Marketing Strategy: Theory and Cases, Canadian Edition, enables students to think and act like marketers and disruptors in a dynamic and fast paced environment. Current events and examples provided through this text serve as reminders of the necessity for marketers to be proactive and adaptable. Students will learn a systematic process for developing long-term, customer-orientated marketing strategies and plans. This edition provides a truly Canadian perspective, including cases that relate to the unique Canadian environment.
MKTG, Fifth Canadian Edition, provides Introduction to Marketing students with an engaging learning experience. The growth of this text over the last 10 years has been shaped not only by reviews from instructors teaching the course, but also by focus groups with over 400 students. The engaging layout, where we consider the pedagogical value of photos, graphics, and white space, is one of the hallmarks of MKTG that students consistently comment they like the most. Within this thoroughly revised and updated edition, we have included over 175 new photos and figures, new feature boxes, and a new continuing case featuring Canadian company, Awake Chocolate. With MKTG, Fifth Canadian Edition, students not only learn the fundamentals of Marketing, but they also develop their soft skills, better preparing them for their careers!
Together, the volumes in this series present all of the data needed at various length scales for a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanism. Therefore, investigation of flows of blood and air in anatomical conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning in quantitative terms. The present volume focuses on macroscopic aspects of the cardiovascular and respiratory systems in pathological conditions, i.e., diseases of the cardiac pump, blood vessels, and airways, as well as their treatments. Only diseases that have a mechanical origin or are associated with mechanical disorders are covered. Local flow disturbances can trigger pathophysiological processes or, conversely, result from diseases of conduit walls or their environment. The ability to model these phenomena is essential to the development and manufacturing of medical devices, which incorporate a stage of numerical tests in addition to experimental procedures.
In The foundations of cognitive archaeology, Marc Abramiuk proposes a multidisciplinary basis for the study of the mind in the past, arguing that archaeology and the cognitive sciences have much to offer one another. Abramiuk draws on relevant topics from philosophy, biological anthropology, cognitive psychology, cognitive anthropology, and archaeology to establish theoretically founded and empirically substantiated principles of a discipline that integrates different approaches to mind-related archaeological research. ..."--Publisher description.
Would you want to live in a factory-molded cube made of plastic, asbestos, and UFFI? With an "H-bomb shelter" and the nuclear furnace underneath? Or a house designed by God to harmonize with the cosmic Muzak? The Canadian Home explains how our housing came to be including the pagan origins of "colonial" homes, why "Tudor" is not Tudor, and where so many predictions went wrong. But the book is not just about tastes and floor plans; it also celebrates technological innovation, from prehistoric Inuit windows (of stretched seal guts) to the R-2000 house and habitation in space. For the first time, records of the Canadian Home Builders' Association have been opened to reveal the power plays of bureaucrats, developers, architects, and financiers and how they affect the quality, affordability, and choice of our housing today. Fiery debates over the sublime and the ridiculous (e.g. 1940s architectural articles on whether Toronto should be bombed) are set against the backdrop of Canadian politics and industrial history. Whether the reader's interest is in construction, politics, or home decor, this book explains why the roof over our heads is the way it is." Pierre Berton "In his fascinating study of Canadian shelter, Marc Denhez takes us on a 20,000-year journey from the days of the cave, the tipi, and the igloo, to the H-bomb shelter and the mobile home. This is, in short, a lively as well as an erudite study of the development of housing . [It] deserves a permanent position on any library shelf." "If you live in a house or own one or build one if you have a roof over your head read this book. A housing book with punch and humour immensely enjoyable." -Charles Lynch author, journalist and former governor of Heritage Canada.
