This is a gentle introduction to the vocabulary and many of the highlights of elementary group theory. Written in an informal style, the material is divided into short sections, each of which deals with an important result or a new idea. Includes more than 300 exercises and approximately 60 illustrations.
This is a gentle introduction to the vocabulary and many of the highlights of elementary group theory. Written in an informal style, the material is divided into short sections, each of which deals with an important result or a new idea. Includes more than 300 exercises and approximately 60 illustrations.
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
This 2007 book provides the most comprehensive examination of American Expeditionary Forces (AEF) combat doctrine and methods ever published. It shows how AEF combat units actually fought on the Western Front in World War I. It describes how four AEF divisions (the 1st, 2nd, 26th, and 77th) planned and conducted their battles and how they adapted their doctrine, tactics, and other operational methods during the war. General John Pershing and other AEF leaders promulgated an inadequate prewar doctrine, with only minor modification, as the official doctrine of the AEF. Many early American attacks suffered from these unrealistic ideas that retained too much faith in the infantry rifleman on the modern battlefield. However, many AEF divisions adjusted their doctrine and operational methods as they fought, preparing more comprehensive attack plans, employing flexible infantry formations, and maximizing firepower to seize limited objectives.
In the exciting and growing field of hospital medicine, you're as concerned with the efficient management of your unit as you are the effective care of your patients. This title is your ideal new clinical reference on both counts. Nationally recognized experts equip you with practical, actionable guidance on all of the challenges you face every day—making it easier for you to provide optimal care for every patient. State-of-the-art, evidence-based, hospital-focused guidelines on clinical assessment, diagnosis, prognosis, treatment, and discharge/follow-up planning help you to effectively manage all of the key disorders in every body system. 20 chapters focused on peri-operative care assist you in navigating this increasingly important component of hospital medicine practice. Expert advice on systems issues explores how to establish and enhance a hospitalist program, provide leadership, manage patient transitions of care, establish a teamwork model with hospital staff, promote patient safety and staff performance improvement, standardize care, and navigate legal and ethical concerns.
Mark Jago offers a new metaphysical account of truth. He argues that to be true is to be made true by the existence of a suitable worldly entity. Truth arises as a relation between a proposition - the content of our sayings, thoughts, beliefs, and so on - and an entity (or entities) in the world.
Colonel Wells investigates the nature of aerial warfare and the men who took part. The book analyzes aircrew selection, reaction to combat, adaptability to stress, morale, leadership and combat effectiveness, and compares the efforts of the US Eighth Air Force and RAF Bomber Command.
During his time in politics Mark Latham not only kept a diary, but also collected quotes and anecdotes that he found inspiring, amusing or enlightening. Here, with an introduction by the author, are words of wisdom and humour, withering ripostes and personal reflections from authors, politicians and public figures-ranging from Ben Chifley to Barry Humphries, from Julius Caesar to Dorothy Parker, and also some of Mark Latham's own memorable turns of phrase. A Conga Line of Suckholes collects together both wit and wisdom, the language of both the academy and the larrikin. It is an essential companion for the reader, writer, browser and public speaker, which will make readers think and laugh.Mark Latham was the Federal Member for Werriwa from 1994 to 2005. He was Leader of the Labor Party between 2003 and 2005. Mark Latham is the author of The Latham Diaries and five other books on Australian public policy, including Civilising Global Capital and From the Suburbs. He lives in the outer suburbs of Sydney with his wife and two children.
This book offers an authoritative overview of the history of evangelicalism as a global movement, from its origins in Europe and North America in the first half of the eighteenth century to its present-day dynamic growth in Africa, Asia, Latin America and Oceania. Starting with a definition of the movement within the context of the history of Protestantism, it follows the history of evangelicalism from its early North Atlantic revivals to the great expansion in the Victorian era, through to its fracturing and reorientation in response to the stresses of modernity and total war in the late nineteenth and early twentieth centuries. It describes the movement's indigenization and expansion toward becoming a multicentered and diverse movement at home in the non-Western world that nevertheless retains continuity with its historic roots. The book concludes with an analysis of contemporary worldwide evangelicalism's current trajectory and the movement's adaptability to changing historical and geographical circumstances.
