This book provides a compilation of mathematical-computational tools that are used to analyze experimental data. The techniques presented are those that have been most widely and successfully applied to the analysis of physiological systems, and address issues such as randomness, determinism, dimension, and nonlinearity. In addition to bringing together the most useful methods, sufficient mathematical background is provided to enable non-specialists to understand and apply the computational techniques. Thus, the material will be useful to life-science investigators on several levels, from physiologists to bioengineer.Initial chapters present background material on dynamic systems, statistics, and linear system analysis. Each computational technique is demonstrated with examples drawn from physiology, and several chapters present case studies from oculomotor control, neuroscience, cardiology, psychology, and epidemiology. Throughout the text, historical notes give a sense of the development of the field and provide a perspective on how the techniques were developed and where they might lead. The overall approach is based largely on the analysis of trajectories in the state space, with emphasis on time-delay reconstruction of state-space trajectories. The goal of the book is to enable readers to apply these methods to their own research.
Part of the in-depth and practical Pattern Recognition series, Practical Pulmonary Pathology, 3rd Edition, helps you accurately identify and interpret neoplastic and non-neoplastic diseases of the lungs by using a pattern-based approach. Leading diagnosticians in pulmonary pathology guide you from a histological pattern, through the appropriate work-up, around the pitfalls, and to the best diagnosis. Superb, full-color illustrations capture key pathological patterns for a full range of common and rare conditions, and a "visual index" at the beginning of the book directs you to the exact location of in-depth diagnostic guidance. A user-friendly design color-codes patterns to specific entities, and key points are summarized in tables, charts, and graphs so you can quickly and easily find what you are looking for. Sweeping content updates keep you at the forefront of recent findings regarding pulmonary hypertension, pediatric lung disease, and all major neoplastic and non-neoplastic diseases of the lung. An online virtual microscope provides access to more than 150 digital slides. A new chapter on Pulmonary Function Testing for Pathologists brings you up to date with relevant aspects of these key tests. Improved pattern call-outs are now linked directly within the chapter, reinforcing the patterns for more efficient and complete understanding. Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
For nearly 50 years, Sleisenger & Fordtran's Gastrointestinal and Liver Disease has been the go-to reference for gastroenterology and hepatology residents, fellows, physicians, and the entire GI caregiving team. Now in a fully revised 11th Edition, this two-volume masterwork brings together the knowledge and expertise of hundreds of global experts who keep you up to date with the newest techniques, technologies, and treatments for every clinical challenge you face in gastroenterology and hepatology. A logical organization, more than 1,100 full-color illustrations, and easy-to-use algorithms ensure that you'll quickly and easily find the information you need. - Features new and expanded discussions of chronic hepatitis B and C, Helicobacter pylori infection, colorectal cancer prevention through screening and surveillance, biologic agents and novel small molecules to treat and prevent recurrences of inflammatory bowel disease (IBD), gastrointestinal immune and autoimmune diseases, and more. - Offers reliable coverage of key topics such as Barrett's esophagus, gut microbiome, enteric microbiota and probiotics, fecal microbiota transplantation, and hepatic, pancreatic, and small bowel transplantation. - Provides more quick-reference algorithms that summarize clinical decision making and practical approaches to patient management. - Employs a consistent, templated, format throughout for quick retrieval of information. - Includes monthly updates online, as well as more than 20 procedural videos. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
The first issue of Clinics in Chest Medicine to be published with this focus, this issue reviews bronchiectasis from numerous angles to provide comprehensive coverage on this important subject. Epidemiology, airway defense mechanisms, pathogenesis, imaging and genetic causes of bronchiectasis are discussed. Allergic bronchopulmonary aspergillosis is addressed, as well as non-tuberculous mycobacteria as a cause of bronchiectasis. Authors examine how to evaluate the success of therapy for bronchiectasis (what endpoints to use) and then discuss a variety of therapy options: inhaled and systemic antibiotic treatment, chest physiotherapy, pharmacologic agents for mucous clearance, antipinflammatory therapy and macrolides. Pulmonary resection and lung transplantation for bronchiectasis are reviewed. Recent advances in Cystic Fibrosis are also discussed.
