Apoptosis, or programmed cell death, is a necessary process by which a cell may die without adversely affecting its environment. It plays a crucial role in normal development, and in the body's defence mechanisms against disease. Too much cell death is destructive, leading to neurodegenerative diseases and impaired development. Conversely, too little cell death can lead to an increased susceptibility to cancer and sustained viral infection. Apoptosis is a matter of balance Dramatic progress has been made in the study of apoptosis over the past decade. One of the most rapidly expanding knowledge bases being established is on the molecular mechanisms controlled by a variety of gene products including Bcl-2, caspases, death receptors, and proteolytic targets, as well as the central role of the mitochondrion. The major challenge in apoptosis research is how the protein products involved operate in an intricate web of signaling pathways that also play a crucial role in cell proliferation and differentiation. This book concentrates on elucidating these signal transduction mechanisms, an area not properly reviewed by other apoptosis texts.
Was Israel founded by Czechoslovakia? A History of Czechs and Jews examines this question and the resulting findings are complex. Czechoslovakia did provide critical, secret military sponsorship to Israel around 1948, but this alliance was short-lived and terminated with the Prague Trial of 1952. Israel’s "Czech guns" were German as much as Czech, and the Soviet Union strongly encouraged Czechoslovakia’s help for Israel. Most importantly however, the Czechoslovak-Israeli military cooperation was only part of a much larger picture. Since the mid-1800s, Czechs and Jews have been systematically comparing themselves to each other in literature, music, politics, diplomacy, media, and historiography. A shared perception of similar fates of two small nations trapped between East and West, in constant existential danger, helped forge a Czech-Jewish "national friendship" amid periods of estrangement. Yet, this Czech-Jewish national friendship, an idea that can be traced from Masaryk and Kafka via Weizman and Ben Gurion to Havel and Netanyahu, was more myth than reality. Relations were often mixed and highly dependent on larger historical developments affecting Central Europe and the Middle East. As the Czech Republic emerges as Israel’s main EU ally, this book provides a timely analysis of this old-new alliance and is essential reading for students and scholars with an interest in History and Jewish Studies.
The building shell is the interface with the outside world, it offers protection and at the same time represents its owners or occupants. But what are the criteria for choosing a specific shell? Why is a particular material used on a particular undercoat? The fifth volume of the SCALE series, Enclose | Build, is not about the curtain, the dressing of the facade that surrounds a building, but rather on a causal level about the exterior termination of a building, the wall, the facade, which can be made of various materials, surfaces, and achieves different design effects. It shows the conditions under which certain constructions can be employed and why; what criteria such as construction costs, issues of sustainability, of energy efficiency, of assembly or of insulation or protection against moisture can also influence the choice of a system. In addition to classical constructions, Enclose | Build offers a look at future developments. How will the facade evolve as an interface for information? What do viable concepts for environmentally active, energy-efficient building shells look like? Enclose | Build is an indispensable tool for every architect and planner.
In the middle of the most destructive conflict in human history, the Second World War, almost 40,000 Germans civilians and prisoners of war were detained in internment and work camps across Canada. Prisoners of the Home Front details the organization and day-to-day affairs of these internment camps and reveals the experience of their inmates. Auger concludes that Canada abided by the Geneva Convention; its treatment of German prisoners was humane. This book sheds light on life behind barbed wire, filling an important void in our knowledge of the Canadian home front during the Second World War.
