Martin P. Simon's Books

Protein-protein Complexes

Analysis, Modeling and Drug Design

By: Martin Zacharias

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Protein-protein Complexes

Analysis, Modeling and Drug Design

By: Martin Zacharias

Given the immense progress achieved in elucidating protein-protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field. This book does just that. It focuses on what can be learned about protein-protein interactions from the analysis of protein-protein complex structures and interfaces. What are the driving forces for protein-protein association? How can we extract the mechanism of specific recognition from studying protein-protein interfaces? How can this knowledge be used to predict and design protein-protein interactions (interaction regions and complex structures)? What methods are currently employed to design protein-protein interactions, and how can we influence protein-protein interactions by mutagenesis and small-molecule drugs or peptide mimetics?The book consists of about 15 review chapters, written by experts, on the characterization of protein-protein interfaces, structure determination of protein complexes (by NMR and X-ray), theory of protein-protein binding, dynamics of protein interfaces, bioinformatics methods to predict interaction regions, and prediction of protein-protein complex structures (docking and homology modeling of complexes, etc.) and design of protein-protein interactions. It serves as a bridge between studying/analyzing protein-protein complex structures (interfaces), predicting interactions, and influencing/designing interactions.

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401

Publisher

World Scientific

Published Date

ISBN 10

184816338X

ISBN 13

9781848163386

The Psychology of Human Possibility and Constraint

By: Jack Martin,Jeff Sugarman

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The Psychology of Human Possibility and Constraint

By: Jack Martin,Jeff Sugarman

Resolves the fundamental debate between cognitivists and social constructionists concerning the metaphysics of human psychology, and offers new insights into therapy, education, and creativity.

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188

Publisher

SUNY Press

Published Date

ISBN 10

0791441237

ISBN 13

9780791441237

Rock: The Primary Text

Developing a Musicology of Rock

By: Allan F Moore,Remy Martin

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Rock: The Primary Text

Developing a Musicology of Rock

By: Allan F Moore,Remy Martin

This thoroughly revised third edition of Allan F. Moore's ground-breaking book, now co-authored with Remy Martin, incorporates new material on rock music theory, style change and the hermeneutic method developed in Moore’s Song Means (2012). An even larger array of musicians is discussed, bringing the book right into the 21st century. Rock's 'primary text' – its sounds – is the focus of attention here. The authors argue for the development of a musicology particular to rock within the context of the background to the genres, the beat and rhythm and blues styles of the early 1960s, 'progressive' rock, punk rock, metal and subsequent styles. They also explore the fundamental issue of rock as a medium for self-expression, and the relationship of this to changing musical styles. Rock: The Primary Text remains innovative in its exploration of an aesthetics of rock.

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348

Publisher

Routledge

Published Date

ISBN 10

0429954107

ISBN 13

9780429954108

Calming the Brain

Benzodiazepines and Related Drugs from Laboratory to Clinic

By: Adam Doble,Ian Martin,David Nutt

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Calming the Brain

Benzodiazepines and Related Drugs from Laboratory to Clinic

By: Adam Doble,Ian Martin,David Nutt

This book covers the entire field of research in the area of minor tranquillizers and its application to current clinical practice in the treatment of anxiety and insomnia. These drugs are principally the benzodiazepines and related drugs with a similar mechanism of action, such as zolpidem and zopiclone. The molecular mechanism of action of benzodiazepines is described, focussing on the interaction of these drugs with the different isoform of the GABAA^O >receptor, and the consequences of this for brain function. Recent advances in this knowledge have provided a framework for defining the physiochemical nature of the interaction between such drugs and their receptor protein, and thus pave the way for the design of new anxiolytic and hypnotic drugs. The animal models available for evaluating the potential of such new therapeutic agents in the treatment of anxiety and insomnia are discussed. Furthermore, understanding of the physiological regulation of the GABAA receptor may provide insights into the aetiopathology of these diseases. The clinical use of benzodiazepines and related drugs in the treatment of anxiety, insomnia, epilepsy and as anaesthetics are explored. The advantages and limitations of such treatments are discussed, and the impact of drugs evaluated. A chapter is devoted to the issue of independence, the clinical pertinence of tolerence and dependence, and evaluates treatment options that may minimise the risk of dependence.

