This volume will try to put current therapy - achievements, shortcomings, remaining medical needs - and emerging new targets into the context of increasing knowledge regarding the genetic and neurodevelopmental contributions to the pathophysiology of schizophrenia. Some of the chapters will also deal with respective experimental and clinical methodology, biomarkers, and translational aspects of drug development. The volume will concentrate on reviewing the ongoing research attempting to identify novel treatments for the cognitive deficits and negative symptoms of schizophrenia, which are not treated adequately by current antipsychotic medications.
The Hughes Court: From Progressivism to Pluralism, 1930 to 1941 describes the closing of one era in constitutional jurisprudence and the opening of another. This comprehensive study of the Supreme Court from 1930 to 1941 – when Charles Evans Hughes was Chief Justice – shows how nearly all justices, even the most conservative, accepted the broad premises of a Progressive theory of government and the Constitution. The Progressive view gradually increased its hold throughout the decade, but at its end, interest group pluralism began to influence the law. By 1941, constitutional and public law was discernibly different from what it had been in 1930, but there was no sharp or instantaneous Constitutional Revolution in 1937 despite claims to the contrary. This study supports its conclusions by examining the Court's work in constitutional law, administrative law, the law of justiciability, civil rights and civil liberties, and statutory interpretation.
This book follows Cronin from his humble beginnings to his position as one of the most powerful figures in baseball. Mark Armour explores Cronin's time as a player as well as his role in some of the game's fiercest controversies, from the creation of the All-Star Game to the issue of integration-his Red Sox were the last team in baseball to field black players. Bringing to richly detailed life one of baseball's definitive characters, the book supplies a crucial and fascinating chapter in the history of America's pastime.
Addressing the relationships between gastroesophageal reflux and airway diseases, this pioneering reference is the only single source that serves as an intensive review of the subject, providing a large spectrum of information facilitating proper diagnosis and treatment of GERD and GERD-related disorders. Focusing on dentition, upper airway disease, cough, and lower airway disease, and presented in a format ideal for primary care providers and specialists, Gastroesophageal Reflux Disease and Airway Disease analyzes practical, in-office approaches to diagnosis provides guidelines for diagnostic modalities and treatment in all age groups clarifies when to consider surgical procedures highlights acid damage to the airway, from the esophagus up to the incisors and down to the lungs alerts physicians to the warning signs of GERD in adult asthmatics contains a questionnaire that helps elicit a history of GERD-related airway disease recommends pediatric medication dosing schedules discusses the benefits and limitations of performing laparoscopic surgical procedures in GERD patients explains paroxysmal laryngospasm and more! Containing over 1100 references, tables, drawings, and photographs, Gastroesophageal Reflux Disease and Airway Disease is an essential reference for clinical immunologists and allergists, pulmonologists, physiologists, gastroenterologists, otolaryngologists, pediatricians, internists and family practitioners, physician assistants, nurse practitioners, and medical students in these disciplines.
This A–Z encyclopedia provides a detailed overview of America's 11th president and connects Polk's public and personal life to his historical significance. In 1844, James K. Polk was not a promising presidential nominee—he was not popular, charismatic, or even well known. But by the time he left office in 1849, he had acquired the enormous Oregon Territory by negotiation and had taken by force more than half of Mexico's territory, an area of about 500,000 square miles. Yet Polk's territorial successes inspired the rancorous debate over whether slavery should be allowed in the new territories—a debate that ended in civil war. Modern critics charge that Polk's actions toward Mexico were amoral if not immoral. In this comprehensive examination of Polk's life and career, our 11th president emerges as a complex man and a skillful politician who pursued power relentlessly.
The rapid growth of the American environmental movement in recent decades obscures the fact that long before the first Earth Day and the passage of the Endangered Species Act, naturalists and concerned citizens recognized—and worried about—the problem of human-caused extinction. As Mark V. Barrow reveals in Nature’s Ghosts, the threat of species loss has haunted Americans since the early days of the republic. From Thomas Jefferson’s day—when the fossil remains of such fantastic lost animals as the mastodon and the woolly mammoth were first reconstructed—through the pioneering conservation efforts of early naturalists like John James Audubon and John Muir, Barrow shows how Americans came to understand that it was not only possible for entire species to die out, but that humans themselves could be responsible for their extinction. With the destruction of the passenger pigeon and the precipitous decline of the bison, professional scientists and wildlife enthusiasts alike began to understand that even very common species were not safe from the juggernaut of modern, industrial society. That realization spawned public education and legislative campaigns that laid the foundation for the modern environmental movement and the preservation of such iconic creatures as the bald eagle, the California condor, and the whooping crane. A sweeping, beautifully illustrated historical narrative that unites the fascinating stories of endangered animals and the dedicated individuals who have studied and struggled to protect them, Nature’s Ghosts offers an unprecedented view of what we’ve lost—and a stark reminder of the hard work of preservation still ahead.
