities, fragmentation of populations, disruption of healthy ecosystem function and so on—all of which will diminish the value of the natural heritage of the region before it is fully understood and appreciated. Written by several experts in the field, the main purpose of this atlas is to compile a comprehensive inventory of the butterflies and diurnal moths of northern Australia to form the scientific baseline against which the extent and direction of change can be assessed in the future. Such information will also assist in identifying the region’s biological assets, to inform policy and management agencies and to set priorities for biodiversity conservation.
The Oxford Textbook of Infectious Disease Control: A Geographical Analysis from Medieval Quarantine to Global Eradication is a comprehensive analysis of spatial theory and the practical methods used to prevent the geographical spread of communicable diseases in humans. Drawing on current and historical examples spanning seven centuries from across the globe, this indispensable volume demonstrates how to mitigate the public health impact of infections in disease hotspots and prevent the propagation of infection from such hotspots into other geographical locations. Containing case studies of longstanding global killers such as influenza, measles and poliomyelitis, through to newly emerged diseases like SARS and highly pathogenic avian influenza in humans, this book integrates theory, data and spatial analysis and locates these quantitative analyses in the context of global demographic and health policy change. Beautifully illustrated with over 100 original maps and diagrams to aid understanding and assimilation, in six sections the authors examine surveillance, quarantine, vaccination, and forecasting for disease control. The discussion covers theoretical approaches, techniques and systems central to mitigating disease spread, and methods that deliver practical disease control. Essential information is also provided on the geographical eradication of diseases, including the design of early warning systems that detect the geographical spread of epidemics, enabling students and practitioners to design spatially-targeted control strategies. Despite the early hope of eradication of many communicable diseases after the global eradication of smallpox by 1979, the world is still working at the control and elimination of the spatial spread of newly-emerging and resurgent infectious diseases. Learning from past examples and incorporating modern surveillance and reporting techniques that are used to design value-for-money spatially-targeted interventions to protect public health, the Oxford Textbook of Infectious Disease Control is an essential resource for all those working in, or studying ways to control the spread of communicable diseases between humans in a timely and cost-effective manner. It is ideal for specialists and students in infectious disease control as well as those in the medical sciences, epidemiology, demography, public health, geography, and medical history.
The euphoria about the defeat of epidemics which surrounded the global eradication of smallpox in the 1970s proved short-lived. The advent of AIDS in the following decade, the widening spectrum of other newly-emergent diseases (from Ebola to Hanta virus), and the resurgence of old diseases such as tuberculosis and malaria all suggest that the threa
The doctrine of glorification is a biblical teaching that has been neglected within the Protestant church and, therefore, underdeveloped in our day. For whatever reason that may be, glorification is a doctrine that will affect every aspect of one's overarching theology, especially the doctrine of soteriology. What one ultimately believes about the future will significantly impact their present. This book shows that this neglect or lack of development has not always been the case within the church, especially within Reformed Protestantism. Looking at one of the most influential second-generation reformers and theologians of the English Reformation, William Perkins (1558-1602), it becomes evident that embedded within the Reformed Scholastic tradition lays a robust development and understanding of the doctrine of glorification. Perkins formulated and wrote a great deal on the final state of the believer in Christ, what his rewards are in Christ, and, ultimately, his complete and final transformation and conformity into his image. This book is a historical and systematic treatment of William Perkins's celebrated hope, eschatological glory.
Edmund Calamy (1600-1666) was a Reformed Presbyterian preacher of the Gospel and one of the distinguished members of the Westminster Assembly. He was active to promote Reformed Theology in his day and was an eminent scholar of the Bible. In this wonderful treatise on godly meditation, Calamy shows that meditation on holy and heavenly things is a work that God requires at the hands of all His people. God requires Christians to pray, read Scripture, study and also requires them to meditate. God requires them to hear sermons, and still, requires them to meditate on the sermons they hear. What good is learning anything without chewing and thinking about it? Yet, there are few Christians who believe this doctrine, and it is all but lost today. In contrast, meditation is to be a regular part of the daily private devotions of the Christian. Meditation cultivates seriousness in the Christian for life and godliness. The highest seriousness makes the best scholar, and consequently, the best Christian. This is a searching and scanning, a deep dive into the things of God. Calamy teaches that meditating on godly truth is not something done once and forgotten; it is something done regularly and daily. It places the mind and will under the influence of the Spirit, and it helps them to avoid sin and glorify Christ. Many make excuses not to meditate because it is difficult. Some neglect it totally, and yet others may have simply never learned to do it rightly. There is a right way and wrong way to meditate or think on these high thoughts of the Lord. Serious thinking is fundamental to all right doing before Jesus Christ. One cannot be subject to Christ if one does not know or understand the will of Christ. To meditate in a godly manner, then, is to think like a Christian. This work is not a scan or facsimile, has been carefully transcribed by hand being made easy to read in modern English, and has an active table of contents for electronic versions.
It is a commonly held belief that medieval Catholics were focussed on the 'bells and whistles' of religious practices, the smoke, images, sights and sounds that dazzled pre-modern churchgoers. Protestantism, in contrast, has been cast as Catholicism's austere, intellective and less sensual rival sibling. With iis white-washed walls, lack of incense (and often music) Protestantism worship emphasised preaching and scripture, making the new religion a drab and disengaged sensual experience. In order to challenge such entrenched assumptions, this book examines Tudor views on the senses to create a new lens through which to explore the English Reformation. Divided into two sections, the book begins with an examination of pre-Reformation beliefs and practices, establishing intellectual views on the senses in fifteenth-century England, and situating them within their contemporary philosophical and cultural tensions. Having established the parameters for the role of sense before the Reformation, the second half of the book mirrors these concerns in the post-1520 world, looking at how, and to what degree, the relationship between religious practices and sensation changed as a result of the Reformation. By taking this long-term, binary approach, the study is able to tackle fundamental questions regarding the role of the senses in late-medieval and early modern English Christianity. By looking at what English men and women thought about sight, hearing, smell, taste and touch, the stereotype that Protestantism was not sensual, and that Catholicism was overly sensualised is wholly undermined. Through this examination of how worship was transformed in its textual and liturgical forms, the book illustrates how English religion sought to reflect changing ideas surrounding the senses and their place in religious life. Worship had to be 'sensible', and following how reformers and their opponents built liturgy around experience of the sacred through the physical allows us to tease out the tensions and pressures which shaped religious reform.
Using over 300 new maps, charts, photographs and associated text, this full-colour Atlas views a century of change in Britain's epidemic landscape. It maps and interprets the retreat of some infectious diseases, the emergence of new infections and the re-emergence of certain historical plagues.
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