The Art and Science of Dermal Formulation Development is a comprehensive guide to the theory and practice of transdermal and topical formulation development, covering preclinical studies, evaluation, and regulatory approval. It enables the reader to understand the opportunities and challenges in developing products and how risks can be mitigated. Over the last 25 years, expertise in this area has declined whilst drug delivery systems for other administration routes have developed significantly. The advantages offered by transdermal and topical drug delivery remain compelling for sectors including the pharmaceutical industry, personal care, and cosmetics. This text addresses the dearth of expertise and discusses how skin can be a route of delivery and the processes in formulation development, but how such an application is very different to that used for oral, IV, and other administration routes. Key Features: Presents a practical guide for both industry and academia Focuses on and draws together the fundamental principles behind transdermal and topical drug delivery Illustrates the practicalities of formulation design using key case studies Gives an understanding of the skin as a route of delivery and how formulation development for such application differs from that for other administration routes
A comprehensive and timely edition on an emerging new trend in time series Linear Models and Time-Series Analysis: Regression, ANOVA, ARMA and GARCH sets a strong foundation, in terms of distribution theory, for the linear model (regression and ANOVA), univariate time series analysis (ARMAX and GARCH), and some multivariate models associated primarily with modeling financial asset returns (copula-based structures and the discrete mixed normal and Laplace). It builds on the author's previous book, Fundamental Statistical Inference: A Computational Approach, which introduced the major concepts of statistical inference. Attention is explicitly paid to application and numeric computation, with examples of Matlab code throughout. The code offers a framework for discussion and illustration of numerics, and shows the mapping from theory to computation. The topic of time series analysis is on firm footing, with numerous textbooks and research journals dedicated to it. With respect to the subject/technology, many chapters in Linear Models and Time-Series Analysis cover firmly entrenched topics (regression and ARMA). Several others are dedicated to very modern methods, as used in empirical finance, asset pricing, risk management, and portfolio optimization, in order to address the severe change in performance of many pension funds, and changes in how fund managers work. Covers traditional time series analysis with new guidelines Provides access to cutting edge topics that are at the forefront of financial econometrics and industry Includes latest developments and topics such as financial returns data, notably also in a multivariate context Written by a leading expert in time series analysis Extensively classroom tested Includes a tutorial on SAS Supplemented with a companion website containing numerous Matlab programs Solutions to most exercises are provided in the book Linear Models and Time-Series Analysis: Regression, ANOVA, ARMA and GARCH is suitable for advanced masters students in statistics and quantitative finance, as well as doctoral students in economics and finance. It is also useful for quantitative financial practitioners in large financial institutions and smaller finance outlets.
Uncovers the labor exploitation occurring in universities across the country As much as we think we know about the modern university, very little has been said about what it's like to work there. Instead of the high-wage, high-profit world of knowledge work, most campus employees—including the vast majority of faculty—really work in the low-wage, low-profit sphere of the service economy. Tenure-track positions are at an all-time low, with adjuncts and graduate students teaching the majority of courses. This super-exploited corps of disposable workers commonly earn fewer than $16,000 annually, without benefits, teaching as many as eight classes per year. Even undergraduates are being exploited as a low-cost, disposable workforce. Marc Bousquet, a major figure in the academic labor movement, exposes the seamy underbelly of higher education—a world where faculty, graduate students, and undergraduates work long hours for fast-food wages. Assessing the costs of higher education's corporatization on faculty and students at every level, How the University Works is urgent reading for anyone interested in the fate of the university.
Visual Diagnosis and Care of the Patient with Special Needs provides a thorough review of the eye and vision care needs of patients with special needs. This book gives you a better understanding of the most frequently encountered developmental and acquired disabilities seen in the eye care practitioner’s office. These disabilities include patients with autism, brain injury, Fragile X syndrome and Down syndrome, as well as those with psychiatric illness, dual diagnosis, and more. The text discusses, in great detail, the visual issues inherent in these populations and their possible treatment. A group of authors with approximately 500 years of experience in the field of eye care and special populations have been brought together to develop this comprehensive reference. It may appear that this book is written primarily for eye care practitioners such as optometrists and ophthalmologists, while vision is the overriding topic, this book serves as an excellent resource for a multitude of professions including those engaged in occupational therapy, physical therapy, speech and language therapy, physiatry, social work, pediatric medicine, and special education.
Making Innovation Work presents a formal innovation process proven to work at HP, Microsoft, and Toyota to help ordinary managers drive top and bottom line growth from innovation. The authors have drawn on their unsurpassed innovation consulting experience -- as well as the most thorough review of innovation research ever performed. They'll show what works, what doesn't, and how to use management tools to dramatically increase the payoff from innovation investments. Learn how to define the right strategy for effective innovation, how to structure an organization to innovate best, how to implement management systems to assess ongoing innovation, how to incentivize teams to deliver, and much more. This book offers the first authoritative guide to using metrics at every step of the innovation process -- from idea creation and selection through prototyping and commercialization. This updated edition refreshes the examples used throughout the book and features a new introduction that gives currency to the principles covered throughout. ¿ For years, Creating Breakthrough Products has offered an indispensable roadmap for uncovering new opportunities, identifying what customers really value, and building products and services that redefine markets -- or create entirely new markets. Now, the authors have thoroughly updated their classic book, adding brand-new chapters on service design and global innovation, plus new insights, best practices, and case studies from both U.S. and global companies. Their new second edition presents: Revolutionary (Apple-style) and evolutionary (Disney-style) approaches to innovation: choosing between them, and making either one work More coverage of Value Opportunity Analysis and ethnography New case studies ranging from Navistar's latest long-haul truck to P+G's reinvention of Herbal Essences, plus updates to existing cases New coverage of the emerging environment of product-service ecosystems Additional visual maps and illustrations that make the book more intuitive and accessible Readers will find new insights into identifying Product Opportunity Gaps that can lead to enormous success, navigating the "Fuzzy Front End" of product development, and leveraging contributions from diverse product teams -- while staying relentlessly focused on their customers' values and lifestyles, from strategy through execution.