This unique text/reference presents an overview of the computational aspects of protein crystallization, describing how to build robotic high-throughput and crystallization analysis systems. The coverage encompasses the complete data analysis cycle, including the set-up of screens by analyzing prior crystallization trials, the classification of crystallization trial images by effective feature extraction, the analysis of crystal growth in time series images, the segmentation of crystal regions in images, the application of focal stacking methods for crystallization images, and the visualization of trials. Topics and features: describes the fundamentals of protein crystallization, and the scoring and categorization of crystallization image trials; introduces a selection of computational methods for protein crystallization screening, and the hardware and software architecture for a basic high-throughput system; presents an overview of the image features used in protein crystallization classification, and a spatio-temporal analysis of protein crystal growth; examines focal stacking techniques to avoid blurred crystallization images, and different thresholding methods for binarization or segmentation; discusses visualization methods and software for protein crystallization analysis, and reviews alternative methods to X-ray diffraction for obtaining structural information; provides an overview of the current challenges and potential future trends in protein crystallization. This interdisciplinary work serves as an essential reference on the computational and data analytics components of protein crystallization for the structural biology community, in addition to computer scientists wishing to enter the field of protein crystallization.
At a time when the French monarchy traced its origins back to ancient Troy, Homeric epic was fated to play a significant political role. Homer came to Renaissance France packaged with an ancient interpretive tradition that made him an authority on all matters but also distinctly separate from Virgil and the Aeneid, rival Italy's foundational myth. Thus, once French humanists learned to read Homer in Greek, they quickly began putting him in the service of their king in order to teach him prudence and amplify his authority. Homer and the Politics of Authority in Renaissance France provides a stimulating perspective on how Homeric authority went from being used by humanists in the role of royal counselors to being exploited by both monarchical and anti-monarchical forces in the service of ideologies, most especially in the Wars of Religion (1562-1598). In turn, French writers of the period transitioned from being monarchical advisors to stirring crowds as actors on the larger political stage. In this study, Marc Bizer not only analyzes a number of works by key authors and humanists-including Michel de Montaigne, Joachim du Bellay, Guillaume Bude, and Jean Dorat, among others- but also examines their poetry, art, pamphlets, and plays. Although there have been several studies of the Homeric legacy in western literature and even in early modern French literature, none has analyzed the political role that Homer played in sixteenth-century France for this circle of important writers. The captivating results of this approach to the post-classical usage of Homer will appeal not only to historians and literary scholars, but also to political scientists, classicists, and art historians.
This handbook is a reference guide for selecting and carrying out numerous methods of soil analysis. It is written in accordance with analytical standards and quality control approaches. It covers a large body of technical information including protocols, tables, formulae, spectrum models, chromatograms and additional analytical diagrams. The approaches are diverse, from the simplest tests to the most sophisticated determination methods.
Completely updated and expanded, Emans, Laufer, and Goldstein’s Pediatric and Adolescent Gynecology, Sixth Edition, covers the medical and surgical approaches to common and uncommon pediatric and adolescent clinical problems. The book discusses the approach to the gynecologic assessment of the child and adolescent, the physiology of puberty and its associated disorders, vulvar dermatology, congenital anomalies of the reproductive tract, endometriosis, ovarian cysts and tumors, vaginitis, STDs, urologic conditions, contraception, teen pregnancy, breast disease, chronic disease, and more. Features: • Now in full color throughout, with more than 700 illustrations to guide the clinician to the correct diagnosis; •Completely redesigned with a new look! 8.5 x 11 trim size and hard cover; • Updated chapters on all aspects of pediatric and adolescent gynecology and new chapters focused on the adolescent interview, vulvar dermatology, gynecologic trauma, imaging techniques, gynecologic issues for cancer patients/survivors, and patient safety in office gynecology; • More than 100 case examples; • Over 40 expert contributors who are leaders in their field; • Up-to-date references; • Companion website with fully searchable text, image bank, extra content, and surgical videos.
