The main goal of the CIME Summer School on "Algebraic Cycles and Hodge Theory" has been to gather the most active mathematicians in this area to make the point on the present state of the art. Thus the papers included in the proceedings are surveys and notes on the most important topics of this area of research. They include infinitesimal methods in Hodge theory; algebraic cycles and algebraic aspects of cohomology and k-theory, transcendental methods in the study of algebraic cycles.
All previous books dealing with prehistoric hunter-gatherers in the high Andes have treated ancient mountain populations from a troglodyte's perspective, as if they were little different from lowlanders who happened to occupy jagged terrain. Early mountain populations have been transformed into generic foragers because the basic nature of high-altitude stress and biological adaptation has not been addressed. In Montane Foragers, Mark Aldenderfer builds a unique and penetrating model of montane foraging that justly shatters this traditional approach to ancient mountain populations. Aldenderfer's investigation forms a methodological and theoretical tour de force that elucidates elevational stress—what it takes for humans to adjust and survive at high altitudes. In a masterful integration of mountain biology and ecology, he emphasizes the nature of hunter-gatherer adaptations to high-mountain environments. He carefully documents the cultural history of Asana, the first stratified, open-air site discovered in the highlands of the south-central Andes. He establishes a number of major occurrences at this revolutionary site, including the origins of plant and animal domestication and transitions to food production, the growth and packing of forager populations, and the advent of some form of complexity and social hierarchy. The rich and diversified archaeological record recovered at Asana—which spans from 10,000 to 3,500 years ago—includes the earliest houses as well as public and ceremonial buildings in the central cordillera. Built, used, and abandoned over many millennia, the Asana structures completely transform our understanding of the antiquity and development of native American architecture. Aldenderfer's detailed archaeological case study of high-elevation foraging adaptation, his description of this extreme environment as a viable human habitat, and his theoretical model of montane foraging create a new understanding of the lifeways of foraging peoples worldwide.
FOAM. This acronym has been used for over ?fty years at Rensselaer to designate an upper-division course entitled, Foundations of Applied Ma- ematics. This course was started by George Handelman in 1956, when he came to Rensselaer from the Carnegie Institute of Technology. His objective was to closely integrate mathematical and physical reasoning, and in the p- cess enable students to obtain a qualitative understanding of the world we live in. FOAM was soon taken over by a young faculty member, Lee Segel. About this time a similar course, Introduction to Applied Mathematics, was introduced by Chia-Ch’iao Lin at the Massachusetts Institute of Technology. Together Lin and Segel, with help from Handelman, produced one of the landmark textbooks in applied mathematics, Mathematics Applied to - terministic Problems in the Natural Sciences. This was originally published in 1974, and republished in 1988 by the Society for Industrial and Applied Mathematics, in their Classics Series. This textbook comes from the author teaching FOAM over the last few years. In this sense, it is an updated version of the Lin and Segel textbook.
Since its beginnings after WWII, Counseling Psychology has grown to become an applied specialty within psychology with unique areas of emphasis. This book introduces readers to the field by presenting its history, emphases, trends and relationships to other areas within psychology, followed by seminal articles that have significantly influenced counselors and researchers. The volume is organized around the six general themes of history and professional development, personal counseling, career counseling, cross-cultural counseling, counseling process and outcome, and internationalizing Counseling Psychology. In presenting articles representing these six themes that have defined counseling psychology, readers are given an essential overview to the past, the present and future directions of this applied specialty in psychology.
