The Complement FactsBook contains entries on all components of the Complement System, including C1q and Lectins, C3 Family, Serine Proteases, Serum Regulators of Complement Activation, Cell Surface Proteins, and Terminal Pathway Proteins. Domain Structure diagrams are incorporated to clearly illustrate the relationships between all the complement proteins, both within families and between families. The FactsBook also includes the cDNA sequences, marked with intron/exon boundaries, which will facilitate genetic studies. Includes the cDNA sequences, marked with intron/exon boundaries, facilitating genetic studies Presents detailed structural information including cDNA and gene structure for all proteins Introduces complement function, simply described for each function Data is as up-to-date as possible, including unpublished work from many contributors Incorporates domain structures diagrams, which beautifully illustrate the relationship between all the complement proteins, both within, and between, familiesEach chapter has been written by an expert in the field Data is as up-to-date as possible, including unpublished work from many contributors Entries provide information on: Alternative nomenclature, Physiochemical properties, Structure and function, Tissue distribution and regulation expression, Protein sequence/modules, Chromosomal location, Genomic structure, Database accession numbers, Deficiency and polymorphic variants, Key references
Asthma is a familiar and growing disease today, but its story goes back to the ancient world, as we know from accounts in ancient texts from China, India, Greece and Rome. It was treated with acupuncture and Ayurveda. As Western medicine developed, the nature of asthma became clearer, and its basis in the lungs recognized. But cultural perceptions of the disease shifted too. By the 18th century, with recognition that the disease was centred on the lungs, the idea of environmental triggers such as dust and smoke first became recognized. And with that, asthma also became identified as a disease of artisans. Things changed again in the 19th century, as medical understanding grew with the advent of the stethoscope and new techniques such as percussion of the chest. New treatments included the promotion of mountain spas, for asthma now rose in social status, and became associated with the upper classes and the literati. For Marcel Proust and Charles Dickens, asthma shaped their lives and their creativity. From early in the 20th century, the idea of asthma as an allergic disease became established, and the search for environmental causes was on. Hay fever was closely linked, and pharmaceutical companies began to make antihistamines, anti-inflammatories and bronchodilators. Asthma sufferers were warned to beware of pets, simplify their furnishings, and take holidays by the sea far from pollens. But a newly emerging concept was that attacks could be triggered by stress and psychological factors. With musicians such as Schoenberg and Berg as celebrity sufferers, the idea of asthma as an élite disease persisted. In recent years, attitudes have changed again, as incidences of asthma grew dramatically across the world, especially among the young. The disease has now become closely linked to modern lifestyles and the many products of civilization. The battle against house-dust mites began, and whole new lines of anti-allergenic products and foods were launched - asthma has proved highly lucrative over the years. But the disease has remained fashionable, even becoming the theme of several pop songs. Asthma: the biography is part of the Oxford series, Biographies of Diseases, edited by William and Helen Bynum. In each individual volume an expert historian of medicine tells the story of a particular disease or condition throughout history - not only in terms of growing medical understanding of its nature and cure, but also shifting social and cultural attitudes, and changes in the meaning of the name of the disease itself.
Whether we want to improve education or cut crime, to enhance public health or to generate clean energy, we need the experimental methods of science - the best tool humanity has yet developed for working out what works. Yet from the way we're governed to the news we're fed by the media we're let down by a lack of understanding and respect for its insights and evidence. In The Geek Manifesto Mark Henderson explains why and how we need to entrench scientific thinking more deeply into every aspect of our society. A new movement is gathering. Let's turn it into a force our leaders cannot ignore. This edition includes an appendix: 'A Geek Manifesto for America' by David Dobbs.
