This text examines the relationship between DNA damage and repair, cellular senescence, genomic instability, and aging. The authors provide in-depth discussions of various types of DNA damage, the DNA repair network, and cellular responses to genetic damage to assess their impact on the modulation of aging processes and age-related diseases, including cancer development. Chromosomal Instability and Aging describes cloning genes for human chromosomal instability disorders, the causal factors and consequences of chromosomal injury, the telomere hypothesis of aging, and age-dependant mitochondrial genetic instability. It includes more than 2200 references to facilitate further research, making it an informative and timely guide.
Apoptosis, or programmed cell death, is a necessary process by which a cell may die without adversely affecting its environment. It plays a crucial role in normal development, and in the body's defence mechanisms against disease. Too much cell death is destructive, leading to neurodegenerative diseases and impaired development. Conversely, too little cell death can lead to an increased susceptibility to cancer and sustained viral infection. Apoptosis is a matter of balance Dramatic progress has been made in the study of apoptosis over the past decade. One of the most rapidly expanding knowledge bases being established is on the molecular mechanisms controlled by a variety of gene products including Bcl-2, caspases, death receptors, and proteolytic targets, as well as the central role of the mitochondrion. The major challenge in apoptosis research is how the protein products involved operate in an intricate web of signaling pathways that also play a crucial role in cell proliferation and differentiation. This book concentrates on elucidating these signal transduction mechanisms, an area not properly reviewed by other apoptosis texts.
This book discusses the ways in which mathematical, computational, and modelling methods can be used to help understand the dynamics of intracellular calcium. The concentration of free intracellular calcium is vital for controlling a wide range of cellular processes, and is thus of great physiological importance. However, because of the complex ways in which the calcium concentration varies, it is also of great mathematical interest.This book presents the general modelling theory as well as a large number of specific case examples, to show how mathematical modelling can interact with experimental approaches, in an interdisciplinary and multifaceted approach to the study of an important physiological control mechanism. Geneviève Dupont is FNRS Research Director at the Unit of Theoretical Chronobiology of the Université Libre de Bruxelles; Martin Falcke is head of the Mathematical Cell Physiology group at the Max Delbrück Center for Molecular Medicine, Berlin; Vivien Kirk is an Associate Professor in the Department of Mathematics at the University of Auckland, New Zealand; James Sneyd is a Professor in the Department of Mathematics at The University of Auckland, New Zealand.
Food is an extraordinary expression of culture; the assortment of flavours, smells, colours and appearance match the diversity of the cultures from which they come and provide very visible evidence of the migration of populations and of the growing multiculturalism of many countries. Adam Lindgreen and Martin K. Hingley draw on research into European, Latin American and (Near and Far) Eastern markets to provide a comprehensive collection of original, cutting-edge research on the opportunities that the changing landscapes of ethnic, religious and cultural populations present for businesses and marketers. The New Cultures of Food uses the perspective of food culture to explore the role of food as a social agent and attitudes to new foodstuffs amongst indigenous populations and to indigenous food amongst immigrant communities. Opportunities and routes to market for exploiting growing demand for ethnic food are also investigated. This is an important book for food and consumer businesses, policy makers and researchers seeking to understand changing global markets and the significance of food as an indicator of social and religious attitude, diet and ethnic identity.
First observed by Galileo, Saturn lies in the distant reaches of the solar system; it is the sixth planet, a gaseous giant between Jupiter and Uranus. It takes its name from the mythological father of Jupiter and Roman god of agriculture. Because of the famous circle of rings Saturn is one of the most well-regarded occupants of the galaxy. Despite their continuous appearance from Earth, the rings are actually space dust and debris trapped by Saturn's gravitational pull, a fact garnered from several satellite passes and telescope observations. The origin of Saturn's rings, however, remains a mystery. Apart from the rings, we also are aware of its moon system, with the most intriguing planetoid called Titan, itself having been the subject of science fiction speculation as a home to life. Saturn has been visited by Pioneer 11 and the two Voyager probes, with Cassini slated to arrive in 2004. Our study of this most intriguing planet will continue into the foreseeable future, with the hopes of resolving the mysteries it hides. This book provides a thorough and interesting overview of Saturn, from its initial observation centuries ago to the contemporary satellite fly-bys. Anyone captivated by the mysteries of space and the wonders of Saturn needs to understand the background covered here. After the overview is a substantial and carefully selected set of abstracts of literature pertaining to Saturn, with easy access then given through author, title, and subject indexes.
