Mandy Mitchell's Books

Under a Greek Sun

A BRAND NEW sizzling summer romance from bestseller Mandy Baggot for summer 2023

By: Mandy Baggot

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Under a Greek Sun

A BRAND NEW sizzling summer romance from bestseller Mandy Baggot for summer 2023

By: Mandy Baggot

Escape to Corfu with this sizzling summer romance, from bestselling author Mandy Baggot Eve Collins is looking forward to the holidays. Her job as a counsellor has been as taxing as it has been rewarding, and she can’t wait for some downtime on the Greek island of Corfu with best-friend, Gabby. But between Eve’s brother, Ben, unexpectedly joining and Gabby’s job at the animal rescue centre keeping her busy, Eve might have to start mucking in... When Gianni arrives in the village of Episkepsi, it’s like a model has stepped straight off the pages of Vogue Italia... with an uptight personality to match. He may be super-sexy but there are obvious chips on those broad shoulders. As Eve and Gianni get to know each other and both start to lean into the Greek customs and avrio mentality, an initial attraction starts to turn into something more. But with so much family drama in both their lives, neither of them were looking for a holiday romance... - 'The slow-burn romance between Eve and Gianni was perfect, and the Greek cast, particularly, adorable. A gorgeous summer read with all the ingredients I like best.' Sue Moorcroft, author of An Italian Island Summer 'Mandy Baggot at her best - equal measures heart, humour and romance. A must read.' Sandy Barker, author of A Sunrise Over Bali 'Mandy Baggot is the queen of sexy, fun, Greek-set stories.’ Isabelle Broom, author of The Summer Trip 'A delightful escapist romance packed with sunshine, second chances and an utterly charming cast of characters.' Nina Kaye, author of Just Like That 'I loved the quirky local characters and even quirkier animals at the sanctuary. It was fun and romantic and a wonderful trip to Corfu!' Leonie Mack, author of A Taste of Italian Sunshine 'A sizzling summer read full of romance, drama and Greek sun! ... Mandy Baggot just gets better and better!' Katie Ginger, author of The Little Library on Cherry Lane 'This is Mandy Baggot's best book yet... Full of Mandy's trademark humour, wonderfully drawn characters and sizzling romance, there is also a deeper emotional level to this book. I loved every word of it.' Sue Fortin, author of Sister Sister 'This book is so cute. I love Eve and Gianni so much. I recommend this book to people who want a good summer holiday romance read' ⭐️⭐️⭐️⭐️⭐️ Netgalley Review 'What a truly stunning read this book is and Mandy never fails to disappoint. Heart warming and beautifully written' ⭐️⭐️⭐️⭐️⭐️ Netgalley Review 'This gorgeous summer read has everything you need to cast your cares aside and simply bask in the warmth of the Greek sun, warm characters and totally absorbing storyline. Love it!' ⭐️⭐️⭐️⭐️⭐️ Netgalley Review

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Page Count

404

Publisher

Boldwood Books Ltd

Published Date

ISBN 10

1805493558

ISBN 13

9781805493556

GCSE Media Studies for WJEC

By: Mandy Esseen

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GCSE Media Studies for WJEC

By: Mandy Esseen

Offers coverage of the WJEC specification. Suitable for students of the WJEC exam, this title provides them with an understanding of and engagement with GCSE Media Studies. It also provides guidance on pre-production, practical production and the supporting account for their coursework folder.

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236

Publisher

Heinemann

Published Date

ISBN 10

0435109677

ISBN 13

9780435109677

Avenging Annabelle

By: Mandy White

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Avenging Annabelle

By: Mandy White

How far would you go to protect the ones you love? For Jim Fraser, the line between right and wrong blurs when he sets out to find his missing daughter. When Annabelle vanishes, Jim fears the worst. His fears are confirmed when Annabelle appears to him in his dreams, showing him things...things he doesn't want to see but must if he is to solve the mystery of her disappearance and have his vengeance on the one responsible Time is running out. The next victim has been chosen - Annabelle's best friend Amy. Annabelle begs her father to keep Amy safe and Jim knows he must act immediately.

