Humans are biologically programmed to seek out pleasurable experiences. These experiences are processed in the mesolimbic system, also referred to as the "reward center" of the brain, where a number of chemical messengers work in concert to provide a net release of dopamine in the Nucleus Accumbens. In some genetically predisposed individuals, addiction occurs when the mechanisms of the mesolimbic system are disrupted by the use of various drugs of abuse. Since Alcoholics Anonymous was founded in 1935, it's 12 step program of spiritual and character development has helped countless alcoholics and drug addicts curb their self-destructive behaviors. However, the program was developed at a time when comparatively little was known about the function of the brain and it has never been studied scientifically. This is the first book to take a systematic look at the molecular neurobiology associated with each of the 12 steps and to review the significant body of addiction research literature that is pertinent to the program.
The Harvey Society was founded in 1905 by thirteen New York scientists and physicians with the purpose of forging a "closer relationship between the purely practical side of medicine and the results of laboratory investigation." The Society distributes scientific knowledge in selected areas of anatomy, physiology, pathology, bacteriology, pharmacology, and physiological and pathological chemistry through public lectures, which are published annually. Series 94, 1998-1999 covers themes in neurogenetic studies, the role of tyrosine phosphorylation in cell growth and disease, the biology of the epidermis and its appendages, and the phenotypic diversity of monogenic disease.
Public health thrives on high-quality evidence, yet acquiring meaningful data on a population remains a central challenge of public health research and practice. Social monitoring, the analysis of social media and other user-generated web data, has brought advances in the way we leverage population data to understand health. Social media offers advantages over traditional data sources, including real-time data availability, ease of access, and reduced cost. Social media allows us to ask, and answer, questions we never thought possible. This book presents an overview of the progress on uses of social monitoring to study public health over the past decade. We explain available data sources, common methods, and survey research on social monitoring in a wide range of public health areas. Our examples come from topics such as disease surveillance, behavioral medicine, and mental health, among others. We explore the limitations and concerns of these methods. Our survey of this exciting new field of data-driven research lays out future research directions.
Neoplastic mimics or ìpseudotumorsî can simulate neoplasms on all levels of analysisóclinical, radiologic, and pathologicóand thus represent particular diagnostic pitfalls for the pathologist that can ultimately lead to therapeutic misdirection. Hundreds of color images and analysis of diagnostic mimics guide the pathologist through recognizing and distinguishing the unusual variants, morphologic anomalies, and misleading features that may easily lead to an inaccurate interpretation and missed diagnosis. Since many of the entities described are uncommon, Neoplastic Mimics in Dermatopathology emphasizes imaging and clinical correlations throughout to support the pathologist as consultant to the entire diagnostic and clinical management team. Every pathologist who sees skin cases will find this book an invaluable working tool to ensure accurate diagnosis. This book provides the pathologist with detailed morphologic descriptions and diagnostic guidance in recognizing these neoplastic mimics as they occur in the skin. In addition, descriptions and diagnostic guidance are provided for the range of skin lesions that may mimic benign masses but are in fact neoplastic. Throughout the book comparisons of neoplastic mimics with true neoplasms are provided, at clinical, gross, and histologic levels. In the presentation of every entity, the points that contribute to differential diagnosis are emphasized. Neoplastic Mimics in Dermatopathology Features: Over 400 high-quality images showcase the full range of nonneoplastic and neoplastic mimics in skin Concise, specific text descriptions to make the book easy to use as a visual reference Expert authors guide the reader to recognizing and distinguishing misleading specimens
Neuro-ophthalmological symptoms frequently arise in disorders which alter the intracranial and intraorbital circulation. Because of the wide range of sensory and cognitive systems involved in vision and eye movements, visual disturbances are typically found in the common vascular disorders, such as atherosclerosis, migraine, and aneurysms, but can also result from practically any, common or rare,local or systemic vascular disorder. The dysfunction can be part of a largersyndrome or the predominant clinical abnormality. Many of the newer concepts concerning the diagnosis and treatment of neurovascular disorders have evolved in consequence of advances in techniques for neuroimaging such as MRI; methods of measuring systemic coagulation and inflammation; and superselective catheterization ofabnormal blood vessels and vascular lesions. The neuroophthalmological evaluation of clinical signs and symptoms often leads to accurate localization and diagnosis of the lesion. Many of these clinical abnormalities, such as visual field defects and ocular misalignments, can be quantified and followed to assess either the natural history of the disorder or the effects of therapies. No one medical specialty can manage these neurovascular neuro-ophthalmological disorders alone. The complexity of diagnosis and treatment planning requires a multi- disciplinary team. This approach, bringing ophthalmologists, neurosurgeons, and neurologists together to confer in the management of these cases, has been pioneered by the authors' group at the New York University Medical Center.
