Completely revised and updated, and now in full color throughout, the Fourth Edition of this definitive reference is a must for all clinicians who treat breast diseases. Leading experts summarize the current knowledge of breast diseases, including their clinical features, management, underlying biologies, and epidemiologies. In addition to complete coverage of malignant breast diseases, benign diseases are discussed in relation to subsequent breast cancer development. The book reviews all major clinical trials and summarizes the information they provide on early detection and management of breast cancer. Close attention is also given to the increasing importance of molecular biology and genetics in this field. This edition features more than thirty new contributors, fourteen new or completely rewritten chapters, and more clinically oriented chapters. A companion Website will offer the fully searchable text and an image bank. Also included with this edition is the Anatomical Chart Company's Breast Anatomy and Disorders Pocket Guide. This durable, portable folding pocket guide provides a visual and textual overview of breast anatomy, disorders, and breast self-examination. With a write-on, wipe-off laminated surface, this guide is perfect for the on-the-go practitioner to show patients, caregivers, and families.
This is the leading international professional reference text that also serves as a bench book, describing all aspects of the pathology of brain tumours - genetics, molecular biology, epidemiology, morphology, immunohistochemistry, diagnostic criteria and prognosis. Beautifully illustrated in colour throughout and comprehensively referenc
Polarization is at an all-time high in the United States. But contrary to popular belief, Americans are polarized not so much in their policy preferences as in their feelings toward their political opponents: To an unprecedented degree, Republicans and Democrats simply do not like one another. No surprise that these deeply held negative feelings are central to the recent (also unprecedented) plunge in congressional productivity. The past three Congresses have gotten less done than any since scholars began measuring congressional productivity. In Why Washington Won’t Work, Marc J. Hetherington and Thomas J. Rudolph argue that a contemporary crisis of trust—people whose party is out of power have almost no trust in a government run by the other side—has deadlocked Congress. On most issues, party leaders can convince their own party to support their positions. In order to pass legislation, however, they must also create consensus by persuading some portion of the opposing party to trust in their vision for the future. Without trust, consensus fails to develop and compromise does not occur. Up until recently, such trust could still usually be found among the opposition, but not anymore. Political trust, the authors show, is far from a stable characteristic. It’s actually highly variable and contingent on a variety of factors, including whether one’s party is in control, which part of the government one is dealing with, and which policies or events are most salient at the moment. Political trust increases, for example, when the public is concerned with foreign policy—as in times of war—and it decreases in periods of weak economic performance. Hetherington and Rudolph do offer some suggestions about steps politicians and the public might take to increase political trust. Ultimately, however, they conclude that it is unlikely levels of political trust will significantly increase unless foreign concerns come to dominate and the economy is consistently strong.
This book includes descriptions of Web sites where readers can find the hottest online real-time games, in addition to how-to and strategy guides, non-real-time, proprietary, e-mail and listserv games.
The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 3 is devoted to the set of mediators of the cell surface, especially ion and molecular carriers and catalytic receptors that, once liganded and activated, initiate signal transduction pathways. Intracellular cascades of chemical reactions trigger the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Primary mediators are included in models of regulated cellular processes, but multiple secondary signaling components are discarded to allow simple, representative modeling and to manage their inverse problems.
Canada's Not-so-Clandestine War to Expropriate Indigenous Lands and Resources: An Anthropologist's Curious Journey Through the Mind-Fields of Indigenous Knowledge, Rights, and Culture
Canada's Not-so-Clandestine War to Expropriate Indigenous Lands and Resources: An Anthropologist's Curious Journey Through the Mind-Fields of Indigenous Knowledge, Rights, and Culture
Part exposé, part memoir, part reference manual for reconciling Indigenous and non-Indigenous rights in Canada, Do You Eat the Red Ones Last? takes the reader on one anthropologist’s journey through the turbulent waters of Canada’s contested lands and resources. Drawing on personal experiences and the wisdom of Indigenous elders and scholars, Marc G. Stevenson offers unique insights into how settler society has dismantled Indigenous knowledge and governance systems while expropriating their lands and resources. In particular, he explores the contentious spaces where the land-use rights and knowledge claims of the two cultures collide and examines why the promise of reconciliation remains so elusive. Lastly, he considers how we might transform our mindsets from that of colonial agents to that of post-colonial allies. In its forward-looking conclusion, Do You Eat the Red Ones Last? identifies some directions that might collectively take us on a more ethical and rewarding path to reparations and co-existence. As such, it joins a growing body of critical thought committed to generating real opportunity for reconciling Indigenous-settler rights in Canada.
