The German edition of this manual appeared in 1979. Its main objective then was to extend help to those engaged in multiaentric therapeutic studies, especially with respect to the "Federal Government's Program on Promoting Research and Development in the Service of Health". Experience with therapeutic studies in the Federal Republic of Germany showed that considerable problems as to methods and implementation of such studies exist. The manual was an attempt to present current metho dological knowledge and the experience obtained from completed studies in the light of the international literature. No radically new methodo logy was produced; however, the information representing the state-of the art, which is widely scattered up to now, has been compiled. For the American edition of this manual a few changes have been made. These concern especially the literature where references to German un published manuscripts were omitted. The authors wish to thank Dr. Andreas Jaffe for the translation, and Evelyn Birke who typewrited the lecture-notes manuscrip~ • . GUnzburg and Munich Sibylle Biefang November 1981 Wolfgang Kopcke Martin A. Schreiber Contents Page Foreword 1. Methods of Therapeutic Studies 2 1. 1. Terminology 4 1. 2. Experimental Design 11 1. 3. Types of Studies 20 1. 4. Steps in Drug Testing 2. Checklist for the Planning, Implementation and Evaluation 22 of Therapeutic Studies 22 2. 1. Planning of Experiments 29 2. 2. Documentation 36 2. 3. Organization 41 2. 4. Statistical Analysis 44 2. 5.
Well illustrated, accessibly presented, and drawing on a comprehensive range of historical documents, including British, German and other European images, and literary as well as non-literary texts (many previously unconsidered in this context), this study offers the first interdisciplinary gendered assessment of early modern performing itinerant healers (mountebanks, charlatans and quacksalvers). As Katritzky shows, quacks, male or female, combined, in widely varying proportions, three elements: the medical, the itinerant and the theatrical. Above all, they were performers. They used theatricality, in its widest possible sense, to attract customers and to promote and advertise their pharmaceuticals and health care services. Katritzky investigates here the performative aspects of quack marketing and healing methods, and their profound links with the rise of Europe’s professional actresses, fields of enquiry which are only now beginning to attract significant attention from historians of medicine, economics or the theatre. Women, Medicine and Theatre also recovers women’s roles in the economy of the itinerant quack stage. Women associated with mountebank troupes were medically and theatrically active at every level from major stage celebrities to humble urine sample collectors, but also included sedentary relatives, non-performing assistants, door- and bookkeepers, wardrobe mistresses, prop and costume loaners, landladies, spectators, patrons and clients. Katritzky’s study of the whole range of women who supported the troupes contextualizes the activities of their male counterparts, and rehabilitates a broad spectrum of diversely occupied women. The strength of this title’s research method lies in its comparative examination of documents that are generally examined from the point of view of either their performative or their medical aspects, by historians of, respectively, the theatre and medicine. Taken as a whole, these handbills, literary descriptions a
Buena Pregunta... ¿Qué necesito para acampar? ¿Cuánto debo cargar? ¿Cómo puedo hornear en el campo? Considerar toda clase de información durante la planeación, invariablemente nos llevará a un viaje exitoso y placentero, lleno de aventuras para recordar el resto de la vida. Si nuestra excursión o campamento nos lleva al aire libre, a la naturaleza, resulta importante saber sobre técnicas de marcha, acampado, el equipo que hay que llevar y las técnicas para hacer fuego y poder cocinar. La preparación adecuada es una valiosa ayuda para cualquiera que desee iniciar una aventura fuera de su hogar. Las autoras iniciaron una amplia investigación para recopilar información que pudiera sacar de apuros a todo amante de la vida al aire libre. Quien finalmente aclare todas sus dudas, conocerá el significado de BP. Las autoras, mexicanas de nacimiento, son entusiastas campistas y amantes de la vida al aire libre. Se han dedicado al entrenamiento de jóvenes por medio de técnicas de supervivencia y liderazgo, con el fin de contribuir a su educación para asumir su rol en una sociedad cambiante y cada vez más demandante. La vida en el campo forja el carácter, lo que hace estos temas más actuales que nunca.
This monograph is devoted to a new method of parallel computing which uses VLSI technology in an effcient manner. By this method, data are fed to the cells of a systolic processor and results are obtained instantly. Some theoretical and algorithmic questions which arise in the design of hardware and software for systolic processing are considered. Special attention is devoted to the complexity of VLSI, complexity of algorithms, parallel algorithms, relations between graphs of algorithms and graphs of processors, parallel programming languages, and the use of systolic algorithms for vector programming. The book is unique for its inclusion of a library of systolic algorithms for solving problems from twelve branches of computer science, and will be useful for designers of hardware and software for parallel processing.