The Dietitian's Guide to Vegetarian Diets: Issues and Applications, Fourth Edition provides the most up-to-date information on vegetarian diets. Written for dietitians and other health care professionals, the Fourth Edition can be used as an aid for counseling vegetarian clients and those interested in becoming vegetarians, or serve as a textbook for students who have completed introductory coursework in nutrition"--
Survival in a world beset by magic and evil takes more than a lucky roll of the dice. Pathfinder Player Core 2 significantly expands options available to Pathfinder players, giving them the edge to take on any adventure. This 320-page hardcover rulebook remasters 8 classes from Pathfinder Second Edition, providing everything you need to create a wide array of new characters, ready to take on the world. It also includes more than 40 archetypes, expanded ancestries, and tons of feats, spells, and alchemical items to provide a near-endless array of exciting options for every Pathfinder character! Pathfinder Player Core 2 is the fourth core rulebook for the fully remastered Pathfinder Second Edition RPG! These rules are compatible with previous Pathfinder Second Edition rulebooks, incorporating comprehensive errata and rules updates and some of the best additions from later books into new, easier-to-access volumes with new presentations inspired by years of player feedback. Along with the Player Core, GM Core, and Monster Core, these books provide a new foundation for the future of tabletop gaming! This deluxe special edition is bound in faux leather with metallic deboss cover elements and a bound-in ribbon bookmark. The ideal character option resource for players looking to move beyond Pathfinder Player Core. Pathfinder Player Core 2 includes: - Eight fully detailed classes, including the alchemist, barbarian, champion, investigator, monk, oracle, sorcerer, and swashbuckler, each with multiple character paths, multiclassing options, and dozens of feats! - Expanded ancestry options include the catfolk, hobgoblin, hyena-like kholo, kobold, lizardfolk, ratfolk, tengu, and frog-like tripkee alongside three versatile heritages--the dhampir, duskwalker, and all-new dragonblood heritage! - More than 40 archetypes, allowing you to further customize your character's story and abilities. Turn your hero into an aerial acrobat, a high-riding cavalier, a treacherous pirate, and so much more! - Spells, alchemical items, and magic items to round out the new classes and to provide some new tricks to the classes from Pathfinder Player Core.
Unleash your imagination, creating worlds and stories beyond measure with the new Pathfinder GM Core for Pathfinder Second Edition! This comprehensive 336-page softcover rulebook gives Game Masters everything they need to craft thrilling tales of adventure, from a single-night's dungeon delve to complex epics spanning years. Within these pages you'll find clear guidelines for creating new hazards and monsters, tools to design challenging, balanced encounters, and rules for rewarding characters for the dastardly challenges you array before them! Pathfinder GM Core also contains a dragon's hoard of magic items and treasure to entice and reward your players, from simple healing potions to magic weapons and armor and legendary artifacts, including dozens of brand-new items! Pathfinder GM Core is the second core rulebook for the fully remastered Pathfinder Second Edition RPG! These rules are compatible with previous Pathfinder Second Edition rulebooks, incorporating comprehensive errata and rules updates and some of the best additions from later books into new, easier-to-access volumes with new presentations inspired by years of player feedback. Along with the Player Core, Monster Core, and Player Core 2, these books provide a new foundation for the future of tabletop gaming! The pocket edition presents the same contents as the standard edition in a smaller sized softcover for a lower price and better portability. Pathfinder GM Core includes: * The rules needed to run a game of Pathfinder, including guidelines for creating challenging encounters, determining success, and giving out rewards. * Advice aimed at making you an incredible Game Master, along with tools to ensure you and everyone else at your table has a safe and enjoyable experience. * Guidelines to help you create your own content, from campaigns and adventures to hazards and monsters. * Rules subsystems to help you handle a wide array of game situations, including rules for chases, duels, research, infiltration, and more! * A guide to the world of Lost Omens, with a look at several important regions, an examination of the peoples and cultures of the world, and a glimpse into what lies beyond the veil of the universe! * Fully integrated errata from the first 4 years of Pathfinder Second Edition, including improvements to staves and talismans and all-new apex magic items! * Published under the new Open RPG Creative (ORC) license, giving players and Game Masters even more freedom for making their own creations based on Pathfinder Second Edition.
