After thirty years, PPID is still the reference of choice for comprehensive, global guidance on diagnosing and treating the most challenging infectious diseases. Drs. Mandell, Bennett, and Dolin have substantially revised and meticulously updated, this new edition to save you time and to ensure you have the latest clinical and scientific knowledge at your fingertips. With new chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 7th Edition helps you identify and treat whatever infectious disease you see. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Get the answers to questions you have with more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than you’ll find in any other infectious disease resource. Find the latest diagnoses and treatments for currently recognized and newly emerging infectious diseases, such as those caused by avian and swine influenza viruses. Put the latest knowledge to work in your practice with new or completely revised chapters on influenza (new pandemic strains); new Middle East respiratory syndrome (MERS) virus; probiotics; antibiotics for resistant bacteria; antifungal drugs; new antivirals for hepatitis B and C; Clostridium difficile treatment; sepsis; advances in HIV prevention and treatment; viral gastroenteritis; Lyme disease; Helicobacter pylori; malaria; infections in immunocompromised hosts; immunization (new vaccines and new recommendations); and microbiome. Benefit from fresh perspectives and global insights from an expanded team of international contributors. Find and grasp the information you need easily and rapidly with newly added chapter summaries. These bulleted templates include diagnosis, therapy, and prevention and are designed as a quick summary of the chapter and to enhance relevancy in search and retrieval on Expert Consult. Stay current on Expert Consult with a thorough and regularly scheduled update program that ensures access to new developments in the field, advances in therapy, and timely information. Access the information you need easily and rapidly with new succinct chapter summaries that include diagnosis, therapy, and prevention. Experience clinical scenarios with vivid clarity through a richly illustrated, full-color format that includes 1500 photographs for enhanced visual guidance.
This text examines the relationship between DNA damage and repair, cellular senescence, genomic instability, and aging. The authors provide in-depth discussions of various types of DNA damage, the DNA repair network, and cellular responses to genetic damage to assess their impact on the modulation of aging processes and age-related diseases, including cancer development. Chromosomal Instability and Aging describes cloning genes for human chromosomal instability disorders, the causal factors and consequences of chromosomal injury, the telomere hypothesis of aging, and age-dependant mitochondrial genetic instability. It includes more than 2200 references to facilitate further research, making it an informative and timely guide.
This book covers competing risks and multistate models, sometimes summarized as event history analysis. These models generalize the analysis of time to a single event (survival analysis) to analysing the timing of distinct terminal events (competing risks) and possible intermediate events (multistate models). Both R and multistate methods are promoted with a focus on nonparametric methods.
Discover New Methods for Dealing with High-Dimensional DataA sparse statistical model has only a small number of nonzero parameters or weights; therefore, it is much easier to estimate and interpret than a dense model. Statistical Learning with Sparsity: The Lasso and Generalizations presents methods that exploit sparsity to help recover the underl
Presenting simple and cost-effective solutions for maintaining and improving mealtime abilities, this book discusses the practical aspects of eating and drinking as part of person-centred dementia care. Due to cognitive decline, changes in mealtime abilities can lead to malnutrition and related issues for people with dementia, alongside feelings of powerlessness and isolation. This research-informed book explains how to make the most of mealtimes for increased nutritional intake, socialising, and food enjoyment, in a range of care settings. The book covers topics such as the physical act of eating and drinking, creating a comfortable and friendly dining environment, using appropriate tableware, and dealing with common issues such as problems with swallowing and choking.
The only text to cover lung function assessment from first principles including methodology, reference values and interpretation New for this edition: - More illustrations to convey concepts clearly to the busy physician - Text completely re-written in a contemporary style: includes user-friendly equations and more diagrams - New material covering the latest advances in the treatment of lung function, including more on sleep-related disorders, a stronger clinical and practical bias and more on new techniques and equipment - Uses the standard Vancouver referencing system What the experts say: "I have always considered Dr Cotes' book the most authoritative book published on lung function. It is also the most comprehensive." —Dr Robert Crapo, Pulmonary Division, LDS Hospital, Salt Lake City, USA "I think I can fairly speak on behalf of staff in lung function departments the length and breadth of the country - that a sixth edition of Cotes would be gratefully received." —Dr Brendan Cooper, Clinical Respiratory Scientist, Nottingham City Hospital
A New Approach to Sound Statistical ReasoningInferential Models: Reasoning with Uncertainty introduces the authors' recently developed approach to inference: the inferential model (IM) framework. This logical framework for exact probabilistic inference does not require the user to input prior information. The authors show how an IM produces meaning
In this concise but authoritative book, the authors take the reader through the epidemiology, risk factors and the basic mechanism of coronary artery disease. In addition, they explain how coronary microvascular dysfunction can lead to angina, even after successful angioplasty following a heart attack. The methods for diagnosis and the options for treatment are explained, ending with a discussion of the evolution of coronary angioplasty from balloon catheters to novel, fully resorbable polymeric drug eluting stents. Enclosed is a list of currently available commercial devices, as well as a listing of experimental products under research and development, so that readers can appreciate the serious nature of this disease and have an understanding of how the medical device sector is attempting to address this major healthcare problem. Globally in 2010, ischemic heart disease was the cause of 13.3% of all deaths. In the US alone, the direct medical costs from coronary artery disease and stroke are currently estimated to be $126 billion per year, and are expected to rise to $309 billion by 2035.
