National Hammered Dulcimer Champion, Mark Wade presents common jam tunes in a unique way that shows beginners how to play the essence of the tunes simply and the intermediate/advanced players the ornamented versions. Each Easy Does It version of a tune is paired with the fancy rendition along with the chords. Now jamming is easier than ever for players of ALL levels!
This book and accompanying audio offer an in-depth look at how to add accompaniment and embellishments to melodies on the hammered dulcimer. The material covered in this book illustrates how to enhance simple melodies toshowcase their inherent musicality. Full of illustrations, examples, preparatoryexercises and easy-to-play arrangements, this book is sure to bring new character to your playing. It begins by explaining, in simple terms, how and why harmony works and teaches the solutions to the common exceptions you will encounter. By the end, you will be able to apply the four most common methods dulcimer playersuse to add accompaniments to melodies. Note-for-note transcriptions of fully arranged songs from the author's own repertoire are also included
The title says it all: "Dirt Simple." This book and accompanying online audio are designed for a rank beginner who knows nothing about the hammered dulcimer, providing them the tools to make music right away. Starting with the fundamentals of how to hold hammers and tune the instrument, it delves deeper into mastery with posture, stand height/angle, and replacing strings to set up the beginner for a lifetime of good habits. Every concept introduced is simultaneously presented with illustrations and songs that demonstrate and reinforce. Whether the student reads music or plays by ear, the result is the same - music making right from the beginning! Dr. Mark Alan Wade is an experienced teacher with an undergraduate degree in music education and years of public school teaching experience. Now teaching music theory and dulcimer at Denison University, Dr. Wade offers a unique perspective on teaching hammered dulcimer and has three students who have also won the National Hammered Dulcimer Contest as evidence of his master teaching. It's all about the music! Dirt Simple Hammered Dulcimer is written so that the carefully selected tunes are the true teacher. Hands-on learning is made easy with the accompanying audio. Each song is played slowly for students to learn by ear in addition to reading notation. This also allows for the students to hear style traits such as swing, that aren't easily conveyed in written notation. With 29 songs, this book and online audio available for download are a year's worth of private lessons in one concise package!
National Hammered Dulcimer Champion, Mark Wade presents common jam tunes in a unique way that shows beginners how to play the essence of the tunes simply and the intermediate/advanced players the ornamented versions. Each Easy Does It version of a tune is paired with the fancy rendition along with the chords. Now jamming is easier than ever for players of ALL levels!
Though often defined as having opposite aims, means, and effects, modernism and modern propaganda developed at the same time and influenced each other in surprising ways. The professional propagandist emerged as one kind of information specialist, the modernist writer as another. Britain was particularly important to this double history. By secretly hiring well-known writers and intellectuals to write for the government and by exploiting their control of new global information systems, the British in World War I invented a new template for the manipulation of information that remains with us to this day. Making a persuasive case for the importance of understanding modernism in the context of the history of modern propaganda, Modernism, Media, and Propaganda also helps explain the origins of today's highly propagandized world. Modernism, Media, and Propaganda integrates new archival research with fresh interpretations of British fiction and film to provide a comprehensive cultural history of the relationship between modernism and propaganda in Britain during the first half of the twentieth century. From works by Joseph Conrad to propaganda films by Alfred Hitchcock and Orson Welles, Mark Wollaeger traces the transition from literary to cinematic propaganda while offering compelling close readings of major fiction by Virginia Woolf, Ford Madox Ford, and James Joyce.
Killer Technique: Hammered Dulcimer is a book that uniquely focuses on improving the everyday elements of dulcimer playing. Some mundane fundamentals of technique may seem mindless and appear to need no attention. In reality though, even the most basic essentials of dulcimer playing can hold us back without careful examination and precision. This book does just that! The author, himself a National Hammered Dulcimer Champion and music professor, draws on over twenty years of experience in playing and teaching to share his recipe for success. The material focuses on dulcimer-specific skills and drills them in effective and engaging new ways. Targeted areas include dexterity, aim, flow, commonly used percussion rudiments, chords, arpeggios, and chord suffixes. Each exercise is carefully designed to isolate the targeted skill, provide instruction for its most efficient execution, and help you acquire new and improved muscle memory in the least amount of repetitions. Admittedly, working on technique can seem like a chore. This book takes the work out of it and presents the exercises in fresh new ways so you get the most out of them in the least amount of time. Dr. Wade's biggest technique secret revealed in this book is his use of varying rhythms to re-engage the brain and to acquire new and lasting muscle memory. The exercises are not only fun to master but also incredibly effective! It's all about efficiency–not just going through the motions!