The classic on-the-go guide to pediatric practice and most up-to-date resource on the diagnosis, understanding, and treatment of the medical problems of children from birth through adolescence A Doody's Core Title for 2017! Known as the go-to resource for pediatric care, Current Diagnosis and Treatment: Pediatrics is updated every two years to keep it relevant, concise, and practical enough for everyday use. As always, the 23rd edition contains critical updates.. Current Diagnosis and Treatment: Pediatrics, Twenty-Third Edition features the popular, easy-to-follow Lange Current outline format: Problem, Essentials of Diagnosis and Treatment, Clinical Findings, Differential Diagnosis, Treatment, and Prognosis. The content is organized by general topics as well as by organ systems. This guide provides concise, evidence-based information on a wide range of pediatric medical conditions and topics, including childhood nutrition and eating disorders, substance abuse, psychiatric disorders, child abuse, oral medicine and dentistry, immunization, and emergencies and injuries. With its comprehensive scope and clinical focus, there is no better, more usable resource for your pediatric practice—and no text so up-to-date. Why Current Diagnosis and Treatment Pediatrics is the ultimate clinical companion: All topics are thoroughly updated with the latest research findings Includes specific disease prevention recommendations Extensive use of decision-speeding diagnostic and treatment algorithms and tables Up-to-date references with unique identifiers (PubMed, PMID numbers) allow for rapid review of the evidence-based source material Written by experienced pediatricians to ensure that every chapter reflects the needs and realities of practice Complete with valuable guide to normal laboratory values
The most practical, up-to-date, and well-referenced guide to the diagnosis and treatment of children—from birth to adolescence A Doody's Core Title for 2021! Following the "Current" outline format to make it super easy for you to find the answers you need, this comprehensive, clinically focused guide delivers evidence-based information on the pediatric medical conditions most often encountered in daily clinical practice. Complete with an invaluable guide to normal laboratory values and 600 photos and illustrations, CURRENT Diagnosis and Treatment Pediatrics offers succinct, authoritative overviews of important pediatric health concerns, such as childhood nutrition and eating disorders; substance abuse; psychiatric disorders; child abuse; oral medicine and dentistry; immunization; and emergencies and injuries. The authors provide detailed descriptions of diseases as well as diagnostic and therapeutic procedures, and everything is presented in the time-saving LANGE CURRENT style: Problem, Essentials of Diagnosis, Clinical Findings, Differential Diagnosis, Treatment, and Prognosis.
The new gold-standard in anesthesiology Written and edited by an internationally known team of experts, Anesthesiology gives you a 360-degree view of the field, covering all of the anesthetic considerations, preparations, and procedures for the surgical patient, the pain patient or the critical care patient. You'll find a unique balance between clinical information, practical clinical procedures, and the molecular and basic scientific underpinnings of anesthesiology practice. Anesthesiology delivers a multi-perspective, wide-ranging view of anesthetic drugs, procedures, co-morbid diseases, and need-to-know postoperative pain management strategies. This essential guide not only focuses on general anesthesia, but also is the first to feature a detailed look at the subspecialty of regional anesthesia. Features: Top-to-bottom coverage of the entire field-from preoperative evaluation and intraoperative anesthesia care to care of the critically ill or chronic pain patient Emphasis on safety, quality and patient-centered care, with an entire section on risk reduction A focus on the clinical applications of anesthesiology Complex concepts explained by graphics and illustrations, not equations and formulas Full-color format and illustrations Specific drug and interventional guidelines for the clinical management of every OR/post-OR scenario in the anesthesiology field Key points and key references presented in each chapter CD that allows you to download illustrations and images to your PowerPoint presentations
With more than 350 classic and brand new monsters, this 320-page hardcover rulebook greatly expands on the foes found in the Pathfinder Bestiary. From classic creatures like serpentfolk and jabberwock, returning favorites like the primal dragons or the Sandpoint devil, to brand new menaces sure to test even the bravest of heroes, this must-have tome of monsters designed to challenge characters of any level is an essential companion to your Pathfinder game Pathfinder Bestiary 2 includes: - More than 350 monsters drawn from mythology, genre classics, and more than a decade of Pathfinder, with plenty of new monsters too - Gorgeous full-color illustrations on nearly every page - Detailed monster lists sorted by level, type, and rarity to help you find the right monster for any situation - Universal monster rules to simplify special attacks, defenses, and qualities like grab, swallow whole, and regeneration. - Detailed lore sidebars offering additional information about even more of Pathfinder's most popular monstrous friends and foes
Expand the limits of what's possible with this collection of exciting new options for your Pathfinder character. Choose from 10 brand-new ancestries and four new classes: the shrewd investigator, the mysterious oracle, the daring swashbuckler, and the hex-slinging witch! Plus, over 40 new archetypes, more options for every ancestry and class in the Pathfinder Core Rulebook, and new backgrounds, feats, spells, and items provide more opportunities for customization than ever before."--Page 4 of cover.
