Gait and mobility are cardinal to maintain autonomy and independency in daily life, also for older persons. Changes in these functions might be critical in the transition towards disability and loss of autonomy during the aging process. The aim of the present work, which collects three years of research conducted between Italy and the United States, was to assess some of the main risk factors for the progressive impairment of mobility and gait in older adults living in the community. According to our results, abnormalities in the nervous and cardiovascular systems, even subtle, are associated with a subsequent worsening of these functions. These data might help to better understand the progressive development of disability in the elderly, and in the future might also have practical implications for prevention.
A Times Literary Supplement Book of the Year A Marginal Revolution Best Non-Fiction Book of the Year A Seminary Co-op Notable Book of the Year A Times Higher Education Book of the Week A Choice Outstanding Academic Title of the Year Marco Santagata’s Dante: The Story of His Life illuminates one of the world’s supreme poets from many angles—writer, philosopher, father, courtier, political partisan. Santagata brings together a vast body of Italian scholarship on Dante’s medieval world, untangles a complex web of family and political relationships for English readers, and shows how the composition of the Commedia was influenced by local and regional politics. “Reading Marco Santagata’s fascinating new biography, the reader is soon forced to acknowledge that one of the cornerstones of Western literature [The Divine Comedy], a poem considered sublime and universal, is the product of vicious factionalism and packed with local scandal.” —Tim Parks, London Review of Books “This is a wonderful book. Even if you have not read Dante you will be gripped by its account of one of the most extraordinary figures in the history of literature, and one of the most dramatic periods of European history. If you are a Dantean, it will be your invaluable companion forever.” —A. N. Wilson, The Spectator
Evolutionary computing, inspired by the biological world, is one of the emergent technologies of our time. Being essentially a software activity, it has been successfully applied, e.g. for optimization and machine learning in various areas. The tremendous increase in computational power and, more recently, the appearance of a new generation of programmable logic devices allow for a new approach to designing computing machines inspired by biological models: it is now possible to make the hardware itself evolve. This book is based on a workshop on evolvable hardware, held in Lausanne, Switzerland, in October 1995. It reports the state of the art of research in this field and presents two introductory chapters, written with the novice reader in mind.
Bioinformatics, that is the interdisciplinary field that blends computer science and biostatistics with biological and biomedical sciences, is expected to gain a central role in next feature. Indeed, it has now affected several fields of biology, providing crucial hints for the understanding of biological systems and also allowing a more accurate design of wet lab experiments. In this work, the analysis of sequence data has be used in different fields, such as evolution (e.g. the assembly and evolution of metabolism), infections control (e.g. the horizontal flow of antibiotic resistance), ecology (bacterial bioremediation).
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