Marginal Models for Dependent, Clustered, and Longitudinal Categorical Data provides a comprehensive overview of the basic principles of marginal modeling and offers a wide range of possible applications. Marginal models are often the best choice for answering important research questions when dependent observations are involved, as the many real world examples in this book show. In the social, behavioral, educational, economic, and biomedical sciences, data are often collected in ways that introduce dependencies in the observations to be compared. For example, the same respondents are interviewed at several occasions, several members of networks or groups are interviewed within the same survey, or, within families, both children and parents are investigated. Statistical methods that take the dependencies in the data into account must then be used, e.g., when observations at time one and time two are compared in longitudinal studies. At present, researchers almost automatically turn to multi-level models or to GEE estimation to deal with these dependencies. Despite the enormous potential and applicability of these recent developments, they require restrictive assumptions on the nature of the dependencies in the data. The marginal models of this book provide another way of dealing with these dependencies, without the need for such assumptions, and can be used to answer research questions directly at the intended marginal level. The maximum likelihood method, with its attractive statistical properties, is used for fitting the models. This book has mainly been written with applied researchers in mind. It includes many real world examples, explains the types of research questions for which marginal modeling is useful, and provides a detailed description of how to apply marginal models for a great diversity of research questions. All these examples are presented on the book's website (www.cmm.st), along with user friendly programs.
This book introduces readers to the living topics of Riemannian Geometry and details the main results known to date. The results are stated without detailed proofs but the main ideas involved are described, affording the reader a sweeping panoramic view of almost the entirety of the field. From the reviews "The book has intrinsic value for a student as well as for an experienced geometer. Additionally, it is really a compendium in Riemannian Geometry." --MATHEMATICAL REVIEWS
The unique and truly French super hero is back, like a phoenix from the ashes, to save France once again and to restore it to greatness in a world going to the dogs. Superdupont's reboot gets a kick-start with the birth of his son who, astonishingly, has inherited the supernatural powers of his father. Perhaps together they can finally bring down the enemies of their wonderful homeland!
One of the most famous anagrams of all time was constructed in the Middle Ages. The unknown author contrived it as a Latin dialogue between Pilate and Jesus. Jesus' answer to Pilate's question "What is truth" is phrased as an ingenious anagram of the letters of that very question: Pilate: Quid est veritas? ("What is truth?") Jesus: Est virqui adest. ("It is the man before you.") The origin of anagrams is shrouded in mystery. One thing is clear, however -- in the ancient world, they were thought to contain hidden messages from the gods. Legend has it that even Alexander the Great (356--323 b.c.) believed in their prophetic power. -- from Chapter Two The most obvious explanation for the popularity of puzzles is that they provide a form of constructive entertainment. But in The Puzzle Instinct Marcel Danesi contends that the fascination with puzzles throughout the ages suggests something much more profound. Puzzles serve a deeply embedded need in people to make sense of things. Emerging at the same time in human history as myth, magic, and the occult arts, the puzzle instinct, he claims, led to discoveries in mathematics and science, as well as revolutions in philosophical thought. Puzzles fill an existential void by providing "small-scale experiences of the large-scale questions that Life poses. The puzzle instinct is, arguably, as intrinsic to human nature as is humor, language, art, music, and all the other creative faculties that distinguish humanity from all other species.
Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The world's most highly regarded reference text on the mechanisms and clinical management of blood diseases A Doody's Core Title for 2020! Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. It is acknowledged worldwide as the leading hematology resource, with editors who are internationally regarded for their research and clinical achievements and authors who are luminaries in their fields. The Ninth Edition of Williams Hematology is extensively revised to reflect the latest advancements in basic science, translational pathophysiology, and clinical practice. In addition to completely new chapters, it features a full-color presentation that includes 700 photographs, 300 of which are new to this edition, and 475 illustrations. Recognizing that blood and marrow cell morphology is at the heart of diagnostic hematology, informative color images of the relevant disease topics are conveniently integrated into each chapter, allowing easy access to illustrations of cell morphology important to diagnosis. Comprehensive in its depth and breath, this go-to textbook begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine.
Financial institutions are often the crucial factor in a society's progress toward sustainable development. Yet financial workers and public policy researchers are largely unaware of this role. Sustainability in Finance seeks to bridge this gap as it posits a theoretical foundation for a finance-policy partnership. The volume presents an innovative analysis of current practices at both global financial institutions and banks in developing countries and ultimately offers a valuable consideration of the future of sustainable development.
Das führende Lehrbuch der Nanotechnologie und ein Kompendium von Lehrveranstaltungen der Penn State University: didaktisch fundiert mit Lernzielen am Beginn der Kapitel, Kapitelzusammenfassungen und Literaturhinweisen.
The landmark text that has guided generations of hematologists and related practitioners―updated with the latest research findings and improved format and presentation Long revered for its comprehensiveness and extraordinary depth of detail, Williams Hematology provides essential coverage of the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood and marrow cells and coagulation proteins. The text contains a wealth of basic science and translational pathophysiology for optimal, lifelong learning. Experts in research and clinical hematology, the editors are known worldwide for their contributions to the field. This new edition contains everything that has made Williams Hematology the go-to resource for decades and has been updated with new chapters and critical new research into the molecular mechanisms responsible for hematological disorders and the impact on diagnosis and treatment. And the new format enables you to access each chapter via content modules covering key topics, with summaries, infographics, and cases―all linked to review questions for self-assessment. The full-color presentation integrates images of blood and tissue findings where they are cited in the text. NEW TO THIS EDITION: Updated and revised content reflecting the latest research and developments Convenient format that streamlines the learning process and improves retention Additional chapters added on: Immune Checkpoint Inhibitors Immune Cell Therapy: Chimeric Antigen Receptor T Cell Therapy Immune Cell Therapy Dendritic Cell and Natural Killer Cell Therapy The processes of cell death and survival Application of Big Data and Deep Learning in Hematology Williams Hematology Cases with multiple-choice questions including detailed explanations—perfect preparation for the boards Continuously updated online content with comprehensive drug therapy database and other resources
Hemostasis and Thrombosis as only Williams can cover them A Doody’s Core Title for 2019! Featuring content derived from Williams Hematology, Ninth Edition. this concise, full-color resource delivers comprehensive and current coverage of hemostasis and thrombosis, and platelet and megakaryocyte disorders. More than a sectional reprint, the book includes updated science and treatment recommendations not found in the 2015 release of Williams Hematology, Ninth Edition. Perfect for use at the point of care, Williams Hemostasis and Thrombosis offers the most current evaluation and treatment options for patients with bleeding and thrombotic disorders. •Covers the latest advances in hemostasis and thrombosis •A handy quick summary appears at the beginning of each chapter •Discusses the physiologic basis for hemostasis and thrombosis
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