Confronting Poverty is a text that introduces students to the dynamics of poverty and economic hardship in the U.S. It address four fundamental question: 1) What is the nature, prevalence, and characteristics of poverty; 2) Why does poverty exist; 3) What are the effects and consequences of poverty upon individuals and the wider society; and 4) How can poverty be reduced and alleviated? In clear and engaging writing, Confronting Poverty provides students with the most up-to-date research and thinking regarding American poverty and inequality. It includes the many insights of the author’s 30 years of writing and teaching on the subject. It is designed to be used as either a primary or secondary text in a wide range of courses across academic disciplines. In addition, Confronting Poverty makes use of an innovative companion website developed by the author. The focal point of the website is an interactive tool, called the Poverty Risk Calculator, that has been constructed with hundreds of thousands of case records extracted from the Panel Study of Income Dynamics (PSID) data set. The website also includes a discussion guide on various aspects of poverty along with many other interactive links and activities (short documentary films, video interviews and lectures, interactive data sources, research briefs, magazine and newspaper articles). Each chapter includes an on-line activity from the companion website for students to engage in, resulting in a dynamic learning experience.
Patent law is crucial to encourage technological innovation. But as the patent system currently stands, diverse industries from pharmaceuticals to software to semiconductors are all governed by the same rules even though they innovate very differently. The result is a crisis in the patent system, where patents calibrated to the needs of prescription drugs wreak havoc on information technologies and vice versa. According to Dan L. Burk and Mark A. Lemley in The Patent Crisis and How the Courts Can Solve It, courts should use the tools the patent system already gives them to treat patents in different industries differently. Industry tailoring is the only way to provide an appropriate level of incentive for each industry. Burk and Lemley illustrate the barriers to innovation created by the catch-all standards in the current system. Legal tools already present in the patent statute, they contend, offer a solution—courts can tailor patent law, through interpretations and applications, to suit the needs of various types of businesses. The Patent Crisis and How the Courts Can Solve It will be essential reading for those seeking to understand the nexus of economics, business, and law in the twenty-first century.
Interpreting the Axe Trade documents the changing character and context of stone axe production and exchange in the British Neolithic. Drawing on a variety of studies, the authors explore some of the problems and potentials that attend archaeological discussions of exchange at both a theoretical and a methodological level. Out of this critique arises an argument for an integrated approach to the production, circulation and consumption of past material - an approach which acknowledges the subtle and complex roles that 'things' may play in the reproduction of social life. These arguments provide the basis for a case study which explores the links between the social contexts within which Neolithic stone axes circulated in Britain, and the social and material conditions under which those objects were originally produced. Field survey, excavation and detailed technological studies at the largest stone axe source in Britain are set alongside analyses of the changing character and social context of axe circulation and deposition across the country as a whole. These different analytical threads are then woven together in the final section of the book, where the authors suggest that the patterns explored in the course of their work reflect major changes in the nature of social life during the Neolithic.
This book is a “How To” guide for modeling population dynamics using Integral Projection Models (IPM) starting from observational data. It is written by a leading research team in this area and includes code in the R language (in the text and online) to carry out all computations. The intended audience are ecologists, evolutionary biologists, and mathematical biologists interested in developing data-driven models for animal and plant populations. IPMs may seem hard as they involve integrals. The aim of this book is to demystify IPMs, so they become the model of choice for populations structured by size or other continuously varying traits. The book uses real examples of increasing complexity to show how the life-cycle of the study organism naturally leads to the appropriate statistical analysis, which leads directly to the IPM itself. A wide range of model types and analyses are presented, including model construction, computational methods, and the underlying theory, with the more technical material in Boxes and Appendices. Self-contained R code which replicates all of the figures and calculations within the text is available to readers on GitHub. Stephen P. Ellner is Horace White Professor of Ecology and Evolutionary Biology at Cornell University, USA; Dylan Z. Childs is Lecturer and NERC Postdoctoral Fellow in the Department of Animal and Plant Sciences at The University of Sheffield, UK; Mark Rees is Professor in the Department of Animal and Plant Sciences at The University of Sheffield, UK.