For over half a century, food policy has mapped a path for progress based upon a belief that the right mix of investment, scientific input, and human skills could unleash a surge in productive capacity which would resolve humanity's food-related health and welfare problems. It assumed that more food would yield greater health and happiness by driving down prices, increasing availability, and feeding more mouths. In the 21st century, this policy mix is quietly becoming unstuck. In a world marred by obesity alongside malnutrition, climate change alongside fuel and energy crises, water stress alongside more mouths to feed, and social inequalities alongside unprecedented accumulation of wealth, the old rubric of food policy needs re-evaluation. This book explores the enormity of what the new policy mix must address, taking the approach that food policy must be inextricably linked with public health, environmental damage, and social inequalities to be effective. Written by three authors with differing backgrounds, one in political science, another in environmental health and health promotion, and the third in social psychology, this book reflects the myriad of perspectives essential to a comprehensive view of modern food policy. It attempts to make sense of what is meant by food policy; explores whether the term has any currency in current policy discourse; assesses whether current policies help or hinder what happens; judges whether consensus can triumph in the face of competing bids for understanding; looks at all levels of governance, across the range of actors in the food system, from companies and the state to civil society and science; considers what direction food policies are taking, not just in the UK but internationally; assesses who (and what) gains or loses in the making of these food policies; and identifies a modern framework for judging how good or limited processes of policy-making are. This book provides a major comprehensive review of current and past food policy, thinking and proposing the need for what the authors call an ecological public health approach to food policy. Nothing less will be fit for the 21st century.
It is the design of this book to preserve for the people of Franklin County an imperishable record of its early history — now existing only in scattering and detached papers and records, which are every year wasting away. To write the history of a single county, may to some appear like a very small business; while to others it is considered very desirable that someone should do so in every county. How else are the names and memory of our early settlers and friends to be preserved? And who is there that would not be pleased to look back, or to have his children look back, upon some record of his early days, and of departed friends? . It has been the writer's object in this compilation, to give a correct statement of all events worthy of remembrance, with their proper dates, so as to form a book of ready reference, such as will be convenient and interesting to all residents of the county.
First published in 1992. Martin Griffiths' book provides a reinterpretation of the terms 'realism' and 'idealism' in international relations, and a thorough critical examination of three key figures in international theory: Hane Morgenthau, Kenneth Waltz and Hedley Bull. This is an important book proving a compelling basis for conceiving international politics as a 'rule-governed' arena among states. It will be of great interest to scholars and students of international relations.
What has been the impact of the EU on UK central government? This book explores the ‘Europeanisation’ of the work of civil servants and ministers and how they engage with the EU. Drawing on fresh empirical evidence, the volume offers the first comprehensive analysis of the spreading impact of European integration across government. The study is placed in the context of political divisions over the EU but outlines the often neglected way in which the EU has transformed the business of government. It charts the process from the Macmillan government’s 1961 application to join the European Communities through to the end of Blair’s premiership. The book examines the character and timing of responses across government, covering the core government departments and also those more recently affected, such as the Ministry of Defence. The authors argue that central government has organized itself efficiently to deal with the demands of EU membership despite the often controversial party political divisions over Europe. However, in placing their findings in comparative context they conclude that the effectiveness of UK governments in the EU has been less striking.
For 25 years, Lewis's Child and Adolescent Psychiatry has been the cornerstone of every child and adolescent psychiatrist’s library. Now, three colleagues of Dr. Lewis at the world-renowned Yale Child Study Center, have substantially updated and revised this foundational textbook for its long-awaited fifth edition, the first in ten years. Encyclopedic in scope, it continues to serve as a broad reference, deftly encompassing and integrating scientific principles, research methodologies, and everyday clinical care.
Designed to overcome flaws during the planning and design stages of educational or training courses, this guide explains the importance of physical factors in the instructional environment, the roles of the instructor and learner, and the gathering of information on the learning environment.
