Dynamic Treatment Regimes: Statistical Methods for Precision Medicine provides a comprehensive introduction to statistical methodology for the evaluation and discovery of dynamic treatment regimes from data. Researchers and graduate students in statistics, data science, and related quantitative disciplines with a background in probability and statistical inference and popular statistical modeling techniques will be prepared for further study of this rapidly evolving field. A dynamic treatment regime is a set of sequential decision rules, each corresponding to a key decision point in a disease or disorder process, where each rule takes as input patient information and returns the treatment option he or she should receive. Thus, a treatment regime formalizes how a clinician synthesizes patient information and selects treatments in practice. Treatment regimes are of obvious relevance to precision medicine, which involves tailoring treatment selection to patient characteristics in an evidence-based way. Of critical importance to precision medicine is estimation of an optimal treatment regime, one that, if used to select treatments for the patient population, would lead to the most beneficial outcome on average. Key methods for estimation of an optimal treatment regime from data are motivated and described in detail. A dedicated companion website presents full accounts of application of the methods using a comprehensive R package developed by the authors. The authors’ website www.dtr-book.com includes updates, corrections, new papers, and links to useful websites.
Nonlinear measurement data arise in a wide variety of biological and biomedical applications, such as longitudinal clinical trials, studies of drug kinetics and growth, and the analysis of assay and laboratory data. Nonlinear Models for Repeated Measurement Data provides the first unified development of methods and models for data of this type, with a detailed treatment of inference for the nonlinear mixed effects and its extensions. A particular strength of the book is the inclusion of several detailed case studies from the areas of population pharmacokinetics and pharmacodynamics, immunoassay and bioassay development and the analysis of growth curves.
From antiquity to the eve of the modern era, rulers of Western empires inspired hero worship by proclaiming their divine origins. In this fascinating original study, Marie Tanner presents the history of the emperor's mythic image and its continuing influence on Western political thought. She shows that these pretensions to divinity were based on the Trojan legend and the myth of Rome as developed in Vergil's Aeneid and that later Christian emperors expanded these claims by tracing their lineage not only to the pagan gods but also to the priest-kings of the Old Testament. Through this amalgam of heritages each successive Holy Roman emperor proclaimed that he was the last descendant of Aeneas, destined to yield the terrestrial rule of Rome to Christ and thereby inaugurate millennial peace. By examining a wide range of literary, artistic, and historical sources plus a corpus of new illustrations, Tanner discovers remarkable chains of evidence for this process, one that culminates with the Renaissance Hapsburgs who imbued the holiest symbols of the faith with dynastic meaning as they attempted to consolidate all priestly and secular powers in their grip. On these foundations Philip II of Spain, son of the Holy Roman Emperor Charles V and the first monarch to rule the four known continents, created a new concept of absolute monarchy that shaped the principles of modern statecraft and determined the dominant form of government in Europe for the next two centuries.
Holly Marie was forty-two years old the day she found out she was missing. At ten months old, Holly Marie was brought to the door of a church by three barefoot women in white robes and head coverings. Adopted by the pastor and raised in a loving Christian home, Holly nevertheless struggled with the ache of not knowing what had happened to her biological parents. She still felt their absence even as she married and started a family of her own. When two detectives showed up at the restaurant where she worked and informed her that she had a large family in Florida who had been searching for her for over 40 years, Holly’s past became the reality of her present, and she began the sometimes painful journey of discovering the truth about her origins: Her parents had been brutally murdered, their case still unsolved. With the help of law enforcement across four states, forensic genealogists, the National Center for Missing and Exploited Children, and her newly discovered family members, the missing pieces began to come together. Except these—why had her parents been murdered? And who had murdered them? She soon found out that the truth leads not always to answers but sometimes to more questions, that it also brings healing and restoration, and that we must surrender our unknowns to God until, in His perfect timing, all truths are revealed. Finding Baby Holly is the true, inspiring story of a wife and mother who was “missing” for over forty years after her parents’ murders, the persistent detectives who never stopped investigating, and the birth family who never lost hope in finding her.
Abgrall, a practicing psychiatrist and professional criminologist who won a case against the Scientologists in Europe, has spent 15 years researching cult phenomena. Well organized and readable. This book is recommended for public and academic libraries.
