Karplus's tales of a turbulent graduate school experience at Caltech will inspire readers to muster fortitude when everything seems to be spinning out of control. Karplus balances rigorous scientific discussions with refreshing chapters expounding his passion for photography and gastronomy.'Nature Chemistry, May 2020Nobel Laureate Martin Karplus was eight when his family fled Nazi-occupied Austria via Switzerland and France for the United States. He would later credit his life as a refugee as a decisive influence on his world view and approach to science.Spinach on the Ceiling is an autobiographical telling of Karplus' life story, and how it led him to win the Nobel Prize in Chemistry in 2013. The book captures pivotal moments in Martin's life — from his escape to Switzerland in 1938 shortly after Hitler's entrance into Austria; to memorable moments like when his parents gave him a microscope which opened his eyes to the wonders of science; to his education in New England and California; and his eventual scientific career which took him to England, Illinois, Columbia, Strasbourg, and Harvard. It relates how Martin's optimistic outlook and belief in his vision made it possible for him to overcome setbacks in his life, and turn a subject of study his colleagues considered a waste of time into a central part of chemistry and structural biology. It is his hope to inspire and aid young readers, in particular, to have a successful trajectory in their own lives. Although research and teaching have been his primary focus, he has traveled the world photographing people and places with a Leica IIIC and has had numerous exhibitions of the photographs. He has also enjoyed a lifelong interest in cooking and worked in some of the best restaurants in France and Spain.
Molecular dynamics simulations have become instrumental in replacing our view of proteins as relatively rigid structures with the realization that they were dynamic systems, whose internal motions play a functional role. Over the years, such simulations have become a central part of biophysics. Applications of molecular dynamics in biophysics range over many areas. They are used in the structure determination of macromolecules with x-ray and NMR data, the modelling of unknown structures from their sequence, the study of enzyme mechanisms, the estimation of ligand-binding free energies, the evaluation of the role of conformational change in protein function, and drug design for targets of known structures. The widespread application of molecular dynamics and related methodologies suggests that it would be useful to have available an introductory self-contained course by which students with a relatively limited background in chemistry, biology and computer literacy, can learn the fundamentals of the field. This Guide to Biomolecular Simulations tries to fill this need. The Guide consists of six chapters which provide the fundamentals of the field and six chapters which introduce the reader to more specialized but important applications of the methodology.
Karplus's tales of a turbulent graduate school experience at Caltech will inspire readers to muster fortitude when everything seems to be spinning out of control. Karplus balances rigorous scientific discussions with refreshing chapters expounding his passion for photography and gastronomy.'Nature Chemistry, May 2020Nobel Laureate Martin Karplus was eight when his family fled Nazi-occupied Austria via Switzerland and France for the United States. He would later credit his life as a refugee as a decisive influence on his world view and approach to science.Spinach on the Ceiling is an autobiographical telling of Karplus' life story, and how it led him to win the Nobel Prize in Chemistry in 2013. The book captures pivotal moments in Martin's life — from his escape to Switzerland in 1938 shortly after Hitler's entrance into Austria; to memorable moments like when his parents gave him a microscope which opened his eyes to the wonders of science; to his education in New England and California; and his eventual scientific career which took him to England, Illinois, Columbia, Strasbourg, and Harvard. It relates how Martin's optimistic outlook and belief in his vision made it possible for him to overcome setbacks in his life, and turn a subject of study his colleagues considered a waste of time into a central part of chemistry and structural biology. It is his hope to inspire and aid young readers, in particular, to have a successful trajectory in their own lives. Although research and teaching have been his primary focus, he has traveled the world photographing people and places with a Leica IIIC and has had numerous exhibitions of the photographs. He has also enjoyed a lifelong interest in cooking and worked in some of the best restaurants in France and Spain.
Given the immense progress achieved in elucidating protein-protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field. This book does just that. It focuses on what can be learned about protein-protein interactions from the analysis of protein-protein complex structures and interfaces. What are the driving forces for protein-protein association? How can we extract the mechanism of specific recognition from studying protein-protein interfaces? How can this knowledge be used to predict and design protein-protein interactions (interaction regions and complex structures)? What methods are currently employed to design protein-protein interactions, and how can we influence protein-protein interactions by mutagenesis and small-molecule drugs or peptide mimetics?The book consists of about 15 review chapters, written by experts, on the characterization of protein-protein interfaces, structure determination of protein complexes (by NMR and X-ray), theory of protein-protein binding, dynamics of protein interfaces, bioinformatics methods to predict interaction regions, and prediction of protein-protein complex structures (docking and homology modeling of complexes, etc.) and design of protein-protein interactions. It serves as a bridge between studying/analyzing protein-protein complex structures (interfaces), predicting interactions, and influencing/designing interactions.
