Conococheague and Potomac Streets, Doubleday Hill, Springfield Farm, the C&O Canalthese names conjure up images of Williamsport, Maryland. The first settlement in what was to become Washington County was located here in the heart of the Cumberland Valley in the late 1730s. This small trading post, set amid local Native American tribes, formed the basis of the town of Williamsport. Gen. Otho Holland Williams, a Revolutionary War hero from the region, laid out what he intended to be a grand city with wide avenues on the banks of the great and mighty Potomac. Upon hearing that George Washington favored a site along the Potomac for the new nations capital, Williams persuaded Washington to visit his town, and Williams Port was given due consideration as a possible location. Williamsport became an important stopping-off point for settlers heading west, and the town quickly grew to be the second largest in Washington County. The arrival of the Chesapeake and Ohio Canal in 1834 brought a boom to Williamsport as warehouses, shipping firms, and many other businesses were established to handle the increased population and trade. The Civil War, the arrival of the railroad, and a series of disastrous floods also impacted the town. Today, Williamsport is a quiet community rich with local history and flavor.
In the heart of the Cumberland Valley, between the Blue Ridge and Allegheny Mountains, lies Washington Countysite of one of the nations oldest settlements dating back to 1737. Its location between Pennsylvania and West Virginia places this county at the crossroads of history and commerce. Washington County celebrates the birth and survival of a place and its people over centuries and mirrors the growth of our nation. American history comes alive in this region created independent of Frederick County in 1776, named for Gen. George Washington, and settled by English, French, Swiss, German, and Scottish settlers. Forgotten images of historic mills and bridges will allow readers to journey to the past. Remember the days of the C&O Canal and a way of life that has disappeared forever. Visit historic sites such as Fort Frederick and the first monument to honor George Washington. Relive the heyday of Pen Mar Park and enjoy the waters of Belinda Springs. Feel the effects that the Civil War, the Battle of Antietam, the National Road, and the coming of the railroad all had on this remarkable area years ago.
Eel Pot, Buffalo Wallows, Coxson Rest, Tankerville, Hawkins Merry-Peep-O-Day, Berlinreaders might not recognize a few of the names the area now known as Brunswick went by in years past. Brunswick, Maryland, just six miles by towpath from historic Harpers Ferry, West Virginia, is rich in history. The area holds Civil War importance and served as a supply depot for the Union army after the Battle of Antietam. Primarily known as a canal town until the late 1800s, the town became an important rail center when the Baltimore and Ohio (B&O) Railroad came to town and set up huge rail operations. Today the town sits on the now-quiet banks of the Chesapeake and Ohio (C&O) Canal, and the train whistles dont sound quite so often, but this community continues to draw visitors seeking history, outdoor recreation, and small-town charm.
Hagerstown has undergone a great deal of change since Jonathan Hager first bought Hagers Fancy in 1739. Changes were wrought by the Civil War, the railroads, and the pioneer settlers themselves. Many historic structures still stand today as a testament to the towns storied past, but growth has also brought inevitable changes. Author and longtime Hagerstown resident Mary H. Rubin shows the dramatic changes as well as places that retain their sense of history using vintage images from the Washington County Free Librarys Western Maryland Room.
From the fights of founding fathers to those fought in the supreme court, the pivotal role of this unassuming canal comes to life with historic images and insider insights. With the founding of his Patowmack Company in 1785, George Washington first hoped to make the Potomac River a viable route to America's West. The skirting canals the company constructed around the Great Falls rapids at Harpers Ferry, Seneca, and Little Falls made the Potomac's rushing waters navigable. The Chesapeake and Ohio Canal Company was chartered by Maryland, Virginia, and Pennsylvania in 1828 to build a truly useful canal through to the Ohio Valley. President John Quincy Adams turned the first spadeful of dirt on Independence Day of 1828 for what was hailed as the "Great National Project" to connect Georgetown to Pittsburgh, Pennsylvania. The canal created an entire community of people and a way of life different from any other. At the height of operations, over 500 boats plied the 184.5 miles of the canal's waters. After many financial difficulties, competition from railroads, and the devastating effects of the Civil War as well as a flood, the canal went into receivership and was closed in 1924. In 1954, Supreme Court Justice William O. Douglas brought attention back to the canal with a fight to preserve the natural beauty for local residents. Today, the canal-listed as a National Historical Park-provides thousands with recreational opportunities, scenic nature trails, and gorgeous views.
An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.
The 7th edition of Management is once again a resource at the leading edge of thinking and research. By blending theory with stimulating, pertinent case studies and innovative practices, Robbins encourages students to get excited about the possibilities of a career in management. Developing the managerial skills essential for success in business—by understanding and applying management theories--is made easy with fresh new case studies and a completely revised suite of teaching and learning resources available with this text.
Mary Ellen Ashcroft invites women to learn who God has created them to be and what he has called them to do with their lives. She offers a unifying vision in which family, career and service all find their proper places.
The life story of a woman who refused to accept life in one of the traditional roles assigned to Black women profiles her background on a poor North Carolina farm and chronicles her road to success
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