Pathophysiology – what is the cause? Clinical significance – what does it mean? Diagnosis and treatment – what is the predictive value? These are questions that all clinicians should continue to ask themselves from the very beginning of medical training and throughout a lifetime of practice. Organised by body system, Mechanisms of Clinical Signs 3e describes the underlying pathway, differential diagnoses and value of the clinical signs seen during physical examination. - Alphabetical listing of clinical signs - Index by sign and conditions for easy reference - Additional flow diagrams - Clinical Pearls highlighting important clinical signs - Summary of the evidence - Access to chapter-based MCQs Access StudentConsult for: - Clinical videos and audio of key signs - Case-based MCQs - An Enhanced eBook. The enhanced eBook allows the end user to access all of the text, figures, and references from the book on a variety of devices.
Addressing the relationships between gastroesophageal reflux and airway diseases, this pioneering reference is the only single source that serves as an intensive review of the subject, providing a large spectrum of information facilitating proper diagnosis and treatment of GERD and GERD-related disorders. Focusing on dentition, upper airway disease, cough, and lower airway disease, and presented in a format ideal for primary care providers and specialists, Gastroesophageal Reflux Disease and Airway Disease analyzes practical, in-office approaches to diagnosis provides guidelines for diagnostic modalities and treatment in all age groups clarifies when to consider surgical procedures highlights acid damage to the airway, from the esophagus up to the incisors and down to the lungs alerts physicians to the warning signs of GERD in adult asthmatics contains a questionnaire that helps elicit a history of GERD-related airway disease recommends pediatric medication dosing schedules discusses the benefits and limitations of performing laparoscopic surgical procedures in GERD patients explains paroxysmal laryngospasm and more! Containing over 1100 references, tables, drawings, and photographs, Gastroesophageal Reflux Disease and Airway Disease is an essential reference for clinical immunologists and allergists, pulmonologists, physiologists, gastroenterologists, otolaryngologists, pediatricians, internists and family practitioners, physician assistants, nurse practitioners, and medical students in these disciplines.
- Clinical Pearls highlight the main signs which students and trainees should look out for to help them identify conditions with which the patients present. - A Student Consult eBook is available with the purchase of a print book, and provides access to a total of 200 multiple choice questions covering the 7 body systems, to test students and trainees' knowledge of the content. - The eBook contains links to audio and video examples of particular signs which have to be heard or observed over a period of time in order to be identified correctly, e.g. Agonal respiration in Chapter 2 Respiratory Signs. - New images are added to depict clinical signs where no images were present in the previous edition.
The new gold-standard in anesthesiology Written and edited by an internationally known team of experts, Anesthesiology gives you a 360-degree view of the field, covering all of the anesthetic considerations, preparations, and procedures for the surgical patient, the pain patient or the critical care patient. You'll find a unique balance between clinical information, practical clinical procedures, and the molecular and basic scientific underpinnings of anesthesiology practice. Anesthesiology delivers a multi-perspective, wide-ranging view of anesthetic drugs, procedures, co-morbid diseases, and need-to-know postoperative pain management strategies. This essential guide not only focuses on general anesthesia, but also is the first to feature a detailed look at the subspecialty of regional anesthesia. Features: Top-to-bottom coverage of the entire field-from preoperative evaluation and intraoperative anesthesia care to care of the critically ill or chronic pain patient Emphasis on safety, quality and patient-centered care, with an entire section on risk reduction A focus on the clinical applications of anesthesiology Complex concepts explained by graphics and illustrations, not equations and formulas Full-color format and illustrations Specific drug and interventional guidelines for the clinical management of every OR/post-OR scenario in the anesthesiology field Key points and key references presented in each chapter CD that allows you to download illustrations and images to your PowerPoint presentations
This book provides a compilation of mathematical-computational tools that are used to analyze experimental data. The techniques presented are those that have been most widely and successfully applied to the analysis of physiological systems, and address issues such as randomness, determinism, dimension, and nonlinearity. In addition to bringing together the most useful methods, sufficient mathematical background is provided to enable non-specialists to understand and apply the computational techniques. Thus, the material will be useful to life-science investigators on several levels, from physiologists to bioengineer.Initial chapters present background material on dynamic systems, statistics, and linear system analysis. Each computational technique is demonstrated with examples drawn from physiology, and several chapters present case studies from oculomotor control, neuroscience, cardiology, psychology, and epidemiology. Throughout the text, historical notes give a sense of the development of the field and provide a perspective on how the techniques were developed and where they might lead. The overall approach is based largely on the analysis of trajectories in the state space, with emphasis on time-delay reconstruction of state-space trajectories. The goal of the book is to enable readers to apply these methods to their own research.
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