Development in Infancy reflects many new discoveries that have transformed our understanding of infants and their place in human development, with an emphasis on 21st century research. Organized topically, the book covers physical, perceptual, cognitive, language, emotional, and social development, in addition to describing theories of development, contexts of development, research methods, and implications of research in infancy for social policies and interventions. Key issues in infancy studies—those having to do with how nature and nurture transact and with interrelations among diverse domains of development—are woven throughout the book. The text also emphasizes infancy as a unique stage of the life cycle. The new edition features new key point summaries at the end of most sections, definitions of boldfaced terms in the margins, and invitations to engage in retrieval practice at the end of each chapter. Each chapter also features Set for Life? text boxes that explore events and developments in infancy that reverberate in later development. This edition also features a new full-color design and over 100 figures, tables, and photos. The text is written in a clear and engaging style and is approachable for students with varying academic backgrounds and experiences. Development in Infancy is the authoritative text for undergraduate and graduate courses on infant development or early child development taught in departments of psychology, child development, education, nursing, and social work. The text is supported by Support Material that features a robust set of instructor and student resources.
The Outcast Majority invites policymakers, practitioners, academics, students, and others to think about three commanding contemporary issues—war, development, and youth—in new ways. The starting point is the following irony: while African youth are demographically dominant, most see themselves as members of an outcast minority. The irony directly informs young people’s lives in war-affected Africa, where differences separating the priorities of youth and those of international agencies are especially prominent. Drawing on interviews with development experts and young people, Marc Sommers shines a light on this gap and offers guidance on how to close it. He begins with a comprehensive consideration of forces that shape and propel the lives of African youth today, particularly those experiencing or emerging from war. They are contrasted with forces that influence and constrain the international development aid enterprise. The book concludes with a framework for making development policies and practices significantly more relevant and effective for youth in areas affected by African wars and other places where vast and vibrant youth populations reside.
Your emotional type as the means to finding the right treatment for your chronic illness or pain • Provides an easy questionnaire to find your emotional type • Identifies the connections between emotional type and 12 common chronic ailments: asthma, allergies, chronic fatigue, depression, fibromyalgia, hypertension, irritable bowel, migraines, PTSD, psoriasis, rheumatoid arthritis, and ulcers • Explains which of 7 mind/body healing therapies works best for each emotional type Different people process their feelings in different ways--your emotional style is a fundamental aspect of who you are. It affects more than just your outlook on life; it can affect your well-being as well. Many chronic ailments are not the result of germs or genes but are rooted in our emotional biology. The link between emotional type and health explains why modern medicine--which views treatment as “one size fits all”--often fails to successfully treat chronic pain and illness. Examining the interplay of emotions, chronic illness and pain, and treatment success, Michael Jawer and Dr. Marc Micozzi reveal how chronic conditions are intrinsically linked to certain emotional types and how these ailments are best treated by choosing a healing therapy in line with your type. Explaining the emotional ties behind the 12 most common chronic illnesses--asthma, allergies, chronic fatigue, depression, fibromyalgia, hypertension, irritable bowel syndrome, migraines, post-traumatic stress disorder, psoriasis, rheumatoid arthritis, and ulcers--the authors provide an easy assessment survey that allows you to identify your emotional type as well as the ailments you are susceptible to. Extending this connection between mind and body, they assess 7 alternative healing therapies--acupuncture, hypnosis, biofeedback, meditation, yoga, guided imagery, and relaxation techniques--and indicate which methods work best for each emotional type. Empowering you as a patient to seek out the therapies that will work best for you, this book offers a welcome path to effective pain relief and sustainable health.