Highly readable, well illustrated, and easy to understand, Obstetrics: Normal and Problem Pregnancies remains your go-to choice for authoritative guidance on managing today’s obstetric patient. Reflecting the expertise of internationally recognized authorities, this bestselling obstetrics reference has been thoroughly revised to bring you up to date on everything from ultrasound assessment of fetal anatomy and growth, to medical complications in pregnancy, to fetal therapy...and much more! Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Benefit from the knowledge and experience of international experts in obstetrics. Gain a new perspective on a wide range of today’s key issues - all evidence based and easy to read. Stay current with new coverage of fetal origins of adult disease, evidence-based medicine, quality assessment, nutrition, and global obstetric practices. Find the information you need quickly with bolded key statements, additional tables, flow diagrams, and bulleted lists for easy reference. Zero in on "Key Points" in every chapter - now made more useful than ever with the inclusion of related statistics. View new ultrasound nomograms in the Normal Values in Pregnancy appendix.
This book addresses what software architects and developers need to know in order to build applications based on blockchain technology, by offering an architectural view of software systems that make beneficial use of blockchains. It provides guidance on assessing the suitability of blockchain, on the roles blockchain can play in an architecture, on designing blockchain applications, and on assessing different architecture designs and tradeoffs. It also serves as a reference on blockchain design patterns and design analysis, and refers to practical examples of blockchain-based applications. The book is divided into four parts: Part I provides a general introduction to the topic and to existing blockchain platforms including Bitcoin, Ethereum, and Hyperledger Fabric, and offers examples of blockchain-based applications. Part II focuses on the functional aspects of software architecture, describing the main roles blockchain can play in an architecture, as well as its potential suitability and design process. It includes a catalogue of 15 design patterns and details how to use model-driven engineering to build blockchain-based applications. Part III covers the non-functional aspects of blockchain applications, which are cross-cutting concerns including cost, performance, security, and availability. Part IV then presents three detailed real-world use cases, offering additional insights from a practical perspective. An epilogue summarizes the book and speculates on the role blockchain and its applications can play in the future. This book focusses on the bigger picture for blockchain, covering the concepts and technical considerations in the design of blockchain-based applications. The use of mathematical formulas is limited to where they are critical. This book is primarily intended for developers, software architects and chief information officers who need to understand the basic technology, tools and methodologies to build blockchain applications. It also provides students and researchers new to this field an introduction to this hot topic.
In this seventh edition of Moon Oregon, Elizabeth and Mark Morris return with the energy and excitment they brought to previous editions. Making sure you will have the best time possible in Oregon this guide covers all corners of the "Beaver State," all the way from big buildings of downtown Portland to Umpqua Hot Springs. Self-proclaimed lovers of the Pacific Northwest Elizabeth and Mark have a history of guide writing, but what they relish most is helping you find new ways to enjoy Oregon for the first, second or fifteenth time. They even include updated strategies: • Best of Oregon • Wine Lover's Tour • Oregon Outdoors • Long Weekend in Oregon Moon Oregon is sure to answer any of your questions while visiting the lush locales of Southeast Oregon's Lost Forest, The Cascades Sparks Lake or dining on orange almond chicken at Williamette Valley's Sassy Onion Grill. In a state filled with fishing, foilage, and Fat Tire Festivals you're sure to see it all with Moon Oregon.
Completely updated, the Fifth Edition of this standard-setting two-volume reference presents the most advanced diagnostic techniques and the latest information on all currently known disease entities. More than 90 preeminent surgical pathologists offer expert advice on the diagnostic evaluation of every type of specimen from every anatomic site. The Fifth Edition contains over 4,400 full-color photographs. This edition provides detailed coverage of the latest developments in the field, including new molecular and immunohistochemical markers for diagnosis and prognosis of neoplasia, improved classification systems for diagnosis and prognosis, the role of pathology in new diagnostic and therapeutic techniques, and the recognition of new entities or variants of entities. All full-color illustrations have been color-balanced to dramatically improve image quality.