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200

Publisher

Lulu.com

Published Date

ISBN 10

1300289155

ISBN 13

9781300289159

It Must Be Christmas

Three Holiday Stories

By: Jennifer Crusie,Mandy Baxter,Donna Alward

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It Must Be Christmas

Three Holiday Stories

By: Jennifer Crusie,Mandy Baxter,Donna Alward

Previously published stories from New York Times bestselling author Jennifer Crusie, Mandy Baxter, and Donna Alward, these hot romantic stories share the spirit of love this season. It’s the most wonderful time of the year, when love is in the cold and frosty air—and desire reaches the boiling point... Hot Toy From New York Times bestselling author Jennifer Crusie comes a hilarious, sexy story about a determined shopper who grabs the last action figure off the shelf, only to find herself plunged into the arms of a sexy secret agent. Mayhem under the mistletoe ensues. Business as usual this Christmas season...right? Christmas with the Billionaire Rancher Nate wants to stay away from all the women who want his money in Mandy Baxter’s story set deep in the heart of Texas. But when gorgeous do-gooder Chloe Benson comes knocking at his door—in search of funds for her charity—Nate can’t ignore the passion he feels for her. Maybe love is priceless after all? Christmas at Seashell Cottage ’Tis the season in Jewell Cove when local doctor Charlie Yang finds her quiet, steady life disrupted by both an abandoned baby in the nativity manger and ex-SEAL Dave Ricker. Are these turn of events too good to be true? Or is Christmas working its magic—for real?

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385

Publisher

St. Martin's Paperbacks

Published Date

ISBN 10

1250106389

ISBN 13

9781250106384

The Keep

By: Mandy Coleman

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The Keep

By: Mandy Coleman

When Mitch stumbles on his special power he can't believe the results. He is thrust into a medieval world of knights, castles and treasure. Can Mitch prove himself and save the High King?

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Blake Education

Published Date

ISBN 10

1865093831

ISBN 13

9781865093833

GCSE Media Studies for AQA

By: Mandy Esseen,Martin Phillips,Anne Riley

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GCSE Media Studies for AQA

By: Mandy Esseen,Martin Phillips,Anne Riley

Providing comprehensive coverage of key concepts and the demands of the AQA exam, this title explains the processes, skills and knowledge students need to succeed at this level.

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Page Count

226

Publisher

Heinemann

Published Date

ISBN 10

0435109693

ISBN 13

9780435109691

Reflective Teaching in Schools

By: Andrew Pollard,Kristine Black-Hawkins,Gabrielle Cliff Hodges,Pete Dudley,Mary James,Holly Linklater,Sue Swaffield,Mandy Swann,Fay Turner,Paul Warwick,Mark Winterbottom,Mary Anne Wolpert

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Reflective Teaching in Schools

By: Andrew Pollard,Kristine Black-Hawkins,Gabrielle Cliff Hodges,Pete Dudley,Mary James,Holly Linklater,Sue Swaffield,Mandy Swann,Fay Turner,Paul Warwick,Mark Winterbottom,Mary Anne Wolpert

Building on best-selling texts over three decades, this thoroughly revised new edition is essential reading for both primary and secondary school teachers in training and in practice, supporting both initial school-based training and extended career-long professionalism. Considering a wide range of professionally relevant topics, Reflective Teaching in Schools presents key issues and research insights, suggests activities for classroom enquiry and offers guidance on key readings. Uniquely, two levels of support are offered: · practical, evidence-based guidance on key classroom issues – including relationships, behaviour, curriculum planning, teaching strategies and assessment processes; · routes to deeper forms of expertise, including evidence-informed 'principles' and 'concepts' to support in-depth understanding of teacher expertise. Andrew Pollard, former Director of the UK's Teaching and Learning Research Programme, led development of the book, with support from primary and secondary specialists from the University of Cambridge, UK. Reflective Teaching in Schools is part of a fully integrated set of resources for primary and secondary education. Readings for Reflective Teaching in Schools directly complements and extends the chapters in this book. Providing a compact and portable library, it is particularly helpful in school-based teacher education. The website, reflectiveteaching.co.uk, offers supplementary resources including reflective activities, research briefings, advice on further reading and additional chapters. It also features a glossary, links to useful websites, and a conceptual framework for deepening expertise. This book is one of the Reflective Teaching Series – inspiring education through innovation in early years, schools, further, higher and adult education.