The editors express their gratitude to the John M. Olin Foundation for its financial assistance and to the Harvard University Russian Research Center for the facilities and staff support that made this project possible. We wish to thank those who contributed their invaluable scholarly advice, including Vernon Aspaturian, Abram Bergson, Steven Blank, Walker Connor, Robert Conquest, Murray Feshbach, Erich Goldhagen, Richard Pipes, and Marc Raeff. We gratefully acknowledge the assistance of Barbara A. Anderson and Brian D. Silver with Soviet demographic data used throughout the volume. Susan Zayer and Karen Taylor-Brovkin provided able administrative help. For skillful technical assistance with the manuscript we are indebted to Jane Prokop, Elizabeth Taylor, and Alison Koff. Catherine Reed, Susan Gardos-Bleich, Christine Porto, and Alex Sich helped generously in diverse ways. Finally, the editors profited at every stage from the congenial working atmosphere and the encouragement of colleagues at the Russian Research Center too numerous to mention. To all of them goes our deep appreciation.
Exploring the genocidal events of the period from 1912 to 1938 this title focuses particularly on the Balkans, the Great War and the emergence of the Stalin and Hitler States, and seeks to integrate them into a single, coherent history.
When most people think of the prohibition era, they think of speakeasies, gin runners, and backwoods fundamentalists railing about the ills of strong drink. In other words, in the popular imagination, it is a peculiarly American event.Yet, as Mark Lawrence Schrad shows in Smashing the Liquor Machine, the conventional scholarship on prohibition is extremely misleading for a simple reason: American prohibition was just one piece of a global wave of prohibition laws that occurred around the same time. Schrad's counterintuitiveglobal history of prohibition looks at the anti-alcohol movement around the globe through the experiences of pro-temperance leaders like Thomas Masaryk, founder of Czechoslovakia, Vladimir Lenin, Leo Tolstoy, and anti-colonial activists in India. Schrad argues that temperance wasn't "Americanexceptionalism" at all, but rather one of the most broad-based and successful transnational social movements of the modern era. In fact, Schrad offers a fundamental re-appraisal of this colorful era to reveal that temperance forces frequently aligned with progressivism, social justice, liberalself-determination, democratic socialism, labor rights, women's rights, and indigenous rights. By placing the temperance movement in a deep global context, he forces us to fundamentally rethink all that we think we know about the movement. Rather than a motley collection of puritanical Americanevangelicals, the global temperance movement advocated communal self-protection against the corrupt and predatory "liquor machine" that had become exceedingly rich off the misery and addictions of the poor around the world, from the slums of South Asia to central Europe to the Indian reservations ofthe American west.Unlike many traditional "dry" histories, Smashing the Liquor Machine gives voice to minority and subaltern figures who resisted the global liquor industry, and further highlights that the impulses that led to the temperance movement were far more progressive and variegated than American readers havebeen led to believe.
Features information on nations, states, and cities, celebrities, sports, consumerism, the arts, health and nutrition, United States and world history, and numerous other subjects.
From Bumper V-2 rocket launches in 1950 to the launch of the Orion spacecraft atop a Delta IV rocket in 2014, NASA's Kennedy Space Center has served as the nation's portal to outer space for over 60 years. Images of Modern America: NASA Kennedy Space Center provides a fascinating look at the evolution of spacecraft technology and vintage images of Florida's scenic Merritt Island, known as the "Space Coast." This photographic history of the nation's premier spaceport looks back at the United States' glorious past in space exploration and ahead to its future.
The most comprehensive, current sickle cell disease resource—for both clinicians and researchers A Doody's Core Title for 2023! The first and only resource of its kind, Sickle Cell Disease examines this blood disorder through both clinical and research lenses. More than 80 dedicated experts in the field present their combined clinical knowledge of basic mechanisms, screening, diagnosis, management, and treatment of myriad complex complications of a single base point mutation in the human genome. Case studies with “How I Treat” authoritative insights provide overviews of common and rare complications, and Key Facts offer at-a-glance high-yield information. Filled with clinical photos, illustrations, numerous original diagrams, and with free updates available online, this unmatched resource covers: Mechanisms of sickle cell disease Historic and current research approaches The latest work in gene therapy and editing Guidelines for patient care, diagnosis, unique cases, and therapies Rare and common complications, including domestic and internationally relevant topics Psychosocial and supportive care The newest standards of therapy and future treatment options in children and adults Cardiopulmonary complications
From aback to ZizEX, the second edition of Jackspeak of the Royal Canadian Navy gives readers a chance to fill their boots with the colourful language of Canada’s senior service.
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