Despite recent advances, therapeutic efforts have not been successful establishing a definitive strategy of treatment for brain gliomas, because of the presence of the blood-brain barrier. Innovative Brain Tumor Therapy presents a synopsis of the studies on nanoparticles as ideal devices for brain tumor treatment. Their nanometric size, electrostatic charge, and lipophilic characteristics allow them to penetrate into the brain tissue freely. Promising in-vitro results have been reported, but remain to be validated in humans. This title focuses on the blood-brain barrier pathophysiology in brain tumors, and the possibilities of overcoming this with nanoparticle-based systems. Relevant patents of nanoparticles used as drug delivery carriers are also reported, as well as future scenarios in nanoparticles and stem cells.
A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years. In particular recent new avenues regarding the role of stem cells and microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to chemotherapeutic agents and radiation therapy has been developed. It is hopeful that this new information will lead to efficacious treatment strategies for these tumors which remain a challenge. In this book a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided.
A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years, and this has lead to the development of novel therapeutic strategies for these patients. In this book a review of the options available for the clinical management of patients with these tumors are outlined. In addition advances in radiology both for pre-operative diagnostic purposes along with surgical planning are described. Furthermore a review of newer developments in chemotherapy along with the evolving field of photodynamic therapy both for intra-operative management and subsequent therapy is provided. A discussion of certain surgical management issues along with tumor induced epilepsy is included. Finally a discussion of the management of certain unique problems including brain metastases, brainstem glioma, central nervous system lymphoma along with issues involving patients with a brain tumor and pregnancy is provided.
A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years. In particular recent new avenues regarding the role of stem cells and microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to chemotherapeutic agents and radiation therapy has been developed. It is hopeful that this new information will lead to efficacious treatment strategies for these tumors which remain a challenge. In this book a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided.
Despite recent advances, therapeutic efforts have not been successful establishing a definitive strategy of treatment for brain gliomas, because of the presence of the blood-brain barrier. Innovative Brain Tumor Therapy presents a synopsis of the studies on nanoparticles as ideal devices for brain tumor treatment. Their nanometric size, electrostatic charge, and lipophilic characteristics allow them to penetrate into the brain tissue freely. Promising in-vitro results have been reported, but remain to be validated in humans. This title focuses on the blood-brain barrier pathophysiology in brain tumors, and the possibilities of overcoming this with nanoparticle-based systems. Relevant patents of nanoparticles used as drug delivery carriers are also reported, as well as future scenarios in nanoparticles and stem cells.
When she was 13, Virginia Galilei, eldest daughter of the great scientist Galileo, was placed by her father in a convent near him in Florence and took the name Suor Maria Celeste. Unable to see him except on his occasional visits, she wrote him continually, as her 124 surviving letters (which Galileo kept) attest. Now, for the first time, all of these letters are reproduced in English, translated by Dava Sobel, and in their original Italian, and Ms. Sobel has also written an introduction and annotations placing the letters in historical context. The 124 letters span only a decade of Maria Celeste's 33 years. In that dramatic period, a pope came to power who battled the Protestant Reformation; the Thirty Years' War embroiled all of Europe; the bubonic plague erupted across Italy; and a new philosophy of science, promulgated most forcefully by Galileo himself, threatened to overturn the order of the universe. Maria Celeste's evocative, beautifully written letters touch on all of these situations, but they dwell in the small details of everyday life; and though Galileo's letters to her have not survived, it is clear from hers that he answered every one. Especially for those who have read Ms. Sobel's Galileo's Daughter, but even for those who haven't, Maria Celeste's letters provide an indelible chronicle of convent life in the early 17th century, a memorable portrait of deep affection between a famous father and his daughter, and fascinating insight into Galileo himself.
Foundations of Statistics for Data Scientists: With R and Python is designed as a textbook for a one- or two-term introduction to mathematical statistics for students training to become data scientists. It is an in-depth presentation of the topics in statistical science with which any data scientist should be familiar, including probability distributions, descriptive and inferential statistical methods, and linear modeling. The book assumes knowledge of basic calculus, so the presentation can focus on "why it works" as well as "how to do it." Compared to traditional "mathematical statistics" textbooks, however, the book has less emphasis on probability theory and more emphasis on using software to implement statistical methods and to conduct simulations to illustrate key concepts. All statistical analyses in the book use R software, with an appendix showing the same analyses with Python. The book also introduces modern topics that do not normally appear in mathematical statistics texts but are highly relevant for data scientists, such as Bayesian inference, generalized linear models for non-normal responses (e.g., logistic regression and Poisson loglinear models), and regularized model fitting. The nearly 500 exercises are grouped into "Data Analysis and Applications" and "Methods and Concepts." Appendices introduce R and Python and contain solutions for odd-numbered exercises. The book's website has expanded R, Python, and Matlab appendices and all data sets from the examples and exercises.
This volume investigates the mechanisms (artworks, treatises, and other forms of cultural patronage) that the Marquises of Villena and their opponents used to operate in the cultural battlefield of the time with the aim of understanding how their conflicting historical memories were constructed and manipulated. Concentrating on the late fifteenth and early sixteenth centuries, the book examines these two aristocrats and demonstrates that political tensions led not only to military conflicts during this period but also to conflicts fought on cultural grounds, through the promotion of artistic, religious, and literary programmes. Maria Teresa Chicote Pompanin investigates why the Marquises of Villena lost in both the military and cultural battlefields and explains how the negative historical memories forged by their opponents in the late fifteenth century managed to become the official historical truth that has remained unchallenged to this day. The book will be of interest to scholars working in art history, cultural history, medieval studies, Renaissance studies, Iberian studies, literary studies, and patronage studies.
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