Only recently have the cellular and molecular aspects of cell suicide (or perhaps euthanasia) been investigated. From a September 1992 symposium in Brisbane, 26 papers report advances in the biochemical mechanisms, DNA fragmentation, genetic regulation, and apoptosis in the immune system and in cancer. Annotation copyright by Book News, Inc., Portland, OR
In August 1952, the distinguished British scientist Sir Jack Drummond, alongside his wife, Lady Ann, and their ten-year-old daughter, Elizabeth, was brutally murdered on a roadside in rural France. Sir Jack, a well-known nutritionist who modernized the classification of vitamins and helped devise UK rationing in World War II, was on holiday with his family in the French Riviera when they stopped to make camp just off the road near a farm called La Grand'Terre in Provence. The family was found murdered the following morning. Gaston Dominici, the illiterate, seventy-five-year-old patriarch of the nearby La Grand'Terre was accused, convicted, and condemned to death by guillotine soon after. When Dominici was first convicted there was general agreement that the ignorant, pitiless, and depraved old peasant had gotten what he deserved. At the time, Dominici stood for everything backwards and brutish about a peasantry left behind in the wake of France's post-war transformation and burgeoning prosperity. But with time perspectives changed. Subsequent enquiries coupled with widespread doubts and misgivings prompted President de Gaulle to order his release from prison in 1960, and by the 1980s many in France came to believe--against all evidence--that Gaston Dominici was innocent. He had become a romanticized symbol of a simpler, genuine, and somehow more honest life from a bygone era. Reconstructing the facts of the case and setting it against broader social, economic, and historical currents in post-war France, The Dominici Affair sheds light on one of the most puzzling and notorious crimes of 20th Century France, illuminating an entire Rorschach of social dynamics in the country.
In War & Homecoming: Veteran Identity and the Post-9/11 Generation, Travis L. Martin explores how a new generation of veterans is redefining what it means to come home. More than 2.7 million veterans served in Iraq and Afghanistan. Their homecomings didn't include parades or national celebrations. Instead, when the last US troops left Afghanistan, American veterans raised millions of dollars for the evacuation of Afghan refugees, especially those who'd served alongside them. This brand of selflessness is one reason civilians regard veterans with reverence and pride. The phrase "thank you for your service" is ubiquitous. Yet, one in ten post-9/11 veterans struggles with substance abuse. Fifteen to twenty veterans die by suicide every day. Veterans aged eighteen to thirty-four die at the highest rates, leading advocates to focus on concepts like moral injury and collective belonging when addressing psychic wounds. Martin argues that many veterans struggle due to decades of stereotyping and a lack of healthy models of veteran identity. In the American unconscious, veterans are treated as either the superficially praised "hero" or the victimized "wounded warrior," forever defined by past accomplishments. They are often appropriated as symbols in competing narratives of national identity. War & Homecoming critically examines representations of veterans in patriotic rhetoric, popular media, literature, and the lives of those who served. From this analysis, a new veteran identity emerges—veterans as storytellers who reject stereotypes, claim their symbolic authority, and define themselves through literature, art, and service. Their dynamic approach to life after military service allows for continued growth, agency, individuality, and inspiring examples of resilience for others.
This is a cutting-edge textbook intended to equip college students in Zimbabwe and abroad with the requisite knowledge as well as skills for a successful and fulfilling career in teacher education. This comprehensive resource goes beyond traditional pedagogical approaches, offering a dynamic blend of theory and practical strategies to address the evolving landscape of 21st century classrooms. From fostering inclusive environments and leveraging technology to promoting student engagement and applying effective assessment methods, this textbook provides a holistic view of the teaching profession. With insights from seasoned college lecturers, the book guides aspiring teachers in developing their unique teaching philosophy and prepares them to navigate the diverse challenges of contemporary education. Whether a novice in the field or a seasoned educator seeking professional growth, this textbook is an indispensable tool for those dedicated to making an impact on the lives of students.
Selected as a Doody's Core Title for 2022! Defining the field of immunology for 40 years, Paul’s Fundamental Immunology continues to provide detailed, authoritative, up-to-date information that uniquely bridges the gap between basic immunology and the disease process. The fully revised 8th edition maintains the excellence established by Dr. William E. Paul, who passed away in 2015, and is now under new editorial leadership of Drs. Martin F. Flajnik, Nevil J. Singh, and Steven M. Holland. It’s an ideal reference and gold standard text for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role.
