What makes the study of aging particularly challenging is the wide spectrum of phenotypical changes that can be observed during its progression. While initial attention was paid to damage accumulation, dysfunction, and failure, it is now realized that aging, and associated diseases including dementias, are influenced by a multitude of interacting factors. Proximal mechanisms beyond passive accumulation of damage include regulatory mechanisms, stress responses, changes in networks, as well as genetic and stochastic effects. The application of computational systems biology in aging, which is in line with other attempts to overcome the study of isolated or compartmentalized mechanisms, has made initial progress allowing us to simulate partial aspects of the aging dynamics and to make new hypotheses about how these aging mechanism shape disease progression. Here we provide examples for analysis of networks, regulatory mechanisms, and spatiotemporal effects in the study of proximal mechanisms of aging and Parkinson’s Disease. In addition, we introduce complexity theories that may contribute to explain the ultimate causes of aging with an evolutionary view.
Sub-Saharan Africa has achieved significant gains in reducing the levels of extreme poverty in recent decades, yet the region continues to experience challenges across the development indicators, including energy access, literacy, delivery of services and goods, and jobs skills, as well as low levels of foreign direct investment. Exacerbating the difficulties faced by many countries are the sequelae of conflict, such as internal displacement and refugee migration. Social Contracts for Development: Bargaining, Contention, and Social Inclusion in Sub-Saharan Africa builds on recent World Bank attention to the real-life social and political economy factors that underlie the power dynamic and determine the selection and implementation of policies. Applying a social contract approach to development policy, the authors provide a framework and proposals on how to measure such a framework to strengthen policy and operational engagements in the region. The key message is that Africa’s progress toward shared prosperity requires looking beyond technical policies to understand how the power dynamics and citizen-state relations shape the menu of implementable reforms. A social contract lens can help diagnose constraints, explain outbreaks of unrest, and identify opportunities for improving outcomes. Social contract assessments can leverage the research on the nexus of politics, power relations, and development outcomes, while bringing into focus the instruments that underpin state-society relations and foster citizen voice. Social contracts also speak directly to many contemporary development trends, such as the policy-implementation gap, the diagnostic of binding constraints to development, fragility and conflict, taxation and service delivery, and social protection. The authors argue that policies that reflect the demands and expectations of the people lead to more stable and equitable outcomes than those that do not. Their focus is on how social contracts are forged in the region, how they change and why, and how a better understanding of social contracts can inform reform efforts. The analysis includes the additional impact of the COVID-19 (coronavirus) pandemic on government-citizen relationships.
The Systems Biology of Parkinson’s Disease will be underpinned by new measurement techniques. This is particularly true of the pathology of Parkinson's Disease, where recent developments in brain imaging have offered new insights into the morphology of dopaminergic neurons that have profound implications for the special vulnerability and role of this class of neurons.
Highlighting the theory and basic principles of metabolic engineering, cell biochemical kinetics, and cell metabolism, Applied Metabolic Engineering focuses on the various approaches of metabolic engineering to help professionals, academic researchers, and students better understand and describe cell biology and the modeling of the control of cell metabolism to solve real world problems. The text provides exercises, examples, and case studies showing the wide potential of applying metabolic engineering, with emphasis being placed in the various fields which can benefit from applying a metabolic engineering approach.
Sub-Saharan Africa has achieved significant gains in reducing the levels of extreme poverty in recent decades, yet the region continues to experience challenges across the development indicators, including energy access, literacy, delivery of services and goods, and jobs skills, as well as low levels of foreign direct investment. Exacerbating the difficulties faced by many countries are the sequelae of conflict, such as internal displacement and refugee migration. Social Contracts for Development: Bargaining, Contention, and Social Inclusion in Sub-Saharan Africa builds on recent World Bank attention to the real-life social and political economy factors that underlie the power dynamic and determine the selection and implementation of policies. Applying a social contract approach to development policy, the authors provide a framework and proposals on how to measure such a framework to strengthen policy and operational engagements in the region. The key message is that Africa’s progress toward shared prosperity requires looking beyond technical policies to understand how the power dynamics and citizen-state relations shape the menu of implementable reforms. A social contract lens can help diagnose constraints, explain outbreaks of unrest, and identify opportunities for improving outcomes. Social contract assessments can leverage the research on the nexus of politics, power relations, and development outcomes, while bringing into focus the instruments that underpin state-society relations and foster citizen voice. Social contracts also speak directly to many contemporary development trends, such as the policy-implementation gap, the diagnostic of binding constraints to development, fragility and conflict, taxation and service delivery, and social protection. The authors argue that policies that reflect the demands and expectations of the people lead to more stable and equitable outcomes than those that do not. Their focus is on how social contracts are forged in the region, how they change and why, and how a better understanding of social contracts can inform reform efforts. The analysis includes the additional impact of the COVID-19 (coronavirus) pandemic on government-citizen relationships.