A critical analysis of the explosive political effects of the religious intermingling with race reveals the profound role of religion in American political history and in the American discourse on race and social justice.
Though calling itself “The Bloody Seventh” after only a few minor skirmishes, the Seventh West Virginia Infantry earned its nickname many times over during the course of the Civil War. Fighting in more battles and suffering more losses than any other West Virginia regiment, the unit was the most embattled Union regiment in the most divided state in the war. Its story, as it unfolds in this book, is a key chapter in the history of West Virginia, the only state created as a direct result of the Civil War. It is also the story of the citizen soldiers, most of them from Appalachia, caught up in the bloodiest conflict in American history. The Seventh West Virginia fought in the major campaigns in the eastern theater, from Winchester, Antietam, and Fredericksburg to Chancellorsville, Gettysburg, and Petersburg. Weaving military, social, and political history, The Seventh West Virginia Infantry details strategy, tactics, battles, campaigns, leaders, and the travails of the rank and file. It also examines the circumstances surrounding events, mundane and momentous alike such as the soldiers’ views on the Emancipation Proclamation, West Virginia Statehood, and Lincoln’s re-election. The product of decades of research, the book uses statistical analysis to profile the Seventh’s soldiers from a socio-economic, military, medical, and personal point of view; even as its authors consult dozens of primary sources, including soldiers’ living descendants, to put a human face on these “sons of the mountains.” The result is a multilayered view, unique in its scope and depth, of a singular Union regiment on and off the Civil War battlefield—its beginnings, its role in the war, and its place in history and memory.
Osiris, god of the dead, was one of ancient Egypt's most important deities. The earliest secure evidence for belief in him dates back to the fifth dynasty (c.2494-2345BC), but he continued to be worshipped until the fifth century AD. Following Osiris is concerned with ancient Egyptian conceptions of the relationship between Osiris and the deceased, or what might be called the Osirian afterlife, asking what the nature of this relationship was and what the prerequisites were for enjoying its benefits. It does not seek to provide a continuous or comprehensive account of Egyptian ideas on this subject, but rather focuses on five distinct periods in their development, spread over four millennia. The periods in question are ones in which significant changes in Egyptian ideas about Osiris and the dead are known to have occurred or where it has been argued that they did, as Egyptian aspirations for the Osirian afterlife took time to coalesce and reach their fullest form of expression. An important aim of the book is to investigate when and why such changes happened, treating religious belief as a dynamic rather than a static phenomenon and tracing the key stages in the development of these aspirations, from their origin to their demise, while illustrating how they are reflected in the textual and archaeological records. In doing so, it opens up broader issues for exploration and draws meaningful cross-cultural comparisons to ask, for instance, how different societies regard death and the dead, why people convert from one religion to another, and why they abandon belief in a god or gods altogether.
First published in 2009. From the founding of Jamestown to the American Civil War, slavery and abolition shaped American national, regional and racial identities. This four-volume reset edition draws together rare sources relating to American slavery systems. Volume 3 includes the Antebellum Period from 1828 to 1859.
Peverelly's Book of American Pastimes, which covered several sports from badminton to horseracing, is best known for its dominant chapter on base ball, "The National Game." It is the first historical-reference book ever published about the sport, and includes the rosters of the most prominent early clubs with results of games played from their beginnings through 1866. The original 200-page chapter, a seminal work of baseball historiography, is reproduced here in full, supplemented by contemporary images and captions by nineteenth-century baseball historians John Freyer and Mark Rucker.
William Castle, for instance, was a master promoter. In one scheme involving The Tingler, Vincent Price warns in the movie that "the only way to stop the monster is to scream. That's the signal to the projectionist to throw the switch. Under ten or twelve seats were some electric motors, war surplus things that Castle got a bargain on. The motors vibrated the seat, in the hope of scaring a scream out of someone. Just in case it didn't Castle planted someone in the audience to get the screams rolling." This book is about flamboyant promotion, the con artist side of the movie world--everything the ballyhoo boys did to separate the customer from the price of a movie ticket--Emergo, HypnoVista, 3-D, Wide Screen, Cinemagic, Duo-Vision, Dynamation, Smell-O-Vision, plenty more. Supporting the text are 107 photos and illustrations, some never-before-published, and a filmography.