A groundbreaking book, THE AGE OF AUTISM explores how mankind has unwittingly poisoned itself for half a millennium For centuries, medicine has made reckless use of one of earth's most toxic substances: mercury—and the consequences, often invisible or ignored, continue to be tragic. Today, background pollution levels, including global emissions of mercury as well as other toxicants, make us all more vulnerable to its effects. From the worst cases of syphilis to Sigmund Freud's first cases of hysteria, from baffling new disorders in 19th century Britain to the modern scourge of autism, THE AGE OF AUTISM traces the long overlooked history of mercury poisoning. Now, for the first time, authors Dan Olmsted and Mark Blaxill uncover that history. Within this context, they present startling findings: investigating the first cases of autism diagnosed in the 1940s revealed an unsuspected link to a new form of mercury in seed disinfectants, lumber fungicides and vaccines. In the tradition of Silent Spring and An Inconvenient Truth, Olmsted and Blaxill demonstrate with clarity how chemical and environmental clues may have been missed as medical "experts," many of them blinded by decades of systemic bias, instead placed blamed on parental behavior or children's biology. By exposing the roots and rise of The Age of Autism, this book attempts to point the way out – to a safer future for our children and the planet.
The only reference available that synthesizes this vast subspecialty into a single trustworthy resource, Cornea, 5th Edition, provides state-of-the-art coverage of the expanding range of contemporary corneal surgery, new diagnostic and imaging technologies, and medical management of corneal and external disease as well as ocular surface disease. Drs. Mark J. Mannis, Edward J. Holland, and a team of more than 200 global experts keep you up to date with both common and more obscure diseases and disorders and the best route to effective treatment and management, making this two-volume text a must-have resource for residents and fellows, general ophthalmologists, and seasoned cornea specialists. Features more than 2,300 exceptionally clear illustrations, diagnostic images, and step-by-step surgical photographs that offer superb visual guidance. Contains 14 new chapters, including Nanothin DSAEK, Aqueous Deficiency Dry Eye Syndrome, Evaluation of Recurrent Corneal Erosions, Evaluation of the Corneal Ulcer, Contemporary Approaches to the Biosynthetic Cornea, and Topography Guided Photorefractive Keratectomy, and more. Includes more than 80 video clips of current corneal surgery techniques, including new clips of the application of cryopreserved amniotic membrane in the treatment of acute stevens , penetrating keratoplasty, DM rupture management in STALK and in the keratonconus patient, and KAMRA corneal inlay implantation. Covers the latest developments in ocular surface transplantation, including new chapters on Conjunctival Limbal Autograft (CLAU); Living Related Conjunctival Limbal Allograft (Lr-CLAL); Keratolimbal Allograft; Cultivated Limbal Epithelial Transplantation; Simple Limbal Epithelial Transplantation; and Outcomes of Ocular Surface Transplantation. Provides key point overviews in each chapter that offer easier access to crucial information.
Treatment of Skin Disease is your definitive source for managing the complete range of dermatologic conditions you’re likely to encounter in practice. This medical reference book boasts an intuitive and easy to use format that covers the full spectrum of options, equipping you with not only standard treatment strategies, but second- and third-line therapies for instances when other alternatives fail. You’ll be thoroughly prepared to offer your patients the expertly informed medical care they deserve when facing common or complex dermatologic diseases. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Address your most difficult clinical challenges by having every possible therapy option at your disposal, including third- and fourth-line therapies, as well as standard treatments for dermatologic disorders. Apply the in-depth knowledge of leading dermatologists through a summary of each treatment strategy along with detailed discussions of treatment choices. Gain insight to the essential features which define each dermatologic disease with chapters presented in a tabular format, using checklists of diagnostic and investigative pearls and color-coded boxed text, for quick at-a-glance summaries of key details. Make the most informed decisions possible with the inclusion of up-to-date evidence levels throughout the text. Stay abreast of emerging drug treatments and research with the very latest options for the 251 most common dermatologic conditions, and take advantage of today’s expert knowledge on hot topics in dermatology such as bed bugs, erosive pustular dermatosis, polycystic ovary syndrome, and more. Achieve effective visual diagnoses by viewing over 250 full-color clinical images of skin diseases, most of which are brand new in this edition.