This book and accompanying audio offer an in-depth look at how to add accompaniment and embellishments to melodies on the hammered dulcimer. The material covered in this book illustrates how to enhance simple melodies toshowcase their inherent musicality. Full of illustrations, examples, preparatoryexercises and easy-to-play arrangements, this book is sure to bring new character to your playing. It begins by explaining, in simple terms, how and why harmony works and teaches the solutions to the common exceptions you will encounter. By the end, you will be able to apply the four most common methods dulcimer playersuse to add accompaniments to melodies. Note-for-note transcriptions of fully arranged songs from the author's own repertoire are also included
Afrosonic Life explores the role sonic innovations in the African diaspora play in articulating methodologies for living the afterlife of slavery. Developing and extending debates on Afrosonic cultures, the book attends to the ways in which the acts of technological subversion, experimentation and production complement and interrupt the intellectual project of modernity. Music making processes such as dub, turntablism, hip-hop dj techniques and the remix, innovate methods of expressing subjecthoods beyond the dominant language of Western “Man” and the market. These sonic innovations utilize sound as a methodology to institute a rehumanizing subjectivity in which sound dislodges the hierarchical ordering of racial schemas. Afrosonic Life is invested in excavating and elaborating the nuanced and novel ways of music making and sound creation found in the African diaspora.
Beatson, Matthews & Elliot's Administrative Law' combines extracts from key cases, articles and other sources with detailed commentary. Aimed at undergraduates studying administrative law, it provides comprehensive coverage of the subject.
Euphoria swept Canada, and especially Ontario, with the outbreak of World War I. But why were people excited by the prospect of war? What popular attitudes about war had become ingrained in the society? This book examines the cult of manliness as it developed in Victorian and Edwardian Ontario, revealing a number of factors that fed the eagerness of youth to prove their mettle on the battlefields of Europe.
100 Things Vikings Fans Should Know & Do Before They Die is the ultimate resources guide for true fans of the Minnesota Vikings. Whether you're a die-hard booster from the days of Fran Tarkenton or a new supporter of Teddy Bridgewater, these are the 100 things all fans need to know and do in their lifetime. It contains every essential piece of Minnesota knowledge and trivia, as well as must-do activities, and ranks them all from 1 to 100, providing an entertaining and easy-to-follow checklist as you progress on your way to fan superstardom.
Intelligence is, by definition, a shadowy business. Yet many aspects of this secret world are now more openly analyzed and discussed, a trend which has inevitably prompted lively debate about intelligence gathering and analysis: what should be allowed? What boundaries, if any, should be drawn? And what changes and challenges lie ahead for intelligence activities and agencies? In this compelling book, leading intelligence scholar Mark Lowenthal explores the future of intelligence. There are, he argues, three broad areas – information technology and intelligence collection; analysis; and governance – that indicate the potential for rather dramatic change in the world of intelligence. But whether these important vectors for change will improve how intelligence works or make it more difficult remains to be seen. The only certainty is that intelligence will remain an essential feature of statecraft in our increasingly dangerous world. Drawing on the author's forty years' experience in U.S. intelligence, The Future of Intelligence offers a broad and authoritative starting point for the ongoing debate about what intelligence could be and how it may function in the years ahead.
Ready for adventure in the Lake District Fells? Cicerone’s Walking the Lake District Fells guides are your ultimate fell-by-fell companions. A series of eight guidebooks, one for each of the main valley bases, cover ALL the routes up ALL the fells in each area – that’s 230 fells in total. This guidebook covers 35 Lakeland summits that can be climbed from Patterdale, Ambleside and the Grasmere, Thirlmere and Ullswater valleys. The area is characterised by lofty ridges, with highlights including Helvellyn, Fairfield, St Sunday Crag and Red Screes, plus a handful of classic ridge routes for longer fell days. Those with some previous hiking experience will find all the info needed to climb the fells with confidence, plus a fresh perspective on both classic and lesser-known fells. Keen summit-baggers can use our tick lists to tick off the fells as they go. What sets these guidebooks apart from the rest? Complete coverage – every route covered, not just the main one. Devise your own routes – a variety of ascents, descents, and ridge routes, so you can choose to climb one fell or combine routes to craft your own adventure. Up-to-date route information – complete route description and HARVEY mapping for each fell. Hand-drawn toposand panoramas – easily see the routes up each fell and views from the top. Fell-friendly routes – designed to minimise environmental impact.