Building upon the success of previous editions, this fully revised edition of Sociology lays the foundations for understanding sociology in Australia. The depth and breadth of the book ensures its value not only for first-year students, but for sociology majors requiring on-going reference to a range of theoretical perspectives and current debates. This fifth Australian edition continues to build on the book’s reputation for coverage, clarity and content, drawing upon the work of leading Australian sociologists as well as engaging with global social trends and sociological developments.
This book describes the development of astronomy in the Extreme Ultraviolet wavelength range, from the first rocket-based experiments to later satellite missions. It will be of great value to graduate students and researchers.
The invasive species Tamarix first attracted the public eye in the 1990's when it was suspected of contributing to widespread drought and wildfires in the Western United States. Once purported to consume as much water as entire cities, very few plant species have received as much scientific, public, and political discussion and debate as Tamarix. Written by 44 of the field's most prominent scholars and scientists, this volume compiles 25 essays on this fascinating species--its biology, ecology, politics, management, and the ethical issues involved with designating a particular species as "good" or "bad". The book analyzes the controversy surrounding the Tamarisk's role in our ecosystems and what should be done about it.
This PhD sought to determine the mechanisms for the reactor explosions by mapping, collecting and analysing samples from across the area of Japan that received radioactive fallout from the explosions. In doing this, the author conducted significant fieldwork in the restricted-access fallout zone using ground and novel UAV-based mapping of radiation to identify hot-spot areas for sample collecting but also using these tools to verify the efficacy of the clean-up operations ongoing in the prefecture. Such fieldwork was both technically pioneering for its use of UAVs (drones) but also selfless in terms of bravely entering a nuclear danger area to collect samples for the greater benefit of the scientific community.
From 1915 to 1935 the inventive community of social scientists at the University of Chicago pioneered empirical research and a variety of qualitative and quantitative methods, shaping the future of twentieth-century American sociology and related fields as well. Martin Bulmer's history of the Chicago school of sociology describes the university's role in creating research-based and publication-oriented graduate schools of social science. "This is an important piece of work on the history of sociology, but it is more than merely historical: Martin Bulmer's undertaking is also to explain why historical events occurred as they did, using potentially general theoretical ideas. He has studied what he sees as the period, from 1915 to 1935, when the 'Chicago School' most flourished, and defines the nature of its achievements and what made them possible . . . It is likely to become the indispensible historical source for its topic."—Jennifer Platt, Sociology
Selected as a Doody's Core Title for 2022! Defining the field of immunology for 40 years, Paul’s Fundamental Immunology continues to provide detailed, authoritative, up-to-date information that uniquely bridges the gap between basic immunology and the disease process. The fully revised 8th edition maintains the excellence established by Dr. William E. Paul, who passed away in 2015, and is now under new editorial leadership of Drs. Martin F. Flajnik, Nevil J. Singh, and Steven M. Holland. It’s an ideal reference and gold standard text for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role.
Globalisation is widely understood as a set of processes driven by technological, economic and cultural change. Few have successfully defined the changing character and role of politics in global change. Political institutions such as the nation-state have been seen as undermined by globalisation, or needing to respond to it. This book clarifies the tensions which global change has provoked in our understanding of politics. Politics and Globalisation suggests that globalisation is a process which is politically contested and even politically constituted. The volume presents five key intellectual and political contests in globalisation: · the extent and political significance of globalising changes in economy and society · how and how far the relations and forms of nation-state organisation are transformed · whether the given concepts and methods of political science as a discipline can be applied to global and regional politics, and whether they require radical reformulation; · the role and significance of ethical questions in global change · whether global change is constituted by, or denies, radical political agency
The rise of American geography as a distinctive science in the United States straddles the 19th and 20th centuries, extending from the post-Civil war period to 1970. American Geography and Geographers: Toward Geographic Science is the first book to thoroughly and richly explicate this history. Its author, Geoffrey J. Martin, the foremost historian on the subject and official archivist of the Association of American Geographers, amassed a wealth of primary sources from archives worldwide, which enable him to chart the evolution of American geography with unprecedented detail and context. From the initial influence of the German school to the emergence of Geography as a unique discipline in American universities and thereafter, Martin clarifies the what, how and when of each advancement. Expansive discussion of the arguments made, controversies ignited and research voyages move hand in hand with the principals who originated and animated them: Davis, Jefferson, Huntington, Bowman, Johnson, Sauer, Hartshorne, and many more. From their grasp of local, regional, global and cultural phenomena, geographers also played pivotal roles in world historical events, including the two world wars and their treaties, as the US became the dominant global power. American Geography and Geographers: Toward Geographical Science is a conclusive study of the birth and maturation of the science. It will be of interest to geographers, teachers and students of geography, and all those compelled by the story of American Geography and those who founded and developed it.