The activities that transpire within the classroom either help or hinder students' learning. Any meaningful discussion of educational renewal, therefore, must focus explicitly and directly on the classroom, and on the teaching and learning that occur within it. This book presents a case for the development of classrooms in which students are encouraged to construct deep understandings of important concepts. Jacqueline Grennon Brooks and Martin Brooks present a new set of images for educational settings, images that emerge from student engagement, interaction, reflection, and construction. They have considerable experience in creating constructivist educational settings and conducting research on those settings. Authentic examples are provided throughout the book, as are suggestions for administrators, teachers, and policymakers. For the new edition of their popular book, the authors have written an introduction that places their work in today's educational renewal setting. Today, they urge, the case for constructivist classrooms is much stronger and the need more critical. Note: This product listing is for the Adobe Acrobat (PDF) version of the book.
Taking a novel, less classical approach to the subject, the authors have written this book with the conviction that signal processing should be fun. Their treatment is less focused on the mathematics and more on the conceptual aspects, allowing students to think about the subject at a higher conceptual level, thus building the foundations for more advanced topics and helping students solve real-world problems. The last chapter pulls together the individual topics into an in-depth look at the development of an end-to-end communication system. Richly illustrated with examples and exercises in each chapter, the book offers a fresh approach to the teaching of signal processing to upper-level undergraduates.
The pause in the traditional structure of schooling due to COVID-19 presents a unique opportunity for openness on many different levels: openness to the science of learning, openness to schoolwork centered around big ideas and authentic problems, openness to responsible assessment practices, and openness to a renewed ethic of social justice. In this book the authors make the case that now is a timely moment to reimagine schools and put the intellectual and social-emotional health of students and teachers at the center of the educational process. They offer practical classroom examples across disciplines and grade levels based on constructivist pedagogy, neuroscience research, psychological theory, and design thinking, as well as on their own experiences in observing and advancing instructional practice that fosters human development. Schools Reimagined will help administrators and teachers to structure their settings in ways that maximize the likelihood of meaningful and enduring student learning. Book Features: An approach for placing the well-being of students, teachers, and community at the center of schools.An accessible explanation of the sophisticated cognitive processes in which all people engage.Strategies and innovations that focus educators on student learning and the student agency that promotes it.Research-based approaches to schooling with specific examples of what they look like in action.Rolling summaries of the main points of each chapter throughout the text.
Sound Synthesis and Sampling' provides a comprehensive introduction to the underlying principles and practical techniques applied to both commercial and research sound synthesizers. This new edition has been updated throughout to reflect current needs and practices- revised and placed in a modern context, providing a guide to the theory of sound and sampling in the context of software and hardware that enables sound making. For the revised edition emphasis is on expanding explanations of software and computers, new sections include techniques for making sound physically, sections within analog and digital electronics. Martin Russ is well known and the book praised for its highly readable and non-mathematical approach making the subject accessible to readers starting out on computer music courses or those working in a studio.
Polarization propagators (PP) are powerful theoretical tools that allow carrying out a deep analysis of the electronic mechanisms underlying any molecular response property. The inner projections of the PP and contributions from localized orbitals within the PP approaches described in were developed to fully take advantage of this power of analysis for the study of NMR spectroscopic parameters. They are based on the use of localized molecular orbitals (LMOs) related to chemically intuitive concepts to decompose the mathematical expression of these parameters into coupling pathways or shielding pathways. Each of them may be furthermore decomposed into two new objects: (i) perturbators, which give information on the efficiency of a given magnetic perturbation to produce local excitations and (ii) the principal propagator matrix elements which provide deep understanding on the way perturbations are transmitted within the electronic framework of the molecule under study. Applications are presented in , both within semiempirical and ab initio approaches: the Karplus rule, a general analysis of the signs of J couplings, σ–π decomposition, hyperconjugative effects in transmission of J couplings, general features of 1J couplings, and intermolecular couplings in hydrogen-bonded systems. All applications were especially selected to cover examples in which qualitative physical insight can be gained.
Molecular simulation is a powerful tool in materials science, physics, chemistry and biomolecular fields. This updated edition provides a pragmatic introduction to a wide range of techniques for the simulation of molecular systems at the atomic level. The first part concentrates on methods for calculating the potential energy of a molecular system, with new chapters on quantum chemical, molecular mechanical and hybrid potential techniques. The second part describes methods examining conformational, dynamical and thermodynamical properties of systems, covering techniques including geometry-optimization, normal-mode analysis, molecular dynamics, and Monte Carlo simulation. Using Python, the second edition includes numerous examples and program modules for each simulation technique, allowing the reader to perform the calculations and appreciate the inherent difficulties involved in each. This is a valuable resource for researchers and graduate students wanting to know how to use atomic-scale molecular simulations. Supplementary material, including the program library and technical information, available through www.cambridge.org/9780521852524.