One can not understand the Sixties without understanding the Fifties. The Fifties were the first time the American youth had excess freedom. Before the 50s they worked on the family farm; dusk till dawn, slaved in the sweat shops, 12 ours a day, six days a week; starved in the depression; and fought not knowing it they would be alive the next day in World War II and the Korean War. Than, suddenly, came the fifties. First there were the beatniks lead by their spiritual leader Williams Burrough, than the bad boys of rock and roll Elvis, Johnny Cochran, and Jerry Lee Lewis prevailed. This excess freedom, led to freedom to think, freedom to question, freedom to challenge. In the sixties, the peaceful non-violent Civil Rights Movement, progressed to the Black Power and the Black Panthers. The Civil Rights Movement was followed by the creeping involvement in Vietnam, first with military advisors, than massive troop deployments to Vietnam resulting in death, violence, destruction, and then disillusion. And complementing the war, initially, the educational teach-ins led to massive antiwar demonstrations, to the Weathermen busting windows on Michigan Ave and planting bombs in the Capital. This all digressed to the second civil war which recently resurfaced with the Iraq War, I afraid now is progressing to the third civil war. Throughout the book we follow the characters lives from romantic innocence to reality to Expressionism. Some fighting in Vietnam, some protesting the war, some marching for civil rights, friendships destroyed and than repaired. Some lives lost, some destroyed, some survived, but all caught up in the hubris characterized by a gross failure of governmental leadership. Those betrayed the most have their names on a black granite wall in Washington DC.
Collecting Captain America (1968) #387-397 And Adventures Of Captain America #1-4. Hell hath no fury! Captain America faces a threat like never before when Superia raises an army of female super villains from Anaconda to M.O.D.A.M.! The roguish gun-for-hire Paladin lends Cap a hand, but can these two mismatched adventurers thwart Superias stratagem? Then, Cap comes face-to-face with his German counterpart, Hauptmann Deutschland. Both men are after the Red Skull until they discover hes been killed by Scourge! But nothing is ever as it seems with the Skull. Plus: Diamondback seeks a quiet life as Caps executive secretary?! Bernie Rosenthal returns! Cap takes on Crossbones, Viper, Taskmaster, Jack OLantern, Doughboy and more! And journey back to World War II for a fresh look at the origin and earliest adventures of Captain America and Bucky!
Now in its 10th edition, Sleisenger and Fordtran?s Gastrointestinal and Liver Disease remains your indispensable source for definitive, state-of-the-art answers on every aspect of gastroenterology and hepatology. Overcome your most complex clinical challenges and make optimal use of the newest techniques, technologies, and treatments?with superb guidance from hundreds of world-renowned authorities. Meticulous updates throughout include the latest approaches and improvements in gastrointestinal and liver disease diagnosis and therapy as well as hundreds of images and 35 new procedural videos. "..one of the most valuable clinical resources in the dynamic field of gastroenterology and hepatology." Reviewed by Brindusa Diaconu on behalf of the Journal of Gastrointestinal and Liver Diseases, July 2015 "..an engaging, educational yet clinically orientated textbook which is relevant to modern clinical practice." Reviewed by Dr Harry Brown on behalf of glycosmedia.com, April 2015 "I can personally attest to the remarkable advances that have been made, as I was author of the chapter on eosinophilic gastroenteritis in the second edition of the textbook, and reading the same chapter in the tenth edition underscores the important advances that have been made in our understanding of the molecular basis as well as the pathophysiology of this and related disorders." Foreword by Norton J. Greenberger, MD Boston, Massachusetts, June 2015 Consult this title on your favorite e-reader. Get the essential gastroenterology information you need from one authoritative source with an outstanding global reputation for excellence. Zero in on the key information you need to know with a consistent, full-color chapter design. Stay up to date with emerging and challenging topics: enteric microbiota and probiotics; fecal microbiota transplantation; Clostridium difficile colitis; and factitious gastrointestinal diseases. Incorporate the latest findings and improvements in care for liver disease patients—from diagnosis and treatment through post-treatment strategies and management of complications. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and videos from the book on a variety of devices.