Fake news, pseudoscience, and quackery have become scourges, spreading through society from social media all the way to Congress. The line between entertainment and reality, between fact and fiction, has become blurred. Some of the most crucial issues of our time—climate change, vaccines, and genetically modified organisms—have become prime targets for nefarious disinformation campaigns. Far too many people have become distrustful of real science. Even those who still trust science no longer know what to believe or how to identify the truth. Not only does this result in the devaluation and distrust of real science, but it is also dangerous: people acting based on false information can hurt themselves or those around them. We must equip ourselves with the knowledge and skills to fight back against all this disinformation. InScience and the Skeptic: Discerning Fact from Fiction, you will learn how science is done, from the basic scientific method to the vetting process that scientific papers must go through to become published; how and why some people intentionally or unintentionally spread misinformation; and the dangers in believing and spreading false information. You'll also find twenty easy-to-follow rules for distinguishing fake science from the real deal. Armed with this book, empower yourself with knowledge, learning what information to trust and what to dismiss as deceit. "We're not just fighting an epidemic; we're fighting an infodemic. . . . This is a time for facts, not fear. This is a time for rationality, not rumors. This is a time for solidarity, not stigma."—Tedros Adhanom Ghebreyesus, director-general of the WHO "Our deepest beliefs should help navigate reality, not determine it."—Michael Gersen, The Washington Post "Journalism is very much about trying to simplify and distribute information about what's new and where advances have been made. That's incompatible with the scientific process, which can take a long time to build a body of evidence."—Kelly McBride, Poynter Institute
How do researchers use dynamic network analysis (DYRA) to explore, model, and try to understand the complex global history of our species? Reduced to bare bones, network analysis is a way of understanding the world around us — a way called relational thinking — that is liberating but challenging. Using this handbook, researchers learn to develop historical and archaeological research questions anchored in DYRA. Undergraduate and graduate students, as well as professional historians and archaeologists can consult on issues that range from hypothesis-driven research to critiquing dominant historical narratives, especially those that have tended to ignore the diversity of the archaeological record.
The governance theories that have developed over the past twenty years offer a new framework to consider and examine the collective conditions of a "Responsible Research and Innovation – RRI" linked up with the policy challenges of a society in transition in all its modes of regulation. This book will recall the genesis of the reflexive point of view in the context of the development of the theory of governance. It will then develop the strengths of the model and finally, will show the fruitfulness of its application to the field of the RRI.
Consistently lauded for its comprehensiveness and full-color color presentation, the latest edition of Rheumatology by Marc C. Hochberg, MD, MPH et al. continues the tradition of excellence of previous editions. Designed to meet the needs of the practicing clinician, it provides extensive, authoritative coverage of rheumatic disease from basic scientific principles to practical points of clinical management in a lucid, logical, user-friendly manner. Find the critical answers you need quickly and easily thanks to a consistent, highly user-friendly format covering all major disorders of the musculoskeletal system in complete, self-contained chapters. Get trusted perspectives and insights from chapters co-authored by internationally renowned leaders in the field, 25% of whom are new to this edition. Track disease progression and treat patients more effectively with the most current information, including 22 new chapters on genetic findings, imaging outcomes, and cell and biologic therapies as well as rheumatoid arthritis and SLE. Incorporate the latest findings about pathogenesis of disease; imaging outcomes for specific diseases like RA, osteoarthritis, and spondyloarthropathies; cell and biologic therapies; and other timely topics.
A provocative exploration of intellectual exchange across four centuries of European history by the author of When the World Spoke French In this fascinating study, preeminent historian Marc Fumaroli reveals how an imagined “republic” of ideas and interchange fostered the Italian Renaissance, the Enlightenment, and the French Revolution. He follows exchanges among Petrarch, Erasmus, Descartes, Montaigne, and others from the fifteenth through the eighteenth centuries, through revolutions in culture and society. Via revealing portraits and analysis, Fumaroli traces intellectual currents engaged with the core question of how to live a moral life—and argues that these men of letters provide an example of the exchange of knowledge and ideas that is worthy of emulation in our own time. Combining scholarship, wit, and reverence, this thought†‘provoking volume represents the culmination of a lifetime of scholarship.