What makes the study of aging particularly challenging is the wide spectrum of phenotypical changes that can be observed during its progression. While initial attention was paid to damage accumulation, dysfunction, and failure, it is now realized that aging, and associated diseases including dementias, are influenced by a multitude of interacting factors. Proximal mechanisms beyond passive accumulation of damage include regulatory mechanisms, stress responses, changes in networks, as well as genetic and stochastic effects. The application of computational systems biology in aging, which is in line with other attempts to overcome the study of isolated or compartmentalized mechanisms, has made initial progress allowing us to simulate partial aspects of the aging dynamics and to make new hypotheses about how these aging mechanism shape disease progression. Here we provide examples for analysis of networks, regulatory mechanisms, and spatiotemporal effects in the study of proximal mechanisms of aging and Parkinson’s Disease. In addition, we introduce complexity theories that may contribute to explain the ultimate causes of aging with an evolutionary view.
This book examines emerging forms of governance in the Arctic region, exploring how different types of state and non-state actors promote and support rules and standards. The authors argue that confining our understandings of Arctic governance to Arctic states and a focus on the Arctic Council as the primary site of circumpolar governance provides an incomplete picture. Instead, they embrace the complexity of governance in the Arctic by systematically analyzing and comparing the position, interventions, and influence of different actor groups seeking to shape Arctic political and economic outcomes in multiple sites of Arctic politics, both formal and informal. This book assesses the potential that sub-national governments, corporations, civil society organizations, Indigenous peoples, and non-Arctic states possess to develop norms and standards to ensure a stable, rule-based Arctic region. It will be of interest to all scholars and students working in the fields of Arctic Sovereignty, Security Studies, Global Governance, and International Political Economy.
With insider tips, sample itineraries, and images from one of Canada's foremost photographers, this exquisite book brings you the best of Québec, providing expert travel inspiration that will help you craft your own amazing journey. This extraordinary visual tour leads you through five regions of Québec, from cosmopolitan cities to picturesque countryside to rugged wilderness. Dazzing images by award-winning photographer Mathieu Dupuis are accompanied by practical travel itineraries and tips from the locals, as well as fascinating information about each region's geography, history, and culture. These colorful pages will inspire you to explore Old Québec's 17th century fortress, soak up the culture and nightlife of bustling Montreal, skim the Laurentian Massif by floatplane, ski Mount Tremblant, or commune with wildlife on Bonaventure Island. Informative and inspiring, this compelling guide celebrates Québec's well-known treasures -- and takes you off the beaten path to explore the best kept secrets of this beautiful province.
This book documents how the Arctic region has been represented in the media: exploring how the media has framed the Arctic and whether this has an impact on governmental decision-making and public preferences. The Arctic region faces profound transformations, due to global warming, spurring intense debates about economic growth, environmental protection, and socio-cultural development. At the same time, most of humanity will never come face-to-face with the realities of the region: the media represents our only opportunity to learn about what this evolving region stands for. Recognizing that media coverage will tend to focus on specific events and relay specific messages, this book scrutinizes the nature of these messages to figure out how the Arctic region is presented by different media outlets. Studying different types of media, Landriault conducts an analysis of 628 newspaper articles, 110 televised reports, 9 magazine articles, and 404 tweets to provide the first systematic and rigorous study of Arctic media representations. This book will interest scholars, practitioners, and students in Arctic studies, critical geography, political science, and communication studies.
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