Cryptography has become essential as bank transactions, credit card infor-mation, contracts, and sensitive medical information are sent through inse-cure channels. This book is concerned with the mathematical, especially algebraic, aspects of cryptography. It grew out of many courses presented by the authors over the past twenty years at various universities and covers a wide range of topics in mathematical cryptography. It is primarily geared towards graduate students and advanced undergraduates in mathematics and computer science, but may also be of interest to researchers in the area. Besides the classical methods of symmetric and private key encryption, the book treats the mathematics of cryptographic protocols and several unique topics such as Group-Based Cryptography Gröbner Basis Methods in Cryptography Lattice-Based Cryptography
Failure in Palestine traces Britain's attempts to reconcile her commitments to Palestine with her interests in the rest of the Middle East through bureaucratic and diplomatic paths to her eventual abandonment of Palestine. The text offers an excellent analysis of British decision making in this crucial period, whose repercussions are felt to the present day.
This title examines a somber historic event – the Holocaust. Compelling text explores the background of the Holocaust, including the events leading up to it, the aftermath and casualties, and the key people involved. Features include a table of contents, timeline, facts, additional resources, Web sites, glossary, bibliography, and index. Essential Events is a series in Essential Library, an imprint of ABDO Publishing Company.
Vol.1: Hydroxybenzophenones Vol.2: Hydroxyacetophenones I Vol.3: Hydroxyacetophenones II Vol.4: Hydroxypropiophenones, Hydroxyisobutyrophenones, Hydroxypivalophenones and Derivatives
Vol.1: Hydroxybenzophenones Vol.2: Hydroxyacetophenones I Vol.3: Hydroxyacetophenones II Vol.4: Hydroxypropiophenones, Hydroxyisobutyrophenones, Hydroxypivalophenones and Derivatives
In four volumes, Aromatic Hydroxyketones provides detailed information on the physical properties and syntheses of 6,000 hydroxyketones. Each entry includes basic identification information, including the Chemical Abstracts Service Registry Number, molecule name, molecular formula, and molecular weight. This resource provides a powerful tool for the synthesis of intermediates of specialty polymers, pharmaceuticals and fine chemicals.
“Sets the record straight on Albert Speer’s assertions of ignorance of the Final Solution and claims to being the ‘good Nazi.’”—Kirkus Reviews In his bestselling autobiography, Albert Speer, Minister of Armaments and chief architect of Nazi Germany, repeatedly insisted he knew nothing of the genocidal crimes of Hitler’s Third Reich. In this revealing new biography, author Martin Kitchen disputes Speer’s lifelong assertions of ignorance and innocence, portraying a far darker figure who was deeply implicated in the appalling crimes committed by the regime he served so well. Kitchen reconstructs Speer’s life with what we now know, including information from valuable new sources that have come to light only in recent years. The result is the first truly serious accounting of the man, his beliefs, and his actions during one of the darkest epochs in modern history, not only countering Speer’s claims of non-culpability but also disputing the commonly held misconception that it was his unique genius alone that kept the German military armed and fighting long after its defeat was inevitable. “A devastating portrait of an empty, narcissistic and compulsively ambitious personality.”—The Wall Street Journal “Kitchen’s exhaustively researched, detailed book nails, one by one, the lies of the man who provided a thick coat of whitewash to millions of old Nazis. Its fascinating account of how the moral degradation of the chaotic Nazi regime corrupted an entire nation is a timely warning for today.”—Daily Mail (“Book of the Month”) “[An] excellent new biography . . . Kitchen has taken a wrecking ball to Speer’s mendacious and meticulously created self-image. And about time, too.”—History Today
Während die Effizienz- und Nachhaltigkeitsoffensive in den meisten Wirtschaftsbereichen in vollem Gang ist, steht das Bauen damit noch ganz am Anfang – ökonomisch wie ökologisch. Die Politik auf globaler, europäischer und nationaler Ebene nimmt sich dieses Defizits inzwischen zunehmend an und versucht es durch rechtliche Anforderungen und Gesetze wie EnEV, Gebäudezertifizierungen und Wettbewerbe wettzumachen. Der Energie Atlas gibt in der bewährten Form der Atlanten eine umfassende Darstellung der konstruktiven Parameter von Energieeffizienz und Nachhaltigkeit wieder. Er nimmt die von der EU geplanten gesetzlichen Regulierungen vorweg und weist als unmittelbar verwendbare Arbeitshilfe für die tägliche Arbeit von Architekten, Ingenieuren und Designern den Weg zu effizientem und nachhaltigem Bauen und Betreiben von Gebäuden. Mit seiner Orientierung am gesamten Lebenszyklus eines Gebäudes leistet er eine ganzheitliche Betrachtung – eine unverzichtbare Voraussetzung für nachhaltiges Wirtschaften.