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196

Publisher

CRC Press

Published Date

ISBN 10

1000144461

ISBN 13

9781000144468

Introduction to Particle Technology

By: Martin J. Rhodes,Jonathan Seville

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Introduction to Particle Technology

By: Martin J. Rhodes,Jonathan Seville

INTRODUCTION TO PARTICLE TECHNOLOGY A new edition of the indispensable guide to particulates and powders Particle technology concerns the formation, processing and properties of the particles and powders which make up many of the products that surround us. Such products range from the cement and aggregate in the built environment to pharmaceuticals and processed foods. Most of the process industries involve particles, either as essential components such as catalysts or as intermediate or final products, and minerals such as the rare earths that are generally mined and processed in particulate form. Particles can have many beneficial uses but they can also cause harm in the environment and, through inhalation, to the individual. In all cases, the powder properties, particularly particle size, are crucially important. This well-known textbook, now in its 3rd edition, provides an easily-understood introduction to the underlying scientific principles of particle technology, together with examples of how these principles can be used in practical design and operation of industrial processes. Each chapter contains both worked examples and exercises for the student. Based on feedback from students and users of the earlier editions, this revised and expanded text includes introductory chapters on particles as products and on computational methods. The topics have been selected to give coverage of the broad areas of particle technology and include: Characterization (size analysis, surface area) Processing (granulation, fluidization) Particle formation (granulation, crystallisation, tableting, size reduction) Storage and transport (hopper design, pneumatic conveying, standpipes) Separation (filtration, settling, cyclones) Safety (fire and explosion hazards, health hazards) Engineering the properties of particulate systems to achieve desired product performance Discrete element modelling of particulate systems Introduction to Particle Technology, 3rd Edition is essential reading for students of chemical engineering. The text is also recommended reading for students of mechanical engineering, applied chemistry, pharmaceutics, physics, mineral processing, and metallurgy, and is an excellent source for practising engineers and scientists looking to establish a working knowledge of the subject.

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501

Publisher

John Wiley & Sons

Published Date

ISBN 10

111993110X

ISBN 13

9781119931102

Textbook of Atopic Dermatitis

By: Sakari Reitamo,Thomas A. Luger,Martin Steinhoff

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Textbook of Atopic Dermatitis

By: Sakari Reitamo,Thomas A. Luger,Martin Steinhoff

Atopic dermatitis or atopic eczema is an extremely common skin disease characterized by red patches, dry, scaling or crusting skin, and intense itch. It frequently develops in children during the first year of life and can become severe, with a consequently major impact on health-related quality of life. This text from international experts draws t

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285

Publisher

CRC Press

Published Date

ISBN 10

0203091442

ISBN 13

9780203091449

Aspartic Proteinases Physiology and Pathology

By: Martin Fusek,Vaclav Vetvicka

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Aspartic Proteinases Physiology and Pathology

By: Martin Fusek,Vaclav Vetvicka

Published in 1995: Aspartic Proteinases: Physiology and Pathology focuses on the advantages and limitations of the use of proteinases and their inhibitors in human pathology. A virus-specific aspartic proteinase enzyme is required for the maturation of a virus. If the enzyme can be eliminated, so can the maturation of the virus. This book reviews the wealth of recently published information sparked by the renewed interest in these enzymes.

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324

Publisher

CRC Press

Published Date

ISBN 10

0429536003

ISBN 13

9780429536007

Angels in Medieval Philosophical Inquiry

Their Function and Significance

By: Martin Lenz

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Angels in Medieval Philosophical Inquiry

Their Function and Significance

By: Martin Lenz

The nature and properties of angels occupied a prominent place in medieval philosophical inquiry. Creatures of two worlds, angels provided ideal ground for exploring the nature of God and his creation, being perceived as 'models' according to which a whole range of questions were defined, from cosmological order, movement and place, to individuation, cognition, volition, and modes of language. This collection of essays is a significant scholarly contribution to angelology, centred on the function and significance of angels in medieval speculation and its history. The unifying theme is that of the role of angels in philosophical inquiry, where each contribution represents a case study in which the angelic model is seen to motivate developments in specific areas and periods of medieval philosophical thought.