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Page Count

571

Publisher

A&C Black

Published Date

ISBN 10

1441175393

ISBN 13

9781441175397

Alcohol

Neurobiology of Addiction

By: George F. Koob,Michael A. Arends,Mandy L McCracken,Michel Le Moal

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Alcohol

Neurobiology of Addiction

By: George F. Koob,Michael A. Arends,Mandy L McCracken,Michel Le Moal

A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Alcohol, Volume 3 in the series, explores the molecular, cellular, and neurocircuitry systems in the brain responsible for alcohol addiction using the heuristic three-stage cycle framework of binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. - Outlines the history and behavioral mechanism of action of alcohol relevant to the neurobiology of alcohol addiction - Includes neurocircuitry, cellular, and molecular neurobiological mechanisms of alcohol addiction in each stage of the addiction cycle - Explores evolving areas of research associated with all three stages of the alcohol addiction cycle, including neurobiological studies of neurodevelopmental effects of early exposure to alcohol, sleep disturbances caused by alcohol, pain interactions with alcohol, sex differences in the response to alcohol, and epigenetic/genetic interactions with alcohol

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Page Count

402

Publisher

Academic Press

Published Date

ISBN 10

0128167947

ISBN 13

9780128167946

The Story of Your Life

Becoming the Author of Your Experience

By: Mandy Aftel

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The Story of Your Life

Becoming the Author of Your Experience

By: Mandy Aftel

Based on a radical new therapeutic approach, this enlightening guide urges readers to view their lives as a novel encompassing three major plots--love, mastery, and loss. Through imaginative exercises and examples from literature and life, "The Story of Your Life" explains how trite or destructive story lines can be eliminated.

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246

Publisher

Simon and Schuster

Published Date

ISBN 10

0684826968

ISBN 13

9780684826967

Death Is Not "The End"

One Agnostic’S Journey on the Bumpy Road to Belief

By: Mandy Berlin

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Death Is Not "The End"

One Agnostic’S Journey on the Bumpy Road to Belief

By: Mandy Berlin

On December 23, 2003, as death released her beloved husband, Max, from the ravages of cancer, Mandy Berlins life also changed. Soon after her husband passed away, Mandy began to experience uncanny, even miraculous happenings. As a retired scientist, she approached the mystery the way she had been trained to do--through empirical observation and analysis. She kept meticulous records of the astounding sights and sounds she witnessed. Her documentation also included the stories of stunned loved ones who called her in the days after Max passed. The result is Death Is Not The End, the detailed account of her journey from grief to hope and faith. An agnostic in the years before her husbands death, she knew that these amazing experiences challenged her lack of belief. Time and again, a synchronistic melody would play as an uncanny episode presented itself to awestruck Mandy and others. Here, she invites readers into detailed accounts of more than fifty experiences beyond natural explanation. On the one-year anniversary of her beloved Maxs departure, another life-changing event opened Mandys eyes to a startling promise, and a new way of living/being. Was Max really gone forever? One year after he died, just minutes before the time recorded on her husbands death certificate, Mandy witnessed a mind-numbing event that had the effect of solidifying her awe-inspiring experiences. She now embraces a new understanding of life, death, and the subtle boundaries between, and shares it all in this memoir.

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340

Publisher

Abbott Press

Published Date

ISBN 10

1458217086

ISBN 13

9781458217080

Remembrance of the Great War in the Irish Free State, 1914–1937

Specters of Empire

By: Mandy Link

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Remembrance of the Great War in the Irish Free State, 1914–1937

Specters of Empire

By: Mandy Link

This book focuses on how Irish remembrance of the First World War impacted the emerging Irish identity in the postcolonial Irish Free State. While all combatants of the “war to end all wars” commemorated the war, Irish memorial efforts were fraught with debate over Irish identity and politics that frequently resulted in violence against commemorators and World War I veterans. The book examines the Flanders poppy, the Victory and Armistice Day parades, the National War Memorial, church memorials, and private remembrances. Highlighting the links between war, memory, empire and decolonization, it ultimately argues that the Great War, its commemorations, and veterans retained political potency between 1914 and 1937 and were a powerful part of early Free State life.