First published in 1986 under the editorial direction of Dr. Henry J.M. Barnett, Stroke: Pathophysiology, Diagnosis, and Management continues to provide the dependable, current answers you need to effectively combat the increasing incidence of this disease. Dr. J.P. Mohr, together with new associate editors Philip A. Wolf, James C. Grotta, Michael A. Moskowitz, Marc Mayberg, and Rüdiger von Kummer as well as a multitude of expert contributors from around the world, offer you updated and expanded coverage of mechanisms of action of commonly used drugs, neuronal angiogenesis and stem cells, basic mechanisms of spasm and hemorrhage, prevention of stroke, genetics/predisposing risk factors, and much more, equipping you to understand the latest scientific discoveries and make effective use of the newest approaches to diagnosis and treatment. Gain fresh perspectives and up-to-date insights from the world’s leading authorities on the pathophysiology, diagnosis, and management of stroke. Access the comprehensive, expert clinical guidance you need to recognize the clinical manifestations of stroke, use the latest laboratory and imaging studies to arrive at a diagnosis, and generate an effective medical and surgical treatment plan. Make efficient and accurate diagnoses with the aid of abundant full-color CT images and pathology slides. Stay up to date on hot topics such as mechanisms of action of commonly used drugs, neuronal angiogenesis and stem cells, basic mechanisms of spasm and hemorrhage, prevention of stroke, genetics/predisposing risk factors, and much more.
Localization is involved everywhere in epidemiology: health phenomena often involve spatial relationships among individuals and risk factors related to geography and environment. Therefore, the use of localization in the analysis and comprehension of health phenomena is essential. This book describes the objectives, principles, methods and tools of spatial analysis and geographic information systems applied to the field of health, and more specifically to the study of the spatial distribution of disease and health–environment relationships. It is a practical introduction to spatial and spatio-temporal analysis for epidemiology and health geography, and takes an educational approach illustrated with real-world examples. Epidemiology and Geography presents a complete and straightforward overview of the use of spatial analysis in epidemiology for students, public health professionals, epidemiologists, health geographers and specialists in health–environment studies.
The U.S. Senate is so sharply polarized along partisan and ideological lines today that it’s easy to believe it was always this way. But in the turbulent 1960s, even as battles over civil rights and the war in Vietnam dominated American politics, bipartisanship often prevailed. One key reason: two remarkable leaders who remain giants of the Senate—Republican leader Everett Dirksen of Illinois and Democratic leader Mike Mansfield of Montana, the longest-serving majority leader in Senate history, so revered for his integrity, fairness, and modesty that the late Washington Post reporter David Broder called him “the greatest American I ever met.” The political and personal relationship of these party leaders, extraordinary by today’s standards, is the lens through which Marc C. Johnson examines the Senate in that tumultuous time. Working together, with the Democrat often ceding public leadership to his Republican counterpart, Mansfield and Dirksen passed landmark civil rights and voting rights legislation, created Medicare, and helped bring about a foundational nuclear arms limitation treaty. The two leaders could not have been more different in personality and style: Mansfield, a laconic, soft-spoken, almost shy college history professor, and Dirksen, an aspiring actor known for his flamboyance and sense of humor, dubbed the “Wizard of Ooze” by reporters. Drawing on extensive Senate archives, Johnson explores the congressional careers of these iconic leaders, their intimate relationships with Presidents John F. Kennedy and Lyndon B. Johnson, and their own close professional friendship based on respect, candor, and mutual affection. A study of politics but also an analysis of different approaches to leadership, this is a portrait of a U.S. Senate that no longer exists—one in which two leaders, while exercising partisan political responsibilities, could still come together to pass groundbreaking legislation—and a reminder of what is possible.
Compact but authoritative, this extensive source includes updated price listings, tips on buying and selling coins, a market review identifying current trends, hundreds of photographs, and more.
This all-inclusive reference lists more than 4,000 prices of coins from over 48 countries, from Argentina to Vietnam. Special sections on how to grade your coins to receive the best value, buying coins online and through mail order, and a complete list of numismatic organizations, associations, and publications from all over the world make this the only book collectors will ever need.
This comprehensive reference contains prices of more than 4,000 coins from almost 50 countries, with tips on buying and selling, a market review identifying current trends, 300 photos, and vital information on grading and evaluating a collection.
World money is an everyone's mind, especially collectors'! The OfficialR Blackbook Price Guide to World Coins provides everything you need to know to build an exciting and profitable collection of world coins. Plus, this essential source gives you important information on how to buy, sell, and grade world coins; how to collect mint errors or oddball world coins; auction sales and prices of world coins over the past year; and international numismatic organizations and publications. With every country's coins listed, this is the perfect book to help you evaluate your own collection or to find new treasures. Special Features: * An up-to-date market review that traces current trends in collecting and investing in world coins. * Exhaustive information on world coins minted by the U.S. Mint. * An exclusive section on technology trends impacting world coin collectors. * Hundreds of illustrations to help identify world coins quickly.