A constructive evaluation of the most significant developments in liquid chromatography-mass spectrometry (LC-MS) and its uses for quantitative bioanalysis and characterization for a diverse range of disciplines, Liquid Chromatography-Mass Spectrometry, Third Edition offers a well-rounded coverage of the latest technological developments and
Part of the extraordinary multi-volume portrait of ancient China written by a court official of the Han Dynasty. The Grand Scribe’s Records, Volume XI presents the final nine memoirs of Ssu-ma Ch’ien’s history, continuing the series of collective biographies with seven more prosopographies on the ruthless officials, the wandering gallants, the artful favorites, those who discern auspicious days, turtle and stalk diviners, and those whose goods increase, punctuated by the final account of Emperor Wu’s wars against neighboring peoples and concluded with Ssu-ma Ch’ien’s postface containing a history of his family and himself. Praise for the series: “[An] indispensable addition to modern sinology.” —China Review International “The English translation has been done meticulously.” —Choice
WHAT IS EPIGENETICS? Epigenetics is an emerging field of science that studies alterations in gene expression caused by factors other than changes in the DNA sequence. Epigenetics: The Death of the Genetic Theory of Disease Transmission is the result of decades of research and its findings that could be as critical to our understanding of human health as Pasteur’s research in bacteriology. Dr. Joel “Doc” Wallach has dedicated his life work to identifying connections between certain nutritional deficiencies and a range of maladies, formerly thought to be hereditary, including Cystic Fibrosis and Muscular Dystrophy. This nexus between nutrition and so-called genetic disease has been observed in both humans and primates, and it is the central theme of Epigenetics. To bring us Epigenetics, Wallach has teamed with noted scholars Dr. Ma Lan and Dr. Gerhard N. Schrauzer. Their collective expertise gives this book its far reaching perspective. Epigenetics is of vital importance to anyone who wants real knowledge about how the human body functions, and it provides a path for better health. Epigentics dispels the dogma and misinformation propagated by medical institutions and doctors resistant to change. Epigenetics is the beginning of a new era of well-being on this planet.
This edited volume on Microbial Diversity includes the chapters on different aspects of microbial diversity, its exploration and exploitation. The contents are broadly categorized into two parts. Part-A includes 25 review articles on diverse aspects of microbial diversity and its applications, contributed by subject experts working in their respective areas. These areas include biotechnology, environment, agriculture, food, public health and nanotechnology. These review articles bring out update information available on selected topics and point out the gaps in our knowledge and further project future lines of research. Part-B includes original research papers on contemporary research areas contributed by active researchers. This book caters the long left needs of university teachers, researchers, students, and industrial entrepreneurs.
Green Energy: A Sustainable Future looks at life cycle assessment theory, practice, and methodologies applied in renewable energy power plants. The state-of-the-art life cycle assessment methodologies applied in power generation units are discussed following LCA analysis and key findings from energy production processes. Providing fundamental knowledge of how to measure sustainability metrics using life cycle assessment in renewable power plants, this title outlines state-of-the-art research about LCA methodologies related to low-carbon energy systems, their outcome, and how to relate the sustainable power concept with a circular economy. With theoretical concepts of LCA applied in low-carbon power generation systems, outlining environmental impacts based on comprehensive examples and case studies in solar PV, solar thermal, hydropower plants and micro-grids, this book is of great interest to engineers, policy makers, researchers and academics in the area of electric power engineering. - Consists of extensive and comprehensive life-cycle assessment examples and case studies for various renewable energy plants - Enables power engineers to evaluate the sustainability index through environmental impact assessment in renewable power plants and micro-grids - Includes assessment results showing future pathways for sustainability enhancement
READ "TOXIC TEETH" TO LEARN SECRETS ABOUT TOXIC TEETH unknown to most people, including most dentists. Sneaky and often silent, many dental issues may go undiagnosed for years, if ever. Mercury and other toxic heavy metals used in fillings, crowns, bridges, partials, dentures, and implants continually seep into every cell in our bodies creating heavy metal poisoning that triggers disease. Whether or not we know it, over half of us harbor gum infections. If we have ever had teeth extracted, it is quite likely that cesspools of infection (cavitations) bubble deep within our jawbones. Root canal teeth seed nasty infections, causing untold suffering. Dental infections spread into our brains, hearts, and other organs, leading to many kinds of diseases, such as heart disease, cancer, autoimmune diseases (allergies, asthma, thyroid problems), and facial pain. Prevent problems with your teeth and gums before they ever happen and reverse problems that you may already be experiencing.