Does God, in His infinite wisdom, convince people to get rid of their car insurance? Does He encourage cannibalism? Does the God of more than six billion people actually have time to root for the Minnesota Vikings? According to some, yes. How do they know? God told them. Luckily, God also told Marc Hartzman to write this book, a collection of the most shocking, absurd, and hilarious things people have ever claimed God asked them to do, and to present them for your pure reading enjoyment. Including: The man that God told to perform surgery on himself God's generous offer to miraculously fill his believer's gas tank The fateful day God (assumedly feeling nostalgic for his teen years) asked a man to TP a police station The woman God instructed to direct traffic—topless And, sadly, many more
Levinas and the Greek Heritage shows that throughout his career, Emmanuel Levinas always admired and recognized his profound debt to Plato and to the philosophical tradition he initiated, which have been largely transmitted to us by the Neoplatonists, most notably Plotinus and Proclus. How can we read Otherwise than Being or Beyond Essence in any other way than as some sort of Neoplatonic programme, prolonging Plato's Good "beyond being" of the republic VI, 509b, in the direction of the "other man," the one which in his "nudity" and "fragility," opens for us the horizon of a new humanism? There are many ways by which one can attempt to go over and above Being, not only a Greek way (primordially metaphysical), but also a Biblical way (mainly ethical). One of the interests of Levinas' philosophy is to show us the hidden community - and perhaps unavoidable interdependency - of these two approaches. One Hundred Years of Neoplatonism in France shows that during the Twentieth century a retrieval of Neoplatonism is a powerful hidden feature of French philosophy and theology, of spiritual and institutional life. Beginning with Henri Bergson, it passes by way of figures like Maurice Blondel, A.J. Festugire, Henri de Lubac, Jean Trouillard, Henry Dumry, and culminates with Michel Henry, Pierre Hadot, and Jean-Luc Marion. The book examines the particular character Neoplatonism takes in this retrieval, and traces connections between leading figures within the French and Anglophone worlds.
Your very own consultation with the world’s leading fertility doctors! The trailblazing fertility program at New York Presbyterian-Weill Cornell Medical Center has pioneered many of the procedures that are now standard practices in fertility centers around the world. If you can’t get to New York for a consultation with Dr. Rosenwaks and Dr. Goldstein, A Baby At Last! puts the doctors’ expertise down on paper, offering all the information you need on the latest fertility treatments in order to make informed decisions. In this comprehensive, practical, and up-to-date handbook for diagnosing and treating infertility in both men and women, you’ll get invaluable advice on: • When to seek help: you may not need to wait at all • Finding the right doctors, and knowing the tough questions you need to ask • What tests to have for him and her, when to have them, and why • Whether or not you’re a candidate for advanced treatments, including IVF, ICSI, and beyond Covering everything from the latest technologies to the emotional hurdles associated with infertility, Drs. Rosenwaks and Goldstein share the knowledge and expertise that make the pregnancy success rates for Weill Cornell patients among the highest in the world. Here, as never before, is a book that can help you, too, bring home a baby at last!
This authoritative book presents the basic knowledge and state-of-the-art techniques necessary to carry out investigations of the cardiovascular system using modeling and simulation. This volume contains chapters on anatomy, physiology, continuum mechanics, as well as pathological changes in the vasculature walls including the heart and their treatments. Methods of numerical simulations are given and illustrated in particular by application to wall diseases.
Becoming Buoyant shows teachers how they can help students to bounce back from daily setbacks and challenges. Drawing on the five main principles of academic buoyancy – confidence, coordination, control, composure and commitment – it investigates the evidence base from which the techniques are drawn and offers practical guidance on applying them in the classroom. Emphasising the role played by internal and external factors, as well as wider school and community influences, the book offers practical guidance on: Choosing and pursuing personal goals Overcoming procrastination Recognising and dealing with anxiety How to use motivation, anxiety and stress management as ways to encourage and nurture self-efficacy. Written by an experienced teacher and chartered psychologist, Becoming Buoyant is essential reading for all teachers that want their students to be resilient and flourish in the classroom.