Molecular Structure and Biological Activity of Steroids focuses on the indentification of steroid structural features that control particular biological effects. Steroid geometry plays a critical role in steroid activity; therefore, the results of X-ray crystallographic, NMR spectroscopic, and theoretical studies on structure-activity relationships form an integral part of the book. Well-established observations and proposed models are presented, summarizing knowledge of molecular features (e.g., steroid backbone structures, side-chain constitutions, substitution sites, configurations, hydrogen-bonding patterns) that can affect steroid action. The book also provides overviews about recent progress in various frontier fields of steroid research, including such areas as sex steroids, glucocorticoids, aromatase inhibitors, vitamin D metabolites, brassinosteroids, neuromuscular blocking agents, and cardiotonic steroids. Molecular Structure and Biological Activity of Steroids is a "must-have" resource for biochemists, pharmacologists, endocrinologists, biophysicists, and others actively involved in steroid research.
After the proton and carbon, nitrogen is, with oxygen, the most impor tant atom in organic and especially bioorganic molecules. However, the development of nitrogen spectroscopy is indeed very recent. This is due to the fact that nitrogen-14, which is the naturally abundant iso tope, suffers, for structural studies, from the disadvantages inherent in nuclei with a quadrupolar moment (Table 1.1). Actually, indirect 15N measurements were reported in the early days of double resonance spectroscopy and the first direct detection of 15N resonance signals at the natural abundance level was realized in 1964 (R 17) at 4.33 MHz 1 (~ 1T) using a 15 mm o.d. cell in the field sweep mode (~ 0.16 min- ). Signal-to-noise ratios only of 3-4 were obtained for neat liquids and this low sensitivity of the 15N resonance still remains the main dis advantage for 15 spectroscopy (Table 1.1). However, nitrogen-15 has, N probably more than any other nucleus, benefited from the advances of NMR technology, i.e. Fourier transformation, multinuclear facilities, wide-bore super conducting solenoids, and, with the new generation of spectrometers, 15N-NMR is entering the field of routine investigation. Nevertheless, in spite of these spectacular improvements, obtaining 15N spectra of diluted species or large biochemical molecules is often not very easy and a good knowledge of the relaxation properties pecu liar to 15N may be necessary in order to adjust the pulse sequences and the decoupler duty cycle correctly (Section 2).
Linking theory and application in a way that is clear and understandable, Groundwater Lowering in Construction: A Practical Guide to Dewatering, Second Edition uses the authors’ extensive engineering experience to offer practical guidance on the planning, design, and implementation of groundwater control systems under real conditions. Discover engineering methods that can help you improve working conditions, increase project viability, and reduce excavation costs. In the decade since publication of this book’s first edition, groundwater lowering and dewatering activities have been increasingly integrated into the wider ground engineering schemes on major excavations to help provide stable and workable conditions for construction below groundwater level. Consequently, many engineering ventures now require a more in-depth assessment of potential environmental impacts of dewatering and groundwater control, and this book details the latest best practices to evaluate and address them. Includes New Chapters Covering: Cutoff methods used for groundwater exclusion Issues associated with permanent or long-term groundwater control systems Groundwater control technologies used on contaminated sites Methods needed to understand, predict, and mitigate potential environmental impacts of groundwater control works Updated to reflect the crucial technological and application advances shaping construction processes, this book contains valuable direction that can give you a true competitive advantage in the planning and execution of temporary and permanent dewatering works. The authors cover cutting-edge methods and key subjects, such as the history of dewatering, working on contaminated sites, site investigation techniques, and operation and maintenance issues, including health, safety, and legal aspects. Written for practising engineers and geologists as well as postgraduate engineering students, this updated manual on design and practice provides numerous case histories and extensive references to enhance understanding.