A Comprehensive Guide to Discipleship in the New Testament and Today's World Although the concept of discipleship is an integral part of New Testament teaching, it has largely faded from discussion in both the academy and the local church. To revive and reclaim this teaching for believers in the twenty-first century, editors John Goodrich and Mark Strauss have assembled an expert team of scholars to uncover what every New Testament book teaches about discipleship, providing a comprehensive, biblical picture. In addition, other contributors explore discipleship in the context of the local church, spiritual formation, and the life of the mind. Together, these essays point the way forward for becoming more like Jesus Christ, and helping others do the same, in our personal and corporate lives. "An impressive roster of scholars who have addressed a vital but often neglected topic in both the church and in the academy. . . . Rich with insight, Following Jesus Christ represents a major advance in this essential area of study." --Craig A. Evans, Houston Baptist University "We are treated here to a survey of what discipleship means in the New Testament from experts in the field, and we also see some of the wider dimensions of discipleship in this important work. All those wanting to understand discipleship will find this to be a valuable resource." --Thomas R. Schreiner, The Southern Baptist Theological Seminary
Nuclear power reactors generate highly radioactive waste. To permanently store this waste, the Dept. of Energy (DoE) has been working to submit a license appl¿n. to the Nuclear Reg¿y. Comm. (NRC) for a nuclear waste repository at Yucca Mountain, about 100 miles from Las Vegas, NV. A high-quality appl¿n. needs to be complete, technically adequate, transparent by clearly justifying underlying assumptions, & traceable back to original source materials. This report examines: DoE¿s develop. of its schedule for submitting a license appl¿n. & the stakeholders with whom it consulted; NRC¿s assessment of DoE¿s readiness to submit a high-quality appl¿n.; & DoE¿s progress in addressing quality assurance recommend. identified in a March 2006 report.
Scientists are increasingly finding themselves engaged in research problems that cross the traditional disciplinary lines of physics, chemistry, biology, materials science, and engineering. Because of its broad scope, statistical mechanics is an essential tool for students and more experienced researchers planning to become active in such an interdisciplinary research environment. Powerful computational methods that are based in statistical mechanics allow complex systems to be studied at an unprecedented level of detail. This book synthesizes the underlying theory of statistical mechanics with the computational techniques and algorithms used to solve real-world problems and provides readers with a solid foundation in topics that reflect the modern landscape of statistical mechanics. Topics covered include detailed reviews of classical and quantum mechanics, in-depth discussions of the equilibrium ensembles and the use of molecular dynamics and Monte Carlo to sample classical and quantum ensemble distributions, Feynman path integrals, classical and quantum linear-response theory, nonequilibrium molecular dynamics, the Langevin and generalized Langevin equations, critical phenomena, techniques for free energy calculations, machine learning models, and the use of these models in statistical mechanics applications. The book is structured such that the theoretical underpinnings of each topic are covered side by side with computational methods used for practical implementation of the theoretical concepts.
A revolutionary, all - natural treatment program for reversing the “silent killer” affecting more than 50 million Americans. Hypertension is a dangerous and deadly disease. There are no symptoms, so most sufferers have no idea anything is wrong—making more than 45 million Americans ticking time bombs. And while there are many drugs on the market that combat this condition, the costs and side effects are often prohibitive. Now, a leading expert and researcher introduces an all-natural solution. His comprehensive treatment regimen controls high blood pressure using the best of traditional and alternative medicine. Readers will learn about Dr. Houston’s own successful all-natural formula, which attacks hypertension from many angles. When used inconjunction with dietary approaches—also outlined in the book— and combined with exercise, stress reduction, and medication, this program has resulted in success for 90% of Dr. Houston’s patients!
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. - Updates to all chapters, including new examples and references - Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book - Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry - Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant - Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis - Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: - for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib - for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid - for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin - Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples - Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites - Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
PRAISE FOR THE BOOK “Despite the existing scholarly literature on criminal defences, many issues remain contested or unresolved. Dr Dsouza offers a thorough and scholarly treatment of a complex topic which can be expected to become a point of reference for future work in the field.” Professor James Chalmers, University of Glasgow “Mark Dsouza has produced an engaging, incisive and cogently argued monograph, that makes an original contribution to criminal law theory. Required reading for scholars and graduate students working on criminal law defences.” Professor Paul Roberts, University of Nottingham Although it is often accepted that rationale-based defences to criminal liability can be justificatory or excusatory, disagreements about how best to conceptualise the categories of justification and excuse have appeared so interminable that some theorists argue that they should be abandoned altogether. This book offers a novel, principled, and intuitively appealing conceptual account of the natures of justifications and excuses, showing how they differ, and why the distinction between them matters. The monograph breaks new ground by defending a model of rationale-based defences that turns solely on the quality of the defendant's reasoning. This model is shown to generate appealing liability outcomes, advance convincing solutions to questions that have puzzled criminal lawyers for years, and offer suggestions for doctrinal reform that are both normatively sound, and practical. By proposing new ways to think about defences, this book makes an original contribution to criminal law theory that will be of benefit to academics, practitioners, and persons interested in law reform.