The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. Volume 5 is devoted to cells, tissues, and organs of the cardiovascular and ventilatory systems with an emphasis on mechanotransduction-based regulation of flow. The blood vessel wall is a living tissue that quickly reacts to loads applied on it by the flowing blood. In any segment of a blood vessel, the endothelial and smooth muscle cells can sense unusual time variations in small-magnitude wall shear stress and large-amplitude wall stretch generated by abnormal hemodynamic stresses. These cells respond with a short-time scale (from seconds to hours) to adapt the vessel caliber. Since such adaptive cell activities can be described using mathematical models, a key objective of this volume is to identify the mesoscopic agents and nanoscopic mediators required to derive adequate mathematical models. The resulting biomathematical models and corresponding simulation software can be incorporated into platforms developed in virtual physiology for improved understanding and training.
Departing from the political economy perspective taken by the vast majority of volumes devoted to Mesoamerican obsidian, Obsidian Reflections is an examination of obsidian's sociocultural dimensions—particularly in regard to Mesoamerican world view, religion, and belief systems. Exploring the materiality of this volcanic glass rather than only its functionality, this book considers the interplay among people, obsidian, and meaning and how these relationships shaped patterns of procurement, exchange, and use. An international group of scholars hailing from Belize, France, Japan, Mexico, and the United States provides a variety of case studies from Mexico, Guatemala, Belize, and Honduras. The authors draw on archaeological, iconographic, ethnographic, and ethnohistoric data to examine obsidian as a touchstone for cultural meaning, including references to sacrificial precepts, powerful deities, landscape, warfare, social relations, and fertility. Obsidian Reflections underscores the necessity of understanding obsidian from within its cultural context—the perspective of the indigenous people of Mesoamerica. It will be of great interest to Mesoamericanists as well as students and scholars of lithic studies and material culture.
The Lord confused the language of all the earth," so the Tower of Babel story in the Hebrew Bible's book of Genesis tells us to explain why the world's people communicate in countless languages while previously they all spoke only one. This book argues that the biblical confusion reallyhappened in the ancient Near East, not in speech, however, but in writing. It examines the millennia-long history of writing in the region and shows a radical change from the third and second millennia to the first millennium BC.Before "Babel" any intellectual who wrote did so as a participant in a cosmopolitan tradition with its roots in Babylonia, its language, and its cuneiform script. After "Babel" scribes from all over the eastern Mediterranean, including Greece, used a profusion of vernacular languages and scripts toexpress themselves. Yet they did so in dialogue with the Babylonian cuneiform tradition still maintained by the successive Assyrian, Babylonian, and Persian empires that controlled their world, oftentimes as acts of resistance, aware of cosmopolitan ideas and motifs but subverting them. In order toframe the rich intellectual history of this region in the ancient past Before and after Babel describes and analyzes the Babylonian cosmopolitan system, how ancient Greek, Hebrew, Aramaic, and other vernacular systems interacted with it in multiple and intricate ways, and their consequences.
Focusing primarily on three early modern French authors, this book explores the erotics and politics of "voluntary servitude" in classical antiquity and the early modern period. These authors-Étienne de La Boétie, Michel de Montaigne, and Marie de Gournay-pursue related inquiries into voluntary servitude and self-control in marriage, friendship, pederasty and politics. Marc Schachter shows how Montaigne's intimate textual relationship with La Boétie provides him the opportunity to honor his beloved friend while transforming many of his ideas. Similarly, Marie de Gournay's editorial voluntary servitude to Montaigne provides her the occasion to authorize her own practice as a woman author and to engage critically with Montaigne's ideas even as she celebrates her friendship with him. Schachter's analyses are pursued particularly through the lens of Michel Foucualt's concept of governmentality which, like voluntary servitude, operates on three interrelated scales: self-control, control in interpersonal relationships, and political control. Schachter argues that thinking about the function of voluntary servitude through the lens of governmentality leads to a more nuanced understanding both of Foucault's late work and of the transformational possibilities offered by friendship and voluntary servitude in early modern France.
