Redefining the Hypernym Mensch:in in German: Gender, Sexuality, and Personhood examines how the verbalization of ‘human’ in gender normative terms results in implicit exclusion. Situated in the tension between traditional rules and progressive language use, this book criticizes the heteronormativity of masculine hypernyms and argues for the adoption of gender-inclusive linguistic practices.
During the last few years several immunotherapies have been shown to induce clinical response and/or improve the clinical outcome in a significant number of cancer patients. However, the lack of a human-centered translational approach has led to the accumulation of a multitude of disjointed clinical and basic researches with a consequent disharmonic growth of the scientific knowledge. The huge number of non-evidence-based conjectural hypotheses has competitively interacted with the few evidence-based hypotheses generated by studies conducted in humans leading to the accumulation of several clinical breakdowns and few “mysterious” successes. In the last decade, the availability of high-throughput gene expression profiling has led to the development of novel discovery-driven approaches capable of investigating the tumor/host integration in its globality. Here, we describe in detail gene expression profiling studies that have led to the formulation of a new generation of evidence-based hypotheses explaining the structural basis of the immune-mediated tumor rejection following immunotherapy.
Immunology has developed quite impressively over the past decade and perhaps very few fields in medicine or biology have grown so explosively. Completely new fields have been elucidated in depth. We recall only the definition of the nature and function of RLA antigens at the molecular level. the chemical and functional identification of several cytokines. and the correlation to particular immunological functions of specific epitopes present on cellular mem branes. The extensive application of immunological techniques and concepts to the neurological sciences has led to the development of neuroimmunology. a disci pline in its infancy until few years ago. In these last years. neuroimmunology has developed researches in various fields. RLA antigens were studied at the cellular level in brain samples and in CSF cells in several diseases. Cytokines. such as interleukin 1 and 2. gamma- and alpha-interferons. and tumor necrosis factor alpha. were studied at the immunohistological level and with quantitative methods in serum and CSF. With these data. new relevant insights were obtained on the molecular mechanisms underlying CNS immunological diseases. Moreover. neuroimmunological researches were carried on through the development of new and more 'specific' technologies for the study of natural and experimental diseases. the most important of which seem to be. at present. the techniques of cell cultures for cell lines specific to the CNS (oligodendrocytes. astroglia. microglia. meningeal cells. brain capillary cells and tumor cells).
Copper has long been known as essential to living systems, in part through its fundamental role in electron transport and respiration. Over the years into the present, its involvement in an ever increasing number of processes in all kinds of organisms has become apparent, and new and exciting vistas of its roles in such areas as the central nervous system, and in humoral functions, are appearing on the horizon. Although the biochemistry of this element has not been studied nearly as much as that of many others, a for midable amount of work has been carried out. It has thus been a challenge to produce a summary of what has been found that provides both breadth and depth. My goal has been to try to be as comprehensive as possible, within some limitations. I have tried to provide basic information and basic data that should continue to be useful for a long time. The goal has also been to interpret where we currently stand in our knowledge of the structure, function, regulation, and metabolism of Cu-dependent processes and sub stances, especially proteins. Thus, I have tried to make this a source book for historic as well as current information on all aspects of copper bio chemistry, and a summary of our current knowledge of copper-dependent proteins and processes. Most of the research on copper has been carried out on vertebrates, especially mammals. This has played a role in the organization of the book.
Redefining the Hypernym Mensch:in in German: Gender, Sexuality, and Personhood examines how the verbalization of ‘human’ in gender normative terms results in implicit exclusion. Situated in the tension between traditional rules and progressive language use, this book criticizes the heteronormativity of masculine hypernyms and argues for the adoption of gender-inclusive linguistic practices.
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.