This essential source lists every coin from nearly 50 countries, each with its current price, and hundreds of photos for easy identification. This edition also includes: - Tips on buying, selling, and grading - How to collect mint errors and oddball world coins - An up-to-date market review - Trends in collecting and investing - Listing of world coin associations and organizations
Now in its third edition, Fundamentals of Microfabrication and Nanotechnology continues to provide the most complete MEMS coverage available. Thoroughly revised and updated the new edition of this perennial bestseller has been expanded to three volumes, reflecting the substantial growth of this field. It includes a wealth of theoretical and practical information on nanotechnology and NEMS and offers background and comprehensive information on materials, processes, and manufacturing options. The first volume offers a rigorous theoretical treatment of micro- and nanosciences, and includes sections on solid-state physics, quantum mechanics, crystallography, and fluidics. The second volume presents a very large set of manufacturing techniques for micro- and nanofabrication and covers different forms of lithography, material removal processes, and additive technologies. The third volume focuses on manufacturing techniques and applications of Bio-MEMS and Bio-NEMS. Illustrated in color throughout, this seminal work is a cogent instructional text, providing classroom and self-learners with worked-out examples and end-of-chapter problems. The author characterizes and defines major research areas and illustrates them with examples pulled from the most recent literature and from his own work.
While political history has plenty to say about the impact of Ronald Reagan’s election to the presidency in 1980, four Senate races that same year have garnered far less attention—despite their similarly profound political effect. Tuesday Night Massacre looks at those races. In examining the defeat in 1980 of Idaho’s Frank Church, South Dakota’s George McGovern, John Culver of Iowa, and Birch Bayh of Indiana, Marc C. Johnson tells the story of the beginnings of the divisive partisanship that has become a constant feature of American politics. The turnover of these seats not only allowed Republicans to gain control of the Senate for the first time since 1954 but also fundamentally altered the conduct of American politics. The incumbents were politicians of national reputation who often worked with members of the other party to accomplish significant legislative objectives—but they were, Johnson suggests, unprepared and ill-equipped to counter nakedly negative emotional appeals to the “politically passive voter.” Such was the campaign of the National Conservative Political Action Committee (NCPAC), the organization founded by several young conservative political activists who targeted these four senators for defeat. Johnson describes how such groups, amassing a great amount of money, could make outrageous and devastating claims about incumbents—“baby killers” who were “soft on communism,” for example—on behalf of a candidate who remained above the fray. Among the key players in this sordid drama are NCPAC chairman Terry Dolan; Washington lobbyist Charles Black, a top GOP advisor to several presidential campaigns and one-time business partner of Paul Manafort; and Roger Stone, self-described “dirty trickster” for Richard Nixon and confidant of Donald Trump. Connecting the dots between the Goldwater era of the 1960s and the ascent of Trump, Tuesday Night Massacre charts the radicalization of the Republican Party and the rise of the independent expenditure campaign, with its divisive, negative techniques, a change that has deeply—and perhaps permanently—warped the culture of bipartisanship that once prevailed in American politics.
Keeping the Republic is an eloquent defense of the American constitutional order and a response to its critics, including those who are estranged from the very idea of a fixed constitution in which “the living are governed by the dead.” Dennis Hale and Marc Landy take seriously the criticisms of the United States Constitution. Before mounting their argument, they present an intellectual history of the key critics, including Thomas Paine, William Lloyd Garrison, Henry David Thoreau, Woodrow Wilson, Robert Dahl, Sanford Levinson, and the authors of The 1619 Project. Why, they ask, if the constitutional order is so well designed, do so many American citizens have a negative view of the American political order? To address that question, they examine the most crucial episodes in American political development from the Founding to the present. Hale and Landy frame their defense of the Constitution by understanding America in terms of modernity, where small republics are no longer possible and there is a need to protect the citizens of a massive modern state while still preserving liberty. The Constitution makes large, popular government possible by placing effective limits on the exercise of power. The Constitution forces the people to be governed by the dead, both to pay the debt we owe to those who came before us and to preserve society for generations yet unborn. The central argument of Keeping the Republic is that the Constitution provides for a free government because it places effective limits on the exercise of power—an essential ingredient of any good government, even one that aims to be a popular government. That the people should rule is a given among republicans; that the people can do anything they want is a proposition that no one could accept with their eyes wide open. Thus, the limits that the Constitution places on American political life are not a problem, but a solution to a problem. Hale and Landy offer both a survey of American anti-constitutionalism and a powerful argument for maintaining the constitutional order of the nation’s Framers.
