This solutions manual is a companion volume to the classic textbook Recursive Methods in Economic Dynamics by Nancy L. Stokey and Robert E. Lucas. Efficient and lucid in approach, this manual will greatly enhance the value of Recursive Methods as a text for self-study.
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. - Updates to all chapters, including new examples and references - Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book - Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry - Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant - Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis - Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: - for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib - for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid - for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin - Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples - Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites - Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
With laboratory animals, especially rabbits, playing such an important role in biomedical research, the humane care of these animals is an ongoing concern. The Laboratory Rabbit, Second Edition presents basic information and common procedures in detail to provide a quick reference for caretakers, technicians, and researchers in a laboratory setting
This brand-new, full-color reference is a foundational text for veterinarians and veterinary students learning about companion exotic animal diseases. Organized by body system, Current Therapy in Exotic Pet Practice walks students through the most relevant information concerning the diagnosis and treatment of exotic animals - including the most relevant information on anatomy, physical examination, diagnostic testing, disease conditions, therapeutics, epidemiology of diseases, and zoonoses. Topics such as captive care, current standards of care for all exotic species, veterinary clinical epidemiology, and the effective prevention and management of infectious diseases are also included. Expert guidance on treating various disease conditions provides authoritative support for veterinarians who are less experienced in companion exotic pet care. Renowned authors and editors carefully selected topics of real clinical importance. Detailed coverage on how to identify and treat diseases (from common to rare) helps alleviate apprehension a veterinarian may feel when treating an unfamiliar species. Includes the latest information from the current scientific literature and addresses hot topics associated with treating companion exotic animals today. Vivid full-color images demonstrate the unique anatomic and medical features of each group of animals covered.
The authors offer an accessible introduction to key ideas in biomedical text mining. The chapters cover such topics as the sources of biomedical text; text-analysis methods in natural language processing; the tasks of information extraction, information retrieval, and text categorization; and methods for empirically assessing textmining systems.
Polygamous marriages are currently recognized in nearly fifty countries worldwide. Although polygamy is technically illegal in the United States, it is practiced by members of some religious communities and a growing number of other "poly" groups. In the radically changing and increasingly multicultural world in which we live, the time has come to define polygamous marriage and address its legal feasibilities. Although Mark Goldfeder does not argue the right or wrong of plural marriage, he maintains that polygamy is the next step - after same-sex marriage - in the development of U.S. family law. Providing a road map to show how such legalization could be handled, he explores the legislative and administrative arguments which demonstrate that plural marriage is not as farfetched - or as far off - as we might think. Goldfeder argues not only that polygamy is in keeping with the legislative values and freedoms of the United States, but also that it would not be difficult to manage or administrate within our current legal system. His legal analysis is enriched throughout with examples of plural marriage in diverse cultural and historical contexts. Tackling the issue of polygamy in the United States from a legal perspective, this book will engage anyone interested in constitutional law, family law, or criminal law, along with sociologists and those who study gender and culture in modern times.
At a time in history when conflict erupts daily in far-flung corners of the world, ending severe deprivation may be critical to global peace and stability. Yet we are far from reaching the goal of reducing hunger by 2025. The authors of this book bring good news: hunger can be banished in our lifetime. They first distill what is already known about fighting hunger and then report on important new research findings and projections that show it can be done, through new and renewed institutions, scientific innovation, global economics and investment, and sustainable environmental practices. Although the book encompasses a wide array of ideas, arguments, facts, and figures, it is not a dry, academic text. Anyone wanting a better understanding of poverty and hunger and how to end it will benefit from reading it.
The most authoritative illustrated book on flying reptiles available For 150 million years, the skies didn't belong to birds—they belonged to the pterosaurs. These flying reptiles, which include the pterodactyls, shared the world with the nonavian dinosaurs until their extinction 65 million years ago. Some pterosaurs, such as the giant azhdarchids, were the largest flying animals of all time, with wingspans exceeding thirty feet and standing heights comparable to modern giraffes. This richly illustrated book takes an unprecedented look at these astonishing creatures, presenting the latest findings on their anatomy, ecology, and extinction. Pterosaurs features some 200 stunning illustrations, including original paintings by Mark Witton and photos of rarely seen fossils. After decades of mystery, paleontologists have finally begun to understand how pterosaurs are related to other reptiles, how they functioned as living animals, and, despite dwarfing all other flying animals, how they managed to become airborne. Here you can explore the fossil evidence of pterosaur behavior and ecology, learn about the skeletal and soft-tissue anatomy of pterosaurs, and consider the newest theories about their cryptic origins. This one-of-a-kind book covers the discovery history, paleobiogeography, anatomy, and behaviors of more than 130 species of pterosaur, and also discusses their demise at the end of the Mesozoic. The most comprehensive book on pterosaurs ever published Features some 200 illustrations, including original paintings by the author Covers every known species and major group of pterosaurs Describes pterosaur anatomy, ecology, behaviors, diversity, and more Encourages further study with 500 references to primary pterosaur literature
The world-wide sales of polysiloxanes or silicones at the beginning of this new millennium is approximately $10 billion per year. Commercial products range from those entirely composed of silicone to products where the silicone is a low level but key component. This symposium covered the recent academic and technological developments behind silicones and silicone-modified materials.
The #1 orthopaedic evidence-based textbook and reference guide A Doody's Core Title for 2021! Dutton’s Orthopaedic: Examination, Evaluation and Intervention provides readers with a systematic logical approach to the examination and intervention of the orthopedic patient. This comprehensive and up-to-date fifth edition strikes the perfect balance in its coverage of the continuum of care of an orthopaedic patient. The content emphasizes the appropriate use of manual techniques and therapeutic exercise while outlining the correct applications of multiple adjuncts to the rehabilitative process. The content reflects the consistent unified voice of a single author–a prominent practicing therapist who delivers step-by-step guidance on the anatomy, biomechanics, examination, and treatment of each joint and region. This in-depth coverage leads you logically through the systems review and differential diagnosis aided by decision-making algorithms and features new coverage on balance, pain assessment, and concussions. New videos on testing and method techniques are available on AccessPT. This edition has an added 10-15 case studies as well as updated chapters to reflect the latest research and treatment techniques.
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