An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.
The papers in this collection are the product of the conference "Hittites, Greeks and Their Neighbors in Ancient Anatolia: An International Conference on Cross-Cultural Interaction," hosted by Emory University in Atlanta, Georgia. They cover an impressive range of issues relating to the complex cultural interactions that took place on Anatolian soil over the course of two millennia, in the process highlighting the difficulties inherent in studying societies that are multi-cultural in their make-up and outlook, as well as the role that cultural identity played in shaping those interactions. Topics include possible sources of tension along the Mycenaean-Anatolian interface; the transmission of mythological and religious elements between cultures; the change across time and space in literary motifs as they are adapted to new milieus and new audiences; the ways in which linguistic data can refine our understanding of the interrelations between the various peoples who lived in Anatolia; and the role that the Anatolian kingdoms of the first millennium played as cultural filters and conduits through which North Syrian or Near Eastern ideas or materials were transmitted to the Greeks.
Select nursing interventions with the book that standardizes nursing language! Nursing Interventions Classification (NIC), 8th Edition provides a research-based clinical tool to help you choose appropriate interventions. It standardizes and defines the knowledge base for nursing practice as it communicates the nature of nursing. More than 610 nursing interventions are described — from general practice to all specialty areas. From an expert author team led by Cheryl Wagner, this book is an ideal tool for practicing nurses and nursing students, educators seeking to enhance nursing curricula, and nursing administrators seeking to improve patient care. It's the only comprehensive taxonomy of nursing-sensitive interventions available! - 614 research-based nursing intervention labels — with 60 new to this edition — are included, along with specific activities used to carry out interventions. - Specialty core interventions are provided for 57 specialties. - Descriptions of each intervention include a definition, a list of activities, a publication facts line, and references. - NEW! 60 interventions are added to this edition, including several related to the care of patients with COVID considerations. - UPDATED! Approximately 220 existing interventions have been revised.
Historian and civil rights activist proves how progressive movements can flourish even in conservative times. Despair and mourning after the election of an antagonistic or polarizing president, such as Donald Trump, is part of the push-pull of American politics. But in this incisive book, historian Mary Frances Berry shows that resistance to presidential administrations has led to positive change and the defeat of outrageous proposals, even in challenging times. Noting that all presidents, including ones considered progressive, sometimes require massive organization to affect policy decisions, Berry cites Indigenous peoples’ protests against the Dakota pipeline during Barack Obama’s administration as a modern example of successful resistance built on earlier actions. Beginning with Franklin D. Roosevelt, Berry discusses that president’s refusal to prevent race discrimination in the defense industry during World War II and the subsequent March on Washington movement. She analyzes Lyndon Johnson, the war in Vietnam, and the antiwar movement and then examines Ronald Reagan’s two terms, which offer stories of opposition to reactionary policies, such as ignoring the AIDS crisis and retreating on racial progress, to show how resistance can succeed. The prochoice protests during the George H. W. Bush administration and the opposition to Bill Clinton’s “Don’t Ask, Don’t Tell” policy, as well as his budget cuts and welfare reform, are also discussed, as are protests against the war in Iraq and the Patriot Act during George W. Bush’s presidency. Throughout these varied examples, Berry underscores that even when resistance doesn’t achieve all the goals of a particular movement, it often plants a seed that comes to fruition later. Berry also shares experiences from her six decades as an activist in various movements, including protesting the Vietnam War and advocating for the Free South Africa and civil rights movements, which provides an additional layer of insight from someone who was there. And as a result of having served in five presidential administrations, Berry brings an insider’s knowledge of government. History Teaches Us to Resist is an essential book for our times which attests to the power of resistance. It proves to us through myriad historical examples that protest is an essential ingredient of politics, and that progressive movements can and will flourish, even in perilous times.
Chemical Induction of Cancer: Structural Bases and Biological Mechanisms Volume IIB deals with the organic and biochemical principles behind cancer. This volume includes Part III of the work, which covers structure-activity relationships of chemical carcinogens, the effect of chemical reactivity, molecular geometry, and metabolism on carcinogenic activity. Under this is Chapter 5, which tackles conjugated aromatic systems. The text is recommended for doctors, organic chemists, and biochemists with an advanced knowledge in biochemistry and organic chemistry and would like to know more the biochemical processes of cancer.
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