This book presents the overall vision and research outcomes of Nano-Tera.ch, which is a landmark Swiss federal program to advance engineering system and device technologies with applications to Health and the Environment, including smart Energy generation and consumption. The authors discuss this unprecedented nation-wide program, with a lifetime of almost 10 years and a public funding of more than 120 MCHF, which helped to position Switzerland at the forefront of the research on multi-scale engineering of complex systems and networks, and strongly impacted the Swiss landscape in Engineering Sciences.
Since the introduction of laser technology into medicine, quite a number of clinical applications in orthopaedics have been developed. This text is the first to provide comprehensive guidelines and how-to-do instructions for the application of lasers in orthopaedics. These cover patient selection and decision-making as well as the benefits and risks of the clinical application of lasers in arthroscopic surgery, spine surgery and open surgery. An overview is given on the basics of laser technology and the various laser types are evaluated in terms of optimal use.
The introduction of micro CHP – the simultaneous production of heat and power in a single building based on small energy conversion units such as Stirling and reciprocating engines or fuel cells – is of increasing political and public interest. This book introduces into micro CHP systems and technologies, and presents the results of the first such investigation carried out by four German research bodies.
This thesis uses high-precision single-photon experiments to shed new light on the role of reality, causality, and uncertainty in quantum mechanics. It provides a comprehensive introduction to the current understanding of quantum foundations and details three influential experiments that significantly advance our understanding of three core aspects of this problem. The first experiment demonstrates that the quantum wavefunction is part of objective reality, if there is any such reality in our world. The second experiment shows that quantum correlations cannot be explained in terms of cause and effect, even when considering superluminal influences between measurement outcomes. The final experiment in this thesis demonstrates a novel uncertainty relation for joint quantum measurements, where the textbook relation does not apply.
Makes connections between diseases, drugs and signaling in those chapters not specifically devoted to pathogens. Reviews background in first 5 chapters then offers chapters on cancers and apoptosis and on bacteria and viruses. Signaling in the immune, endocrine (hormonal) and nervous systems covered along with cancer, apoptosis and gene regulation. Each chapter ends with a problem section to facilitate discussion.
With almost 100,000 copies sold in earlier editions, this revised edition provides the most up-to-date information on natural alternatives to synthetic hormone replacement therapy A must-read for any woman taking synthetic hormones for infertility, birthcontrol, PMS, or menopause • Includes the latest research on using natural progesterone to combat osteoporosis, endometriosis, heart disease, PMS, fibroids, and breast, ovarian, and uterine cancer More and more women are seeking alternatives to synthetic hormones and their harmful side effects. Despite increasing awareness of the dangers of synthetic hormones, over-prescription of estrogen is still rampant, as is confusion among doctors and patients whether the benefits of conventional hormone replacement therapy (HRT) outweigh the risks. This updated fourth edition offers the latest information on how botanical progesterone therapy, also known as natural HRT, can provide safe, natural relief for many of the problems women face from hormone deficiency, including PMS, fibromyalgia, depression, menstrual irregularity, miscarriages, uterine fibroids, and infertility. Botanical progesterone supplementation can be also extremely effective in relieving hot flashes, insomnia, night sweats, vaginal dryness, and even cancer. The authors sift through misinformation and contradictory studies, warning against corporate-sponsored research in a multi-billion dollar menopausal industry, and guide readers to natural alternatives. This fourth edition also includes new studies regarding the dangers of a diet rich in soy contributing to the onset of premature menopause, as well as thyroid disorders. The dangers of mammography and the importance of focusing on safer, more effective methods of cancer detection are also well documented.
