The Latest Applications For Cellmechanism Research in Drug Discovery Designed to connect research on cell mechanisms with the drug discovery process, Therapeutic Targets: Modulation, Inhibition, and Activation introduces readers to a range of new concepts and novel approaches to drug screening and therapeutic drug targeting to help inform future avenues of drug research. Highly topical, this accessible edited volume features chapters contributed by respected experts from around the globe. The book helps postgraduate students and professional scientists working in academia and industry understand the molecular mechanisms of pharmacology, current pharmacological knowledge, and future perspectives in drug discovery, focusing on important biochemical protein targets and drug targeting strategies for specific diseases. Examining the pharmacology of therapeutically undefined targets and their potential applications, it includes chapters on traditional therapeutic targets, including enzymes (phosphodiesterases and proteases), ion channels, and G protein-coupled receptors, as well as more recently identified avenues of exploration, such as lipids, nuclear receptors, gene promoters, and more. Since different diseases require different targeting techniques, the book also includes dedicated chapters on strategies for investigating Alzheimer's, diabetes, pain, and inflammation treatments. Concluding with a cross-sectional look at new approaches in drug screening, Therapeutic Targets is an invaluable resource for understanding where the next generation of drugs are likely to emerge.
We have witnessed in recent years a revival of Conjectural Variations in Game Theory. This reincarnation of an old idea, using a dynamic point of view, aims at combining the adequacy with facts to the requirements of a firmly grounded theory.This book presents, for the first time, a comprehensive account of conjectural variations equilibria in their static inceptions, featuring new comparative results of equilibria with regard to efficiency. It then describes several advances in Dynamic Game Theory, allowing to understand Conjectural Variations Equilibria as dynamic equilibria. The question of how conjectures evolve in strategic and learning situations with boundedly rational agents is also discussed.
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