America's fascination with celebrities never gets old. From People magazine, with a readership of 43 million to Internet sites like JustJared.com with over 80 million monthly views, celebrity information not only sells, it educates people about important issues––including cancer. Information is empowering and reading about a famous person coping with cancer can not only be inspiring, it can save a life. That's what Reimagining Cancer exemplifies through each of the books in the series Cancer doesn't have to be a death sentence. About half of all cancers are preventable and can be avoided if current medical knowledge is better delivered*. Reimagining Men's Cancers—focusing on cancers of the prostate, penis, and testicles—provides readers with that critical information to help them manage, cope, and recover through a concise, easy-to-read style and format. Beginning with a view of basic anatomy and an overview of how we view a particular cancer today, chapters flow easily into an explanation of signs, symptoms, diagnosis, scientific information and guidelines, and include a comprehensive survey of treatments and prevention. Woven throughout are stories, both medical and anecdotal, from men such as Joe Torre, Robert De Niro, Sir Ian McKellen, and Scott Hamilton. Education is the key, and by using celebrity stories, Reimagining Men's Cancers can attract countless readers who might otherwise not pay attention to an epidemic that is likely to affect them or a loved one. * The recent World Cancer Report from the World Health Organization
Focusing on cancer of the breasts, ovaries, uterus, cervix, vagina and vulva - provides readers with that critical information to help them manage, cope, and recover through a concise, easy-to-read style and format. Beginning with a view of basic anatomy and an overview of how we view a particular cancer today, chapters flow easily into an explanation of signs, symptoms, diagnosis, scientific information and guidelines, and include a comprehensive survey of treatments and prevention.
Focusing on cancers of the prostate, penis, and testicles--provides readers with that critical information to help them manage, cope, and recover through a concise, easy-to-read style and format. Beginning with a view of basic anatomy and an overview of how we view a particular cancer today, chapters flow easily into an explanation of signs, symptoms, diagnosis, scientific information and guidelines, and include a comprehensive survey of treatments and prevention.
Focusing on cancer of the breasts, ovaries, uterus, cervix, vagina and vulva - provides readers with that critical information to help them manage, cope, and recover through a concise, easy-to-read style and format. Beginning with a view of basic anatomy and an overview of how we view a particular cancer today, chapters flow easily into an explanation of signs, symptoms, diagnosis, scientific information and guidelines, and include a comprehensive survey of treatments and prevention.
This book embraces a fundamental issue for the modern information economy, namely the creation, negotiation and institutionalization of private and public knowledge. The authors argue that as new biological knowledge develops, the actors must help create and negotiate the boundaries of what can be considered private and public knowledge. By using an Instituted Economic Process approach, the authors come to grips with these dynamics of the economics of knowledge. This approach therefore helps us analyze who is involved, who benefits, and why conflicts occur within an innovation-driven economy. The authors provide very interesting empirical material, as well, because they develop their analytical points, through well-written and thick descriptions of cases from biodata, bioinformatic, and a case of gene sequencing. Hence, this book makes interesting conceptual and empirical contributions, to our understanding of modern biological sciences in the economy. Maureen McKelvey, Chalmers University of Technology, Sweden It once was believed that scientific knowledge was public and technological knowledge was proprietary, and this was the way it should be. However, recent developments, particularly in biology, have unsettled this belief. This superb book examines what determines whether a body of knowledge is public or private. The consideration of the theoretical issues is thorough and thoughtful. The study of how things have played out in various fields of biology, and why, is smashing. What the authors have to say is important and fascinating, and makes for a great read. Richard R. Nelson, Columbia University, US The great divide between public and private knowledge in capitalism is an unstable frontier at the core of contemporary economic transformations. Based on research in the USA, Europe and Brazil into the cutting edge of biological science and technology, this book presents a novel framework for understanding this historically shifting fault-line. Over the last quarter of a century, major controversies have accompanied the dramatic developments in biological science and technology. At critical points, leading commercial companies were poised to take ownership over the human genome and much new post-genomic knowledge. The software tools for analysing the deluge of data also appeared, as did expanding new markets for private enterprise. At the same time, huge new public programmes of biological research were accompanied by radical innovation in the institutions and organisation of public knowledge. Would private marketable knowledge dominate over the new public domain or vice versa? Surprisingly, the dynamism and expansion of the public domain, and new forms of differentiation and interdependence between public and private economies of knowledge, now characterise the landscape. This book presents an analytical framework for understanding the shifting great divide in capitalist economies of knowledge. The authors develop a novel economic sociology of innovation, based on the instituted economic process approach. By focusing on economies of knowledge, they seek to demonstrate that capitalism is multi-modal at its core, with interdependent growth of market and non-market modes of production, distribution, exchange and use. Public or Private Economies of Knowledge? will appeal to those with an interest in innovation studies, economic sociology and economic theory.