One of Britain's most acclaimed historians presents the experiences and ramifications of the last day of World War II in Europe May 8, 1945, 23:30 hours: With war still raging in the Pacific, peace comes at last to Europe as the German High Command in Berlin signs the final instrument of surrender. After five years and eight months, the war in Europe is officially over. This is the story of that single day and of the days leading up to it. Hour by hour, place by place, this masterly history recounts the final spasms of a continent in turmoil. Here are the stories of combat soldiers and ordinary civilians, collaborators and resistance fighters, statesmen and war criminals, all recounted in vivid, dramatic detail. But this is more than a moment-by-moment account, for Sir Martin Gilbert uses every event as a point of departure, linking each to its long-term consequences over the following half century. In our attempts to understand the world we inherited in 1945, there is no better starting point than The Day the War Ended.
This is a textbook covering the transition from energy releasing reactions on the early Earth to energy releasing reactions that fueled growth in the first microbial cells. It is for teachers and college students with an interest in microbiology, geosciences, biochemistry, evolution, or all of the above. The scope of the book is a quantum departure from existing “origin of life” books in that it starts with basic chemistry and links energy-releasing geochemical processes to the reactions of microbial metabolism. The text reaches across disciplines, providing students of the geosciences an origins/biology interface and bringing a geochemistry/origins interface to students of microbiology and evolution. Beginning with physical chemistry and transitioning across metabolic networks into microbiology, the timeline documents chemical events and organizational states in hydrothermal vents – the only environments known that bridge the gap between spontaneous chemical reactions that we can still observe in nature today and the physiology of microbes that live from H2, CO2, ammonia, phosphorus, inorganic salts and water. Life is a chemical reaction. What it is and how it arose are two sides of the same coin. Key Features Provides clear connections between geochemical reactions and microbial metabolism Focuses on chemical mechanisms and transition metals Richly illustrated with color figures explaining reactions and processes Covers the origin of the Earth, the origin of metabolism, the origin of protein synthesis and genetic information as well as the escape into the wild of the first free-living cells: Bacteria and Archaea
A complete reference to the latest understanding of lymphocytic infiltrates The Cutaneous Lymphoid Proliferations provides a complete, authoritative treatment of the clinical features, phenotypes, pathogenesis, histopathology, diagnosis, and treatment of lymphocytic infiltrates of the skin. Incorporating the latest findings from the fields of light microscopy, immunohistochemistry, and flow cytometry, the book brings readers up to date on the most current thinking in the field. Those readers familiar with the authors' critically acclaimed The Melanocytic Proliferations will find a similar structure and the same attention to detail and quality in this latest reference. The book starts off with a clinical atlas and introduction to the ontogeny and biology of the lymphoid system. Next, the authors explore novel molecular approaches to the diagnosis of cutaneous lymphoid proliferations and benign lymphocytic infiltrates. The remaining chapters concentrate on major inflammatory skin diseases and lymphoproliferative disorders, including chronic lymphocytic leukemia, lupus, adult T cell leukemia, and primary cutaneous Hodgkin's disease. As a reference to lymphocytic infiltrates, this book is unsurpassed. Novice and experienced practitioners alike will gain important insights into the field, including: The role of the immune system in the pathogenesis of cutaneous disease Relationships between therapeutic drugs and cutaneous eruptions Important drug reactions Hundreds of full-color, high-quality clinical and histologic photographs help readers visualize the various infiltrates and their treatments. Having this reference on hand is essential for all dermatologists, dermatopathologists, oncologists, and general pathologists who need a synthesis of the current thinking in the field.