Math Education for America? analyzes math education policy through the social network of individuals and private and public organizations that influence it in the United States. The effort to standardize a national mathematics curriculum for public schools in the U.S. culminated in 2010 when over 40 states adopted the Common Core State Standards for Mathematics. Rather than looking at the text of specific policy documents, this book complements existing critical reviews of the national math education curriculum by employing a unique social network analysis. Breaking new ground in detailing and theorizing the politics of math education, Wolfmeyer argues that the private interests of this network are closely tied to a web of interrelated developments: human capital education policy, debates over traditional and reform pedagogy, the assumed content knowledge deficit of math teachers, and the proliferation of profit-driven educational businesses. By establishing the interconnectedness of these interests with the national math education curriculum, he shows how the purported goals of math education reform are aligned with the prevailing political agendas of this social network rather than the national interest.
How can people best develop their leadership skills to match their personality, to amplify their strengths, and to compensate for their weaknesses? This is the first book to answer this question with the latest version of the DiSC model of human behavior, which is one of the most widely used, most scientifically based, and most effective approaches to assessing and improving leadership styles and skills.
Most Dallas Mavericks fans have attended a game at the American Airlines Center, marveled at Dirk Nowitzki's highlight-reel plays, and remember exactly where they were when the Mavs won the NBA Championship in 2011. But only real fans supported the team through an 11-win season, know the full story of the team coming to Dallas, and followed along every step of the way during the DeAndre Jordan fiasco. 100 Things Mavericks Fans Should Know & Do Before They Die is the ultimate resource guide for true fans of Mavs Basketball. Whether you're a die-hard fan from the days of Mark Aguirre and Rolando Blackman or a newer supporter in the Mark Cuban era, this book contains everything Mavericks fans should know, see, and do in their lifetime.
In November 1989 in El Salvador, six Jesuit priests and their two female housekeepers were rousted from their beds and shot as they lay face down on the ground. At first, the George H. W. Bush administration echoed the Salvadoran military's line that the rebels must have done it. When House Speaker Tom Foley tasked a senior congressman with investigating the murders, the people of El Salvador found an unlikely champion in the person of John Joseph Moakley, representative from South Boston. In Joe Moakley's Journey, Mark Robert Schneider charts one of the most unusual transformations in American politics. A native son of South Boston, Moakley was an effective and influential House member, whose greatest influence and legacy is, paradoxically, far from home in the fields of El Salvador and Central America. Though firmly, fiercely grounded in his hometown of South Boston--he never lived anywhere else--from the beginning of this investigation until his death in 2001, issues of Central American justice, peace, and economic development became Joe Moakley's cause.
Covering a full range of topics from cardiovascular and pulmonary disease to ophthalmology, hematology and pediatrics, this is the only single volume, quick reference designed for use in daily practice. The 150+ clinical prediction rules as well as the background information necessary to determine its validity and relevance are essential for every physician in a time of limited health care resources. Designed as an aid in diagnosis and treatment, these rules allow more accurate diagnosis and treatment decisions while eliminating superfluous testing.
Annuity insurance products help protect retirees against outliving their incomes. Dramatic advances in life expectancy mean that today's retirees must plan on living into their eighties, their nineties, and even beyond. Longer life expectancies are the symbol of a prosperous society, but this progress also means that some retirees will need to plan conservatively and cut back substantially on their living standards or risk living so long that they exhaust their resources. This book examines the role that life annuities can play in helping people protect themselves against such outcomes. A life annuity is an insurance product that pays out a periodic amount for as long as the annuitant is alive, in exchange for a premium. The book begins with a history of life annuity markets during the twentieth century in the United States and elsewhere. It then explores recent trends in annuity pricing and money's worth, as well as the economic value generated for purchasers of these products. The book explains the potential importance of inflation-protected annuities and stock-market-linked variable annuities in providing more complete retirement security. The concluding chapters examine life annuities in various institutional settings and the tax treatment of annuity products.
