As a Holocaust survivor, neurologist and psychiatrist Dr Viktor E. Frankl had a personal stake in the effectiveness of his approach to psychology: he lived the suffering about which he wrote. With this new reading of the Book of Job, Lewis further develops Frankl’s concept of Logotherapy as a literary hermeneutic, presenting readers with the opportunity to discover unique meanings and clarify their attitudes toward pain, guilt, and death. Key issues emerge from the discussion of three different movements, which address Frankl’s concept of the feeling of meaninglessness and his rejection of reductionism and nihilism, the dual nature of meaning, and his ideas of ultimate meaning and self-transcendence. Discovering meaning through participation with the text enables us to see that Job’s final response can become a site for transcending suffering.
This comprehensive reference work brings together for the first time information on every aspect of the parvoviruses in a single volume. It presents the new system of parvovirus classification, as agreed by the International Committee for the Taxonomy of Viruses (ICTV), and includes cutting edge information on the virology, molecular and cellular biology, immunology and clinical manifestations of infection with each known and proposed member of the family Parvoviridae. The book also describes the rapidly expanding basic and clinical science which underpins gene therapy applications using helper-dependent and helper-independent parvoviruses. The respected editorial group has drawn together renowned contributors from around the world to produce what will undoubtedly become the standard reference on the subject. It is essential reading for clinical or research virologists and microbiologists, infectious disease specialists, and public health specialists and laboratories.
Since its discovery by Europeans in 1500, explorers, visionaries, soldiers of fortune, men of God, scientists, and slavers have been drawn to the legendary Amazon. The River Sea is a sweeping chronicle of those brave and hardy souls, ranging from the Spanish seafarer Vicente Pinzón, who discovered the river, to contemporary heroes and heroines, like Sister Dorothy Stang and Chico Mendes, whose efforts to save the rain forest cost them their lives. Among the vast cast of characters who people this drama of the Amazon are Francisco de Orellana, the first European to traverse the river from the Andes to the sea; the fiery priest Bartolomé de las Casas, defender of the indigenous peoples; the great scientist explorers Alexander von Humboldt and Alfred Russel Wallace; the madman and psychopath Lope de Aguirre; and the Peruvian Evangeline, Isabel Godin, who in 1769 crossed the continent, braving the terrors of the jungles to reunite with her husband, whom she had not seen in twenty years. The River Sea is a compelling account of five centuries of the history, the myths, and the legends of Río Amazonas, the most exotic and fascinating locale on earth.
The landmark text that has guided generations of hematologists and related practitioners―updated with the latest research findings and improved format and presentation Long revered for its comprehensiveness and extraordinary depth of detail, Williams Hematology provides essential coverage of the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood and marrow cells and coagulation proteins. The text contains a wealth of basic science and translational pathophysiology for optimal, lifelong learning. Experts in research and clinical hematology, the editors are known worldwide for their contributions to the field. This new edition contains everything that has made Williams Hematology the go-to resource for decades and has been updated with new chapters and critical new research into the molecular mechanisms responsible for hematological disorders and the impact on diagnosis and treatment. And the new format enables you to access each chapter via content modules covering key topics, with summaries, infographics, and cases―all linked to review questions for self-assessment. The full-color presentation integrates images of blood and tissue findings where they are cited in the text. NEW TO THIS EDITION: Updated and revised content reflecting the latest research and developments Convenient format that streamlines the learning process and improves retention Additional chapters added on: Immune Checkpoint Inhibitors Immune Cell Therapy: Chimeric Antigen Receptor T Cell Therapy Immune Cell Therapy Dendritic Cell and Natural Killer Cell Therapy The processes of cell death and survival Application of Big Data and Deep Learning in Hematology Williams Hematology Cases with multiple-choice questions including detailed explanations—perfect preparation for the boards Continuously updated online content with comprehensive drug therapy database and other resources
Everything you need to know about red cell disorders, from basic science to clinical application. When red blood cells do not have enough hemoglobin, oxygen cannot reach all parts of the body—as a result, organs start to malfunction and may lead to a host of issues including deformities, enlarged spleen, heart problems and other diseases. There are myriad red cell disorders, such as iron deficiency anemia, pernicious anemia, aplastic anemia, autoimmune hemolytic anemia, sickle cell, thalassemia and other hemoglobinopathies. The Red Cells and its Diseases provides clinicians with a practical diagnostic and treatment framework for identifying and successfully managing acute, congenital, and chronic red blood cell disorders. Presented in an accessible template format, the book includes classifications, etiology and pathogenesis, clinical and laboratory features, differential diagnosis, treatment, management, and supportive care. This comprehensive, yet concise resource covers: Structure and physiology of the red cell Classification of red cell diseases Diseases of red cell production Anemias resulting principally from inherited disorders Anemia as a result of exogenous factors Polyclonal erythrocytosis Red cell transfusion
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