We are experiencing major health crises in America today. Obesity, chronic illnesses, illicit drug use, mental health issues, sexually transmitted infections, and the abuse of alcohol are all on the rise. These public health issues are killing Americans every day, not to mention greatly affecting their quality of life. Christians are hurting physically, mentally, and spiritually and desperately searching for answers. There is a great disconnect among professing Christians, regarding how a lack of obedience can greatly impact oneaEUR(tm)s health. The Bible serves not only to teach us but protect us. Did you know that GodaEUR(tm)s word is the ultimate vaccine to many of these health problems? In between the front and back cover of our Bibles, lies the great truths that prevent a great number of these issues. Obedience to GodaEUR(tm)s word is protection from the enemy. The intent of this book is to reveal how a lack of obedience will lead to negative and preventable health consequences. The Bible and our health are connected. There are answers to the different health crises we face today, in GodaEUR(tm)s Holy Word. In order to create future healthy generations, we must educate ourselves and our children on these issues. LetaEUR(tm)s explore some of them together.
Enter the matrix of the Taormina community, and meet the exceptional individuals who have been responsible for Taormina's evolution and continuation.Find out about the extraordinary artists, scientists, musicians, writers, poets, environmentalists, and spiritual leaders who have lived there.You will discover how the community was formed and why. From the specially chosen architectural style to the legal proceedings that changed the course of its destiny, nothing is left unexamined and unconnected.-----"Helene Vachet presents an intriguing story of a small section of the Ojai Valley. While most writers concentrate on the charm and beauty of our valley, few think to preserve the historical aspects. In this book you will learn about the fascinating history of Ojai's Taormina Community and its connections to Ojai and the world beyond." --David Mason, past chairman of the County of Ventura Cultural Heritage Board, the City of Ojai's Historic Preservation Commission.
Symposium of the Working Groups for Succession research on permanent plots, and Data-processing in phytosociology of the International Society for Vegetation Science, held at Montpellier, France, September 1980
Symposium of the Working Groups for Succession research on permanent plots, and Data-processing in phytosociology of the International Society for Vegetation Science, held at Montpellier, France, September 1980
Symposium of the Working Group for Succession Research on Permanent Plots, and Data-Processing of the International Society for Vegetation Sciences, Held at Montpellier, France, September 1980
Offers the most current, evidence-based information for helping specific populations affected by disasters Vulnerable populations such as children, older adults, and people with disabilities are disproportionately affected by large-scale disasters. This hands-on resource for students and professionals in social work, counseling, nursing, and mental health encompasses the best and most current evidence-based interventions for effectively responding to the needs of vulnerable populations following disasters. Using an all-hazards perspective, the book also provides a dedicated section containing population-specific personal preparedness considerations and discusses the role of preparedness in mitigating negative consequences. The resource is unique in its provision of vital information for locating requisite assessment tools, preparedness checklists, and forms. It also provides a list of mobile applications offered through national organizations. The resource addresses the specific psychosocial needs of vulnerable populations after a disaster. It delivers best practices for crisis intervention with specific populations including children, older adults, people with disabilities, people with mental health issues, and people with substance abuse issues. The authors present a theoretical foundation for understanding disasters, response systems, common guidelines for preparedness, and basic crisis theory. This is a resource that will be valuable not only to practitioners in a great variety of health disciplines, but also to volunteer professionals and paraprofessionals involved in disaster preparedness and response. Case vignettes are included in each chapter to illustrate issues particular to each population Key Features: Offers the highest quality, best available evidence for choosing appropriate interventions Focuses on vulnerable populations including children, older adults, and people with disabilities, mental health issues and substance abuse issues Comprises a practical, hands-on manual for mental health and medical professionals and volunteers regarding disaster preparedness and response Provides assessment tools and preparedness checklists and forms Includes case vignettes to illustrate issues specific to each population
Dynamics and Advanced Motion Control of Unmanned Ground Off-Road Vehicles details both theoretical concepts such as planning and perception when working with UGVs, as well as more practical, hands-on aspects such as torque vectoring control. The book also covers related technologies such as intelligent and electrification of ground vehicles. After an introduction, initial chapters include an exploration of wheel-soil and track-soil interaction mechanisms, motion stability, motion control, fault detection and identification, and fault tolerance control. This book offers readers a detailed understanding of Unmanned Ground Vehicles by combining theory, applications and further developments. Topics are covered in such a way that readers will be well versed on the current field of UGVs and will be able to implement future design and research in a feasible and effective way. - Gives a comprehensive analysis and introduction to the dynamics and advanced motion control of unmanned ground off-road vehicles - Covers key related technology concepts, such as intelligent and electrification of ground vehicles - Details the entire control framework of off-road UGVs and the implementation of controller design