Pathfinder GM Core is the second core rulebook for the fully remastered Pathfinder Second Edition RPG. These rules are compatible with previous Pathfinder Second Edition rulebooks, incorporating comprehensive errata and rules updates and some of the best additions from later books into new, easier-to-access volumes with new presentations inspired by years of player feedback. Along with the Player Core, Monster Core, and Player Core 2, these books provide a new foundation for the future of tabletop gaming!--Publisher website.
This comprehensive guide to the Pathfinder roleplaying game provides everything you need to set out into a world of limitless fantasy adventure! Choose from ancestries like elf, human, and goblin and classes like alchemist, fighter, and sorcerer to create a hero of your own design, destined to become a legend! The new Pathfinder rules are easier to learn and faster to play, and they offer deeper customization than ever before! This indispensable volume contains the core rules for players and Game Masters, and is your first step on a heroic new journey!" -- Back cover.
A concise, yet comprehensive source of current information on the medical problems of children –-- from birth through adolescence A Doody’s Core Title for 2019! •A practical, up-to-date well-referenced guide to the diagnosis and treatment of the most commonly seen medical conditions in children •Excellent coverage of The Council on Medical Student Education in Pediatrics (COMSEP) curriculum used in pediatric clerkship •46 chapters cover a wide range of topics, including neonatal medicine, child development and behavior, emergency and critical care medicine, and diagnosis and treatment of specific disorders according to major problems, etiologies, and organ systems •A wealth of tables and figures provide quick access to important information, such as acute and critical care procedures in the delivery room, the office, the emergency room, and the critical care unit; anti-infective agents, drug dosages, immunization schedules, differential diagnoses, and developmental disorders •Includes detailed descriptions of diseases as well as diagnostic and therapeutic procedures •Complete with handy guide to normal laboratory values •Presented in the consistent, easy-to-follow CURRENT format •Valuable to medical students, pediatric residents, pediatricians, family practitioners, nurses, nurse practitioners, physician assistants, and other healthcare providers who work with infants, children, and adolescents •Authors are practicing pediatricians to ensure that each chapter reflects the needs and realities of day-to-day practice
Pathfinder GM Core is the second core rulebook for the fully remastered Pathfinder Second Edition RPG. These rules are compatible with previous Pathfinder Second Edition rulebooks, incorporating comprehensive errata and rules updates and some of the best additions from later books into new, easier-to-access volumes with new presentations inspired by years of player feedback. Along with the Player Core, Monster Core, and Player Core 2, these books provide a new foundation for the future of tabletop gaming!--Publisher website.
Survival in a world beset by magic and evil takes more than a lucky roll of the dice. Pathfinder Player Core 2 significantly expands options available to Pathfinder players, giving them the edge to take on any adventure. This 320-page hardcover rulebook remasters 8 classes from Pathfinder Second Edition, providing everything you need to create a wide array of new characters, ready to take on the world. It also includes more than 40 archetypes, expanded ancestries, and tons of feats, spells, and alchemical items to provide a near-endless array of exciting options for every Pathfinder character! Pathfinder Player Core 2 is the fourth core rulebook for the fully remastered Pathfinder Second Edition RPG! These rules are compatible with previous Pathfinder Second Edition rulebooks, incorporating comprehensive errata and rules updates and some of the best additions from later books into new, easier-to-access volumes with new presentations inspired by years of player feedback. Along with the Player Core, GM Core, and Monster Core, these books provide a new foundation for the future of tabletop gaming! The ideal character option resource for players looking to move beyond Pathfinder Player Core. Pathfinder Player Core 2 includes: - Eight fully detailed classes, including the alchemist, barbarian, champion, investigator, monk, oracle, sorcerer, and swashbuckler, each with multiple character paths, multiclassing options, and dozens of feats! - Expanded ancestry options include the catfolk, hobgoblin, hyena-like kholo, kobold, lizardfolk, ratfolk, tengu, and frog-like tripkee alongside three versatile heritages--the dhampir, duskwalker, and all-new dragonblood heritage! - More than 40 archetypes, allowing you to further customize your character's story and abilities. Turn your hero into an aerial acrobat, a high-riding cavalier, a treacherous pirate, and so much more! - Spells, alchemical items, and magic items to round out the new classes and to provide some new tricks to the classes from Pathfinder Player Core.
