A greater understanding of cerebrovascular health and disease requires the consideration of recent neuroscience advances concerning neuroplasticity in the context of classical developmental neurology principles. Consideration of the ontogenetic interplay of nature and nurture influencing brain development during prenatal and early postnatal time periods should consider the concept of the developmental origins of neurological health and disease. Adaptive and maladaptive effects of neuroplasticity require a systems biology approach integrating molecular, receptor, cellular, neural network, and behavioral perspectives, culminating in the structural and functional cerebrovascular phenotypes that express health or disease across the lifespan. Cognizance of the interrelationships among maternal, placental, fetal, and neonatal factors requires an interdisciplinary appreciation of genetic/epigenetic forces of neuroplasticity during early life that incrementally influence cerebrovascular health or disease throughout childhood and adulthood. Knowledge of the systemic effects of multiorgan function on cerebrovascular development further broadens the systems biology approach to general plasticity of the individual as a whole organism. Short- and long-term consequences of the positive and negative effects of neuroplasticity must consider ongoing gene–environment interactions with maturation and aging, superimposed on earlier fetal/neonatal experiences that sustain neurological health or contribute to disease during childhood and adulthood.
Using a highly readable, conversational writing style, Practical Approach to Electroencephalography, 2nd Edition, makes a complex and critically important subject easier to understand. It provides just the right amount of guidance you need, explaining EEG waveforms starting with the basics, then bringing you to a sophisticated level in interpreting EEG tracings—explaining what to do, what not to do, what to look for, and what the results mean. Emphasizing pattern recognition and also why the patterns look the way they do, Dr. Libenson's approachable text focuses on the types of EEG tracings you are likely to encounter in your EEG laboratory, both in the outpatient lab and in the ICU, concentrating at first on the questions and problems encountered by the beginner and non-expert, but bringing you up to the level of an expert. - Goes beyond the technical aspects of performing EEGs by discussing the link between the EEG findings and the neurologic disorders and conditions in which they occur. - Uses numerous EEG examples with abundant labels, arrows, and annotations to help you recognize normal and abnormal EEGs in all situations. Illustrations have been carefully reviewed for clarity and optimal usefulness. - Contains new self-assessment questions that allow you to check your understanding. - Provides expert pearls from Dr. Libenson that guide you in best practices in EEG testing. - Features a user-friendly writing style from a single author that makes learning easy. - Includes a new introduction to the interpretation of invasive EEG monitoring. - Equips you to handle a wide variety of EEG situations, including the strategies used to distinguish EEG artifacts from true brain waves. - Any additional digital ancillary content may publish up to 6 weeks following the publication date.
Offering a state-of-the-art, authoritative summary of the most relevant scientific and clinical advances in the field, Principles and Practice of Movement Disorders provides the expert guidance you need to diagnose and manage the full range of these challenging conditions. Superb summary tables, a large video library, and a new, easy-to-navigate format help you find information quickly and apply it in your practice. Based on the authors' popular Aspen Course of Movement Disorders in conjunction with the International Parkinson and Movement Disorder Society, this 3rd Edition is an indispensable resource for movement disorder specialists, general neurologists, and neurology residents. - Explores all facets of movement disorders, including the latest rating scales for clinical research, neurochemistry, clinical pharmacology, genetics, clinical trials, and experimental therapeutics. - Provides the essential information you need for a clinical approach to diagnosis and management, with minimal emphasis on basic science. - Reflects recent advances in areas such as the genetics of Parkinsonian and other movement disorders, diagnostic brain imaging, new surgical approaches to patients with movement disorders, and new treatment guidelines for conditions such as restless legs syndrome. - Features a reader-friendly, full-color format, with plentiful diagrams, photographs, and tables. - Includes access to several hundred updated, professional-quality video clips that illustrate the manifestations of all the movement disorders in the book along with their differential diagnoses.
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