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250

Publisher

Routledge

Published Date

ISBN 10

1317181093

ISBN 13

9781317181095

Lightning

Physics and Effects

By: Vladimir A. Rakov,Martin A. Uman

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Lightning

Physics and Effects

By: Vladimir A. Rakov,Martin A. Uman

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734

Publisher

Cambridge University Press

Published Date

ISBN 10

0521583276

ISBN 13

9780521583275

High-Frequency Statistics with Asynchronous and Irregular Data

By: Ole Martin

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High-Frequency Statistics with Asynchronous and Irregular Data

By: Ole Martin

Ole Martin extends well-established techniques for the analysis of high-frequency data based on regular observations to the more general setting of asynchronous and irregular observations. Such methods are much needed in practice as real data usually comes in irregular form. In the theoretical part he develops laws of large numbers and central limit theorems as well as a new bootstrap procedure to assess asymptotic laws. The author then applies the theoretical results to estimate the quadratic covariation and to construct tests for the presence of common jumps. The simulation results show that in finite samples his methods despite the much more complex setting perform comparably well as methods based on regular data. About the Author: Dr. Ole Martin completed his PhD at the Kiel University (CAU), Germany. His research focuses on high-frequency statistics for semimartingales with the aim to develop methods based on irregularly observed data.

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328

Publisher

Springer Nature

Published Date

ISBN 10

3658284188

ISBN 13

9783658284183

Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases E-Book

By: John E. Bennett,Raphael Dolin,Martin J. Blaser

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Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases E-Book

By: John E. Bennett,Raphael Dolin,Martin J. Blaser

After thirty five years, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th Edition is still the reference of choice for comprehensive, global guidance on diagnosing and treating the most challenging infectious diseases. Drs. John E. Bennett and Raphael Dolin along with new editorial team member Dr. Martin Blaser have meticulously updated this latest edition to save you time and to ensure you have the latest clinical and scientific knowledge at your fingertips. With new chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th Edition helps you identify and treat whatever infectious disease you see. Get the answers to any questions you have with more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than you’ll find in any other ID resource. Apply the latest knowledge with updated diagnoses and treatments for currently recognized and newly emerging infectious diseases, such as those caused by avian and swine influenza viruses. Put the latest knowledge to work in your practice with new or completely revised chapters on Influenza (new pandemic strains); New Middle East Respiratory Syndrome (MERS) Virus; Probiotics; Antibiotics for resistant bacteria; Antifungal drugs; New Antivirals for hepatitis B and C; Clostridium difficile treatment; Sepsis; Advances in HIV prevention and treatment; Viral gastroenteritis; Lyme Disease; Helicobacter pylori; Malaria; Infections in immunocompromised hosts; Immunization (new vaccines and new recommendations); and Microbiome. Benefit from fresh perspectives and expanded global insights from an expanded team of American and International contributors. Martin Blaser, MD, a leading expert and Muriel G. and George W. Singer Professional of Translational Medicine at New York University School of Medicine, joins veteran PPID editors John E. Bennett, MD, and Raphael Dolin, MD to continue a legacy of excellence. Find and grasp the information you need easily and rapidly with newly added chapter summaries.

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5094

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0323263739

ISBN 13

9780323263733

Urban Ecosystems

Function, Management and Development

By: Jürgen Breuste,Stephan Pauleit,Dagmar Haase,Martin Sauerwein

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Urban Ecosystems

Function, Management and Development

By: Jürgen Breuste,Stephan Pauleit,Dagmar Haase,Martin Sauerwein

This textbook on urban ecosystems answers important questions about the ecological structure, functions and socio-ecological development of cities worldwide. Based on how cities are developing today in an increasingly urbanized world, it explains ecological challenges for cities of the 21st century such as resource efficiency, climate change, moderation of quality of life and resilience. The book combines theories of urban development and ecology with practical applications and case studies, thus identifying potential for improvement and examples of good ecological urban development worldwide. It shows that cities are by far not only problem areas but also offer great potential for a good life and that the various urban ecosystems can make a considerable contribution to this. The "eco-city" is thus not a utopia,but a real goal that can be pursued step by step in a targeted manner, taking into account the local and regional context. Four renowned urban ecologists have contributed their specific experience in sub-areas without losing sight of the big picture. Jürgen Breuste is an urban ecologist and works at the Paris Lodron University in Salzburg, Austria, on the topics of sustainable urban development, urban biodiversity, ecosystem services and eco-cities. Dagmar Haase is Landschaftsökologin and works at the Humboldt University of Berlin on urban ecosystem services and land use modeling. Stephan Pauleit is a landscape planner and works at the Technical University of Munich on strategies for the sustainable development of urban landscapes. Martin Sauerwein is a geographer and works at the University of Hildesheim on geo-ecology in cultural landscapes, geoarchaeology and soil protection. The textbook addresses a broad audience of students, teachersand also to practitioners in the fields of ecology, urban ecology, urban development, sustainability, urban geography, nature and landscape conservation, spatial planning, landscape ecology, social sciences and urban studies. The numerous photos and graphics, many of them in four colors, as well as clear tables illustrate the facts. Case studies, examples and explanations allow a deeper insight. Questions at the end of each chapter allow the progress of knowledge to be checked, and a comprehensive bibliography for each chapter provides further studies.This book is a translation of the original German 1st edition Stadtökosysteme by Jürgen Breuste published by Springer Fachmedien Wiesbaden GmbH, part of Springer Nature in 2016. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors. This springer essential is a translation of the original German 1st edition essentials,Stadtökosysteme by Jürgen Breuste published by Springer Fachmedien Wiesbaden GmbH, part of Springer Nature in 2016. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors.