Praise for the Second Edition: "This is the book that the dewatering sector really needs – it is reliably based on sound theory and profound understanding of the physical processes, yet is presented in a very accessible and user-friendly manner. It draws on many, many decades of experience, and yet is utterly up to date. . . . It is a one-stop shop for the dewatering practitioner – who can nonetheless rest assured that the theoretical basis of the methods presented is flawless." — Professor Paul L. Younger, FGS, FICE, C.Geol., C.Eng., FREng, University of Glasgow, Scotland, UK "The best reference on this topic available . . . and will prove useful to a wide variety of readers ranging from junior construction engineers or dewatering contractors to theoretical hydrogeologists and environmental managers. It is rare that a book is able to bridge the gap between theoretical design guidance and practical application." — S.N. Sterling, University of Waterloo, Canada The extensively updated Groundwater Lowering in Construction: A Practical Guide to Dewatering, 3rd Edition offers practical advice on all phases of groundwater control systems, from planning and design, through installation and maintenance, and ultimately decommissioning. The expertise provided in this book can help you improve working conditions, increase project viability, save time and reduce excavation costs. Designers and managers of construction and engineering projects are given the tools necessary to effectively control groundwater. The content is divided into three sections – Principles, Design and Construction. The Principles section explains the fundamentals of groundwater flow as it relates to civil engineering excavations. The Design section explores in extensive detail site investigation, permeability assessment methods and groundwater control strategies. Chapters in the Construction section describe dewatering and exclusion techniques, and examine the complete life cycle of a groundwater control scheme, including monitoring, maintenance and decommissioning. This section incorporates eleven case histories from the authors’ casebook. The 3rd edition has been greatly revised and updated, and contains more than 200 new illustrations. The new content covers: Permeability of soils and rocks Groundwater problems for excavations in rock Groundwater control for tunnelling projects, such as shafts and cross passages Methods for assessing permeability Decommissioning of dewatering systems Optimisation of groundwater control schemes. The new, expanded content offers valuable direction that can give you a true competitive advantage in the planning and execution of temporary and permanent dewatering works for excavation and tunnelling. Written for practising engineers, geologists and construction managers, as well as postgraduate engineering students, this revamped manual on design and practice presents numerous case studies and extensive references to enhance understanding.
The Middle Paraná river is one of the largest in the world. Exceptionally rich in fauna and flora, it provides researchers with a glimpse into an ecosystem yet undisturbed by human civilization. This fascinating book covers all the key aspects of the Paraná’s fluvial limnology and ecology, arranged in discrete and easily navigable sections. First, the physical and chemical environment is explained, then the river’s plant life, followed by its invertebrate life, and finally the vertebrates that inhabit the river.
After the second edition introduced first density functional theory aspects, this third edition expands on this topic and offers unique practice in molecular mechanics calculations and DFT. In addition, the tutorial with its interactive exercises has been completely revised and uses the very latest software, a full version of which is enclosed on CD, allowing readers to carry out their own initial experiments with forcefield calculations in organometal and complex chemistry.
Martin Oliver Steinhauser deals with several aspects of multiscale materials modeling and simulation in applied materials research and fundamental science. He covers various multiscale modeling approaches for high-performance ceramics, biological bilayer membranes, semi-flexible polymers, and human cancer cells. He demonstrates that the physics of shock waves, i.e., the investigation of material behavior at high strain rates and of material failure, has grown to become an important interdisciplinary field of research on its own. At the same time, progress in computer hardware and software development has boosted new ideas in multiscale modeling and simulation. Hence, bridging the length and time scales in a theoretical-numerical description of materials has become a prime challenge in science and technology.
This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer’s disease and Parkinson’s disease to Huntington’s disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today’s forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.
Groundwater Lowering in Construction outlines the practical aspects of groundwater lowering which are of assistance for the successful and economical completion of construction projects. This book is the definitive reference for the practising engineer, engineering geologist, and advanced civil engineering or engineering geology student dealing with below ground excavations and constructions.
Makes connections between diseases, drugs and signaling in those chapters not specifically devoted to pathogens. Reviews background in first 5 chapters then offers chapters on cancers and apoptosis and on bacteria and viruses. Signaling in the immune, endocrine (hormonal) and nervous systems covered along with cancer, apoptosis and gene regulation. Each chapter ends with a problem section to facilitate discussion.
Demonstrating that many useful resources, such as databases, can benefit most bioinformatics projects, the Handbook of Hidden Markov Models in Bioinformatics focuses on how to choose and use various methods and programs available for hidden Markov models (HMMs). The book begins with discussions on key HMM and related profile methods, incl
Charts the flight of some of this century's most important thinkers from Nazi Germany to the United States. Jay explores the theories of The Frankfurt School -- among them, the work of Theodor Adorno, Leo Lowenthal and Herbert Marcuse -- as well, such as George Lichtheim, Hannah Arendt, and Henry Pachter.
A rigorous theory of money, credit, and bankruptcy in the context of a mixed economy, uniting Walrasian general equilibrium with macroeconomic dynamics and Schumpeterian innovation. This book offers a rigorous study of control, guidance, and coordination problems of an enterprise economy, with attention to the roles of money and financial institutions. The approach is distinctive in drawing on game theory, methods of physics and experimental gaming, and, more generally, a broader evolutionary perspective from the biological and behavioral sciences. The proposed theory unites Walrasian general equilibrium with macroeconomic dynamics and Schumpeterian innovation utilizing strategic market games. Problems concerning the meaning of rational economic behavior and the concept of solution are noted. The authors argue that process models of the economy can be built that are consistent with the general equilibrium system but become progressively more complex as new functions are added. Explicit embedding of the economy within the framework of government and society provides a natural, both formal and informal, control system. The authors describe how to build and analyze multistate models with simple assumptions about behavior, and develop a general modeling methodology for the construction of models as playable games.
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.