An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.
Musculoskeletal Disorders Hands-on guidance and tools for the prevention of musculoskeletal injuries in the workplace In Musculoskeletal Disorders: The Fatigue Failure Mechanism, a team of accomplished occupational health experts delivers an essential and incisive discussion of how musculoskeletal disorders (MSDs) develop and progress, as well as how they can be prevented and controlled. Offering a novel, evidence-based approach to this costly problem, the book has broad implications for employers, insurers, and other stakeholders in workplace health and safety. The authors identify new risk assessment approaches based on the cumulative effects of exposure to highly variable loading conditions. These new approaches can also be applied to evaluate the efficacy of job rotation scenarios and to quantify exoskeleton efficacy. The complexities associated with fatigue failure in biological environments are also explored in addition to suggested models for understanding how the body maintains musculoskeletal homeostasis. Readers will also find: Thorough introductions to the material properties of musculoskeletal tissues and the fundamental principles of fatigue failure analysis In-depth explorations of the structure and function of the musculoskeletal system and up-to-date epidemiological research on MSDs Comprehensive discussions of validated fatigue failure risk assessment methods, including continuous exposure assessment to better quantify injury risk Insightful treatments of remodeling and healing processes as they apply to MSD risk, as well as factors that impair the healing process, like stress, obesity, and aging Perfect for occupational and environmental health and safety (OEHS) professionals, Musculoskeletal Disorders: The Fatigue Failure Mechanism will also earn a place in the libraries of ergonomists, physical therapists, biomechanists, industrial hygienists, occupational physicians, orthopedists, and musculoskeletal disorder researchers.
This is the story of Reverend Roosevelt Matthews and his beloved wife, Mary, whose work saved many in one of the poorest and most dangerous neighborhoods on Chicago's West Side. But as Roosevelt emphasizes, it's not his story but God's story. In 1952, Roosevelt and Mary came to Chicago from Rolling Fork, Mississippi, as part of the Great Migration of six million Southern Blacks. Shortly after they married, Mary became a sixth-grade Chicago Public School teacher at Faraday Elementary where she taught for thirty years. With his teaching degree and certificate in hand, Roosevelt headed out to the Chicago Board of Education to be assigned the school he would teach in. But God had other ideas. As he walked down his front steps, he saw troubled youth in the street where gangs and drugs were prevalent. He suddenly came to an abrupt halt; struck with the Lord's call to help these young people. Forging a career as a schoolteacher, Roosevelt founded the Albany Youth Center and Albany Baptist Church, which he and Mary ran for the next forty-five years. As one youth center attendee stated, "The gangs in the area did not bother the kids who attended the youth center. They respected the efforts of Reverend Matthews and his wife to make the life of those kids better." With the violence and racism in our country today, the work of Roosevelt and Mary is a big part of the solution. This book documents the "But God" moments where the Lord provided their needs: But God, when Roosevelt went to buy a defunct factory as a place to put his youth center's outdoor basketball court, the owner looked him in the face and said, "I'd rather burn the factory down than sell it to an N-word". A few months later, Dr. King was assassinated and in the resulting riots the factory was burned to the ground. The factory then became property of the City of Chicago and sold to Roosevelt for a much lower price. But God, teaching Interracial friendship by living in each other's homes, Roosevelt established the Friendship Outreach program between white churches and Albany Baptist Church in 1972. White children came to live with Black families on Chicago's West Side and vice versa. In 2018, one of the original exchange students from Minnesota returned to Albany Church with her own children, continuing this wonderful long-term friendship. But God, Mary got the smooth transition she prayed for after being diagnosed with ovarian cancer. She never suffered from the ravages of the disease. Looking as beautiful as ever, she played piano in church just three days before she passed from her beloved Roosevelt's loving arms to God's kingdom. But God, as Roosevelt said, "The Lord directed such fine people to help us along the way". One was "Mother" Vera Stephens, who taught Roosevelt and Mary child evangelism. Vera later felt the call to go to Liberia, where she established the Bethesda Christian Mission School that is still inspiring the lives of many children today. In 2011, "Mother" Stephens was posthumously honored for her work by both the president and vice president of Liberia. But God, while Mary and Roosevelt were not able to have biological children, many former pupils, attributing much of their success to "Mom" and "Dad," still call, send letters, and emails. Several have become Bible teachers and ministers themselves while others include a college president and a corporate executive.
The book was written to assist those who plan to work as student affairs educators soon and those who are new student affairs educators to become competent in social justice and inclusion. It will provide trainees and new student affairs educators not only content knowledge and skills but also strategies and ways to develop competency in social justice and inclusion. Twenty-six additional individuals consist of both scholars/researchers and practitioners who have authored the book chapters. Through their writing these experts have offered their first-hand experiences and wisdom for being a competent student affairs educator in higher education. It will provide the reader with an understanding of multicultural competency and professional identity in student affairs practice, an opportunity to develop a professional identity that centers on social justice, a comprehension of historical development of multiculturalism and diversity in student affairs practice, knowledge of multicultural theory and its application, an understanding of ethical and legal issues from a multiculturalism, diversity, and social justice perspective, knowledge of culturally appropriate intervention strategies in practice, and understanding of evidence-based practice in student affairs. Moreover, this book will offer the reader knowledge and skills in utilizing theory, research, and assessment to enhance practice, forming professional identity through social justice and inclusion, and on how to create a social justice and inclusive environment for minoritized students and students with special needs. Finally, the book teaches the reader how to work with minoritized students and students with special needs.
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