Paracrine and autocrine regulation of cardiac function by "endothelial" mediators is becoming important both physiologically and pathophysiologically. This volume brings the researcher completely up to date with all aspects of endothelial regulation and cardiac function. Acknowledged experts in each field have contributed, making this work indispensable for researchers and of great interest to the clinical cardiologist. The Endothelial Cell Research Series publishes significant reviews by experts in the field. The individual volumes provide invaluable guides to researchers studying endothelial cells and are effective reference texts for anyone working in the general areas of vascular biology and neurotransmission. Endothelium was originally considered to be an inert lining for the blood vessels, but during the last fifteen years, this view has had to be completely revised. It is now accepted that the endothelium plays an important role in many diverse functions. This volume concentrates on the effect of the endothelium on cardiac function. It has been widely demonstrated that the endothelium exerts a paracrine influence on contraction of adjacent cardiac muscle through the release of several mediators, such as endothelin and nitric oxide. Recent studies also show that the effects of such mediators upon the heart are not limited to contraction alone.
The future growth and development of Asia ? the most dynamic economic region in the world today ? will have important implications for the rest of the global economy. This book offers a futuristic perspective of a wide array of developmental challenges and opportunities facing Asian economies over the next two decades. The future is approached from several different developmental paradigms including technological change and innovation, regional cooperation within Asia and between Asia and the West, poverty reduction, ethics and corruption, and environmental challenges. Future prospects for the two giant economies of China and India are also explored. By offering a comprehensive look at the medium-term future of Asia from such a wide range of different viewpoints, this fascinating book will interest economists, social scientists, politicians, international investment managers and the general public alike.
Efforts to increase efficient nutrient use by crops are of growing importance as the global demand for food, fibre and fuel increases and competition for resources intensifies. The Molecular and Physiological Basis of Nutrient Use Efficiency in Crops provides both a timely summary of the latest advances in the field as well as anticipating directions for future research. The Molecular and Physiological Basis of Nutrient Use Efficiency in Crops bridges the gap between agronomic practice and molecular biology by linking underpinning molecular mechanisms to the physiological and agronomic aspects of crop yield. These chapters provide an understanding of molecular and physiological mechanisms that will allow researchers to continue to target and improve complex traits for crop improvement. Written by leading international researchers, The Molecular and Physiological Basis of Nutrient Use Efficiency in Crops will be an essential resource for the crop science community for years to come. Special Features: coalesces current knowledge in the areas of efficient acquisition and utilization of nutrients by crop plants with emphasis on modern developments addresses future directions in crop nutrition in the light of changing climate patterns including temperature and water availability bridges the gap between traditional agronomy and molecular biology with focus on underpinning molecular mechanisms and their effects on crop yield includes contributions from a leading team of global experts in both research and practical settings
This study of Margaret Beaufort, mother of Henry VII and the founder of two Cambridge colleges is the first biography to explore the full range of archival sources and one of the best-documented studies of any late-medieval woman.
Malcolm K. Read employs a psychoanalytic model which sees civilization as a manner of instinctual renunciation in this analysis of selected texts from the sixteenth, seventeenth, and eighteenth centuries. Focusing on their moments of silence and contradiction, he demonstrates that certain attitudes toward the body expressed in these texts have a basis, albeit unconscious, in a motivation which is ultimately political. The central topics, deeply intertwined thematically and theoretically, relate to the nature and development of language; to the Baroque art of Gongora and Quevedo; to Feijoo's defense of the rationalist subject set against Torres Villarroel's subversion of the same; and to the neo-classical aesthetics of Luzan and Arteaga. The result is an interdisciplinary approach that challenges traditional assumptions in both literary criticism and linguistic historiography.
This text examines the latest evidence about the most sucessful forms of intervention when working with children and their families. The book covers a wide range of methods and services with emphasis on helping children with known problems.
A practical guide for students undertaking their dissertation, Writing Successful Undergraduate Dissertations in Social Sciences uses a mixture of exercises, strategies, case study material and further reading to give hints and tips on beginning and managing a research project and working with supervisors. Providing an accessible overview of the essential steps in conducting research and writing dissertations, this fully updated edition contains new sections on: • The varied sources of support for students and how to make use of them • The use of modern technologies, and digital platforms in data collection, storage and processing • The important issues relating to ethnographic and feminist research • How to publish through peer review publications or using self-publishing platforms • The General Data Protection Regulation and legal issues relating to collection, storage and use of personal data • The skills that students have acquired through writing dissertations and how those skills could become useful for future career and employability • How students can relate their dissertations to existing theories and concepts in social sciences that relate to their dissertation. Packed with proven practical advice from ‘real-life’ data, case studies and examples, Writing Successful Undergraduate Dissertations in Social Sciences is an essential and dependable starting point and guide for any student beginning their dissertation journey in the social sciences.
An essential new account of how anti-submarine warfare is conducted, with a focus on both historic and present-day operations. This new book shows how until 1944 U-boats operated as submersible torpedo craft which relied heavily on the surface for movement and charging their batteries. This pattern was repeated in WWII until Allied anti-submarine countermeasures had forced the Germans to modify their existing U-boats with the schnorkel. Countermeasures along also pushed the development of high-speed U-boats capable of continuously submerged operations. This study shows how these improved submarines became benchmark of the post-war Russian submarine challenge. Royal Navy doctrine was developed by professional anti-submarine officers, and based on the well-tried combination of defensive and offensive anti-submarine measures that had stood the press of time since 1917, notwithstanding considerable technological change. This consistent and holistic view of anti-submarine warfare has not been understood by most of the subsequent historians of these anti-submarine campaigns, and this book provides an essential and new insight into how Cold War, and indeed modern, anti-submarine warfare is conducted.
This book traces the origins and development of social work as we now know it. Providing an ambitious synthesis of historical and international material, it explores the different faces of social work, whether defined by social policy developments, professionalization, changes in client group, or shifts in practice orientation. This is a unique book undertaken by an author with a strong international reputation and, as such, it promises to be a landmark for years to come in the social work literature.
Children’s Services: Working Together brings together contributions from a number of authors in the field. The book covers policy, theory, research and practice relevant to students and professionals working with children in a wide range of roles. The emphasis on working collaboratively with other professionals, where appropriate, and the holistic approach to children make this a valuable resource to anyone working with children today.
Scholars, government officials, students and corporate and union representatives concerned with employment, labor and training policies and issues will find the data and analysis in this book a valuable addition to their knowledge."--BOOK JACKET.
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