Sequence analysis (SA) was developed to study social processes that unfold over time as sequences of events. It has gained increasing attention as the availability of longitudinal data made it possible to address sequence-oriented questions. This volume introduces the basics of SA to guide practitioners and support instructors through the basic workflow of sequence analysis. In addition to the basics, this book outlines recent advances and innovations in SA. The presentation of statistical, substantive, and theoretical foundations is enriched by examples to help the reader understand the repercussions of specific analytical choices. The extensive ancillary material supports self-learning based on real-world survey data and research questions from the field of life course research. Data and code and a variety of additional resources to enrich the use of this book are available on an accompanying website.
The author of this e-book is an engineer and physicist who specialized in space technologies. After a few years at the European Space Agency, he occupied for some 30 years the position of director of studies in a Paris-based industrial think tank. He is the father of ten children. After his retirement, he endeavored to obtain a degree in theology in an academic institution frequented by numerous seminarians and members of religious orders. He was appalled by what he discovered there. It has been said that in the Bible everything can be put in doubt with the exception of the footnotes. This is exactly what he found out. Where he had expected to receive an in-depth intellectual introduction to theological matters, he found himself subjected to a sort of brain washing aiming at replacing all what he had learned in his childhood and in a lifetime as a practicing catholic by the most futile modern fantasies and in particular by the imaginations of the theory of evolution. Evolution is for our time what Arianism was in the first centuries: the major heresy. It is even more than an heresy, an anti-theology which attributes to materialistic processes what used to be and should always be attributed to God's power and love. Nevertheless a large crowd of theologians, exegetes, professors and bishops adhere to this theory with an enthusiasm that they justify by claiming that science has proven its adequation to reality without any doubt. Evolution is more than a theory, they claim, this is the consensus of the scientists and it would be a sin against truth not to admit it. Refusing to accept that, the author decided to inquire about the scientific foundations of evolution. He quickly discovered that not only were such foundations most unconvincing, but that several of the most vocal defenders of the theory candidly admitted the patent absurdity of some of its constructs (Richard Lewontin) and that their aim was purely ideological or rather anti-religious. The results of his work were published in two books : “La terrible Responsabilité de l'exégèse moderne dans la crise de l'Église” (Edilivre, Paris, 2015) and “Modern Exegesis, the Theory of Evolution and the Decline of Catholicism in the West” (2016, Available on Amazon). The present e-book summarizes the scientific arguments opposing evolution with a special focus on the time line of the beginnings of mankind.
Europe is in a period of transition and there is great uncertainty about its direction. No country plays a greater role in influencing Europe's future path than Germany, which is either seen as overbearing or indecisive in its imposition of policies-and sometimes is seen as both at once. In The Germany Illusion, Marcel Fratzscher provides a distinctive corrective to common misunderstandings of Germany's domestic political economy and how it affects its European and global roles. Fratzscher's trenchant analysis sheds light on the true state of Germany's economy, which is neither as rosy as optimists believe nor as hidebound as pessimists fear. He covers the breadth of the German economy, from its deceptive employment miracle, the sources and underlying problems of its export strengths, its large investment gap, and not least the differences between east and west that continue since reunification. Understanding the domestic scene in Germany is crucial to understanding its relationships with other European countries, the European Union, and the United States. Fratzscher traces the sources and implications of the differences and conflict between Germany and its neighbors on European policymaking generally and in particular during the European economic and financial crisis, the Brexit debate, the refugee crisis, the rising populism and protectionism in the United States and in Europe, and over fundamental reforms of European institutions. The Germany Illusion is a balanced and nuanced examination of pressing and complex issues that enhances our understanding of German policies-the strengths and weaknesses, the possibilities and the limits. It also proposes a realistic path for Germany to re-engage with its European neighbors and with the United States, and to help re-build Europe's future.
It has long been recognized that metal spin states play a central role in the reactivity of important biomolecules, in industrial catalysis and in spin crossover compounds. As the fields of inorganic chemistry and catalysis move towards the use of cheap, non-toxic first row transition metals, it is essential to understand the important role of spin states in influencing molecular structure, bonding and reactivity. Spin States in Biochemistry and Inorganic Chemistry provides a complete picture on the importance of spin states for reactivity in biochemistry and inorganic chemistry, presenting both theoretical and experimental perspectives. The successes and pitfalls of theoretical methods such as DFT, ligand-field theory and coupled cluster theory are discussed, and these methods are applied in studies throughout the book. Important spectroscopic techniques to determine spin states in transition metal complexes and proteins are explained, and the use of NMR for the analysis of spin densities is described. Topics covered include: DFT and ab initio wavefunction approaches to spin states Experimental techniques for determining spin states Molecular discovery in spin crossover Multiple spin state scenarios in organometallic reactivity and gas phase reactions Transition-metal complexes involving redox non-innocent ligands Polynuclear iron sulfur clusters Molecular magnetism NMR analysis of spin densities This book is a valuable reference for researchers working in bioinorganic and inorganic chemistry, computational chemistry, organometallic chemistry, catalysis, spin-crossover materials, materials science, biophysics and pharmaceutical chemistry.
Introduction to building façades as revised edition Façades determine the appearance of a building. Hence, they constitute a major element in architecture. At the same time, the building’s envelope has important functions to fulfil, such as lighting, weatherproofing, thermal insulation, load transfer and sound insulation. Over the past 15 years, façades have become increasingly complex – ‘intelligent’ facades, for instance, adapt to changing climate and lighting conditions. Newly developed materials and technologies have broadened the scope of façade functions. This book demonstrates the principles of façade construction. It systematically describes the most common types, such as post-and-beam façade, curtain wall, corridor façade or double façade, and provides guidelines for appropriate detailing. Numerous drawings made especially for the book explain the principles of different types of facades, which are then illustrated with built examples. For this second edition, all chapters were revised and all four examples in the case studies chapter were replaced by new material. The new chapter “Future Façades” offers insights into what’s next.
