Featuring excerpts of essays collected from over one thousand young adults while in the throes of divorce, this book paints a picture of the pain and the hope shown by the storytellers. By framing the narratives with an analysis of the most recent divorce literature, the authors provide readers with a greater and more vivid understanding of the effects of divorce. Challenging the contention that most children will be irretrievably hurt by their parents' divorce, some stories clearly demonstrate the strength and resilience many have learned in dealing with a divorce in the family. Emphasis is placed on how hope about the possibilities of having close relationships - as well as a willingness to create stronger families in their own lives - represent abiding motivations in this sample of young people. The authors hope that the use of the raw input of respondents will make the experiences more realistic and ultimately help people deal with major loss events in their lives. Highlights of the new edition include: A new chapter (7) that demonstrates the messiness of divorce (infidelity, dysfunctional interactions, multiple marriages/relationships, and the financial expense), the fading stigma of divorce, the latest divorce rates, the increased average age of first time marriages, and the recent hook-up phenomenon wherein young people are showing a reluctance to commitment Updated throughout with the most current demographic data, new findings from the top researchers in the field, and the latest intervention programs A review of the Divorce Variability and Fluidity Model (DVFM) that helps predict variability in adjusting to divorce More suggestions to help children adapt to divorce, including material on parenting education classes and mediation as a method for easing the process A list of readings and suggested websites for further review More tables and graphs to summarize key concepts. An ideal supplement for courses on divorce, family studies, close relationships, and loss and trauma taught in human development and family studies, and clinical, counseling, and social psychology, as well as communication, social work, and sociology, these engaging stories also appeal to practitioners and those interested in the effects of divorce in general.
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. - Updates to all chapters, including new examples and references - Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book - Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry - Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant - Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis - Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: - for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib - for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid - for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin - Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples - Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites - Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
This volume will try to put current therapy - achievements, shortcomings, remaining medical needs - and emerging new targets into the context of increasing knowledge regarding the genetic and neurodevelopmental contributions to the pathophysiology of schizophrenia. Some of the chapters will also deal with respective experimental and clinical methodology, biomarkers, and translational aspects of drug development. The volume will concentrate on reviewing the ongoing research attempting to identify novel treatments for the cognitive deficits and negative symptoms of schizophrenia, which are not treated adequately by current antipsychotic medications.
Since the Personal Responsibility and Work Opportunity Reconciliation Act of 1996 was enacted, policy makers, agency administrators, community activists, and academics from a broad range of disciplines have debated and researched the implications of welfare reform in the United States. Most of the attention, however, has focused on urban rather than rural America. Welfare Reform in Persistent Rural Poverty examines welfare participants who live in chronically poor rural areas of the United States where there are few job opportunities and poor systems of education, transportation, and child care. Kathleen Pickering and her colleagues look at welfare reform as it has been experienced in four rural and impoverished regions of the United States: American Indian reservations in South Dakota, the Rio Grande region, Appalachian Kentucky, and the Mississippi Delta. Throughout these areas the rhetoric of reform created expectations of new opportunities to find decent work and receive education and training. In fact, these expectations have largely gone unfulfilled as welfare reform has failed to penetrate poor areas where low-income families remain isolated from the economic and social mainstream of American society. Welfare Reform in Persistent Rural Poverty sheds welcome light on the opportunities and challenges that welfare reform has imposed on low-income families situated in disadvantaged areas. Combining both qualitative and quantitative research, it will be an excellent guide for scholars and practitioners alike seeking to address the problem of poverty in rural America.
Point-of-care testing (POCT) refers to pathology testing performed in a clinical setting at the time of patient consultation, generating a rapid test result that enables informed and timely clinical action to be taken on patient care. It offers patients greater convenience and access to health services and helps to improve clinical outcomes. POCT also provides innovative solutions for the detection and management of chronic, acute and infectious diseases, in settings including family practices, Indigenous medical services, community health facilities, rural and remote areas and in developing countries, where health-care services are often geographically isolated from the nearest pathology laboratory. A Practical Guide to Global Point-of-Care Testing shows health professionals how to set up and manage POCT services under a quality-assured, sustainable, clinically and culturally effective framework, as well as understand the wide global scope and clinical applications of POCT. The book is divided into three major themes: the management of POCT services, a global perspective on the clinical use of POCT, and POCT for specific clinical settings. Chapters within each theme are written by experts and explore wide-ranging topics such as selecting and evaluating devices, POCT for diabetes, coagulation disorders, HIV, malaria and Ebola, and the use of POCT for disaster management and in extreme environments. Figures are included throughout to illustrate the concepts, principles and practice of POCT. Written for a broad range of practicing health professionals from the fields of medical science, health science, nursing, medicine, paramedic science, Indigenous health, public health, pharmacy, aged care and sports medicine, A Practical Guide to Global Point-of-Care Testing will also benefit university students studying these health-related disciplines.