From the 1930s to the early 1960s civil rights law was made primarily through constitutional litigation. Before Rosa Parks could ignite a Montgomery Bus Boycott, the Supreme Court had to strike down the Alabama law which made segregated bus service required by law; before Martin Luther King could march on Selma to register voters, the Supreme Court had to find unconstitutional the Southern Democratic Party's exclusion of African-Americans; and before the March on Washington and the Civil Rights Act of 1964, the Supreme Court had to strike down the laws allowing for the segregation of public graduate schools, colleges, high schools, and grade schools. Making Civil Rights Law provides a chronological narrative history of the legal struggle, led by Thurgood Marshall and the NAACP Legal Defense Fund, that preceded the political battles for civil rights. Drawing on interviews with Thurgood Marshall and other NAACP lawyers, as well as new information about the private deliberations of the Supreme Court, Tushnet tells the dramatic story of how the NAACP Legal Defense Fund led the Court to use the Constitution as an instrument of liberty and justice for all African-Americans. He also offers new insights into how the justices argued among themselves about the historic changes they were to make in American society. Making Civil Rights Law provides an overall picture of the forces involved in civil rights litigation, bringing clarity to the legal reasoning that animated this "Constitutional revolution", and showing how the slow development of doctrine and precedent reflected the overall legal strategy of Thurgood Marshall and the NAACP.
The authors' carefully crafted analysis will influence thought and the policy debate on the tradeoff between unilateralism and multilateralism for decades to come." -Todd Sandler, Robert R. and Katheryn A. Dockson Professor of International Relations & Economics, University of Southern California "Boyer and Bobrow's well-written, data-rich analysis of such pressing issues as development assistance, debt management, UN peacekeeping, and environmental protection makes Defensive Internationalism a highly original and provocative contribution to the study of global governance." -Yale H. Ferguson, Co-Director, Center for Global Change and Governance, Rutgers University In this pathbreaking study, authors Davis B. Bobrow and Mark A. Boyer argue for "muted optimism" about the future of international cooperation. Leaders of a growing movement that integrates constructivism into traditional international studies concepts and methods, Bobrow and Boyer analyze four key international issues: development cooperation, debt management, peacekeeping operations, and environmental affairs. Their approach integrates elements of public goods theory, identity theory, new institutionalism, and rational choice. Defensive Internationalism is a well-written, creative and coherent synthesis of ideas that have up to now been considered irreconcilable. It is appropriate for upper-level undergraduate and graduate students in international relations, conflict studies, and political economy, and promises to become a foundational work in its field. Davis B. Bobrow is Professor of Public and International Affairs and Political Science at the University of Pittsburgh. Mark A. Boyer is Professor of Political Science at the University of Connecticut.
Successfully fighting cancer starts with understanding how it begins. This thoroughly revised 3rd Edition explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of cancer. A team of leading experts thoroughly explain the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating cutting-edge advances and the newest research, the book provides thorough descriptions of everything from molecular abnormalities in common cancers to new approaches for cancer therapy. Features sweeping updates throughout, including molecular targets for the development of anti-cancer drugs, gene therapy, and vaccines...keeping you on the cutting edge of your specialty. Offers a new, more user-friendly full-color format so the information that you need is easier to find. Presents abundant figures-all redrawn in full color-illustrating major concepts for easier comprehension. Features numerous descriptions of the latest clinical strategies-helping you to understand and take advantage of today’s state-of-the-art biotechnology advances.
Forest mensuration – the science of measurement applied to forest vegetation and forest products – holds value for basic ecology as well as sustainable forest management. As demands on the world’s forests have grown, scientists and professionals are increasingly called on to quantify forest composition, structure, and the goods and services forests provide. Grounded in geometry, sampling theory, and ecology as well as practical field experience, forest mensuration offers opportunities for creative problem solving and critical thinking. This fifth edition of the classic volume, Forest Mensuration, includes coverage of traditional and emerging topics, with attention to SI and Imperial units throughout. The book has been reorganised from the fourth edition to better integrate non-timber and ecological aspects of forest mensuration at the tree, stand, forest, and landscape scales throughout. The new edition includes new chapters that specifically address the integration of remotely sensed data in the forest inventory process, and inventory methods for dead and downed wood. One unifying theme, not only for traditional forestry but for the non-timber inventory and for remote sensing, is the use of covariates to make sampling more efficient and spatially explicit. This is introduced in the introductory chapter on statistics and the chapter on sampling designs has been restructured to highlight this approach and lay the foundation for further learning. New examples will be developed throughout the textbook with an emphasis on current issues and international practice. Students in applied forestry programs will find ample coverage of forest products and timber inventory, while expanded material on biodiversity, biomass and carbon inventory, downed dead wood, and the growing role of remote sensing in forest assessment will be valuable to a broader audience in applied ecology.