Someone murdered Brian's girfriend, Amanda. The police think it was her father. Brian isn’t so sure. But everyone he knows is telling him to move on, get over it, focus on the present. Focus on basketball. Focus on hitting the perfect shot. Brian hopes that the system will work for Amanda and her father. An innocent man couldn’t be wrongly convicted, could he? But then Brian does a school project on Leo Frank, a Jewish man lynched decades ago for the murder of a teenage girl—a murder he didn’t commit. Worse still, Brian’s teammate Julius gets arrested for nothing more than being a black kid in the wrong place at the wrong time. Brian can’t deny any longer that the system is flawed. As Amanda’s father goes on trial, Brian admits to himself that he knows something that could break the case. But if he comes forward, will the real killer try for another perfect shot—this time against Brian?
Over the past twenty years or so it has finally been understood that Jacopo Tintoretto (1518/19-1594) is an old master of the very highest calibre, whose sharp visual intelligence and brilliant oil technique provides a match for any painter of any time. Based on papers given at a conference held at Keble College, Oxford, to mark the quincentenary of Tintoretto’s birth, this volume comprises ten new essays written by an international range of scholars that open many fresh perspectives on this remarkable Venetian painter. Reflecting current ‘hot spots’ in Tintoretto studies, and suggesting fruitful avenues for future research, chapters explore aspects of the artist’s professional and social identity; his graphic oeuvre and workshop practice; his secular and sacred works in their cultural context; and the emergent artistic personality of his painter-son Domenico. Building upon the opening-up of the Tintoretto phenomenon to less fixed or partial viewpoints in recent years, this volume reveals the great master’s painting practice as excitingly experimental, dynamic, open-ended, and original.
They provoke you with anger because fear-filled people are easier to manipulate. The tricks, tools and tactics used to influence you and your loved ones—along with the history of propaganda—explained and explored. We live in an age of disinformation, misinformation, and outright lies. The modern world blasts us with information, talking points, spin, advertising, and attempts to persuade. But what are we to believe and whom should we trust? Examining the history of propaganda and disinformation in war, politics, polling, media, entertainment, cults, advertising, science, medicine, today’s media landscape, and even in our personal interactions, Disinformation and You: Identify Propaganda and Manipulation helps you spot and counter the seductive and deceptive tactics to influence individual behavior. It provides helpful suggestions and tips for identifying disinformation and fighting back against manipulation and censorship. Engaging and useful, this book’s helpful topics include ... the money behind politics and the media predictive programming as a form of social engineering advertising sales tactics how things go viral the power of memes and hashtags to push a story or idea censorship in the media and on social media networks sponsored news, fake news, and the mainstream media cult mentality and groupthink disinformation campaigns and false flags how conspiracy theories work how to identify fake news and propaganda Disinformation and You shows you the tricks used to influence your behavior. So, get on the bandwagon with the rest of us decent folk and stop listening to fools. After all, two out of three people have seen their IQ scores rise by buying this book! Really, buy this book and be smarter (in recognizing propaganda, that is). With many photos, illustrations, and other graphics, this tome is richly illustrated, and its helpful bibliography and extensive index add to its usefulness.
From CRC Press's unrivaled pool of author experts comes the ultimate reader on terrorism. With information drawn from premier titles in the CRC Press collection, it focuses on how to prepare for, mitigate, counter, and respond to terror threats and acts. Policy issues, critical infrastructure protection, terrorism funding, and target selection is discussed, along with weapons of mass destruction, intelligence and antiterrorism efforts, terrorism crisis management, and responder issues. The book goes beyond theory to provide practitioner knowledge from the field straight into the reader‘s hands, delivering real-world solutions to terrorist threats and acts at home and abroad.
Nowadays the term dose-response is used in many different contexts and many different scientific disciplines including agriculture, biochemistry, chemistry, environmental sciences, genetics, pharmacology, plant sciences, toxicology, and zoology. In the 1940 and 1950s, dose-response analysis was intimately linked to evaluation of toxicity in terms of binary responses, such as immobility and mortality, with a limited number of doses of a toxic compound being compared to a control group (dose 0). Later, dose-response analysis has been extended to other types of data and to more complex experimental designs. Moreover, estimation of model parameters has undergone a dramatic change, from struggling with cumbersome manual operations and transformations with pen and paper to rapid calculations on any laptop. Advances in statistical software have fueled this development. Key Features: Provides a practical and comprehensive overview of dose-response analysis. Includes numerous real data examples to illustrate the methodology. R code is integrated into the text to give guidance on applying the methods. Written with minimal mathematics to be suitable for practitioners. Includes code and datasets on the book’s GitHub: https://github.com/DoseResponse. This book focuses on estimation and interpretation of entirely parametric nonlinear dose-response models using the powerful statistical environment R. Specifically, this book introduces dose-response analysis of continuous, binomial, count, multinomial, and event-time dose-response data. The statistical models used are partly special cases, partly extensions of nonlinear regression models, generalized linear and nonlinear regression models, and nonlinear mixed-effects models (for hierarchical dose-response data). Both simple and complex dose-response experiments will be analyzed.