Medical Liability and Treatment Relationships, Fifth Edition is the only current casebook devoted to medical liability, including medical malpractice. This book is based on Part I, “The Provider and the Patient,” from Health Care Law and Ethics, Tenth Edition, and adds additional coverage of professional licensure and regulating access to drugs, and new cases and materials covering medical malpractice. Integrating public health and financial and ethical issues, this casebook uses compelling case law, clear notes, and comprehensive background information to illuminate the complex and dynamic field of health care law. New to the Fifth Edition: New author: Nadia N. Sawicki Substantial updates to the medical malpractice chapter Challenges posed by artificial intelligence in medicine Benefits for instructors and students: Comprehensive yet concise, this casebook covers all aspects of medical liability and the treatment relationships between patient and provider. Includes cases and materials on Medical Malpractice not found in the parent book, including: Financial considerations in treatment decisions Constitutionality of damage caps Cases and notes about special discovery rules, such as prohibiting ex parte contacts with treating physicians ERISA preemption of managed care liability Additional discussion problems Integrates public policy and ethics issues from a relational perspective. Clear notes provide smooth transitions between cases and background information.
NEW YORK TIMES BESTSELLER • In this refreshing and inspiring memoir, Lauren Akins, the wife of country music star Thomas Rhett, shows what it’s really like to be “the perfect couple” fans imagine, and reveals what it actually takes to live in love, stay in love, and grow together. NAMED ONE OF THE BEST BOOKS OF THE YEAR BY PARADE When country music star Thomas Rhett won the ACM Award for Single of the Year with “Die a Happy Man,” his wife, Lauren Akins, was overjoyed. Her childhood best friend and now husband was being anointed the hottest new star in country music—for a song he had written about her. He was living his dream. Lauren was elated, but she was also wrestling with some big questions, not the least of which was, How can I live my own life of purpose? Lauren Akins never wanted to be in the spotlight, but as Thomas Rhett made his relationship with Lauren the subject of many of his hit songs, she was tossed into the role of one of America’s sweethearts. Revered by fans for her down-to-earth ease and charm, her commitment to humanitarian work, and the pure love she exudes for her family, Lauren has never shared her side of their story—full as it’s been with deep love, painful loss, tremendous joy, and a struggle to stay grounded in faith along the way—until now. In Live in Love, Lauren shares details about her childhood friendship with Thomas Rhett, explaining how they reconnected as young adults. She offers a rare behind-the-scenes look at the challenges of being married to her best friend, who just happens to be a music star, and the struggle to find her own footing in the frenzy of her husband’s fame. And in heart-wrenching detail, she opens up about her life-changing experiences doing mission work in Haiti, and then in Uganda, where she met the precious baby who would become their first daughter. From sharing the romance of their handwritten wedding vows to the challenges they faced as they adjusted to the reality of becoming first-time parents, Live in Love takes an intimate look at one couple’s life—and opens a window into all of our journeys on the path to self-discovery. Live in Love is a deeply personal memoir that offers inspiring guidance for anyone looking to keep romance alive, balance children and marriage, express true faith, and live a life of purpose.
This survey assembles recent theoretical and empirical advances in the literature on economic informality and analyzes the causes and costs of informality in developed and developing economies. Using recent evidence, the survey discusses the nature and roots of informal economic activity across countries, distinguishing between informality as the result of exclusion and exit. The survey provides an extensive review of recent international experience with policies aimed at reducing informality, in particular, policies that facilitate the formalization process, create a framework for the transition from informality to formality, lend support to newly created firms, reduce or eliminate inconsistencies across regulation and government agencies, increase information flows, and increase enforcement.