Now in its Second Edition, The 5-Minute Sports Medicine Consult is a clinically oriented quick consult reference for sports medicine. Common sports-related problems faced by primary care practitioners are thoroughly and concisely presented in the famous fast-access 5-Minute Consult format. Chapters on musculoskeletal problems cover basics; diagnosis; acute treatment, including on-field management; long-term treatment, including rehabilitation and referrals; and commonly asked questions. Other chapters address the special populations of children, adolescents, females, geriatric athletes, and disabled athletes and general medical problems in athletic individuals. Appendices include musculoskeletal radiography, office rehabilitation, and joint and soft tissue injection.
The essential guide to more than 450 of the most commonly performed diagnostic tests – updated with the latest molecular, genetic, and microbiological tests A Doody's Core Title for 2019! Guide to Diagnostic Tests, Seventh Edition is a concise guide to the selection and interpretation of more than 450 of the laboratory and microbiology tests most relevant to the general practice of medicine. This on-the-spot clinical companion also includes coverage of diagnostic imaging, electrocardiology, echocardiography, and the use of tests in differential diagnosis. Features: • Covers areas of internal medicine, pediatrics, surgery, neurology, and obstetrics and gynecology • Over 25 new or substantially revised laboratory tests • New and updated coverage of emerging and re-emerging pathogens and infectious agents,including the Zika and Ebola viruses • Updated material on molecular and genetic tests, including pharmacogenetics tests • An entire section of diagnostic algorithms • Full literature citations with PubMed identification (PMID) numbers included for each reference • Details costs and risks of various procedures and tests • Full section on electrocardiography and echocardiography If you’ve been looking for an authoritative, up-to-date, and easy-to-carry guide to the latest diagnostic testing procedures, your search ends here.
A quick reference guide to the selection and interpretation of more than 450 commonly used diagnostic tests COVERS: Basic principles of diagnostic testing, common blood, urine and cerebrospinal fluid laboratory tests, therapeutic drug monitoring, microbiologic test selection and interpretation and diagnostic imaging tests by body system , electrocardiography, and differential diagnosis tables & algorithms Tests used in internal medicine, pediatrics, surgery, neurology and obstetrics and gynecology INCLUDES: Costs and risks of diagnostic tests Evidence-based information Diseases associated with abnormal test results, including test sensitivities Full literature citations with PubMed (PMID) numbers included for each reference More than 24 NEW clinical laboratory test entries, 6 NEW differential diagnosis tables 5 NEW diagnostic algorithms NEW sections on point-of-care testing, provider-performed microscopy, pharmacogenetic testing, and diagnostic echocardiography
SELECT. INTERPRET. DIAGNOSE. A Doody's Core Title! 5 STAR DOODY'S REVIEW! "This is a valuable book, packed with useful, immediately understandable information. I highly recommend it to all as a reference." -- Doody's Review Service 350+ laboratory tests, microbiology tests, plus coverage of diagnostic imaging and electrocardiology Evidence-based information Convenient tables and algorithms Key references accompany each test Diseases associated with abnormal results More than two dozen NEW clinical laboratory test entries PMID numbers for all literature references to facilitate online research
Gives background to the business learner's world and strategies for approaching the training task, focusing on the learner's professional knowledge and experience. This book is suitable for teachers, trainers, and course organizers in the field of Business English or considering a move into it.
Kobayashi and Mark present the most up-to-date analytical models, simulation techniques, and computational algorithms useful for performance evaluation of complex systems - including computer systems, communication networks, transportation systems, and manufacturing systems. Broader in scope than other texts, this book provides more in-depth coverage of topics such as computational algorithms and approximations. It appeals to students with a background or interest in a wide range of areas, including systems analysis or telecommunication networks."--Publisher's website.
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