DID YOU KNOW THAT: - Low testosterone can kill you? Yes, it's true (Circulation, Dec 2007)! - Low testosterone doesn't just happen to older men? Testosterone is dropping in ALL men (on average), all over the world, even YOUNG men! - Most doctors will NOT treat men with moderately-low testosterone? IMAGINE IF YOU COULD: - Live longer with decreased risk for heart disease, cancer, and even accidents! - Maximize your testosterone no matter what your age! - Find a doctor who can recognize and treat ALL testosterone disorders! YOU DON'T HAVE TO IMAGINE IT! This fascinating book shares the real-life success stories of men of all ages who suffered from low testosterone for years before they finally consulted Dr. Joe Swartz. Dr. Joe asked the right questions, listened, and got the right tests before arriving at a treatment plan that worked to address the different causes of each man's low testosterone. After maximizing their testosterone, each of these men had improved health, energy, and sexuality.
Provides comprehensive coverage of the interpretation of LC–MS–MS mass spectra of 1300 drugs and pesticides Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes This is the reference book for the interpretation of MS–MS mass spectra of small organic molecules Covers related therapeutic classes of compounds such as drugs for cardiovascular diseases, psychotropic compounds, drugs of abuse and designer drugs, antimicrobials, among many others Covers general fragmentation rule as well as specific fragmentation pathways for many chemical functional groups Gives an introduction to MS technology, mass spectral terminology, information contained in mass spectra, and to the identification strategies used for different types of unknowns
CHOICE Award WinnerTransport and transformation processes are key for determining how humans and other organisms are exposed to chemicals. These processes are largely controlled by the chemicals' physical-chemical properties. This new edition of the Handbook of Physical-Chemical Properties and Environmental Fate for Organic Chemicals is a comprehen
This book is concerned with the configuration of polymers at the interfacial zone between two other phases or immiscible components. In recent years, developments in technology combined with increased attention from specialists in a wide range of fields have resulted in a considerable increase in our understanding of the behavior of polymers at interfaces. Inevitably these advances have generated a wealth of literature and although there have been numerous reviews, a critical treatment with adequate descriptions of both theory and experiment, including detailed analysis of the two, has been missing. This text hopes to fill this gap, providing a timely and comprehensive account of the field as it stands today. This long needed work will be invaluable to experts as well as newcomers in the broad field of polymers, interfaces and colloids, both in industry and academia. Whilst industrial laboratories involved in this field will find it indispensable, it will be equally important to anyone with an interest in interfacial polymer or colloidal research.
Life Cycle Assessment for Sustainable Mining addresses sustainable mining issues based on life cycle assessment, providing a thorough guide to implementing LCAs using sustainability metrics. The book details current research on LCA methodologies related to mining, their outcomes, and how to relate sustainable mining concepts in a circular economy. It is an in-depth, foundational reference for developing ideas for technological advancement through designing reduced-emission mining equipment or processes. It includes literature reviews and theoretical concepts of life cycle assessments applied in mining industries, sustainability metrics and problems related to mining and mineral processing industries identified by the life cycle assessment results. This book will aid researchers, students and academics in the field of environmental science, mining engineering and sustainability to see LCA technology outcomes which would be useful for the future development of environmentally-friendly mining processes. - Details state-of-the-art life cycle assessment theory and practices applied in the mining and mineral processing industries - Includes in-depth, practical case studies outlined with life cycle assessment results to show future pathways for sustainability enhancement - Provides fundamental knowledge on how to measure sustainability metrics using life cycle assessment in mining industries
Cholesterol is a soft, waxy substance found among the lipids (fats) in the bloodstream and in all the body's cells. It's an important part of a healthy body because it's used to form cell membranes, some hormones and is needed for other functions. But a high level of cholesterol in the blood -- hypercholesterolemia -- is a major risk factor for coronary heart disease, which leads to heart attack. Cholesterol and other fats can't dissolve in the blood. They have to be transported to and from the cells by special carriers called lipoproteins. There are several kinds, but the key ones are low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Low-density lipoprotein is the major cholesterol carrier in the blood. If too much LDL cholesterol circulates in the blood, it can slowly build up in the walls of the arteries feeding the heart and brain. Together with other substances it can form plaque, a thick, hard deposit that can clog those arteries. This field is alive with exciting new research in all areas including frontal advances in the areas of managing cholesterol as well as cholesterol lowering drugs.