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Page Count

220

Publisher

Springer

Published Date

ISBN 10

3030195112

ISBN 13

9783030195113

Opioids

By: George F. Koob,Michael A. Arends,Mandy L McCracken,Michel Le Moal

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Opioids

By: George F. Koob,Michael A. Arends,Mandy L McCracken,Michel Le Moal

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426

Publisher

Academic Press

Published Date

ISBN 10

0128169893

ISBN 13

9780128169896

Killing Kebble

An Underworld Exposed

By: Mandy Wiener

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Killing Kebble

An Underworld Exposed

By: Mandy Wiener

In September 2005 one of South Africa’s most eminent mining magnates and businessmen Brett Kebble was killed on a quiet suburban street in Johannesburg. The investigation into the case was a tipping point for democratic South Africa. The top-level investigation that followed exposed the corrupt relationship between the country’s Chief of Police and Interpol President Jackie Selebi and suave Mafioso Glenn Agliotti. A lawless Johannesburg underbelly was exposed – dominated by drug lords, steroid-reliant bouncers, an international smuggling syndicate, a shady security unit moonlighting for the police and sinister self-serving sleuths abusing state agencies. The new paperback edition of the bestselling non-fiction title, Killing Kebble includes: A Postscript that updates the reader on events and people since the publication of the book in April 2011; An extensive author interview that explores the author’s background, the success of the book and people’s reactions to it as well as the impact it has had on Mandy’s life. The additional new material will also be available in a Kindle Single via Amazon – as Postscript to Killing Kebble.

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Page Count

419

Publisher

Pan Macmillan South africa

Published Date

ISBN 10

1770102728

ISBN 13

9781770102729

One Wish in Manhattan

A gorgeously festive romance from Mandy Baggot for 2024

By: Mandy Baggot

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One Wish in Manhattan

A gorgeously festive romance from Mandy Baggot for 2024

By: Mandy Baggot

The uplifting holiday romance from bestseller Mandy Baggot Christmas: it’s the most wonderful time of the year...to fall in love The temperature is dropping, snow is on its way and Hayley Walker is heading for New York with one wish... to start over. With her daughter Angel, Hayley is ready for adventure. But there’s more to New York than twinkly lights and breathtaking skyscrapers. Angel has her own Christmas wish – to find her real dad. While Hayley tries to fulfil her daughter’s wish, she crosses paths with billionaire Oliver Drummond. Restless and bored with fast living, there’s something intriguing about him that has Hayley hooked. Can Hayley dare to think her own dreams might come true – could A New York Christmas turn into a New York Forever? Travel to the Big Apple this Christmas and join Hayley and Oliver as they realise life isn’t just about filling the minutes... it’s about making every moment count. A big warm-hearted story, full of Christmas sparkle that will delight fans of Jane Costello, Miranda Dickinson and Lucy Diamond. Previously published in 2015 What everyone’s saying about One Wish in Manhattan: ‘If you love Christmas, and are looking for a book that will fit with absolute perfection, this is the book for you. I really loved it.’ Being Anne Reading ‘I LOVED THIS BOOK... I loved the style of humour. The setting of New York City is just perfection for a book set around Christmas. This is a perfect example of how well this genre can be written - it's warm, sweet, romantic, likeable, cosy - just the perfect book to curl up on the couch in front of an open fire with. Gorgeous.’ Behind Green Eyes ‘Sweet, cozy and just romantic.’ Rachel’s Random Reads ‘A fun, lighthearted read. If you're looking for something to curl up with during the Christmas season, this one is a good choice.’ For the Love of the Read Praise for Mandy Baggot: 'Mandy Baggot at her best - equal measures heart, humour and romance. A must read.' Sandy Barker 'Mandy Baggot is the queen of sexy, fun, Greek-set stories.’ Isabelle Broom 'A delightful escapist romance packed with sunshine, second chances and an utterly charming cast of characters.' Nina Kaye 'A sizzling summer read full of romance, drama and Greek sun! ... Mandy Baggot just gets better and better!' Katie Ginger

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496

Publisher

Boldwood Books Ltd

Published Date

ISBN 10

1836334648

ISBN 13

9781836334644

One Summer in Nashville

An absolutely emotional and passionate romance to fall in love with in 2024

By: Mandy Baggot

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One Summer in Nashville

An absolutely emotional and passionate romance to fall in love with in 2024

By: Mandy Baggot

Welcome to Nashville, where the music is everything... Honor Blackwood was once the crowning glory of Nashville. Tipped as the next big thing, her future was paved in gold. Until a terrible accident changed everything and now all she has are the platinum discs and the memories. Jared Marshall is the new guy hitting all the right notes in the country music charts. Everyone wants a piece of him; he's sexy, he's wild, and he looks like trouble. But there's one girl who might just be able to tame him, if she'll open her heart. As a new opportunity arises, Honor has a serious decision to make; does she try for a second chance at her old life? Or will the scars of her past continue to haunt her? There are secrets aplenty in Nashville, and they may well cause havoc on the heart. Previously published as Made in Nashville. *** Readers LOVE Mandy Baggot: 'Made In Nashville is a wonderful romantic story that will take you on an emotional roller coaster ride with its dramatic twists and turns, but ultimately it will leave you with a satisfied smile on your lips.' - Amazon reviewer, 5* 'This story had me on the edge of my seat, with ups and downs, big enough to keep the pages turning and to know if everything is going to turn out how you want it to.' - Amazon reviewer, 5* ' I would argue that it is her best novel yet!!!' - Amazon reviewer, 5* 'I devoured MADE IN NASHVILLE like warm, chocolate chip cookies, loving every morsel.' - Amazon reviewer, 5* 'This is the first book I've read of Mandy Baggot's, it certainly is not the last!' - Amazon reviewer, 5*

