Martin Fiegl's Books

Cancer Genomics

Chapter 2. Second-Generation Sequencing for Cancer Genome Analysis

By: Hye-Jung E. Chun,Jaswinder Khattra,Martin Krzywinski,Samuel A. Aparicio,Marco A. Marra

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Cancer Genomics

Chapter 2. Second-Generation Sequencing for Cancer Genome Analysis

By: Hye-Jung E. Chun,Jaswinder Khattra,Martin Krzywinski,Samuel A. Aparicio,Marco A. Marra

Cancer results from accumulated mutations in the genome. Sequencing is an accurate method to detect mutations. Second-generation sequencing technology, commonly referred to as next-generation sequencing technology, enables rapid, efficient and affordable DNA sequencing, and is transforming the scale and scope of cancer research. The technology is sufficiently flexible and affordable to allow sequencing of many cancer genomes, and thus facilitates both sequencing of samples from large patient cohorts and during disease progression in individual cancer patients. The high depths of redundant sequence coverage that can be obtained using some second-generation sequencing technologies, along with sequencing reads amplified from single DNA molecules, facilitate detection of subclones of cells in tumors. Large-scale genome sequencing of hundreds or even thousands of cancer samples is being conducted by several groups that aim to identify and characterize cancer driver mutations. Goals of such work, previously infeasible with Sanger sequencing instruments, are to use this information to improve cancer prognosis, diagnosis and therapeutic decision-making. The speed of data analysis is rate limiting, and investigators are struggling to accommodate and interpret the data deluge produced by second-generation technologies. In this chapter, we discuss cancer properties that are revealed by sequencing and the implication of such properties in experimental design and data interpretation. We describe past, current and upcoming sequencing technologies and the application of second-generation sequencing technologies in cancer genomics. Finally, we discuss the impact of second-generation sequencing technology in shaping personalized medicine.

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Elsevier Inc. Chapters

Published Date

ISBN 10

0128060999

ISBN 13

9780128060995

Abeloff's Clinical Oncology E-Book

By: Martin D. Abeloff,James O. Armitage,John E. Niederhuber,Michael B. Kastan,W. Gillies McKenna

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Abeloff's Clinical Oncology E-Book

By: Martin D. Abeloff,James O. Armitage,John E. Niederhuber,Michael B. Kastan,W. Gillies McKenna

Carrying on the tradition established by its founding editor, the late Dr. Martin Abeloff, the 4th Edition of this respected reference synthesizes all of the latest oncology knowledge in one practical, clinically focused, easy-to-use volume. It incorporates basic science, pathology, diagnosis, management, outcomes, rehabilitation, and prevention – all in one convenient resource – equipping you to overcome your toughest clinical challenges. What's more, you can access the complete contents of this Expert Consult title online, and tap into its unparalleled guidance wherever and whenever you need it most! Equips you to select the most appropriate tests and imaging studies for diagnosing and staging each type of cancer, and manage your patients most effectively using all of the latest techniques and approaches. Explores all of the latest scientific discoveries' implications for cancer diagnosis and management. Employs a multidisciplinary approach - with contributions from pathologists, radiation oncologists, medical oncologists, and surgical oncologists - for well-rounded perspectives on the problems you face. Offers a user-friendly layout with a consistent chapter format • summary boxes • a full-color design • and more than 1,445 illustrations (1,200 in full color), to make reference easy and efficient. Offers access to the book's complete contents online – fully searchable – from anyplace with an Internet connection. Presents discussions on cutting-edge new topics including nanotechnology, functional imaging, signal transduction inhibitors, hormone modulators, complications of transplantation, and much more. Includes an expanded color art program that highlights key points, illustrates relevant science and clinical problems, and enhances your understanding of complex concepts.

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2586

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

1437720560

ISBN 13

9781437720563

Sấo Paulo

90 Colorfotos

By: Felix Richter,Arnaldo Borensztajn,Martin Fiegl,Silvestre Silva

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Sấo Paulo

90 Colorfotos

By: Felix Richter,Arnaldo Borensztajn,Martin Fiegl,Silvestre Silva

In a select group of the world's cities, life seems to take on an additional dimension. The continual buzzing of crowds, thousands of restaurants, cultural events and an enormous array of leisure offerings fill such cities with an atmosphere of enjoyment and emotion. It is quite possible that São Paulo is the liveliest of them all. There is a proverb that says that it takes longer than one lifetime to get to know São Paulo. For those who don't have that long, this book offers an ideal alternative. Welcome to São Paulo. Discover São Paulo through the eyes of the photographers Felix Richter and Martin Fiegl.

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New Zealand Visitor Publications Limited

Published Date

ISBN 10

1877339946

ISBN 13

9781877339943

On the Wild Side

By: Martin Gardner

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On the Wild Side

By: Martin Gardner

I have always been intrigued by fringe science," writes Martin Gardner in the preface to this book, "perhaps for the same reason that I enjoy freak shows and circuses. Pseudoscientists, especially the extreme cranks, are fascinating creatures for psychological study. Moreover, I have found that one of the best ways to learn something about any branch of science is to find out where its crackpots go wrong."A unique combination of horse sense and drollery has made Martin Gardner the undisputed dean of the critics of pseudoscience. This bountiful collection of essays and articles will be wholeheartedly greeted by Gardner''s fans, as well as by new readers.This collection of articles - many of which first appeared in the Skeptical Inquirer, the New York Review of Books, and Free Inquiry - explores pseudoscience and strange religious beliefs with the author''s trademark wit and verve. Destined to be a classic of skeptical literature, this book covers a wide range of topics - including UFOs, rainmaking, ghosts, the Big Bang, ESP, Oral Roberts, as well as the early history of spiritualism and today''s bizarre "trance channeling" cults.

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Page Count

258

Publisher

Prometheus Books

Published Date

ISBN 10

1616140593

ISBN 13

9781616140595

Are Universes Thicker Than Blackberries

By: Martin Gardner

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Are Universes Thicker Than Blackberries

By: Martin Gardner

In a society begging to be duped, Martin Gardner, the most devastating debunker of scientific fraud and chicanery of our time, ranges here from science and mathematics to literature, philosophy, religion, and mysticism. With keen skepticism, he skewers the fallacies of pseudoscience, from Dr. Bruno Bettelheim's erroneous theory of autism to the farce of Primal Scream therapy, and he examines the bizarre tangents produced by Freudians and deconstructionists in their critiques of "Little Red Riding Hood." Book jacket.

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Page Count

306

Publisher

W. W. Norton & Company

Published Date

ISBN 10

0393325725

ISBN 13

9780393325720

Book's by Martin Fiegl

Cancer Genomics

Cancer Genomics

Abeloff's Clinical Oncology E-Book

Abeloff's Clinical Oncology E-Book

Sấo Paulo

Sấo Paulo

On the Wild Side

On the Wild Side

Are Universes Thicker Than Blackberries

Are Universes Thicker Than Blackberries

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