Oogenesis - the process by which female germ cells develop into mature eggs, or ova - is a complex process involving many important elements of developmental and cellular biology: from cell-cell interactions, complex signalling cascades, specialized cell cycles and cytoskeleton organization. Oocytes from various species (including clam, starfish, xenopus and mouse) are excellent model systems to study the biochemistry of cell division with important implications for basic and clinical research. This book describes the entire process of oogenesis in chronological order with contributions from leading international researchers and chapters covering medical and ethical considerations in oogenic biology. Topics include sex determination and gonadal development, control of meiotic chromosome pairing and homologous recombination, control of meiotic divisions and the remodelling of the oocyte into a totipotent zygote as well as medically-assisted reproduction. This volume is an essential resource for all students, researchers and clinicians in developmental and reproductive biology. Key features: Reaches beyond the study of simply meiosis to cover all aspects of oogenesis Synthesizes recent advances in the field, drawing on studies from different model species Chapter sequence designed to follow the time line in vivo Written by an international panel of expert researchers
Like fine wine, books become better with age. This title is an incredible source to the current values of thousands of titles, from the old and rare to the more modern. Photos throughout.
Nonlinear measurement data arise in a wide variety of biological and biomedical applications, such as longitudinal clinical trials, studies of drug kinetics and growth, and the analysis of assay and laboratory data. Nonlinear Models for Repeated Measurement Data provides the first unified development of methods and models for data of this type, with a detailed treatment of inference for the nonlinear mixed effects and its extensions. A particular strength of the book is the inclusion of several detailed case studies from the areas of population pharmacokinetics and pharmacodynamics, immunoassay and bioassay development and the analysis of growth curves.
Nonlinear measurement data arise in a wide variety of biological and biomedical applications, such as longitudinal clinical trials, studies of drug kinetics and growth, and the analysis of assay and laboratory data. Nonlinear Models for Repeated Measurement Data provides the first unified development of methods and models for data of this type, with a detailed treatment of inference for the nonlinear mixed effects and its extensions. A particular strength of the book is the inclusion of several detailed case studies from the areas of population pharmacokinetics and pharmacodynamics, immunoassay and bioassay development and the analysis of growth curves.
In Called by God: Discernment and Preparation for Religious Life, Rachael Marie Collins provides an overview of the spiritual life—both its joys and its challenges—and guides women as they discern whether they are called to be religious sisters or nuns. In a series of letters written by the author to a trusted friend discerning whether to enter religious life, Called by God explores both discernment and spirituality. The key to discernment, Collins argues, is to prepare for religious life by entering deeply into a life of prayer and sacrifice so that one experiences and begins to understand the “work” of a religious before entering the convent. Called by God draws heavily on the wisdom of great Catholic women such as Teresa of Ávila, Thérèse of Lisieux, Zélie Martin, Edith Stein, Teresa of the Andes, Elizabeth of the Trinity, Miriam Teresa Demjanovich, Elizabeth Leseur, and Caryll Houselander, among others. Women discerning a vocation will benefit immensely from the discussions about the difference between religious life and marriage, the nature of a vocation, the supernatural superiority of religious life, and spiritual motherhood in Called by God.
2017 Reprint of 1947 Edition. Full facsimile of the original edition, not reproduced with Optical Recognition software. Considered by many to be one of the greatest single books of Marian spirituality ever written, Secret of Mary is St Louis de Montfort's classic statement on the spiritual way to Jesus Christ though the Blessed Virgin Mary. Beloved by countless souls, this book sums up the entire Christian life, showing a way of holiness that is short, easy, secure, and perfect--a way of life chosen by Our Lord Himself. In this book, de Montfort explains the wonderful spiritual effects which true devotion to Mary brings about in a person's life. It is primarily an interior practice to be carried out daily, from moment to moment, and if followed faithfully, it will help to cultivate in the individual a profound sense of holiness. In his 1987 encyclical, Redemptoris Mater the Pope cited Saint Louis Marie Grignion de Montfort as a teacher of Marian spirituality.