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Page Count

346

Publisher

Bloomsbury Publishing

Published Date

ISBN 10

1789546303

ISBN 13

9781789546309

Psychostimulants

By: George F. Koob,Michael A. Arends,Mandy L McCracken,Michel Le Moal

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Psychostimulants

By: George F. Koob,Michael A. Arends,Mandy L McCracken,Michel Le Moal

A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction are detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Psychostimulants, Volume 2 in the series, explores the molecular and cellular systems in the brain responsible for psychostimulant addiction, including both direct/indirect sympathomimetics and nonsympathomimetics. This volume introduces the readers to the history of psychostimulant use. The authors clearly differentiate the neurobiological effects into three distinct stages of the addiction cycle: binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. - Highlights recent advances in psychostimulant addiction - Includes neurocircuitry, cellular and molecular neurobiological mechanisms of psychostimulant addiction - Defines the abuse and addiction potentials of both direct and indirect sympathomimetics and nonsympathomimetics

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Page Count

264

Publisher

Academic Press

Published Date

ISBN 10

0128169915

ISBN 13

9780128169919

Podiatry

A Psychological Approach

By: Anne Mandy,Kevin Lucas,Janet McInnes,Jodie Lucas

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Podiatry

A Psychological Approach

By: Anne Mandy,Kevin Lucas,Janet McInnes,Jodie Lucas

Podiatry: A Psychological Approach provides a problem and case-based approach to understanding psychological and social difficulties commonly experienced by clients and presented to practitioners. This book is designed to be an introduction to important applied psychology in clinical practice. The main chapters are organized as individual patient case studies with relevant psychological theory attached. Attention is also given to social-psychological issues pertinent to both newly qualified and experienced podiatric practitioners.

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Page Count

216

Publisher

John Wiley & Sons

Published Date

ISBN 10

0470746327

ISBN 13

9780470746325

Today and Tomorrow

By: Mandy Rice-Davies

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Today and Tomorrow

By: Mandy Rice-Davies

LOVE WAS AN EASY GAME UNTIL SHE BROKE ALL OF THE RULES ... Amethyst Barclay was everything a modern woman craves, independent, talented, successful and achingly attractive. She had charmed her way into becoming one of the country's most sought-after freelance journalists and her sweet felicity with words quickly won the hearts of the rich and famous. But then she fell for Henry Brauner, a highly influential American politician and a man of extraordinary charisma and brute sexuality. His dizzying world of champagne, palm beaches, sumptuous wealth and frivolity masked a predatory ambition honed by the instincts of someone who knwe how to kill. And, like the nightmare of a terrible past that can never be forgotten, behind the intoxicating ayra of power, money, opulence and sex stalked one man, silently and constantly watching the couple through the sights of a high powered gun ... Drawing on a controversial and colourful life of bizarre adventure, Mandy Rice-Davies has written anovel as riveting and readable as it is robust.

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Page Count

202

Publisher

Marilyn foreman

Published Date

ISBN 10

1908720255

ISBN 13

9781908720252

Y'all Fired

A Southern Belle's Guide to Restoring Federalism and Draining the Swamp

By: Mandy M. Gunasekara

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Y'all Fired

A Southern Belle's Guide to Restoring Federalism and Draining the Swamp

By: Mandy M. Gunasekara

From a State Department-arranged German sex hotel to costly, unsubstantiated investigations brought on by anonymous sources, Y'all Fired shows readers the unfortunate reality of a young woman’s fight to institute America First reforms and what the permanent government of DC will do to resist it. Buckle up, because this gets personal. Y'all Fired: A Southern Belle’s Guide to Restoring Federalism and Draining the Swamp provides an insider account of an outsider’s service in the Trump Administration. It brings to life first-hand experiences of deep state bullying and the frustrating reality of having few tools to effectively push back. Having grown up in small-town Mississippi where people treat people with courtesy and believe in America’s constitutional tradition, life within the modern Deep State was a wakeup call for Mandy Gunasekara. Where some political appointees cut and run, and others find ways to simply blend in by “going native,” this small-town girl is determined to fix it. Y'all Fired cuts through the politics and provides a substantive assessment of how we got here by explaining the enduring institutional challenges to reform, including passage of the Sixteenth Amendment that forever changed the relationship between the federal government and the states, and the broken promises of FDR’s New Deal. This blend of personal anecdotes alongside policy solutions is not about revenge for the unfortunate souls that never learned their manners; it’s a reckoning for the American people to finally institute overdue reforms.