As the irreversible effects of glaucoma can lead to blindness, there is high demand for early diagnosis and an ongoing need for practitioners to adopt new and evolving medical and surgical treatment options to improve patient outcomes. Glaucoma, Second Edition is the most comprehensive resource in the field delivering expert guidance for the most timely and effective diagnosis and treatment of glaucoma – aimed at specialists, fellows and general ophthalmologists. More than 300 contributors from six continents provide a truly global perspective and explore new approaches in this user friendly reference which has been updated with enhanced images, more spotlights, new videos, and more. - Get all the accuracy, expertise, and dependability you could ask for from leading specialists across six continents, for expert guidance and a fresh understanding of the subject. - Develop a thorough, clinically relevant understanding of all aspects of adult and pediatric glaucoma in Volume One, and the latest diagnostic imaging techniques including ultrasound biomicroscopy and optical coherence tomography. - Stay at the forefront of your field with 10 brand new chapters on trending topics including: new surgical approaches such as trabeculotomy and canaloplasty; glaucoma implications in cataract and ocular surface disease; and, updates in the cost-effectiveness of medical management. - Avoid pitfalls and achieve the best outcomes thanks to more than 40 brand new spotlight commentaries from key leaders providing added insight, tips and pearls of wisdom across varying hot topics and advances in the field. - Refine and improve your surgical skills by watching over 50 video clips depicting the latest techniques and procedures including: new trabeculectomy methods, needling, implants, valve complications, and more. - Prevent and plan for complications in advance by examining over 1,600 illustrations, photos and graphics (1,250 in color) capturing essential diagnostics techniques, imaging methods and surgical approaches. - Grasp each procedure and review key steps quickly with chapter summary boxes that provide at-a-glance quick comprehension of the key take away points. - Broaden your surgical repertoire with the latest surgical techniques - such as trabeculectomy, gonio-surgery, combined surgeries, and implant procedures - in Volume Two. - Glean all essential, up-to-date, need-to-know information about stem cell research, gene transfer, and implants. - Find answers fast thanks to a well-organized, user-friendly full-color layout. - eBook version included with purchase.
In 2011, National Institute on Aging and Alzheimer's Association joint task forces released proposed criteria for Alzheimer' disease diagnosis. These proposals included revisions to the nearly 30-year-old NINDS-ADRDA criteria for Alzheimer's diagnosis and added criteria for diagnosis of Mild Cognitive Impairment (MCI) due to Alzheimer's disease. The same year the American Psychiatric Association proposed new criteria for major and minor neurocognitive disorders (the entities previously known as dementia and mild cognitive impairment, respectively). These new criteria reflect the research and clinical advances in identifying mild cognitive impairment and offer new opportunities for prevention, treatment, and management of neurodegenerative conditions. A major focus of this book is on the mild cognitive impairment prodrome of the common dementias. In addition to discussing the most common neurodegenerative conditions, many rare neurodegenerative conditions are highlighted. Most chapters include an autopsy-confirmed case presentation from the authors' files. Following the case presentation, those chapters present current diagnostic criteria, epidemiology, neuropathology/neurophysiology, genetics, neuroimaging studies as relevant, associated clinical features, differential neuropsychological features and possible interventions for each disorder. The pace of change in research and practice in the field of normal cognitive aging and dementia is increasing almost as fast as the median age of the population. The massive baby boom population bubble is currently entering the age of risk for neurodegenerative conditions. Neuropsychologists will play a major role in refining and applying these diagnoses, and in developing, testing, and refining interventions for these diagnoses, and in caring for this population. This book is intended to prepare neuropsychologists and others interested in neuropsychology to serve this fastest growing segment of our population.
The development of new drugs is very complex, costly and risky. Its success is highly dependent on an intense collaboration and interaction between many departments within the drug development organization, external investigators and service providers, in constant dialogue with regulatory authorities, payers, academic experts, clinicians and patient organizations. Within the different phases of the drug life cycle, drug development is by far the most crucial part for the initial and continued success of a drug on the market. This book offers an introduction to the field of drug development with a clear overview of the different processes that lead to a successful new medicine and of the regulatory pathways that are used to launch a new drug that are both safe and efficacious. "This is the most comprehensive and detailed book on drug development I have ever read and I feel that it is likely to become a staple of drug development courses, such as those taught at Masters Level in my own University.... I think in the light of increasing integration of company and academic approaches to drug development both sides can read this book... (and, therefore)... this book could not be more timely." —Professor Mike Coleman, University of Aston, UK ( from his review of the final manuscript)
When social workers draw on experience, theory, or data in order to develop new strategies or enhance existing ones, they are conducting intervention research. This relatively new field involves program design, implementation, and evaluation and requires a theory-based, systematic approach. Intervention Research presents such a framework. The five-step strategy described in this brief but thorough book ushers the reader from an idea's germination through the process of writing a treatment manual, assessing program efficacy and effectiveness, and disseminating findings. Rich with examples drawn from child welfare, school-based prevention, medicine, and juvenile justice, Intervention Research relates each step of the process to current social work practice. It also explains how to adapt interventions for new contexts, and provides extensive examples of intervention research in fields such as child welfare, school-based prevention, medicine, and juvenile justice, and offers insights about changes and challenges in the field. This innovative pocket guide will serve as a solid reference for those already in the field, as well as help the next generation of social workers develop skills to contribute to the evolving field of intervention research.