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339

Publisher

Springer Nature

Published Date

ISBN 10

3662632799

ISBN 13

9783662632796

Geomorphology and the Carbon Cycle

By: Martin Evans

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Geomorphology and the Carbon Cycle

By: Martin Evans

The first systematic examination of the role of geomorphological processes in the cycling of carbon through the terrestrial system. Argues that knowledge of geomorphological processes is fundamental to understanding the ways in which carbon is stored and recycled in the terrestrial environment Integrates classical geomorphological theory with understanding of microbial processes controlling the decomposition of organic matter Develops an interdisciplinary research agenda for the analysis of the terrestrial carbon cycle Informed by work in ecology, microbiology and biogeochemistry, in order to analyse spatial and temporal patterns of terrestrial carbon cycling at the landscape scale Considers the ways in which, as Humanity enters the Anthropocene, the application of this science has the potential to manage the terrestrial carbon cycle to limit increases in atmospheric carbon

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304

Publisher

John Wiley & Sons

Published Date

ISBN 10

1119393248

ISBN 13

9781119393245

Rubber Analysis

Characterisation, Failure Diagnosis and Reverse Engineering

By: Martin J. Forrest

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Rubber Analysis

Characterisation, Failure Diagnosis and Reverse Engineering

By: Martin J. Forrest

Rubber analysis plays a vital part in ensuring that manufactured products are fit for purpose. This comprehensive, application-based book with up-to-date referencing covers all important applications and subject area associated with the analysis of rubber compounds and rubber products. Includes characterization of rubber polymers, rubber fumes, identification of extractables and leachables, as well as reverse engineering on compounded products.

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Page Count

360

Publisher

Walter de Gruyter GmbH & Co KG

Published Date

ISBN 10

3110640287

ISBN 13

9783110640281

Traffic Flow Dynamics

Data, Models and Simulation

By: Martin Treiber,Arne Kesting

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Traffic Flow Dynamics

Data, Models and Simulation

By: Martin Treiber,Arne Kesting

This textbook provides a comprehensive and instructive coverage of vehicular traffic flow dynamics and modeling. It makes this fascinating interdisciplinary topic, which to date was only documented in parts by specialized monographs, accessible to a broad readership. Numerous figures and problems with solutions help the reader to quickly understand and practice the presented concepts. This book is targeted at students of physics and traffic engineering and, more generally, also at students and professionals in computer science, mathematics, and interdisciplinary topics. It also offers material for project work in programming and simulation at college and university level. The main part, after presenting different categories of traffic data, is devoted to a mathematical description of the dynamics of traffic flow, covering macroscopic models which describe traffic in terms of density, as well as microscopic many-particle models in which each particle corresponds to a vehicle and its driver. Focus chapters on traffic instabilities and model calibration/validation present these topics in a novel and systematic way. Finally, the theoretical framework is shown at work in selected applications such as traffic-state and travel-time estimation, intelligent transportation systems, traffic operations management, and a detailed physics-based model for fuel consumption and emissions.

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Page Count

505

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3642324606

ISBN 13

9783642324604

Meaning, Quantification, Necessity

Themes in Philosophical Logic

By: Martin Davies

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Meaning, Quantification, Necessity

Themes in Philosophical Logic

By: Martin Davies

Originally published in 1981. This is a book for the final year undergraduate or first year graduate who intends to proceed with serious research in philosophical logic. It will be welcomed by both lecturers and students for its careful consideration of main themes ranging from Gricean accounts of meaning to two dimensional modal logic. The first part of the book is concerned with the nature of the semantic theorist’s project, and particularly with the crucial concepts of meaning, truth, and semantic structure. The second and third parts deal with various constructions that are found in natural languages: names, quantifiers, definite descriptions, and modal operators. Throughout, while assuming some familiarity with philosophical logic and elementary formal logic, the text provides a clear exposition. It brings together related ideas, and in some places refines and improves upon existing accounts.