George Buchanan (1506-82) was one of the most distinguished humanists of the Northern European Renaissance. Hailed by his contemporaries as the greatest Latin poet of his age, he is chiefly remembered today as a radical political theorist whose Dialogus, first published in Edinburgh in 1579, justified the deposition of Mary, Queen of Scots in 1567 on the basis of a theory of popular sovereignty, which vested in the people the right to resist, depose and kill tyrannical monarchs. Immensely influential in radical circles both in Britain and on the Continent, it made a notable contribution to the debates over the nature and location of sovereignty which would finally bear fruit in the writings of John Locke. This critical edition and translation of the Dialogus makes available for the first time a modern scholarly version of one of the key texts in the history of early modern British political thought.
Tapping into selected works of Erasmus of Rotterdam, this book offers a series of philosophical meditations designed to retrieve and deploy a distinctively Erasmian manner of thinking - one that is capacious in its perception, agile in its judgments, and unsettling in its irony. In purpose, it takes a philosophical route, addressing perennial questions of self-knowledge - what we can know and how best to communicate what we take to be true, what we ought to do or how we should live, and what we might hope for or what would offer us fulfilment. In method, however, this work taps into the various strategies of irony at play in the works of Erasmus, looking for guidance in handling these age-old questions. What readers will find in Erasmus is a knack for playfully reversing appearances and realities, a penchant for pushing disturbing questions relentlessly to the limit, and a skill for juxtaposing oddly matched opposites. Again and again, Erasmus presses readers to rethink these fundamental questions with dexterity and nuance, ever ready to appreciate the surprising and unsettling upshot of ironic insight.
Ecosystem Dynamics focuses on long-term terrestrial ecosystems and their changing relationships with human societies. The unique aspect of this text is the long-time scale under consideration as data and insights from the last 10,000 years are used to place present-day ecosystem status into a temporal perspective and to test models that generate forecasts of future conditions. Descriptions and assessments of some of the current modelling tools that are used, along with their uncertainties and assumptions, are an important feature of this book. An overarching theme explores the dynamic interactions between human societies and ecosystem functioning and services. This book is authoritative but accessible and provides a useful background for all students, practitioners, and researchers interested in the subject.
Now in its third edition, Senate Procedure and Practice explains why and how the Senate has worked for more than 200 years. The book is filled with fascinating stories and insights that highlight why certain rules are in place, how they are practiced, and the ways in which those practices have changed throughout history as our federal government and the needs of our electorate have evolved. Anyone with an interest in the pillars of Senate procedure and practice will find a useful companion in this book
The Essential Psychology Series bridges the gap between simple introductory texts aimed at pre-university students and higher level textbooks for upper level undergraduates. Each volume in the series is designed to provide concise yet up-to-date descriptions of the major areas of psychology for first year undergraduates or students taking psychology as a supplement to other courses of study. The authors, who are acknowledged experts in their field, explain the basics carefully and engagingly without the over-simplification often found in introductory textbooks, at the same time providing the reader with insights into current thinking. Essential Biological Psychology is an accessible, well-illustrated and well-written account of the study of the role of the body in behaviour and the effect of behaviour on the working of the body. Covering all the major topics within biopsychology, and evaluating the most up-to-date findings, particularly within neuroscience and neuroimaging research, this textbook is essential reading for first and second level undergraduates taking courses in biological or physiological psychology as well as anyone studying courses in neuropsychology or behavioural neuroscience.
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.