Organizational change impacts upon all organizations regardless of size and sector. In this unique organizational change textbook, important ongoing debates about managing change and leading change are combined, giving a broader perspective that encourages readers to engage with both management and leadership. In combination, management and leadership insights inform how organizations are changing and how we can make a positive difference in such processes of change. Managing and Leading Organizational Change speaks both to the applied and practical aspects of organizational change, as well as questioning the research and evidence base of organizational change practices. Chapters begin with real-world insights, followed by coverage of the major theories. The ongoing nature of these debates is signposted through the inclusion of questioning sections with research case studies showcased. This textbook will be particularly beneficial for final year undergraduates and postgraduates studying organizational change, strategic change, change management and change leadership modules.
Takes a fresh look at American suburbs, explains why they are changing, and discusses the housing crisis, growth, local government, and demand for services.
Discovering World Prehistory introduces the general field of archaeology and highlights for students the difference between obtaining data (basic archaeology) and interpreting those data into a prehistory, a coherent model of the past. The opening section of the book covers the history, methods, and techniques of archaeology to provide a detailed examination of archaeological investigation. It highlights the excitement of archaeological discovery and how archaeologists analyze and interpret evidence. The second half covers global prehistory and shows how archaeological data is interpreted through theoretical frameworks to create a picture of the past. Starting with human evolution, chapters detail the key stages, from around the world, of prehistory, finishing with the transition to post-prehistoric societies. Including chapter overviews, highlight boxes, chapter summaries, key concepts, and suggested reading, Discovering World Prehistory is designed to support introductory courses in archaeology and allows students to experience both methods and interpretation, offering a perfect introduction to the discipline.
Get 24 months FREE access to an interactive eBook when purchasing the paperback* The Sixth Edition continues to give students a comprehensive overview of what is needed to carry-out successful and effective research, with practical hands-on guidance on how to conduct a dissertation project or research thesis, in business and management. New to This Edition: Complimentary fully integrated interactive eBook version. Coverage of online data collection, netnography, big data and data visualization. Research philosophy in chapter 3 is further supported and enhanced by an author video overview available online and a pull out at the back of the book that gives a useful visual representation of each key component of the research process using a tree as a metaphor. Annotated further reading recommendations. An important new feature is the "Research in Action" textboxes, which consist of engaging accounts of real-world research experiences from academics, practitioners and students. Examples include measuring the impact of development programmes on Chinese rural communities, and qualitative data being used to measure the experiences of UK taxi drivers. Each contributor has also given a practical ‘top tip’ for doing research successfully. The book is complemented by a FREE Interactive eBook and online resources including PowerPoint slides, datasets, multiple-choice questions, e-flashcards and links to additional online material. Suitable reading for any student carrying out a research project, dissertation or thesis in business and management. *Interactivity only available through the eBook included as part of paperback product (ISBN 9781526446954). Access not guaranteed on second-hand copies (as access code may have previously been redeemed).
In the second edition of Emerging Nanotechnologies for Manufacturing, an unrivalled team of international experts explores existing and emerging nanotechnologies as they transform large-scale manufacturing contexts in key sectors such as medicine, advanced materials, energy, and electronics. From their different perspectives, the contributors explore technologies and techniques as well as applications and how they transform those sectors. With updated chapters and expanded coverage, the new edition of Emerging Nanotechnologies for Manufacturing reflects the latest developments in nanotechnologies for manufacturing and covers additional nanotechnologies applied in the medical fields, such as drug delivery systems. New chapters on graphene and smart precursors for novel nanomaterials are also added. This important and in-depth guide will benefit a broad readership, from R&D scientists and engineers to venture capitalists. - Covers nanotechnology for manufacturing techniques and applications across a variety of industries - Explores the latest developments such as nanosuspensions and nanocarriers in drug delivery systems, graphene applications, and usage of smart precursors to develop nanomaterials - Proven reference guide written by leading experts in the field
Based on the Diagnostic and Statistical Manual for Primary Care: Child and Adolescent Version (DSM-PC), this state-of-the-art reference expertly guides you through normal and abnormal development and behavior for all pediatric age groups. See how neurobiological, environmental, and human relationship factors all contribute to developmental and behavioral disorders and know how to best diagnose and treat each patient you see. Accurately identify developmental and behavioral problems using the Diagnostic and Statistical Manual for Primary Care criteria, and evidence-based guidelines. Gain a clear understanding of the "normal" boundaries and variations within specific disorders. Make informed therapeutic decisions with the integration of basic science and practical information and recommendations from the Society of Developmental and Behavioral Pediatrics and the American Academy of Pediatrics. Avoid legal and ethical implications by consulting the Law, Policy, and Ethics chapter. Download the DSM PC criteria from the included CD, as well as tables and illustrations for use in electronic presentations.