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178

Publisher

Simon and Schuster

Published Date

ISBN 10

1510782842

ISBN 13

9781510782846

Legal Responses to Domestic Violence

By: Mandy Burton

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Legal Responses to Domestic Violence

By: Mandy Burton

This book aims to examine legal responses to domestic violence in a holistic way. In England and Wales, as in other jurisdictions, much attention has been paid to the criminal justice response to domestic violence. The response of the civil justice system has not been ignored, but has been somewhat marginalized. Legal Responses to Domestic Violence takes a systematic approach to examining legal responses, encompassing the full range of decision makers within the legal system to analyze developments in substantive law and practice, in particular the movement towards an integrated justice approach.

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295

Publisher

Routledge

Published Date

ISBN 10

1134051972

ISBN 13

9781134051977

English Legal System in Context 6e

By: Fiona Cownie,Anthony Bradney,Mandy Burton

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English Legal System in Context 6e

By: Fiona Cownie,Anthony Bradney,Mandy Burton

This title has been written with a very simple aim in mind - to provide a text which will enable the English legal system to be taught as an interesting, intellectually stimulating course.

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Page Count

428

Publisher

Oxford University Press

Published Date

ISBN 10

0199656568

ISBN 13

9780199656561

Hedgewitch Book of Days

Spells, Rituals, and Recipes for the Magical Year

By: Mitchell, Mandy

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Hedgewitch Book of Days

Spells, Rituals, and Recipes for the Magical Year

By: Mitchell, Mandy

Recipes, Spells, and Wisdom from the Hedgerow Once upon a time the witch held a place of esteem in the village; her knowledge of local plants and wayside herbs were used to heal; her wisdom and empathy made her the village matchmaker and marriage counselor; and her ability to commune with nature and animals gave her a place of revelry and wisdom. She was the Hedgewitch. Aimed at the busy witch, who is both breadmaker and breadwinner, this book revives the spirit of the Hedgewitch and teaches you how to make every day one full of wisdom, healing, and magic. For the practicing or would-be witch whose life is more jeans, chaos, and the never-ending question of what’s for dinner than it is black robes, cauldrons, and incantations, Mandy Mitchell has a recipe for you! “I want to demonstrate how daily chores can become magical rituals with the potential to enrich and transform your life—everything from the way we form relationships with our families and friends to cooking, cleaning, and healing.”—from the introduction Journey through the wheel of the year with one eye on the kettle and the other on the magical!

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Page Count

288

Publisher

Weiser Books

Published Date

ISBN 10

157863556X

ISBN 13

9781578635566

Contemporary Topics in Molecular Immunology

By: F. P. Inman,W. J. Mandy

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Contemporary Topics in Molecular Immunology

By: F. P. Inman,W. J. Mandy

Included in this volume is a broad range of topics. Immunology is such a diverse field that many of the subspecialties overlap, and one finds it convenient and necessary to integrate information from several of them. We try to focus on the molecular aspects of immunology as much as is reasonable, but some con tributions consist of ablend of molecular and cellular immunology and even immunopathology. This is as it should be, since information at the molecular level often provides an explanation of phenomena observed at other levels. Myelin basic protein holds the interest of immunologists because it is impli cated in the induction of the autoimmune disease called experimental allergie encephalomyelitis (EAE). Although much biochemical and immunological information about this protein has been uncovered, it is not understood how such an inaccessible self-antigen can serve as the focal point in the central ner vous system for myelin basic protein-specific EAE-inducing T cells. Day dis cusses the problem by first reviewing the sequences of the proteins from several species and the antigenicity of the proteins and peptides derived from them. The reader is then led into a thorough discussion of the immunological relation ships that do and do not influence development of the encephalitis. From this discussion, the author promulgates the bystander model as the best overall mechanism to explain why different fragments of the highly conserved protein are needed by various species to give rise to the same type of localized central nervous system disease.

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Page Count

250

Publisher

Springer

Published Date

ISBN 10

0306406616

ISBN 13

9780306406614

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