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Page Count

243

Publisher

Routledge

Published Date

ISBN 10

1000735516

ISBN 13

9781000735512

The Papers of Martin Luther King, Jr., Volume VI

Advocate of the Social Gospel, September 1948–March 1963

By: Martin Luther King Jr.

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The Papers of Martin Luther King, Jr., Volume VI

Advocate of the Social Gospel, September 1948–March 1963

By: Martin Luther King Jr.

Dedicated to documenting the life of America's best-known advocate for peace and justice, The Papers of Martin Luther King, Jr. breaks the chronology of its series to present King's never-before-published sermon file. In 1997 Mrs. Coretta Scott King granted the King Papers Project permission to examine papers kept in boxes in the basement of the Kings' home. The most significant finding was a battered cardboard box that held more than two hundred folders containing documents King used to prepare his celebrated sermons. This private collection that King kept in his study sheds considerable light on the theology and preaching preparation of one of the most noted orators of the modern era. These illuminating papers reveal that King's concern about poverty, human rights, and social justice was clearly present in his earliest handwritten sermons, which conveyed a message of faith, hope, and love for the dispossessed. His enduring message can be charted through his years as a seminary student, as pastor of Dexter Avenue Baptist Church, as a leader of the Montgomery bus boycott, and, ultimately, as an internationally renowned proponent of human rights who saw himself mainly as a preacher and "advocate of the social gospel." Ten of the original and unedited sermons King submitted for publication in the 1963 book Strength to Love and audio versions of King's most famous sermons are the culmination of this groundbreaking work.

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Page Count

755

Publisher

Univ of California Press

Published Date

ISBN 10

0520341945

ISBN 13

9780520341944

Molecular Biology of the Cell

By: Bruce Alberts,Dennis Bray,John Howard Wilson (biochemist),Hunt,Julian Lewis,Martin Raff,Keith Roberts,James D. Watson

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Molecular Biology of the Cell

By: Bruce Alberts,Dennis Bray,John Howard Wilson (biochemist),Hunt,Julian Lewis,Martin Raff,Keith Roberts,James D. Watson

New edition of a text in which six researchers from leading institutions discuss what is known and what is yet to be understood in the field of cell biology. The material on molecular genetics has been revised and expanded so that it can be used as a stand-alone text. A new chapter covers pathogens, infection, and innate immunity. Topics include introduction to the cell, basic genetic mechanisms, methods, internal organization of the cell, and cells in their social context. The book contains color illustrations and charts; and the included CD-ROM contains dozens of video clips, animations, molecular structures, and high-resolution micrographs. Annotation copyrighted by Book News Inc., Portland, OR.

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Page Count

1340

Publisher

Courier Corporation

Published Date

ISBN 10

0824036956

ISBN 13

9780824036959

Contemporary Surgical Management of Fractures and Complications

Volume 3 - Pediatrics

By: Martin J Herman,B David Horn

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Contemporary Surgical Management of Fractures and Complications

Volume 3 - Pediatrics

By: Martin J Herman,B David Horn

Contemporary Surgical Management of Fractures and Complications, Volume Three provides orthopaedic surgeons with the most up to date information on the treatment of paediatric fractures and avoidance of complications. Each of the twelve chapters presents a specific type of paediatric fracture, guiding surgeons step by step through the history, clinical presentation, diagnosis, treatment, complications and their management. A complete chapter is dedicated to paediatric spine trauma and the importance of early diagnosis and appropriate management. Authored by internationally recognised experts from Pennsylvania, this comprehensive guide includes numerous clinical photographs, illustrations and tables. Volumes one and two, authored by Asif Ilyas and Saqib Rahman, also from Pennsylvania, published in March 2013. Key points Provides orthopaedic surgeons with most recent information on treatment of paediatric fractures Complete chapter dedicated to paediatric spine trauma Internationally recognised Pennsylvania-based authors Volumes one and two published in March 2013

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Page Count

315

Publisher

JP Medical Ltd

Published Date

ISBN 10

9351521206

ISBN 13

9789351521204

Little Visits with God

By: Mary Manz Simon,Martin P. Simon,Alan H. Jahsmann

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Little Visits with God

By: Mary Manz Simon,Martin P. Simon,Alan H. Jahsmann

A collection of more than 200 devotions on such topics as daily activities, the Ten Commandments, and holidays. Includes interactive discussion questions, Bible verses, and prayers.

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304

Published Date

ISBN 10

0570058090

ISBN 13

9780570058090

Book's by Martin P. Simon

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