Biomechanics and Motor Control: Defining Central Concepts provides a thorough update to the rapidly evolving fields of biomechanics of human motion and motor control with research published in biology, psychology, physics, medicine, physical therapy, robotics, and engineering consistently breaking new ground. This book clarifies the meaning of the most frequently used terms, and consists of four parts, with part one covering biomechanical concepts, including joint torques, stiffness and stiffness-like measures, viscosity, damping and impedance, and mechanical work and energy. Other sections deal with neurophysiological concepts used in motor control, such as muscle tone, reflex, pre-programmed reactions, efferent copy, and central pattern generator, and central motor control concepts, including redundancy and abundance, synergy, equilibrium-point hypothesis, and motor program, and posture and prehension from the field of motor behavior. The book is organized to cover smaller concepts within the context of larger concepts. For example, internal models are covered in the chapter on motor programs. Major concepts are not only defined, but given context as to how research came to use the term in this manner. - Presents a unified approach to an interdisciplinary, fragmented area - Defines key terms for understanding - Identifies key theories, concepts, and applications across theoretical perspectives - Provides historical context for definitions and theory evolution
Democratic Governance examines the changing nature of the modern state and reveals the dangers these changes pose to democracy. Mark Bevir shows how new ideas about governance have gradually displaced old-style notions of government in Britain and around the world. Policymakers cling to outdated concepts of representative government while at the same time placing ever more faith in expertise, markets, and networks. Democracy exhibits blurred lines of accountability and declining legitimacy. Bevir explores how new theories of governance undermined traditional government in the twentieth century. Politicians responded by erecting great bureaucracies, increasingly relying on policy expertise and abstract notions of citizenship and, more recently, on networks of quasi-governmental and private organizations to deliver services using market-oriented techniques. Today, the state is an unwieldy edifice of nineteenth-century government buttressed by a sprawling substructure devoted to the very different idea of governance--and democracy has suffered. In Democratic Governance, Bevir takes a comprehensive look at governance and the history and thinking behind it. He provides in-depth case studies of constitutional reform, judicial reform, joined-up government, and police reform. He argues that the best hope for democratic renewal lies in more interpretive styles of expertise, dialogic forms of policymaking, and more diverse avenues for public participation.
A bold, urgent argument on the misplacement of value in financial markets and how we can and need to maximize value for the many, not few. As an economist and former banker, Mark Carney has spent his life in various financial roles, in both the public and private sector. VALUE(S) is a meditation on his experiences that examines the short-comings and challenges of the market in the past decade which he argues has led to rampant, public distrust and the need for radical change. Focusing on four major crises-the Global Financial Crisis, the Global Health Crisis, Climate Change and the 4th Industrial Revolution-- Carney proposes responses to each. His solutions are tangible action plans for leaders, companies and countries to transform the value of the market back into the value of humanity.
Brexit, populism, and Euroscepticism seem to have challenged old assumptions about European integration and raised the prospect of disintegration. This book re-examines why the European Union and its forerunners were created and investigates how and why they have changed. It links contemporary events to historical explanation, arguing that there were long-term sets of conditions, dating back to the 1920s, which pushed European governments to cooperate economically and to try to resolve their diplomatic differences. The failure of the French and German governments to create what Aristide Briand had called a 'European federal union' demonstrated both the precariousness of the enterprise and its connection to the domestic politics of European states. After 1945, the unexpected advent of a 'Cold War' and the military, diplomatic and economic presence of the United States in Europe facilitated the gradual development of habits of cooperation and institutional 'integration', but they also placed limits on European governments' activities, as did disagreements between political parties and the expectations of citizens. As a consequence, supranational bodies such as the European Commission have been accompanied - and often overshadowed - by intergovernmental institutions such as the European Council, with the EU as a whole functioning in important respects as a type of confederation. The volume addresses a series of large-scale historical questions which are integral to an understanding of the European Union. It asks how and why citizens of member states have identified with the EU; how matters of 'security' affected the development of the European Community during and after the Cold War; whether economic and social convergence have taken place, and with what consequences; and why European institutions have come to function as they have. The study is thematic, focusing on the most important aspects of European integration and explaining why member states have decided to carry out - or have consented to - the unique experiment of the European Union.