It has been little more than a century since Emil von Behring and his colleagues (1890) showed that the blood of tetanus-immune rabbits contained a factor that could be transferred to nonimmune animals to protect them against tetanus. These observations, together with the work of Paul Ehrlich, started scientists on the long and complex path to our present understanding of the humoral, or B-cell, immune system. These early studies led to Nobel prize awards for von Behring (1901 ) and Ehrlich (1908), each of whom contributed much to our knowledge of the B-cell immune system. In the early 20th century it was recognized that the serum of individuals who had recently suffered an infection contained a protective humoral factor that could be transferred to a nonimmune person, thereafter affording that individual protection against the infectious agent that had caused disease. In 1933 McKhann and Chu reported that a placental extract containing the globulin fraction could modify measles. However, it was not until 1939 that Tiselius and Kabat demonstrated that the antibodies responsible for protection against these infectious disorders resided within the gammaglobulin plasma fraction. In a major step forward, Cohn in 1944 established a method for the fractionation and purification of this plasma gammaglobulin fraction. These procedures, which are based on cold ethanol precipitation of plasma, produce a readily adaptable, large-scale fractionation procedure that is still utilized to this day in the preparation of commercial gammaglobulin.
This is an ideal text for an introduction to biomedical engineering. The book presents the basic science knowledge used by biomedical engineers at a level accessible to all students and illustrates the first steps in applying this knowledge to solve problems in human medicine. Biomedical engineering encompasses a range of fields of specialization including bioinstrumentation, bioimaging, biomechanics, biomaterials, and biomolecular engineering. This introduction to bioengineering assembles foundational resources from molecular and cellular biology and physiology and relates them to various sub-specialties of biomedical engineering. The first two parts of the book present basic information in molecular/cellular biology and human physiology; quantitative concepts are stressed in these sections. Comprehension of these basic life science principles provides the context in which biomedical engineers interact. The third part of the book introduces sub-specialties in biomedical engineering, and emphasizes - through examples and profiles of people in the field - the types of problems biomedical engineers solve.
Dental emergencies are common and require rapid response. Order today and keep readily accessible in your dental practice! Filled with clinical examples and step-by-step procedures, Dental Emergencies covers the full range of both common and complex traumatic injuries, pain, and oral lesions. From clinical examination and assessment of potential complications to key considerations in pain management, acute oral medical and surgical conditions, restorative emergencies, treating special needs patients, and beyond, you get a comprehensive reference that: distills essential information on dental emergencies offers succinct, practical instruction for immediate treatment highlights conditions for referral and much more!
Highly praised in its first three editions, Cornea has become a market-leading cornerstone text and the immediate go-to resource for anyone working in this hugely popular and evolving sub-specialty. Offered over two volumes and featuring the knowledge of over 200 experts worldwide, it presents state-of-the-art coverage of the expanding range of contemporary corneal surgery, new diagnostic technology, and medical management of corneal and external disease as well as ocular surface disease. This updated edition includes 20 brand-new chapters, while an enhanced focus on images provides key visual guidance in this challenging field. Exceptionally clear illustrations, diagnostic images, and step-by-step surgical photographs offer superb visual guidance. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos, and references from the book on a variety of devices. 20 brand-new chapters cover the latest advances in the field, such as DMEK, Ultra-Thin DSEK and DSAEK techniques; endothelial cell transplantation; keratoplasty and prosthokeratoplasty techniques; collagen cross-linking; and new refractive surgical techniques (presbyopic implants and SMILE surgery). 60 video clips on Expert Consult show new footage of the latest corneal surgery techniques, including Boston Keratoprosthesis, corneal inlay surgery, and lenticule extraction. Boasts over 170 chapters with unique, cutting-edge content, as well as 2,300 clear illustrations – 670 of which are new to this edition. Presents a detailed exposition of the growing number of techniques for lamellar keratoplasty, including outcomes. Includes new sections on the latest developments in the management of ocular surface disease. Key point overviews in each chapter offer easier access to crucial information.