After thirty five years, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th Edition is still the reference of choice for comprehensive, global guidance on diagnosing and treating the most challenging infectious diseases. Drs. John E. Bennett and Raphael Dolin along with new editorial team member Dr. Martin Blaser have meticulously updated this latest edition to save you time and to ensure you have the latest clinical and scientific knowledge at your fingertips. With new chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th Edition helps you identify and treat whatever infectious disease you see. Get the answers to questions you have with more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than you'll find in any other infectious disease resource. Find the latest diagnoses and treatments for currently recognized and newly emerging infectious diseases, such as those caused by avian and swine influenza viruses. Put the latest knowledge to work in your practice with new or completely revised chapters on influenza (new pandemic strains); new Middle East respiratory syndrome (MERS) virus; probiotics; antibiotics for resistant bacteria; antifungal drugs; new antivirals for hepatitis B and C; Clostridium difficile treatment; sepsis; advances in HIV prevention and treatment; viral gastroenteritis; Lyme disease; Helicobacter pylori; malaria; infections in immunocompromised hosts; immunization (new vaccines and new recommendations); and microbiome. Benefit from fresh perspectives and global insights from an expanded team of international contributors. Find and grasp the information you need easily and rapidly with newly added chapter summaries. These bulleted templates include diagnosis, therapy, and prevention and are designed as a quick summary of the chapter and to enhance relevancy in search and retrieval on Expert Consult. Stay current on Expert Consult with a thorough and regularly scheduled update program that ensures access to new developments in the field, advances in therapy, and timely information. Access the information you need easily and rapidly with new succinct chapter summaries that include diagnosis, therapy, and prevention. Experience clinical scenarios with vivid clarity through a richly illustrated, full-color format that includes 1500 photographs for enhanced visual guidance.
The best-selling Samuels’s Manual of Neurologic Therapeutics is a practical, accessible handbook for the diagnosis and treatment of neurologic disorders. Completely updated to reflect the most recent developments in the field, the book features a concise, intuitive outline format that makes today’s best approaches easy to find and apply. Implement the current strategies to combat neurological diseases. Highlights include new pharmacologic and non-pharmacologic treatments for seizures; new molecular techniques and personalized approaches to neurologic cancers; new approaches for treating pain; the most recent intra-arterial therapies for acute stroke; and new treatments for neurologic infectious diseases. Manage benign autoimmune conditions with the aid of a new chapter that discusses diagnosis via serological testing as well as therapies involving immune modulation. Treat patients in resource-limited environments, thanks to a new chapter that focuses on cost-effective management options. Locate the information you need quickly through accessible and well-organized chapters and an outline format.
With a foreword by John T. Queenan, MD, Professor and Chair Emeritus of Obstetrics and Gynecology, Georgetown University School of Medicine, Washington. Fetal medicine has emerged as a separate subspecialty over the last 30 years as a result of major advances in a number of areas, in particular ultrasound imaging, cytogenetics, molecular biology and biochemistry. The widespread use of antenatal screening and diagnostic tests has led to an increased need for obstetricians to have knowledge and skills in fetal medicine. This book provides the information that underpins training programmes in fetal medicine and integrates science and clinical disciplines in a practical and useful way. Basic science sections provide clinicians with a vital introduction to the new language of science that will help them understand new and development treatment options. Clinical sections include: the latest advances in prenatal screening; a systems-based presentation of the diagnosis and management of fetal malformations; complete coverage of common and rare fetal conditions including growth restriction, endocrine and platelet disorders, early pregnancy loss, and twins/multiple pregnancy. Highly illustrated with over 500 ultrasound scans and line drawings. International team of expert contributors. Features new self-assessment section. Written by an international team of experts. Shorter, more focused on fetal medicine Clinical sections written in an up-to-date, problem-based style Case studies and vignettes to illustrate clinical points More focus on important basic-science concepts, such as maternofetal cell trafficking, and the relevance to clinical management Expansion of information on bereavement due to fetal loss New self-assessment section
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