An argument that we must read code for more than what it does—we must consider what it means. Computer source code has become part of popular discourse. Code is read not only by programmers but by lawyers, artists, pundits, reporters, political activists, and literary scholars; it is used in political debate, works of art, popular entertainment, and historical accounts. In this book, Mark Marino argues that code means more than merely what it does; we must also consider what it means. We need to learn to read code critically. Marino presents a series of case studies—ranging from the Climategate scandal to a hactivist art project on the US-Mexico border—as lessons in critical code reading. Marino shows how, in the process of its circulation, the meaning of code changes beyond its functional role to include connotations and implications, opening it up to interpretation and inference—and misinterpretation and reappropriation. The Climategate controversy, for example, stemmed from a misreading of a bit of placeholder code as a “smoking gun” that supposedly proved fabrication of climate data. A poetry generator created by Nick Montfort was remixed and reimagined by other poets, and subject to literary interpretation. Each case study begins by presenting a small and self-contained passage of code—by coders as disparate as programming pioneer Grace Hopper and philosopher Friedrich Kittler—and an accessible explanation of its context and functioning. Marino then explores its extra-functional significance, demonstrating a variety of interpretive approaches.
Focusing on the most prevalent conditions affecting seniors - including diabetes, cardiovascular disease, osteoporosis, arthritis, and fibromyalgia - Morewitz and Goldstein analyze the impact of chronic disease on aging. Separate chapters are devoted to cognitive changes, psychological problems, and trends in health care utilization, and all chapters are amplified by current research findings.
All previous books dealing with prehistoric hunter-gatherers in the high Andes have treated ancient mountain populations from a troglodyte's perspective, as if they were little different from lowlanders who happened to occupy jagged terrain. Early mountain populations have been transformed into generic foragers because the basic nature of high-altitude stress and biological adaptation has not been addressed. In Montane Foragers, Mark Aldenderfer builds a unique and penetrating model of montane foraging that justly shatters this traditional approach to ancient mountain populations. Aldenderfer's investigation forms a methodological and theoretical tour de force that elucidates elevational stress—what it takes for humans to adjust and survive at high altitudes. In a masterful integration of mountain biology and ecology, he emphasizes the nature of hunter-gatherer adaptations to high-mountain environments. He carefully documents the cultural history of Asana, the first stratified, open-air site discovered in the highlands of the south-central Andes. He establishes a number of major occurrences at this revolutionary site, including the origins of plant and animal domestication and transitions to food production, the growth and packing of forager populations, and the advent of some form of complexity and social hierarchy. The rich and diversified archaeological record recovered at Asana—which spans from 10,000 to 3,500 years ago—includes the earliest houses as well as public and ceremonial buildings in the central cordillera. Built, used, and abandoned over many millennia, the Asana structures completely transform our understanding of the antiquity and development of native American architecture. Aldenderfer's detailed archaeological case study of high-elevation foraging adaptation, his description of this extreme environment as a viable human habitat, and his theoretical model of montane foraging create a new understanding of the lifeways of foraging peoples worldwide.