Summer, 1942. The Second World War rages on but Britain now faces the Nazi threat with America at its side. In a bombed-out London swarming with gangsters and spies, DCI Frank Merlin continues his battle against rampant wartime crime. A mangled body is found in the Thames just as some items of priceless art go mysteriously missing. What sinister connection links the two? Merlin and his team follow a twisting trail of secrets and lies as they investigate a baffling and deadly puzzle . 'This is to my shame the first Mark Ellis book I've read. If the others evoke a vanished London so impressively, are graced with such complex plots and deep characterisation, and, above all, are written so well I shall have to read them all.' THE TIMES - PICKS OF THE WEEK 'Extraordinarily atmospheric and compelling, DEAD IN THE WATER is a wonderfully intelligent and complex story' CHRIS LLOYD, HWA Gold Crown Award winner. Praise for the DCI Frank Merlin series: 'Masterly . . . compelling . . . one of the most attractive characters to emerge in recent detective-thriller fiction' ANDREW ROBERTS, SUNDAY TIMES BESTSELLING AUTHOR 'Against the backdrop of Blitz-hit London, this stylish thriller sees Scotland Yard's Frank Merlin investigate a tangled conspiracy' SUNDAY MIRROR
When social workers draw on experience, theory, or data in order to develop new strategies or enhance existing ones, they are conducting intervention research. This relatively new field involves program design, implementation, and evaluation and requires a theory-based, systematic approach. Intervention Research presents such a framework. The five-step strategy described in this brief but thorough book ushers the reader from an idea's germination through the process of writing a treatment manual, assessing program efficacy and effectiveness, and disseminating findings. Rich with examples drawn from child welfare, school-based prevention, medicine, and juvenile justice, Intervention Research relates each step of the process to current social work practice. It also explains how to adapt interventions for new contexts, and provides extensive examples of intervention research in fields such as child welfare, school-based prevention, medicine, and juvenile justice, and offers insights about changes and challenges in the field. This innovative pocket guide will serve as a solid reference for those already in the field, as well as help the next generation of social workers develop skills to contribute to the evolving field of intervention research.
The massive economic transformations and political upheavals that have been sweeping China and the Soviet Union in the final decades of the twentieth century are among the great dramas of our time. Yet the origins of these revolutionary changes are murky and their outcomes unclear. Have we witnessed the demise of an archaic authoritarian order and the rise of pluralism and democracy, or are the tumultuous events of the post-Mao era and the period of perestroika more usefully viewed in light of broader patterns of power and politics in Chinese and Russian history? Considering these questions with a new interpretation of power relations and political processes in China and Russia, Mark Lupher explores the imperial era, the communist period, and the current situation in both countries. Rather than speaking of “reform,” which too often is understood as liberalization along Western lines, his discussion is focused on power restructuring—the ebb and flow of state power; the centralization and decentralization of political and economic power; and the three-way struggles between central rulers, various elites, and nonprivileged groups that drive these processes. Lupher’s power-restructuring analysis is noteworthy in combining broad comparative-historical analysis and conceptualization with a closely focused discussion and reinterpretation of the Chinese Cultural Revolution—the core of his book. By comparing and bringing new light to bear on a series of pivotal episodes in Chinese and Russian history, he furthers our understanding and assessment of processes that will continue to unfold in China, Russia, and the former Soviet republics.
Port Aransas, known colloquially as Port A, is on Mustang Island, one of the Texas barrier islands. This community grew from the seed of El Mar Rancho, the homestead an Englishman established for his family in 1855--the name Port Aransas was adopted in 1910. The evolution of Port A includes the guiding of sport fishermen to the hard-fighting tarpon fish, bouncing back from five major hurricanes, and the development of tourism that has made the town a nationally sought out destination. Despite all of the changes that have visited Port Aransas, the pace there still conforms to "island time." Indeed, a number of images in this book were selected for how they portray that unique quality of life.
This significant collection of essays examines the cultural, literary, philosophical and historical representation of beauty in British, Irish and American literature. Contributors use the works of Charles Dickens, T S Eliot, W H Auden and Stephen Spender among others to explore the role of beauty and its wider implications in art and society.
