Martin Krzywinski's Books

Cancer Genomics

Chapter 2. Second-Generation Sequencing for Cancer Genome Analysis

By: Hye-Jung E. Chun,Jaswinder Khattra,Martin Krzywinski,Samuel A. Aparicio,Marco A. Marra

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Cancer Genomics

Chapter 2. Second-Generation Sequencing for Cancer Genome Analysis

By: Hye-Jung E. Chun,Jaswinder Khattra,Martin Krzywinski,Samuel A. Aparicio,Marco A. Marra

Cancer results from accumulated mutations in the genome. Sequencing is an accurate method to detect mutations. Second-generation sequencing technology, commonly referred to as next-generation sequencing technology, enables rapid, efficient and affordable DNA sequencing, and is transforming the scale and scope of cancer research. The technology is sufficiently flexible and affordable to allow sequencing of many cancer genomes, and thus facilitates both sequencing of samples from large patient cohorts and during disease progression in individual cancer patients. The high depths of redundant sequence coverage that can be obtained using some second-generation sequencing technologies, along with sequencing reads amplified from single DNA molecules, facilitate detection of subclones of cells in tumors. Large-scale genome sequencing of hundreds or even thousands of cancer samples is being conducted by several groups that aim to identify and characterize cancer driver mutations. Goals of such work, previously infeasible with Sanger sequencing instruments, are to use this information to improve cancer prognosis, diagnosis and therapeutic decision-making. The speed of data analysis is rate limiting, and investigators are struggling to accommodate and interpret the data deluge produced by second-generation technologies. In this chapter, we discuss cancer properties that are revealed by sequencing and the implication of such properties in experimental design and data interpretation. We describe past, current and upcoming sequencing technologies and the application of second-generation sequencing technologies in cancer genomics. Finally, we discuss the impact of second-generation sequencing technology in shaping personalized medicine.

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Elsevier Inc. Chapters

Published Date

ISBN 10

0128060999

ISBN 13

9780128060995

Science Journalism

An Introduction

By: Martin W Angler

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Science Journalism

An Introduction

By: Martin W Angler

Science Journalism: An Introduction gives wide-ranging guidance on producing journalistic content about different areas of scientific research. It provides a step-by-step guide to mastering the practical skills necessary for covering scientific stories and explaining the business behind the industry. Martin W. Angler, an experienced science and technology journalist, covers the main stages involved in getting an article written and published; from choosing an idea, structuring your pitch, researching and interviewing, to writing effectively for magazines, newspapers and online publications. There are chapters dedicated to investigative reporting, handling scientific data and explaining scientific practice and research findings to a non-specialist audience. Coverage in the chapters is supported by reading lists, review questions and practical exercises. The book also includes extensive interviews with established science journalists, scholars and scientists that provide tips on building a career in science journalism, address what makes a good reporter and discuss the current issues they face professionally. The book concludes by laying out the numerous available routes into science journalism, such as relevant writing programs, fellowships, awards and successful online science magazines. For students of journalism and professional journalists at all levels, this book offers an invaluable overview of contemporary science journalism with an emphasis on professional journalistic practice and success in the digital age.

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Page Count

274

Publisher

Routledge

Published Date

ISBN 10

1317369815

ISBN 13

9781317369813

The Red Land

The Illustrated Archaeology of Egypt's Eastern Desert

By: Steven E. Sidebotham,Martin Hense,Hendrikje M. Nouwens

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The Red Land

The Illustrated Archaeology of Egypt's Eastern Desert

By: Steven E. Sidebotham,Martin Hense,Hendrikje M. Nouwens

For thousands of years Egypt has crowded the Nile Valley and Delta. The Eastern Desert, however, has also played a crucial-though until now little understood-role in Egyptian history. Ancient inhabitants of the Nile Valley feared the desert, which they referred to as the Red Land, and were reluctant to venture there, yet they exploited the extensive mineral wealth of this region. They also profited from the valuable wares conveyed across the desert between the Nile and the Red Sea ports, which originated from Arabia, Africa, India, and elsewhere in the east. Based on twenty years of archaeological fieldwork conducted in the Eastern Desert, The Red Land reveals the cultural and historical richness of this little known and seldom visited area of Egypt. A range of important archaeological sites dating from Prehistoric to Byzantine times is explored here in text and illustrations. Among these ancient treasures are petroglyphs, cemeteries, fortified wells, gold and emerald mines, hard stone quarries, roads, forts, ports, and temples. With 250 photographs and fascinating artistic reconstructions based on the evidence on the ground, along with the latest research and accounts from ancient sources and modern travelers, the authors lead the reader into the remotest corners of the hauntingly beautiful Eastern Desert to discover the full story of the area's human history.

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Page Count

590

Publisher

American University in Cairo Press

Published Date

ISBN 10

1617972266

ISBN 13

9781617972263

Telling Science Stories

Reporting, Crafting and Editing for Journalists and Scientists

By: Martin W. Angler

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Telling Science Stories

Reporting, Crafting and Editing for Journalists and Scientists

By: Martin W. Angler

A practical manual for anyone who wants to turn scientific facts into gripping science stories, this book provides an overview of story elements and structure, guidance on where to locate them in scientific papers and a step-by-step guide to applying storytelling techniques to writing about science. In this book, Martin W. Angler outlines basic storytelling elements to show how and where fledgling science storytellers can find them in scientific output. Journalistic techniques like selection through news values and narrative interviews are covered in dedicated chapters. A variety of writing techniques and approaches are presented as a way of framing science stories in ways that are informative and compelling in different media – from short films to news articles. Practical examples, selected interviews and case studies complement each chapter, with exercises and experimentation suggestions included for deeper understanding. Review questions at the end of each chapter cement the newly gained knowledge to make sure readers absorb it, with links to articles and online tools inviting further reading. A valuable resource for students of journalism and science communication as well as professional journalists, scientists and scientists-in-training who want to engage with the public or simply improve their journal papers. This book is a one-stop shop on science storytelling with a clear focus on providing practical techniques and advice on how to thrive as science writers and communicate science in all of its complexity.

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Page Count

258

Publisher

Routledge

Published Date

ISBN 10

1351035088

ISBN 13

9781351035088

Book's by Martin Krzywinski

Cancer Genomics

Cancer Genomics

Science Journalism

Science Journalism

The Red Land

The Red Land

Telling Science Stories

Telling Science Stories

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