This contemporary textbook and manual for aspiring or new environmental managers provides the theory and practical examples needed to understand current environmental issues and trends. Each chapter explains the specific skills and concepts needed for today's successful environmental manager, and provides skill development exercises that allow students to relate theory to practice in the profession. Readers will obtain an understanding not only of the field, but also of how professional accountability, evolving science, social equity, and politics affect their work. This foundational textbook provides the scaffolds to allow students to understand the environmental regulatory infrastructure, and how to create partnerships to solve environmental problems ethically and implement successful environmental programs.
The perennial favorite for parents who want to get their kids to sleep with ease—now in its fifth edition, fully revised and updated, with a new step-by-step guide for a good night’s sleep. With more than 1.5 million copies in print, Dr. Marc Weissbluth’s step-by-step regimen for instituting beneficial habits within the framework of your child’s natural sleep cycles has long been the standard-setter in baby sleep books. Now with a new introduction and quick-start guide to getting your child to sleep, Healthy Sleep Habits, Happy Child has been totally rewritten and reorganized to give tired parents the information they need quickly and succinctly. This new edition also includes the very latest research on the importance of • implementing bedtime routines • practicing parental presence at bedtime • recognizing drowsy signs • the role of the father as an active partner in helping the child sleep better • overcoming challenges families face to help their child sleep better • different cultural sleep habits from around the world • individualized and nonjudgmental approaches to sleep training Sleep is vital to your child’s health, growth, and development. The fifth edition of Healthy Sleep Habits, Happy Child gives parents proven strategies to ensure healthy, high-quality sleep for children at every age.
Drawing upon the many disciplines that have contributed to brain research -- anatomy, physiology, clinical neurology, psychology, psychiatry -- the author traces three centuries of ideas about movement and the brain.
The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors. Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled. Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction.
This issue of Surgical Clinics of North America focuses on Vascular Surgery: Current Concepts and Treatments for Venous Disease, and is edited by Dr. Marc Passman. Articles will include: Catheter Directed Therapy Options for Iliofemoral Venous Thrombosis; Evidence Based Algorithms for Pharmacologic Prevention and Treatment of Acute Deep Venous Thrombosis and Pulmonary Embolism; Phlebectomy Techniques for Varicose Veins; Pulmonary Embolism: Current Role of Catheter Treatment Options and Operative Thrombectomy; Endovenous and Operative Treatment of Superior Vena Cava Syndrome; Pathophysiology of Chronic Venous Insufficiency and Venous Ulcers; New Trends in Anticoagulation Therapy; Open Surgical Reconstruction for Venous Occlusion and Valvular Incompetence; Liquid and Foam Sclerotherapy for Spider and Varicose Veins; Inferior Vena Cava Filters: Current Indications, Techniques, and Recommendations; Thermal and Non-Thermal Endovenous Ablation Options for Treatment of Superficial Venous Insufficiency; Role of Venous Stenting for Iliofemoral and Vena Cava Venous Obstruction; Advances in Operative Thrombectomy for Lower Extremity Venous Thrombosis; Optimal Compression Therapy and Wound Care for Venous Ulcers; Duplex Ultrasound for the Diagnosis of Acute and Chronic Venous Diseases; and more!
This book argues that we should regard walking and talking in a single rhythmic vision. In doing so, it contributes to the theory of prosody, our understanding of respiration and looking, and, in sum, to the particular links, across the board, between the human characteristics of bipedal walking and meaningful talk. The author first introduces the philosophical, neurological, anthropological, and aesthetic aspects of the subject in historical perspective, then focuses on rhetoric and introduces a tension between the small and large issues of rhythm. He thereupon turns his attention to the roles of breathing in poetry—as a life-and-death matter, with attention to beats and walking poems. This opens onto technical concepts from the classical traditions of rhetoric and philology. Turning to the relationship between prosody and motion, he considers both animals and human beings as both ostensibly able-bodied creatures and presumptively disabled ones. Finally, he looks at dancing and writing as aspects of walking and talking, with special attention to motion in Arabic and Chinese calligraphy. The final chapters of the book provide a series of interrelated representative case studies.