“Biofuels for Road Transport: A Seed to Wheel Perspective” provides a review of the history, the current status and perspectives for biofuels used in road transport, across the full ‘seed-to-wheel’ life cycle of these fuels. Successive chapters cover the history of biofuels; the first- and second-generation liquid fuels and biofuels for powering electric vehicles; fossil fuel replacement, land requirement, greenhouse gas balances and environmental burdens of ethanol, esters derived from fatty acids (‘biodiesel’), Fischer-Tropsch diesel and HTU diesel; competing technologies (fossil fuels, increases in energy-efficiency and photovoltaic power) and how they compare to biofuels; and the perspectives for biofuels. Cost, availability, technological development, competition with biomass for food and for soil organic carbon and environmental perspectives are also discussed.
The belief that dead people could assume non-human forms is attested in Egyptian texts of all periods, from the Old Kingdom down to Graeco-Roman times. It was thought that assuming such forms enhanced their freedom of movement and access to nourishment in the afterlife, as well as allowing them to join the entourages of different deities and participate in their worship. Spells referring to or enabling the deceased’s transformations occur in the Pyramid Texts, the Coffin Texts, and the Book of the Dead. But it is not until the Graeco-Roman Period that we find entire compositions devoted to this theme. Two of the most important are P. Louvre N. 3122 and P. Berlin P. 3162, both written in hieratic and dating to the 1st century AD. Both texts have been known to Egyptologists for more than a century, but neither is currently available in an up-to-date comprehensive edition. This book provides such an edition, including high-resolution images of the manuscripts, hieroglyphic transcriptions, translations, descriptions of their material aspects, studies of their owners, their titles, and their families, reconstructions of their context of usage, analyses of their orthography and grammar, and detailed commentaries on their contents.
At the turn of the twentieth century, railroads meant progress, growth and development. In the 1890s Southport, North Carolina became the target destination for a major coaling terminal for ships sailing the Atlantic coast. A new terminal would require a railroad to bring in coal and other supplies. More than twenty companies were formed to pursue this idea over the years, with a few actual accomplishments, but most were purely speculative. Wearying the expectant town for more than twenty-five years, the vision for a great port was whittled down until local entrepreneurs finally built a 30-mile rail line to connect the town to Wilmington. Local author and railroad historian Mark Koenig chronicles the short life of a short line and the long process of making it a reality.
This book is for students and researchers who have a specific interest in learning and memory and want to understand how computational models can be integrated into experimental research on the hippocampus and learning. It emphasizes the function of brain structures as they give rise to behavior, rather than the molecular or neuronal details. It also emphasizes the process of modeling, rather than the mathematical details of the models themselves. The book is divided into two parts. The first part provides a tutorial introduction to topics in neuroscience, the psychology of learning and memory, and the theory of neural network models. The second part, the core of the book, reviews computational models of how the hippocampus cooperates with other brain structures -- including the entorhinal cortex, basal forebrain, cerebellum, and primary sensory and motor cortices -- to support learning and memory in both animals and humans. The book assumes no prior knowledge of computational modeling or mathematics. For those who wish to delve more deeply into the formal details of the models, there are optional "mathboxes" and appendices. The book also includes extensive references and suggestions for further readings.
This book will offer an account not so much of God’s Providence an sich, but rather of divine providence as experienced by believers and unbelievers. It will not ask questions about whether and how God knows the future, or how suffering can be accounted for (as is the case in the treatments by William Lane Craig, Richard Swinburne, or J. Sanders), but will focus on prayer and decision-making as a faithful and/or desperate response to the perception of God as having some controlling influence. The following gives an idea of the ground to be covered: The patristic foundations of the Christian view of Providence; The medieval synthesis of ‘objective’ and ‘subjective’ views; Reformational and Early Modern: the shift towards piety; Modern Enlightenment: Providence and Ethics; Barth and the Sceptics; The sense of Providence in the Modern Novel and World.
Although later made an icon of "rugged individualism," the American cowboy was a grossly exploited and underpaid seasonal worker, who waged a series of militant strikes in the generally isolated and neglected corners of the Old West. Mark Lause examines those neglected labour conflicts, couching them in the context of the bitter and violent "range wars" that broke out periodically across the region, and locating both among the political insurgencies endemic to the American West in the so-called Gilded Age.
This book narrates the important role that international law has played in America and the crucial if complex story of America's place in promoting and frustrating international law. Based on the stories of key figures in American history and written in an accessible style, it is a must read for anyone interested in America's place in the world.
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