The new, therapeutically-focused Botulinum Toxin presents comprehensive, cross-disciplinary guidance on current practices, covering more than 100 non-cosmetic conditions that occur in neurology, physical medicine and rehabilitation, pain medicine, ophthalmology, gastroenterology, urology, orthopedics, and surgery. International contributors review the current understanding of the biology and cellular mechanisms along with relevant research so you can easily apply them to the pathophysiology of the numerous disorders that botulinum toxin is used to treat—such as botulinum toxin applications for the treatment of cranial-cervical dystonias, motor disorders in cerebral palsy, bruxism and temporomandibular disorders, headache, overactive bladder, chronic pelvic pain syndromes, arthritis joint pain, and wound healing. With discussions of the latest in approved treatment practices as well as new and emerging uses, you’ll get in-depth management guidance on the application of the toxin. Provides clinical applications of botulinum toxin for over 100 disorders for immediate access and easy reference during practice and treatment. Covers a broad array of hot topics, including botulinum toxin applications for the treatment of cranial-cervical dystonias, motor disorders in cerebral palsy, bruxism and temporomandibular disorders, headache, overactive bladder, chronic pelvic pain syndromes, arthritis joint pain, and wound healing. Focuses on approved uses with expert advice on thoroughly tested applications but also discusses new and emerging applications to expose you to additional treatment options. Presents the most comprehensive and up-to-date material available so you get all the information you need from this one resource. Offers the cross-disciplinary guidance of the best world-class expertise through an authoritative, international group of authors who demonstrate the applications of botulinum toxin across various specialties.
Russia is famous for its vodka, and its culture of extreme intoxication. But just as vodka is central to the lives of many Russians, it is also central to understanding Russian history and politics. In Vodka Politics, Mark Lawrence Schrad argues that debilitating societal alcoholism is not hard-wired into Russians' genetic code, but rather their autocratic political system, which has long wielded vodka as a tool of statecraft. Through a series of historical investigations stretching from Ivan the Terrible through Vladimir Putin, Vodka Politics presents the secret history of the Russian state itself-a history that is drenched in liquor. Scrutinizing (rather than dismissing) the role of alcohol in Russian politics yields a more nuanced understanding of Russian history itself: from palace intrigues under the tsars to the drunken antics of Soviet and post-Soviet leadership, vodka is there in abundance. Beyond vivid anecdotes, Schrad scours original documents and archival evidence to answer provocative historical questions. How have Russia's rulers used alcohol to solidify their autocratic rule? What role did alcohol play in tsarist coups? Was Nicholas II's ill-fated prohibition a catalyst for the Bolshevik Revolution? Could the Soviet Union have become a world power without liquor? How did vodka politics contribute to the collapse of both communism and public health in the 1990s? How can the Kremlin overcome vodka's hurdles to produce greater social well-being, prosperity, and democracy into the future? Viewing Russian history through the bottom of the vodka bottle helps us to understand why the "liquor question" remains important to Russian high politics even today-almost a century after the issue had been put to bed in most every other modern state. Indeed, recognizing and confronting vodka's devastating political legacies may be the greatest political challenge for this generation of Russia's leadership, as well as the next.
Memory is often the primary evidence in the courtroom, yet unfortunately this evidence may not be fit for purpose. This is because memory is both fallible and malleable; it is possible to forget and also to falsely remember things which never happened. The legal system has been slow to adapt to scientific findings about memory even though such findings have implications for the use of memory as evidence, not only in the case of eyewitness testimony, but also for how jurors, barristers, and judges weigh evidence. Memory and Miscarriages of Justice provides an authoritative look at the role of memory in law and highlights the common misunderstandings surrounding it while bringing the modern scientific understanding of memory to the forefront. Drawing on the latest research, this book examines cases where memory has played a role in miscarriages of justice and makes recommendations from the science of memory to support the future of memory evidence in the legal system. Appealing to undergraduate and postgraduate students of psychology and law, memory experts, and legal professionals, this book provides an insightful and global view of the use of memory within the legal system.
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. - Updates to all chapters, including new examples and references - Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book - Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry - Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant - Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis - Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: - for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib - for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid - for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin - Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples - Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites - Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
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