Mark Laird offers a wealth of visual and literary materials to revolutionize our understanding of the English landscape garden as a powerful cultural expression.
Perfect for reminders, calendar notes, homework notes, name tags, and much more! Each pad features 36 acid-free, lignin-free sheets and measures approx. 3.5” x 3.5”. Available in a variety of prints, notepads are an essential addition to any teacher's desk! --Illustrations (C) Dianne J. Hook Published by Carson-Dellosa Publishing, LLC (C) Carson-Dellosa Publishing, LLC
Now in its 10th edition, Sleisenger and Fordtran?s Gastrointestinal and Liver Disease remains your indispensable source for definitive, state-of-the-art answers on every aspect of gastroenterology and hepatology. Overcome your most complex clinical challenges and make optimal use of the newest techniques, technologies, and treatments?with superb guidance from hundreds of world-renowned authorities. Meticulous updates throughout include the latest approaches and improvements in gastrointestinal and liver disease diagnosis and therapy as well as hundreds of images and 35 new procedural videos. "..one of the most valuable clinical resources in the dynamic field of gastroenterology and hepatology." Reviewed by Brindusa Diaconu on behalf of the Journal of Gastrointestinal and Liver Diseases, July 2015 "..an engaging, educational yet clinically orientated textbook which is relevant to modern clinical practice." Reviewed by Dr Harry Brown on behalf of glycosmedia.com, April 2015 "I can personally attest to the remarkable advances that have been made, as I was author of the chapter on eosinophilic gastroenteritis in the second edition of the textbook, and reading the same chapter in the tenth edition underscores the important advances that have been made in our understanding of the molecular basis as well as the pathophysiology of this and related disorders." Foreword by Norton J. Greenberger, MD Boston, Massachusetts, June 2015 Consult this title on your favorite e-reader. Get the essential gastroenterology information you need from one authoritative source with an outstanding global reputation for excellence. Zero in on the key information you need to know with a consistent, full-color chapter design. Stay up to date with emerging and challenging topics: enteric microbiota and probiotics; fecal microbiota transplantation; Clostridium difficile colitis; and factitious gastrointestinal diseases. Incorporate the latest findings and improvements in care for liver disease patients—from diagnosis and treatment through post-treatment strategies and management of complications. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and videos from the book on a variety of devices.
This book is the first full evaluation of the Proto-Australian hypothesis, which proposes that most Australian languages have a common ancestor: Proto-Australian [PA]. Using the standard methodologies of historical linguistics, the authors show that nearly all Australian languages descend from PA. Given that PA was a single language, it was spoken only in a small area of Australia. Its descendants have spread across the continent. Current theories of language spread do not offer clear motivations for large-scale spread in hunter-gatherer economies. This raises significant questions for analyses of Australian prehistory and archaeology specifically, and more widely for general theories of hunter-gatherer prehistory and language spread.
Short Stories / Anicdotes relating to African Hunting Safaris/As a small boy growing up in Kenya, I would listen to the stories my mother told me with avid interest. I would hang on to her every word and vowed that one day I was going to be a hunter too. Many of my parent's safari boys were my friends and would scare the daylights out of me by telling me hair-raising stories of their own. Each chapter of this book is a complete story in itself. The book is designed to make light and amusing reading.
Human Reproductive Biology focuses on the processes, concerns, and trends in human reproduction. Divided into four parts with 19 chapters, the book starts by tracing the history of human reproduction biology and the questions and choices involved. The first part focuses on the male and female reproductive systems. The text notes the different organs involved in reproduction, including the penis, scrotum, vagina, oviducts, and mammary glands. The book discusses sexual development and differentiation, particularly noting the variance of sex ducts and glands, external genitalia, and disorders of sexual development and determination. The text also looks at puberty. Concerns include gonadal changes from birth to puberty; mechanisms that influence puberty; and puberty and psychosocial adjustment. The second part deals with menstrual cycle, fertilization, pregnancy, labor, and birth. Some of the concerns include length of menstrual cycle; absence of menstruation; transport of sperm and ovum in the oviduct; and semen release. The text also highlights labor and birthing processes as well as the relationship of neonates and parents. The third part looks at the medical aspects of human reproduction, infertility, and sexually transmitted diseases. Concerns include contraception, abortion, herpes genitalis, and vaginitis. The text folds with discussions on human sexual behavior, population growth, and family planning. Concerns include sexual dysfunction; the effects of overpopulation; and population control. The book is a vital source of data for readers interested in human reproduction.
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