Marek Kimmel's Books

Bioinformatics

By: Andrzej Polanski,Marek Kimmel

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This textbook presents mathematical models in bioinformatics and describes biological problems that inspire the computer science tools used to manage the enormous data sets involved. The first part of the book covers mathematical and computational methods, with practical applications presented in the second part. The mathematical presentation avoids unnecessary formalism, while remaining clear and precise. The book closes with a thorough bibliography, reaching from classic research results to very recent findings. This volume is suited for a senior undergraduate or graduate course on bioinformatics, with a strong focus on mathematical and computer science background.

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Page Count

386

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3540690220

ISBN 13

9783540690221

Branching Processes in Biology

By: Marek Kimmel,David E. Axelrod

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Branching Processes in Biology

By: Marek Kimmel,David E. Axelrod

This book provides a theoretical background of branching processes and discusses their biological applications. Branching processes are a well-developed and powerful set of tools in the field of applied probability. The range of applications considered includes molecular biology, cellular biology, human evolution and medicine. The branching processes discussed include Galton-Watson, Markov, Bellman-Harris, Multitype, and General Processes. As an aid to understanding specific examples, two introductory chapters, and two glossaries are included that provide background material in mathematics and in biology. The book will be of interest to scientists who work in quantitative modeling of biological systems, particularly probabilists, mathematical biologists, biostatisticians, cell biologists, molecular biologists, and bioinformaticians. The authors are a mathematician and cell biologist who have collaborated for more than a decade in the field of branching processes in biology for this new edition. This second expanded edition adds new material published during the last decade, with nearly 200 new references. More material has been added on infinitely-dimensional multitype processes, including the infinitely-dimensional linear-fractional case. Hypergeometric function treatment of the special case of the Griffiths-Pakes infinite allele branching process has also been added. There are additional applications of recent molecular processes and connections with systems biology are explored, and a new chapter on genealogies of branching processes and their applications. Reviews of First Edition: "This is a significant book on applications of branching processes in biology, and it is highly recommended for those readers who are interested in the application and development of stochastic models, particularly those with interests in cellular and molecular biology." (Siam Review, Vol. 45 (2), 2003) “This book will be very interesting and useful for mathematicians, statisticians and biologists as well, and especially for researchers developing mathematical methods in biology, medicine and other natural sciences.” (Short Book Reviews of the ISI, Vol. 23 (2), 2003)

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Page Count

293

Publisher

Springer

Published Date

ISBN 10

1493915592

ISBN 13

9781493915590

System Engineering Approach to Planning Anticancer Therapies

By: Andrzej Świerniak,Marek Kimmel,Jaroslaw Smieja,Krzysztof Puszynski,Krzysztof Psiuk-Maksymowicz

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System Engineering Approach to Planning Anticancer Therapies

By: Andrzej Świerniak,Marek Kimmel,Jaroslaw Smieja,Krzysztof Puszynski,Krzysztof Psiuk-Maksymowicz

This book focuses on the analysis of cancer dynamics and the mathematically based synthesis of anticancer therapy. It summarizes the current state-of-the-art in this field and clarifies common misconceptions about mathematical modeling in cancer. Additionally, it encourages closer cooperation between engineers, physicians and mathematicians by showing the clear benefits of this without stating unrealistic goals. Development of therapy protocols is realized from an engineering point of view, such as the search for a solution to a specific control-optimization problem. Since in the case of cancer patients, consecutive measurements providing information about the current state of the disease are not available, the control laws are derived for an open loop structure. Different forms of therapy are incorporated into the models, from chemotherapy and antiangiogenic therapy to immunotherapy and gene therapy, but the class of models introduced is broad enough to incorporate other forms of therapy as well. The book begins with an analysis of cell cycle control, moving on to control effects on cell population and structured models and finally the signaling pathways involved in carcinogenesis and their influence on therapy outcome. It also discusses the incorporation of intracellular processes using signaling pathway models, since the successful treatment of cancer based on analysis of intracellular processes, might soon be a reality. It brings together various aspects of modeling anticancer therapies, which until now have been distributed over a wide range of literature. Written for researchers and graduate students interested in the use of mathematical and engineering tools in biomedicine with special emphasis on applications in cancer diagnosis and treatment, this self-contained book can be easily understood with only a minimal basic knowledge of control and system engineering methods as well as the biology of cancer. Its interdisciplinary character and the authors’ extensive experience in cooperating with clinicians and biologists make it interesting reading for researchers from control and system engineering looking for applications of their knowledge. Systems and molecular biologists as well as clinicians will also find new inspiration for their research.