Phylogenies in Ecology is the first book to critically review the application of phylogenetic methods in ecology, and it serves as a primer to working ecologists and students of ecology wishing to understand these methods. This book demonstrates how phylogenetic information is transforming ecology by offering fresh ways to estimate the similarities and differences among species, and by providing deeper, evolutionary-based insights on species distributions, coexistence, and niche partitioning. Marc Cadotte and Jonathan Davies examine this emerging area's explosive growth, allowing for this new body of hypotheses testing. Cadotte and Davies systematically look at all the main areas of current ecophylogenetic methodology, testing, and inference. Each chapter of their book covers a unique topic, emphasizes key assumptions, and introduces the appropriate statistical methods and null models required for testing phylogenetically informed hypotheses. The applications presented throughout are supported and connected by examples relying on real-world data that have been analyzed using the open-source programming language, R. Showing how phylogenetic methods are shedding light on fundamental ecological questions related to species coexistence, conservation, and global change, Phylogenies in Ecology will interest anyone who thinks that evolution might be important in their data.
A multifaceted analysis of how Jewish leaders in medieval and early modern times responded to the challenges they faced. Based largely on the study of sermons and responsa—genres that show Jewish leaders addressing real situations in the lives of their people—it reveals how rabbis have handled intellectual, social, and political diversity and conflict in various vibrant Jewish communities.
A new, hopeful pathway to understanding children’s trauma and providing effective interventions to build healthier communities Each year at least a billion children around the world are victims of adverse childhood experiences (ACEs) that range from physical abuse to racial discrimination to neglect and food deprivation. The brain plasticity of our most vulnerable makes the adverse effects of trauma only that much more damaging to mental and physical development. Those dealt a hand of ACEs are more likely to drop out of school, have a shorter life, abuse substances, and suffer from myriad mental health and behavioral issues. The crucial question is: How do we intervene to offer these children a more hopeful future? Neurobiologist and educator Dr. Marc Hauser provides a novel, research-based framework to understand a child’s unique response to ACEs that goes beyond our current understanding and is centered around the five Ts—the timing during development when the trauma began, its type, tenure, toxicity, and how much turbulence it has caused in a child’s life. Using this lens, adults can start to help children build resilience and recover—and even benefit—from their adversity through targeted community and school interventions, emotional regulation tools, as well as a new frontier of therapies focused on direct brain stimulation, including neurofeedback and psychedelics. While human suffering experienced by children is the most devastating, it also presents the most promise for recovery; the plasticity of young people’s brains makes them vulnerable, but it also makes them apt to take back the joy, wonder, innocence, and curiosity of childhood when given the right support. Vulnerable Minds is a call to action for parents, policymakers, educators, and doctors to reclaim what’s been lost and commit ourselves to our collective responsibility to all children.
MEMS technology and applications have grown at a tremendous pace, while structural dimensions have grown smaller and smaller, reaching down even to the molecular level. With this movement have come new types of applications and rapid advances in the technologies and techniques needed to fabricate the increasingly miniature devices that are literally changing our world. A bestseller in its first edition, Fundamentals of Microfabrication, Second Edition reflects the many developments in methods, materials, and applications that have emerged recently. Renowned author Marc Madou has added exercise sets to each chapter, thus answering the need for a textbook in this field. Fundamentals of Microfabrication, Second Edition offers unique, in-depth coverage of the science of miniaturization, its methods, and materials. From the fundamentals of lithography through bonding and packaging to quantum structures and molecular engineering, it provides the background, tools, and directions you need to confidently choose fabrication methods and materials for a particular miniaturization problem. New in the Second Edition Revised chapters that reflect the many recent advances in the field Updated and enhanced discussions of topics including DNA arrays, microfluidics, micromolding techniques, and nanotechnology In-depth coverage of bio-MEMs, RF-MEMs, high-temperature, and optical MEMs. Many more links to the Web Problem sets in each chapter
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