In a chemical system with many chemical species several questions can be asked: what species react with other species: in what temporal order: and with what results? These questions have been asked for over one hundred years about simple and complex chemical systems, and the answers constitute the macroscopic reaction mechanism. In Determination of Complex Reaction Mechanisms authors John Ross, Igor Schreiber, and Marcel Vlad present several systematic approaches for obtaining information on the causal connectivity of chemical species, on correlations of chemical species, on the reaction pathway, and on the reaction mechanism.Basic pulse theory is demonstrated and tested in an experiment on glycolysis. In a second approach, measurements on time series of concentrations are used to construct correlation functions and a theory is developed which shows that from these functions information may be inferred on the reaction pathway, the reaction mechanism, and the centers of control in that mechanism. A third approach is based on application of genetic algorithm methods to the study of the evolutionary development of a reaction mechanism, to the attainment given goals in a mechanism, and to the determination of a reaction mechanism and rate coefficients by comparison with experiment. Responses of non-linear systems to pulses or other perturbations are analyzed, and mechanisms of oscillatory reactions are presented in detail. The concluding chapters give an introduction to bioinformatics and statistical methods for determining reaction mechanisms.
Origins of Biodiversity is a unique introduction to the fields of macroevolution and macroecology, which explores the evolution and distribution of biodiversity across time, space and lineages. Using an enquiry-led framework to encourage active learning and critical thinking, each chapter is based around a case-study to explore concepts and research methods from contemporary macroevolution and macroecology. The book focuses on the process of science as much as the biology itself, to help students acquire the research skills and intellectual tools they need to understand and investigate the biological world around them. In particular, the emphasis on hypothesis testing encourages students to develop and test their own ideas. This text builds upon the foundations offered in most general introductory evolutionary biology courses to introduce an exciting range of ideas and research tools for investigating patterns of biodiversity.
This handbook is derived from the online reference "Corrosion Handbook", bringing together the relevant information about corrosion protection and prevention for steels, one of the most widely used materials. It provides comprehensive information, including tabulated data and references, on the corrosion properties of the following materials: Unalloyed steels and cast steel, unalloyed cast iron, high-alloy cast iron, high-silicon cast iron, structural steels with up to 12% chromium, ferritic chromium steels with more than 12% chromium, ferritic-austenitic steels with more than 12% chromium, high-alloy multiphase steels, ferritic/perlitic-martensitic steels, ferritic-austenitic steels/duplex steels, austenitic chromium-nickel steels, austenitic chromium-nickel-molybdenum steels, austenitic chromium-nickel steels with special alloying additions, special iron-based alloys, and zinc. The following corrosive media are considered: Seawater, brackish water, industrial waste water, municipal waste water, drinking water, high-purity water.
Sequence analysis (SA) was developed to study social processes that unfold over time as sequences of events. It has gained increasing attention as the availability of longitudinal data made it possible to address sequence-oriented questions. This volume introduces the basics of SA to guide practitioners and support instructors through the basic workflow of sequence analysis. In addition to the basics, this book outlines recent advances and innovations in SA. The presentation of statistical, substantive, and theoretical foundations is enriched by examples to help the reader understand the repercussions of specific analytical choices. The extensive ancillary material supports self-learning based on real-world survey data and research questions from the field of life course research. Data and code and a variety of additional resources to enrich the use of this book are available on an accompanying website.
Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The world's most highly regarded reference text on the mechanisms and clinical management of blood diseases A Doody's Core Title for 2020! Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. It is acknowledged worldwide as the leading hematology resource, with editors who are internationally regarded for their research and clinical achievements and authors who are luminaries in their fields. The Ninth Edition of Williams Hematology is extensively revised to reflect the latest advancements in basic science, translational pathophysiology, and clinical practice. In addition to completely new chapters, it features a full-color presentation that includes 700 photographs, 300 of which are new to this edition, and 475 illustrations. Recognizing that blood and marrow cell morphology is at the heart of diagnostic hematology, informative color images of the relevant disease topics are conveniently integrated into each chapter, allowing easy access to illustrations of cell morphology important to diagnosis. Comprehensive in its depth and breath, this go-to textbook begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine.
The landmark text that has guided generations of hematologists and related practitioners―updated with the latest research findings and improved format and presentation Long revered for its comprehensiveness and extraordinary depth of detail, Williams Hematology provides essential coverage of the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood and marrow cells and coagulation proteins. The text contains a wealth of basic science and translational pathophysiology for optimal, lifelong learning. Experts in research and clinical hematology, the editors are known worldwide for their contributions to the field. This new edition contains everything that has made Williams Hematology the go-to resource for decades and has been updated with new chapters and critical new research into the molecular mechanisms responsible for hematological disorders and the impact on diagnosis and treatment. And the new format enables you to access each chapter via content modules covering key topics, with summaries, infographics, and cases―all linked to review questions for self-assessment. The full-color presentation integrates images of blood and tissue findings where they are cited in the text. NEW TO THIS EDITION: Updated and revised content reflecting the latest research and developments Convenient format that streamlines the learning process and improves retention Additional chapters added on: Immune Checkpoint Inhibitors Immune Cell Therapy: Chimeric Antigen Receptor T Cell Therapy Immune Cell Therapy Dendritic Cell and Natural Killer Cell Therapy The processes of cell death and survival Application of Big Data and Deep Learning in Hematology Williams Hematology Cases with multiple-choice questions including detailed explanations—perfect preparation for the boards Continuously updated online content with comprehensive drug therapy database and other resources
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.