A Doody's Core Title for 2023! The most practical, up-to-date guide available for accurately diagnosing and effectively treating child patients—from birth to adolescence The authoritative resource to pediatric medical conditions most often encountered in daily practice, CURRENT Diagnosis and Treatment Pediatrics provides the evidence-based information readers need to deliver effective care in every situation. Packed with 200 photos and illustrations, this evidence-based text offers succinct, accurate overviews of important pediatric health concerns, such as childhood nutrition and eating disorders; substance use; psychiatric disorders; child abuse; oral medicine and dentistry; immunization; and emergencies and injuries. Complete with an invaluable guide to normal laboratory values, it provides detailed descriptions of diseases, as well as diagnostic and therapeutic procedures, and present all information in the time-saving style that makes LANGE CURRENT books so popular: Problem, Essentials of Diagnosis, Clinical Findings, Differential Diagnosis, Treatment, and Prognosis. NEW to this edition:
Gear Up and Throw Down! When sword and spell just won't be enough to win the day, it's time to power up your game with clockwork gears, lightning coils, and black powder! Guns & Gears (Remastered), the latest hardcover rulebook for the Pathfinder Roleplaying Game, brings the excitement of firearms and fantasy technology to your tabletop, updated to work perfectly with the remastered Pathfinder Second Edition rules! Unravel the secrets of clockworks with the new inventor class or blow away your opposition as a firearm-wielding gunslinger! In addition to new classes, a plethora of archetypes, backgrounds, vehicles, siege engines, gadgets, and the remastered automaton ancestry are all ready to expand your game with options for battlefields large and small. Pathfinder RPG: Guns & Gears (Remastered) features: - Two new classes: the clever inventor and the sharpshooting gunslinger, updated to work perfectly with the Remastered Pathfinder Second Edition rules - The remastered automaton ancestry for players who want to play a customizable construct - Firearms of all stripes, from the simple and effective flintlock pistol to versatile gunblades - Dozens of new archetypes - Scores of new gadgets and vehicles - Siege engines and accompanying rules - A gazetteer of Golarion revealing how firearms and technology fit into the Age of Lost Omens, including a look at the technology of the continents of Arcadia and Tian Xia and never-before-revealed secrets of the rough-and-tumble, gritty city of Alkenstar
The Pathfinder Player Core presents a new entry point to Pathfinder Second Edition, with everything a player needs to learn how to play the game! Choose from eight ancestries, eight complete character classes, and hundreds of feats and spells to make unique characters ready for deadly adventures in a world beset by magic and evil! This 464-page softcover tome is the definitive rules resource for all Pathfinder Second Edition players! Pathfinder Player Core is the first core rulebook for the fully remastered Pathfinder Second Edition RPG! These rules are compatible with previous Pathfinder Second Edition rulebooks, incorporating comprehensive errata and rules updates and some of the best additions from later books into new, easier-to-access volumes with new presentations inspired by years of player feedback. Along with the GM Core, Monster Core, and Player Core 2, these books provide a new foundation for the future of tabletop gaming! The pocket edition presents the same contents as the standard edition in a smaller sized softcover for a lower price and better portability. Pathfinder Player Core includes: * Easier to Learn! We've taken feedback from the Beginner Box and the Core Rulebook and made this new entry into the Pathfinder Roleplaying Game easier to navigate and get right into the fun. * Complete character creation rules, walking you through building a character by selecting your Ancestry, Background, and Class, with a focus on the bard, cleric, druid, fighter, ranger, rogue, witch, and wizard! Core ancestry options include human, dwarf, elf, gnome, goblin, halfling, leshy, and orc! * A mountain of options allowing you to customize your character including versatile heritages, like the changeling and nephilim, skills and feats, and hundreds of spells (including dozens of new ones), ensuring that the character you build represents your hero not just in story, but in rules as well! * Everything you need to know to start playing, from advice on how to explore the world to tips on surviving deadly combats with terrifying foes. * A primer on the world of Lost Omens so that your character can be a part of an exciting and diverse world! * Rules and tools to advance your character through play, taking them from a fresh-faced adventurer ready to take on the world to a veteran hero, wielding powerful magic that can reshape reality! * Fully integrated errata from the first 4 years of Pathfinder Second Edition, including revisions to the witch, expanded options for every character class, streamlined spells, new equipment, and more! * This is the first Pathfinder product published under the new Open RPG Creative (ORC) license, giving players and Game Masters even more freedom for making their own creations based on Pathfinder Second Edition.
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