Finally! A book that can help you understand how and what you need to get a website online. Written for the average person, this book is designed to help you with the process of launching a website.
This is the leading international professional reference text that also serves as a bench book, describing all aspects of the pathology of brain tumours - genetics, molecular biology, epidemiology, morphology, immunohistochemistry, diagnostic criteria and prognosis. Beautifully illustrated in colour throughout and comprehensively referenced, Russell & Rubinstein is regarded as the ultimate source for key information. For this seventh edition, the book returns to a single, clearly organised volume, and basic sciences are once again fully integrated within sections devoted to individual tumour entities. Entirely revised and updated throughout by a wide range of internationally revered authorities, the content reflects the latest tumour classification and grading while neuroradiologic correlation via state of the art neuroimaging techniques continues to be emphasised in all diagnostic entities. The offering is completed by a companion CD-ROM, providing quick and easy access to all the images from the book, retrievable by figure number, chapter title and keyword searches.
Stay on top of the latest knowledge in the field with this must-have resource for all clinicians who treat breast diseases. Expand your knowledge of every aspect of breast diseases as a diverse and distinguished group of internationally-recognized experts summarize the current knowledge, including biology and epidemiology, clinical features, and management. Ideal for any clinician seeing patients with breast disease, especially carcinoma of the breast, This full color 5th Edition of the authoritative text in the field is designed to foster the understanding necessary to provide optimal patient care.. Features Covering the latest major clinical trials, along with concise management summaries for each clinical chapter. Illustrations and tables that emphasize breast imaging, microscopic and gross histology, anatomy, and procedural technique enhance visual understanding. Algorithms on problem management in all aspects of breast disease from benign processes to breast carcinoma inform clinical practice. eBook with content updates is included with purchase New chapters have been added on pathology of in situ carcinomas, prophylactic contralateral mastectomy, implications of obesity in breast cancer, and an overview of survivorship issues To keep perspectives fresh and updated, over one third of the authors are new to this edition
Mutual funds form the bedrock of retirement savings in the United States, and, considering their rapid growth, are sure to be more critical in the future. Because the size of fees paid by investors to mutual fund advisers can strongly affect the return on investment, these fees have become a contentious issue in Congress and the courts, with many arguing that investment advisers grow rich at the expense of investors. This ground-breaking book not only conceptualizes a new economic model of the mutual fund industry, but also uses this model to test for price competition between investment advisers, evaluating the assertion that market forces fail to protect investors' returns from excessive fees. Highly experienced authors track the growth of the industry over the past twenty-five years and present arguments and evidence both for and against theories of adviser malfeasance. The authors review the regulatory history of mutual fund fees and summarize leading case decisions addressing excessive fees. Revealing the extent to which the governance structure of mutual funds truly impacts fund performance, this book provides the best understanding of today's mutual fund industry and is a vital tool for investors, money managers, fund directors, securities lawyers, economists, and anyone concerned with the regulation of mutual funds.
Over the past ten years, the discovery of extrasolar planets has opened a new field of astronomy, and this area of research is rapidly growing, from both the observational and theoretical point of view. The presence of many giant exoplanets in the close vicinity of their star shows that these newly discovered planetary systems are very different from the solar system. New theoretical models are being developed in order to understand their formation scenarios, and new observational methods are being implemented to increase the sensitivity of exoplanet detections. In the present book, the authors address the question of planetary systems from all aspects. Starting from the facts (the detection of more than 300 extraterrestrial planets), they first describe the various methods used for these discoveries and propose a synthetic analysis of their global properties. They then consider the observations of young stars and circumstellar disks and address the case of the solar system as a specific example, different from the newly discovered systems. Then the study of planetary systems and of exoplanets is presented from a more theoretical point of view. The book ends with an outlook to future astronomical projects, and a description of the search for life on exoplanets. This book addresses students and researchers who wish to better understand this newly expanding field of research.
Policy debates are often grounded within the conceptual confines of a state-market dichotomy, as though the two existed in complete isolation. In this innovative text, Marc Allen Eisner portrays the state and the market as inextricably linked, exploring the variety of institutions subsumed by the market and the role that the state plays in creating the institutional foundations of economic activity. Through a historical approach, Eisner situates the study of American political economy within a larger evolutionary-institutional framework that integrates perspectives in American political development and economic sociology. This volume provides a rich understanding of the complexity of U.S. economic policy, explaining how public policies become embedded in bureaucracy and reinforced by organized beneficiaries and public expectations. This path dependent layering process helps students better understand the underlying historical dynamics, which provide a clearer sense of the constraints faced by policymakers now and in the future. Thorough coverage of the entitlement crisis, globalization’s impact on the U.S. political economy, and the recent financial crisis in the final chapters demonstrate the importance of this historical institutionalist framework.
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