This is the only book completely devoted to the popular BLAST (Basic Local Alignment Search Tool), and one that every biologist with an interest in sequence analysis should learn from.
Successfully fighting cancer starts with understanding how it begins. This thoroughly revised 3rd Edition explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of cancer. A team of leading experts thoroughly explain the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating cutting-edge advances and the newest research, the book provides thorough descriptions of everything from molecular abnormalities in common cancers to new approaches for cancer therapy. Features sweeping updates throughout, including molecular targets for the development of anti-cancer drugs, gene therapy, and vaccines...keeping you on the cutting edge of your specialty. Offers a new, more user-friendly full-color format so the information that you need is easier to find. Presents abundant figures-all redrawn in full color-illustrating major concepts for easier comprehension. Features numerous descriptions of the latest clinical strategies-helping you to understand and take advantage of today’s state-of-the-art biotechnology advances.
A concise introduction to fundamental methods for finding and extracting relevant information from the ever-increasing amounts of biomedical text available The introduction of high-throughput methods has transformed biology into a data-rich science. Knowledge about biological entities and processes has traditionally been acquired by thousands of scientists through decades of experimentation and analysis. The current abundance of biomedical data is accompanied by the creation and quick dissemination of new information. Much of this information and knowledge, however, is represented only in text form—in the biomedical literature, lab notebooks, Web pages, and other sources. Researchers' need to find relevant information in the vast amounts of text has created a surge of interest in automated text-analysis. In this book, Hagit Shatkay and Mark Craven offer a concise and accessible introduction to key ideas in biomedical text mining. The chapters cover such topics as the relevant sources of biomedical text; text-analysis methods in natural language processing; the tasks of information extraction, information retrieval, and text categorization; and methods for empirically assessing text-mining systems. Finally, the authors describe several applications that recognize entities in text and link them to other entities and data resources, support the curation of structured databases, and make use of text to enable further prediction and discovery.
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
This book is the first of its kind to provide a large collection of bioinformatics problems with accompanying solutions. Notably, the problem set includes all of the problems offered in Biological Sequence Analysis, by Durbin et al. (Cambridge, 1998), widely adopted as a required text for bioinformatics courses at leading universities worldwide. Although many of the problems included in Biological Sequence Analysis as exercises for its readers have been repeatedly used for homework and tests, no detailed solutions for the problems were available. Bioinformatics instructors had therefore frequently expressed a need for fully worked solutions and a larger set of problems for use on courses. This book provides just that: following the same structure as Biological Sequence Analysis and significantly extending the set of workable problems, it will facilitate a better understanding of the contents of the chapters in BSA and will help its readers develop problem-solving skills that are vitally important for conducting successful research in the growing field of bioinformatics. All of the material has been class-tested by the authors at Georgia Tech, where the first ever MSc degree program in Bioinformatics was held.
Pulitzer Prize-winning journalists Mark Johnson and Kathleen Gallagher chronicle the story of a young boy with a never-before-seen disease and the doctors who take a bold step into the future of medicine to save him"--Page 4 of cover
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