TRUE DEVOTION TO MARY: WITH PREPARATION FOR TOTAL CONSECRATION SAINT LOUIS DE MONTFORT - The Original and Best 1863 Translation from the French by Reverend Frederick William Faber, D.D. - Two Books in One, True Devotion to Mary and 33-Day Preparation for Total Consecration - Includes Prefaces, an Introduction, information on True Devotion and Saint Louis De Montfort - A Classic Masterpiece of Marian Theology - Over 68,000 words including illustrations by Bartolome Esteban Murillo Publisher: Two Paperbacks and a Hardback Edition are available: 5"x8" Paperback Book: ISBN-13: 978-1-78379-000-5 6"x9" Paperback Book: ISBN-13: 978-1-78379-011-1 6"x9" Hardback Book: ISBN-13: 978-1-78379-004-3 A Treatise on the True Devotion to the Blessed Virgin or True Devotion to Mary is considered the greatest book on the Blessed Virgin Mary ever written and has been recommended and practiced by eight Popes. This is the original 'scrupulously faithful' translation by Reverend Frederick William Faber, D.D.. The great Marian Pope, Blessed Pope John Paul II practiced this Devotion to Mary, in his Letter to the Montfort Fathers he says: "A work destined to become a classic of Marian spirituality was published 160 years ago. St. Louis Marie Grignion de Montfort wrote the Treatise on True Devotion to the Blessed Virgin at the beginning of the 1700s, but the manuscript remained practically unknown for more than a century. When, almost by chance, it was at last discovered in 1842 and published in 1843, the work was an instant success, proving extraordinarily effective in spreading the "true devotion" to the Most Holy Virgin." "My motto; 'Totus Tuus' is inspired by the teaching of St. Louis Marie Grignion de Montfort. These two words express total belonging to Jesus through Mary: 'Tuus totus ego sum, et omnia mea tua sunt, ' St Louis Marie wrote, and he translates his words: 'I am all yours, and all that I have is yours, O most loving Jesus, through Mary, your most holy Mother' (Treatise on True Devotion, n. 233). This Saint's teaching has had a profound influence on the Marian devotion of many of the faithful and on my own life. It is a lived teaching of outstanding ascetic and mystical depth, expressed in a lively and passionate style that makes frequent use of images and symbols." "All our perfection," St. Louis Marie Grignion de Montfort writes, "consists in being conformed, united and consecrated to Jesus Christ; and therefore, the most perfect of all devotions is, without any doubt, that which most perfectly conforms, unites and consecrates us to Jesus Christ. Now, Mary being the most conformed of all creatures to Jesus Christ, it follows that, of all devotions, that which most consecrates and conforms the soul to Our Lord is devotion to his holy Mother, and that the more a soul is consecrated to Mary, the more it is consecrated to Jesus." (Treatise on True Devotion, n. 120) "When we praise her, love her, honour her or give anything to her, it is God who is praised, God who is loved, God who is glorified, and it is to God that we give, through Mary and in Mary." (Treatise on True Devotion, n. 225) Saint Louis-Marie Grignon De Montfort was a Catholic Priest and Missionary in Brittany and Vendee, France. He was born in Montfort-sur-Meu in 1673 and died in 1716. He was canonized by Pius XII in 1947. His feast day is on April 28th. He is considered one of the early proponents of the field of Mariology as it is known today, and a candidate to become a Doctor of the Church. PUBLISHER: CATHOLIC WAY PUBLISHING
2017 Reprint of 1955 Edition. Full facsimile of the original edition, not reproduced with Optical Recognition software. Considered by many to be the greatest single book of Marian spirituality ever written, True Devotion to Mary is St Louis de Montfort's classic statement on the spiritual way to Jesus Christ though the Blessed Virgin Mary. Beloved by countless souls, this book sums up the entire Christian life, showing a way of holiness that is short, easy, secure, and perfect--a way of life chosen by Our Lord Himself. In this book, de Montfort explains the wonderful spiritual effects which true devotion to Mary brings about in a person's life. True Devotion to Mary attracted attention in the 20th century when in an address to the Montfort Fathers, Pope John Paul II said that reading this book had been a "decisive turning point" in his life. According to his Apostolic Letter Rosarium Virginis Mariae he borrowed his apostolic motto Totus Tuus from the book. In his 1987 encyclical, Redemptoris Mater the Pope cited Saint Louis Marie Grignion de Montfort as a teacher of Marian spirituality.
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