Alzheimer's disease (AD) is a devastating pathology of the central nervous system (CNS) of unknown etiology which represents the most common neurodegenerative disorder. AD is the major cause of senile dementia, affecting approximately 5% of the population over 70. This syndrome is characterized by loss of short-term memory and progressive impairment of intellectual functions. No established therapeutic strategy has been found so far.Until recently, much of the literature on AD discussed the effects of this syndrome on the CNS. In the last few years, however, a large amount of information has appeared which underscored the importance of studying AD from other perspectives with the view of identifying reliable biological markers. The amyloid precursor proteins (APPs), for instance, constitute a complex family of membrane-bound and soluble glycoproteins that are derived by alternative splicing of a gene on chromosome 21. In the hemopoietic system, APPs have been detected in a number of cell types, such as leukocytes, megakaryocytes and platelets. In addition plasma contains picomolar concentrations of APP isoforms most likely derived from platelets. Abnormalities were also detected in the electrophoretic profile of erythrocytic membranes from AD patients. Numerous abnormalities have been proposed as peripheral markers for AD and several laboratories around the world are deeply involved in this challenging research.This book provides up-to-date information, as review chapters, on non-neuronal cells, with the aim of stimulating the formulation of potential diagnostic-therapeutic strategies.
2011 Winner of the Phyllis Goodhart Gordan Book Prize of the Renaissance Society of America Naples in the sixteenth and seventeenth centuries managed to maintain a distinct social character while under Spanish rule. John A. Marino's study explores how the population of the city of Naples constructed their identity in the face of Spanish domination. As Western Europe’s largest city, early modern Naples was a world unto itself. Its politics were decentralized and its neighborhoods diverse. Clergy, nobles, and commoners struggled to assert political and cultural power. Looking at these three groups, Marino unravels their complex interplay to show how such civic rituals as parades and festival days fostered a unified Neapolitan identity through the assimilation of Aragonese customs, Burgundian models, and Spanish governance. He discusses why the relationship between mythical and religious representations in ritual practices allowed Naples's inhabitants to identify themselves as citizens of an illustrious and powerful sovereignty and explains how this semblance of stability and harmony hid the city's political, cultural, and social fissures. In the process, Marino finds that being and becoming Neapolitan meant manipulating the city's rituals until their original content and meaning were lost. The consequent widening of divisions between rich and poor led Naples's vying castes to turn on one another as the Spanish monarchy weakened. Rich in source material and tightly integrated, this nuanced, synthetic overview of the disciplining of ritual life in early modern Naples digs deep into the construction of Neapolitan identity. Scholars of early modern Italy and of Italian and European history in general will find much to ponder in Marino's keen insights and compelling arguments.
Alzheimer's disease (AD) is a devastating pathology of the central nervous system (CNS) of unknown etiology which represents the most common neurodegenerative disorder. AD is the major cause of senile dementia, affecting approximately 5% of the population over 70. This syndrome is characterized by loss of short-term memory and progressive impairment of intellectual functions. No established therapeutic strategy has been found so far.Until recently, much of the literature on AD discussed the effects of this syndrome on the CNS. In the last few years, however, a large amount of information has appeared which underscored the importance of studying AD from other perspectives with the view of identifying reliable biological markers. The amyloid precursor proteins (APPs), for instance, constitute a complex family of membrane-bound and soluble glycoproteins that are derived by alternative splicing of a gene on chromosome 21. In the hemopoietic system, APPs have been detected in a number of cell types, such as leukocytes, megakaryocytes and platelets. In addition plasma contains picomolar concentrations of APP isoforms most likely derived from platelets. Abnormalities were also detected in the electrophoretic profile of erythrocytic membranes from AD patients. Numerous abnormalities have been proposed as peripheral markers for AD and several laboratories around the world are deeply involved in this challenging research.This book provides up-to-date information, as review chapters, on non-neuronal cells, with the aim of stimulating the formulation of potential diagnostic-therapeutic strategies.
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