Carrying on the tradition established by its founding editor, the late Dr. Martin Abeloff, the 4th Edition of this respected reference synthesizes all of the latest oncology knowledge in one practical, clinically focused, easy-to-use volume. It incorporates basic science, pathology, diagnosis, management, outcomes, rehabilitation, and prevention – all in one convenient resource – equipping you to overcome your toughest clinical challenges. What's more, you can access the complete contents of this Expert Consult title online, and tap into its unparalleled guidance wherever and whenever you need it most! Equips you to select the most appropriate tests and imaging studies for diagnosing and staging each type of cancer, and manage your patients most effectively using all of the latest techniques and approaches. Explores all of the latest scientific discoveries' implications for cancer diagnosis and management. Employs a multidisciplinary approach - with contributions from pathologists, radiation oncologists, medical oncologists, and surgical oncologists - for well-rounded perspectives on the problems you face. Offers a user-friendly layout with a consistent chapter format • summary boxes • a full-color design • and more than 1,445 illustrations (1,200 in full color), to make reference easy and efficient. Offers access to the book's complete contents online – fully searchable – from anyplace with an Internet connection. Presents discussions on cutting-edge new topics including nanotechnology, functional imaging, signal transduction inhibitors, hormone modulators, complications of transplantation, and much more. Includes an expanded color art program that highlights key points, illustrates relevant science and clinical problems, and enhances your understanding of complex concepts.
Atopic dermatitis or atopic eczema is an extremely common skin disease characterized by red patches, dry, scaling or crusting skin, and intense itch. It frequently develops in children during the first year of life and can become severe, with a consequently major impact on health-related quality of life. This text from international experts draws t
For four decades, physicians and other healthcare providers have trusted Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases to provide expert guidance on the diagnosis and treatment of these complex disorders. The 9th Edition continues the tradition of excellence with newly expanded chapters, increased global coverage, and regular updates to keep you at the forefront of this vitally important field. Meticulously updated by Drs. John E. Bennett, Raphael Dolin, and Martin J. Blaser, this comprehensive, two-volume masterwork puts the latest information on challenging infectious diseases at your fingertips. - Provides more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than any other infectious disease resource. - Features an increased focus on antibiotic stewardship; new antivirals for influenza, cytomegalovirus, hepatitis C, hepatitis B., and immunizations; and new recommendations for vaccination against infection with pneumococci, papillomaviruses, hepatitis A, and pertussis. - Covers newly recognized enteroviruses causing paralysis (E-A71, E-D68); emerging viral infections such as Ebola, Zika, Marburg, SARS, and MERS; and important updates on prevention and treatment of C. difficile infection, including new tests that diagnose or falsely over-diagnose infectious diseases. - Offers fully revised content on bacterial pathogenesis, antibiotic use and toxicity, the human microbiome and its effects on health and disease, immunological mechanisms and immunodeficiency, and probiotics and alternative approaches to treatment of infectious diseases. - Discusses up-to-date topics such as use of the new PCR panels for diagnosis of meningitis, diarrhea and pneumonia; current management of infected orthopedic implant infections; newly recognized infections transmitted by black-legged ticks in the USA: Borrelia miyamotoi and Powassan virus; infectious complications of new drugs for cancer; new drugs for resistant bacteria and mycobacteria; new guidelines for diagnosis and therapy of HIV infections; and new vaccines against herpes zoster, influenza, meningococci. - PPID continues its tradition of including leading experts from a truly global community, including authors from Australia, Canada and countries in Europe, Asia, and South America. - Includes regular updates online for the life of the edition. - Features more than 1,500 high-quality, full-color photographs—with hundreds new to this edition. - Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices.
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