Electronic Inspection Copy available for instructors here Now in its Fourth Edition, this much loved text offers theoretical and philosophical depth without sacrificing what you need to know in practical terms. With an impressive suite of in-text features and online materials, as well as the authors' ability to tackle complex issues in a clear and accessible way, this textbook makes the whole scope of management research methods approachable. Inside you will find painless coverage of the entire research process as well as a critical, thoughtful treatment of important issues like ethics and politics, making this an invaluable companion to any student or researcher who needs to know about business and management research methods. New to the Fourth Edition: - Expanded coverage of mixed methods - Further guidance on choosing a research question and writing a research proposal - More visual material and an improved, full-colour layout The book's companion website has been fully updated to include: - An instructor's manual - Lecture slides - Links to further reading - More full-text articles from SAGE Journals Online - An online glossary - An author podcast Visit the Companion Webiste at www.sagepub.co.uk/easterbysmith
Treatment of Skin Disease: Comprehensive Therapeutic Strategies has been thoroughly revised to give you the latest treatment options for dermatologic conditions. Mark G. Lebwohl, Warren R. Heymann, John Berth-Jones, and Ian Coulson present an intuitive and easy-to-use, definitive treatment reference that covers the full range of choices for each condition so that you are prepared even when your patients do not respond to primary or secondary therapies. With new chapters on today’s hot topics-methocillin-resistant staphylococcus aureus, atypical nevi, autoimmune progesterone dermatitis, and more-and new contributions from international experts, you’ll have a global and current perspective on therapeutic options. Offer your patients the full range of choices and be prepared when your patients do not respond to primary or secondary therapies. Offers guidance for even the most difficult clinical problems by including third and fourth line therapies, as well as standard treatments, so you have options to try when all else fails. Features a summary of each treatment strategy along with detailed discussions of treatment choices so that you can apply the in-depth knowledge of the authors and editors. Presents each chapter in a tabular format, with checklists of diagnostic and investigative pearls and color-coded boxed text, for quick at-a-glance summaries of key details. Includes a full-color clinical photograph of each disease to help you diagnose more effectively. Includes access to the full text, Gold Standard drug database, and all the images online-fully searchable-at expertconsult.com. Covers new and more commonly presenting disorders in 12 new chapters on today’s hot topics, such as methocillin-resistant staphylococcus aureus, atypical nevi, autoimmune progesterone dermatitis, and more. Presents up-to-date evidence and the latest treatments to keep you on the cutting edge of practice. Describes global best practice on the treatment of key disorders through new contributions from international experts.
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. - Updates to all chapters, including new examples and references - Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book - Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry - Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant - Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis - Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: - for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib - for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid - for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin - Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples - Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites - Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
For nearly 50 years, Sleisenger & Fordtran's Gastrointestinal and Liver Disease has been the go-to reference for gastroenterology and hepatology residents, fellows, physicians, and the entire GI caregiving team. Now in a fully revised 11th Edition, this two-volume masterwork brings together the knowledge and expertise of hundreds of global experts who keep you up to date with the newest techniques, technologies, and treatments for every clinical challenge you face in gastroenterology and hepatology. A logical organization, more than 1,100 full-color illustrations, and easy-to-use algorithms ensure that you'll quickly and easily find the information you need. - Features new and expanded discussions of chronic hepatitis B and C, Helicobacter pylori infection, colorectal cancer prevention through screening and surveillance, biologic agents and novel small molecules to treat and prevent recurrences of inflammatory bowel disease (IBD), gastrointestinal immune and autoimmune diseases, and more. - Offers reliable coverage of key topics such as Barrett's esophagus, gut microbiome, enteric microbiota and probiotics, fecal microbiota transplantation, and hepatic, pancreatic, and small bowel transplantation. - Provides more quick-reference algorithms that summarize clinical decision making and practical approaches to patient management. - Employs a consistent, templated, format throughout for quick retrieval of information. - Includes monthly updates online, as well as more than 20 procedural videos. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Among maternal deities of the Greek pantheon, the Mother of the Gods was a paradox. She is variously described as a devoted mother, a chaste wife, an impassioned lover, and a virgin daughter; she is said to be both foreign and familiar to the Greeks. In this erudite and absorbing study, Mark Munn examines how the cult of Mother of the Gods came from Phrygia and Lydia, where she was the mother of tyrants, to Athens, where she protected the laws of the Athenian democracy. Analyzing the divergence of Greek and Asiatic culture at the beginning of the classical era, Munn describes how Kybebe, the Lydian goddess who signified fertility and sovereignty, assumed a different aspect to the Greeks when Lydia became part of the Persian empire. Conflict and resolution were played out symbolically, he shows, and the goddess of Lydian tyranny was eventually accepted by the Athenians as the Mother of the Gods, and as a symbol of their own sovereignty. This book elegantly illustrates how ancient divinities were not static types, but rather expressions of cultural systems that responded to historical change. Presenting a new perspective on the context in which the Homeric and Hesiodic epics were composed, Munn traces the transformation of the Asiatic deity who was the goddess of Sacred Marriage among the Assyrians and Babylonians, equivalent to Ishtar. Among the Lydians, she was the bride to tyrants and the mother of tyrants. To the Greeks, she was Aphrodite. An original and compelling consideration of the relations between the Greeks and the dominant powers of western Asia, The Mother of the Gods, Athens, and the Tyranny of Asia is the first thorough examination of the way that religious cult practice and thought influenced political activities during and after the sixth and fifth centuries B.C.
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