Robert’s therapeutic autobiography begins with his experience as a child flying out of the window in a car accident and ends with the pandemic twilight zone of COVID-19. He uses his background in psychology to examine projection errors of the mind that have plagued mankind for centuries. What is unique is that Robert uses examples from his own life, re-enacting events using therapeutic techniques, providing the reader insight into the secret of life’s stories. While the book could be used as a college text, it is written for multi age and education levels. As Robert moves from his first formative experience to his later life as a teacher, counselor, and Psychodramatist, he introduces the reader to important psychological concepts. Robert’s book is part memoir and psychological guide. The Secret in the Story is written as a sequel to the Story has a Secret. Robert shows you how to apply the same therapeutic perspective to your own life and to examine memories, turning them into your memoires, that can lead you to a more fulfilling life.
Many dynamical systems in physics, chemistry and biology exhibit complex be haviour. The apparently random motion of a fluid is the best known example. How ever also vibrating structures, electronic oscillators, magnetic devices,lasers, chemical oscillators, and population kinetics can behave in a complicated manner. One can find irregular oscillations, which is now known as chaotic behaviour. The research field of nonlinear dynamical systems and especially the study of chaotic systems has been hailed as one of the important breaktroughs in science this century. The sim plest realization of a system with chaotic behaviour is an electronic oscillator. The purpose of this book is to provide a comprehensive introduction to the application of chaos theory to electronic systems. The book provides both the theoretical and experimental foundations of this research field. Each electronic circuit is described in detail together with its mathematical model. Controlling chaos of electronic oscilla tors is also included. End of proofs and examples are indicated by •. Inside examples the end of proofs are indicated with O. We wish to express our gratitude to Catharine Thompson for a critical reading of the manuscript. Any useful suggestions and comments are welcome. Email address of the first author: MVANWYK@TSAMAIL. TRSA. AC. ZA Email address of the first author: WHS@RAU3. RAU. AC. ZA Home page of the authors: http://zeus. rau. ac. za/steeb/steeb. html xi Chapter 1 Introduction 1.
This book offers a comprehensive introduction to the developmental history and structural framework of Chinese competition law from a law and economics perspective. It examines the philosophical foundations, the substantive law, and enforcement issues concerning competition law and policy in China by pursuing an economic and comparative approach. Further, the book presents and analyzes competition cases involving monopolistic agreements, abuse of dominant position, and concentration. The book will help professionals and business practitioners to understand the distinct features of competition law and policy in China, and how the substance and enforcement of the law can be compared with competition regulations in the US and EU from an economic perspective. Given its scope, it offers a valuable guide for academic, public sector and professional audiences alike, and will appeal to researchers, students and anyone with an interest in economic law and policy in China. The book can also be used as reading material to accompany courses such as China’s Competition Law and Policy, Comparative Competition Law, and Market Regulation in China for foreign students studying Chinese law and policy at the undergraduate, graduate and doctoral levels.
A remarkable document of ancient Chinese history: “[An] indispensable addition to modern sinology.” —China Review International This volume of The Grand Scribe’s Records includes the second segment of Han-dynasty memoirs and deals primarily with men who lived and served under Emperor Wu (r. 141–87 B.C.). The lead chapter presents a parallel biography of two ancient physicians, Pien Ch’üeh and Ts’ang Kung, providing a transition between the founding of the Han dynasty and its heyday under Wu. The account of Liu P’i is framed by the great rebellion he led in 154 B.C. and the remaining chapters trace the careers of court favorites, depict the tribulations of an ill-fated general, discuss the Han’s greatest enemy, the Hsiung-nu, and provide accounts of two great generals who fought them. The final memoir is structured around memorials by two strategists who attempted to lead Emperor Wu into negotiations with the Hsiung-nu, a policy that Ssu-ma Ch’ien himself supported.
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