This book is an indispensable, easy-to-use sourcebook for collectors. Filled with the most current values and the latest market reports, this guide has all the information you need to become a knowledgeable coin collector.
Secrets of Recruiting Revealed: How to Achieve Your College Soccer Dreams" is a book unique in its approach to the exciting world of college soccer. In helping high school players and their parents navigate the confusing waters
Focusing on the world coins most prized by collectors, a handy guide--illustrated with black-and-white photographs--lists more than four thousand prices of coins from more than fifty countries and offers tips on trading, grading, and collecting them. Original.
This book covers important biological, immunological, and molecular information essential for understanding the rationale and results of experiments and clinical observations on cell-cell and cell substrate adhesion; hydrolytic activities, cell motility; immunological and other host elements of the host-tumor ecosystem (at different sites of the metastic process); genetic and epigenetic elements of the acquisition and the expression of invasive phenotypes. 38 tables and 60 computer-drawn figures provide comprehensive overviews, and a methodological chapter emphasizing the differences and similarities between assays and their relevance for natural situations has also been included. Clinical and experimental cancer researchers, as well as as post-graduate students interested in cancer research, will find this book to be an indispensable reference resource.
From MEMS to Bio-MEMS and Bio-NEMS: Manufacturing Techniques and Applications details manufacturing techniques applicable to bionanotechnology. After reviewing MEMS techniques, materials, and modeling, the author covers nanofabrication, genetically engineered proteins, artificial cells, nanochemistry, and self-assembly. He also discusses scaling laws in MEMS and NEMS, actuators, fluidics, and power and brains in miniature devices. He concludes with coverage of various MEMS and NEMS applications. Fully illustrated in color, the text contains end-of-chapter problems, worked examples, extensive references for further reading, and an extensive glossary of terms. Details the Nanotechnology, Biology, and Manufacturing Techniques Applicable to Bionanotechnology Topics include: Nonlithography manufacturing techniques with lithography-based methods Nature as an engineering guide and contrasts top-down and bottom-up approaches Packaging, assembly, and self-assembly from ICs to DNA and biological cells Selected new MEMS and NEMS processes and materials, metrology techniques, and modeling Scaling laws, actuators, power generation, and the implementation of brains in miniaturizes devices Different strategies for making micromachines smarter The transition out of the laboratory and into the marketplace The third volume in Fundamentals of Microfabrication and Nanotechnology, Third Edition, Three-Volume Set, the book discusses top-down and bottom-up manufacturing methods and explains how to use nature as a guide. It provides a better understanding of how to match different manufacturing options with a given application that students can use to identify additional killer MEMS and NEMS applications. Other volumes in the set include: Solid-State Physics, Fluidics, and Analytical Techniques in Micro- and Nanotechnology Manufacturing Techniques for Microfabrication and Nanotechnology
Through research, physical oceanography aims to solve the numerous problems stated by thermal, optical and dynamical properties of the oceans. Instrumentation and Metrology in Physical Oceanography describes the means used in oceanography to determine physical properties of the oceans by medium of in situ measurements. This book explores the theoretical functioning of sensors and instruments, as well as different practical aspects of using these tools. The content of this book appeals directly to technicians or engineers wishing to enhance their knowledge of instrumentation and application to environment surveillance. Instrumentation and Metrology in Physical Oceanography details the functioning of sensors and instruments used to assess the following parameters in oceanography: temperature, conductivity, pressure, sound velocity, current in magnitude and direction, time and position with GPS, height of water and tide, waves, optical and chemical properties (turbidity), dissolved gas (O2, CO2), pH, nutrients and other dissolved elements. Furthermore, this book also elaborates on the different means used to obtain measurements at sea (boats, drifting floats, moorings, undersea platforms, gliders...) and techniques currently being developed.
From BBC Antiques Roadshow specialist and author Marc Allum comes the second instalment of his annual almanac, revealing the current news, tall tales and tasty titbits from the year in art, antiques and collectables: What do London Bridge and a £40,000 corkscrew have in common? Which famous pop star depicted by Andy Warhol realised £51.6 million at a recent auction? How much did Oliver Cromwell’s coffin plate sell for, and what happened to his famous wart? Which Hollywood film led to the recovery of a Hungarian avant garde masterpiece? What would a collector pay for the real Batmobile? Why did a tiny portrait of Mozart - only four centimetres high - sell for £218,500? Answers to these and many other fascinating questions make this the essential guide this autumn for all ardent fans of art, antiques and collectables.
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