The new gold-standard in anesthesiology Written and edited by an internationally known team of experts, Anesthesiology gives you a 360-degree view of the field, covering all of the anesthetic considerations, preparations, and procedures for the surgical patient, the pain patient or the critical care patient. You'll find a unique balance between clinical information, practical clinical procedures, and the molecular and basic scientific underpinnings of anesthesiology practice. Anesthesiology delivers a multi-perspective, wide-ranging view of anesthetic drugs, procedures, co-morbid diseases, and need-to-know postoperative pain management strategies. This essential guide not only focuses on general anesthesia, but also is the first to feature a detailed look at the subspecialty of regional anesthesia. Features: Top-to-bottom coverage of the entire field-from preoperative evaluation and intraoperative anesthesia care to care of the critically ill or chronic pain patient Emphasis on safety, quality and patient-centered care, with an entire section on risk reduction A focus on the clinical applications of anesthesiology Complex concepts explained by graphics and illustrations, not equations and formulas Full-color format and illustrations Specific drug and interventional guidelines for the clinical management of every OR/post-OR scenario in the anesthesiology field Key points and key references presented in each chapter CD that allows you to download illustrations and images to your PowerPoint presentations
Keep pace with current anesthesiology practice—with the new edition of this standard-setting guide This classic text—-written and edited by an internationally renowned author team—-defines today’s anesthesia practice for residents and practitioners alike. The book features crisp, readable prose that focuses on the most relevant topics in anesthesiology, perioperative medicine, critical care medicine, and pain medicine. Features NEW Increased focus on perioperative medicine, including outstanding sections on pre-op assessment, critical care medicine, and pain management NEW Expanded information on regional anesthesia reflects the best of current anesthesia practice, including ultrasound-guided techniques NEW Downloadable video clips of common procedures Complete coverage that spans the entire field, including all of the anesthetic considerations, preparations, and procedures for the surgical patient, the pain patient, and critical care patient Ideal for anesthesiology residents and practitioners preparing for the Maintenance of Certification in Anesthesiology (MOCA) exam Balanced presentation surveys clinical information, practical clinical procedures, and the molecular and basic scientific foundations of anesthesiology practice Timely emphasis on safety, quality, and patient-centered care Learning aids such as key points, numerous tables and algorithms, and key references Engaging full-color presentation
Convert the latest genomic data to the most effective patient management and treatment approaches Clinical Genomics helps healthcare providers translate the vast amount of new genomic data into successful clinical application. It is a comprehensive textbook and practical guide to the use of this information across a broad spectrum of adult diseases – from individual differences in drug responses, cardiac andcancer risks to Alzheimer's and other neurological and psychiatric disorders. While traditional textbooks on medical genetics focus on classic Mendelian disorders, Clinical Genomics discusses the everyday application of genetic assessment and the diagnostic, therapeutic, and preventiveimplications to the most common adult diseases that healthcare providers encounter. Covering approximately 200 conditions, it is a true clinical text for use across all of internal medicine. Coverage of each condition is presented in a consistent,clinically relevant manner and includes: Key Points Diagnostic Criteria and Clinical Characteristics Screening and C ounseling Management and Treatment Molecular Genetics and Molecular Mechanism Supplementary Information More than ten valuable appendices, include Genetic Privacy; Race, Ancestry, and Genetics; Personalized Medicine in Clinical Practice; Clinical Interpretationof Genomic Data; and Genetic Risk Profiling in the Genomics Era. Clinical Genomics is essential for internists, primary care physicians, and other healthcare providers who wish to increase their knowledge of the gene-and-protein level care of patients in a clinical setting.
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