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Page Count

241

Publisher

Springer

Published Date

ISBN 10

3319280953

ISBN 13

9783319280950

Forward-Time Population Genetics Simulations

Methods, Implementation, and Applications

By: Bo Peng,Marek Kimmel,Christopher I. Amos

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Forward-Time Population Genetics Simulations

Methods, Implementation, and Applications

By: Bo Peng,Marek Kimmel,Christopher I. Amos

The only book available in the area of forward-time population genetics simulations—applicable to both biomedical and evolutionary studies The rapid increase of the power of personal computers has led to the use of serious forward-time simulation programs in genetic studies. Forward-Time Population Genetics Simulations presents both new and commonly used methods, and introduces simuPOP, a powerful and flexible new program that can be used to simulate arbitrary evolutionary processes with unique features like customized chromosome types, arbitrary nonrandom mating schemes, virtual subpopulations, information fields, and Python operators. The book begins with an overview of important concepts and models, then goes on to show how simuPOP can simulate a number of standard population genetics models—with the goal of demonstrating the impact of genetic factors such as mutation, selection, and recombination on standard Wright-Fisher models. The rest of the book is devoted to applications of forward-time simulations in various research topics. Forward-Time Population Genetics Simulations includes: An overview of currently available forward-time simulation methods, their advantages, and shortcomings An overview and evaluation of currently available software A simuPOP tutorial Applications in population genetics Applications in genetic epidemiology, statistical genetics, and mapping complex human diseases The only book of its kind in the field today, Forward-Time Population Genetics Simulations will appeal to researchers and students of population and statistical genetics.

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Page Count

258

Publisher

John Wiley & Sons

Published Date

ISBN 10

0470503483

ISBN 13

9780470503485

Masculinities and Desire

A Deleuzian Encounter

By: Marek Wojtaszek

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Masculinities and Desire

A Deleuzian Encounter

By: Marek Wojtaszek

Masculinities and Desire considers the question of male subjectivity in relation to Deleuze and Guattari’s theory of desire. Western tradition has thought of desire from the vantage point of masculine subjectivity; what happens when the order is reversed, and desire speaks through masculinity? Can masculinity be conceived beyond the gender binary and thus affirm its potential to transcend the patriarchal order? In answer, Masculinities and Desire calls for a radically new approach to traditional cultural criticism. Contributing a critical male perspective, the book sheds new light on the conceptual and ethical limits of established, representational (gender) criticism. Reflecting on masculinity with Deleuze, the book explores what happens to the masculine subject in his becoming-minoritarian and thus emerging as a work of desire. Wojtaszek examines the confining representations of masculinity in realms long associated with men, such as violence, virulent psychosis, metaphysical cannibalism and virtualization. Inspired by Deleuze’s appeal for immanence, Wojtaszek argues that films including American Psycho, Fight Club, Becoming John Malkovich and The Matrix are adventures of deterritorialization that imaginatively tackle various masculinities, affirming their creative resistance and reinvention of subjectivity. Desire is revealed to be a powerful catalyst for escaping the regime of patriarchal representation.

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Page Count

317

Publisher

Routledge

Published Date

ISBN 10

0429793693

ISBN 13

9780429793691

An Operator Semigroup in Mathematical Genetics

By: Adam Bobrowski,Marek Kimmel

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An Operator Semigroup in Mathematical Genetics

By: Adam Bobrowski,Marek Kimmel

This authored monograph presents a mathematical description of the time evolution of neutral genomic regions in terms of the differential Lyapunov equation. The qualitative behavior of its solutions, with respect to different mutation models and demographic patterns, can be characterized using operator semi group theory. Mutation and drift are two of the main genetic forces, which act on genes of individuals in populations. Their effects are influenced by population dynamics. This book covers the application to two mutation models: single step mutation for microsatellite loci and single-base substitutions. The effects of demographic change to the asymptotic of the distribution are also covered. The target audience primarily covers researchers and experts in the field but the book may also be beneficial for graduate students.

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