Important Notice: The digital edition of this book is missing some of the images or content found in the physical edition.The gold standard for midwives and students is back with Varney’s Midwifery, Fifth Edition. New to this edition are chapters describing the profession of midwifery, reproductive physiology, clinical genetics, and support for women in labor. Interwoven throughout is information on primary care, gynecology, maternity care, and neonatal care. With chapters written by a variety of expert midwives and an increased emphasis on reproductive anatomy and physiology, this new edition assists students and clinicians in understanding not only what to do but why. Updated to reflect evidence-based care, this edition also discusses the pathophysiology of various conditions in the context of normal changes in the reproductive cycle. Also included are numerous new anatomical and clinical illustrations.
The new edition of the most detailed and comprehensive single-volume reference on major semiconductor devices The Fourth Edition of Physics of Semiconductor Devices remains the standard reference work on the fundamental physics and operational characteristics of all major bipolar, unipolar, special microwave, and optoelectronic devices. This fully updated and expanded edition includes approximately 1,000 references to original research papers and review articles, more than 650 high-quality technical illustrations, and over two dozen tables of material parameters. Divided into five parts, the text first provides a summary of semiconductor properties, covering energy band, carrier concentration, and transport properties. The second part surveys the basic building blocks of semiconductor devices, including p-n junctions, metal-semiconductor contacts, and metal-insulator-semiconductor (MIS) capacitors. Part III examines bipolar transistors, MOSFETs (MOS field-effect transistors), and other field-effect transistors such as JFETs (junction field-effect-transistors) and MESFETs (metal-semiconductor field-effect transistors). Part IV focuses on negative-resistance and power devices. The book concludes with coverage of photonic devices and sensors, including light-emitting diodes (LEDs), solar cells, and various photodetectors and semiconductor sensors. This classic volume, the standard textbook and reference in the field of semiconductor devices: Provides the practical foundation necessary for understanding the devices currently in use and evaluating the performance and limitations of future devices Offers completely updated and revised information that reflects advances in device concepts, performance, and application Features discussions of topics of contemporary interest, such as applications of photonic devices that convert optical energy to electric energy Includes numerous problem sets, real-world examples, tables, figures, and illustrations; several useful appendices; and a detailed solutions manual Explores new work on leading-edge technologies such as MODFETs, resonant-tunneling diodes, quantum-cascade lasers, single-electron transistors, real-space-transfer devices, and MOS-controlled thyristors Physics of Semiconductor Devices, Fourth Edition is an indispensable resource for design engineers, research scientists, industrial and electronics engineering managers, and graduate students in the field.
The Latest Applications For Cellmechanism Research in Drug Discovery Designed to connect research on cell mechanisms with the drug discovery process, Therapeutic Targets: Modulation, Inhibition, and Activation introduces readers to a range of new concepts and novel approaches to drug screening and therapeutic drug targeting to help inform future avenues of drug research. Highly topical, this accessible edited volume features chapters contributed by respected experts from around the globe. The book helps postgraduate students and professional scientists working in academia and industry understand the molecular mechanisms of pharmacology, current pharmacological knowledge, and future perspectives in drug discovery, focusing on important biochemical protein targets and drug targeting strategies for specific diseases. Examining the pharmacology of therapeutically undefined targets and their potential applications, it includes chapters on traditional therapeutic targets, including enzymes (phosphodiesterases and proteases), ion channels, and G protein-coupled receptors, as well as more recently identified avenues of exploration, such as lipids, nuclear receptors, gene promoters, and more. Since different diseases require different targeting techniques, the book also includes dedicated chapters on strategies for investigating Alzheimer's, diabetes, pain, and inflammation treatments. Concluding with a cross-sectional look at new approaches in drug screening, Therapeutic Targets is an invaluable resource for understanding where the next generation of drugs are likely to emerge.
This book adopts a detailed and methodological algorithmic approach to explain the concepts of pattern recognition. While the text provides a systematic account of its major topics such as pattern representation and nearest neighbour based classifiers, current topics — neural networks, support vector machines and decision trees — attributed to the recent vast progress in this field are also dealt with. Introduction to Pattern Recognition and Machine Learning will equip readers, especially senior computer science undergraduates, with a deeper understanding of the subject matter.
Thoroughly revised to reflect new advances in the field, Savage & Aronson’s Comprehensive Textbook of Perioperative and Critical Care Echocardiography, Third Edition, remains the definitive text and reference on transesophageal echocardiography (TEE). Edited by Drs. Alina Nicoara, Robert M. Savage, Nikolaos J. Skubas, Stanton K. Shernan, and Christopher A. Troianos, this authoritative reference covers material relevant for daily clinical practice in operating rooms and procedural areas, preparation for certification examinations, use of echocardiography in the critical care setting, and advanced applications relevant to current certification and practice guidelines.
A concise introduction to the chemistry and design principles behind important metal-organic frameworks and related porous materials Reticular chemistry has been applied to synthesize new classes of porous materials that are successfully used for myraid applications in areas such as gas separation, catalysis, energy, and electronics. Introduction to Reticular Chemistry gives an unique overview of the principles of the chemistry behind metal-organic frameworks (MOFs), covalent organic frameworks (COFs), and zeolitic imidazolate frameworks (ZIFs). Written by one of the pioneers in the field, this book covers all important aspects of reticular chemistry, including design and synthesis, properties and characterization, as well as current and future applications Designed to be an accessible resource, the book is written in an easy-to-understand style. It includes an extensive bibliography, and offers figures and videos of crystal structures that are available as an electronic supplement. Introduction to Reticular Chemistry: -Describes the underlying principles and design elements for the synthesis of important metal-organic frameworks (MOFs) and related materials -Discusses both real-life and future applications in various fields, such as clean energy and water adsorption -Offers all graphic material on a companion website -Provides first-hand knowledge by Omar Yaghi, one of the pioneers in the field, and his team. Aimed at graduate students in chemistry, structural chemists, inorganic chemists, organic chemists, catalytic chemists, and others, Introduction to Reticular Chemistry is a groundbreaking book that explores the chemistry principles and applications of MOFs, COFs, and ZIFs.
Tremendous progress has been made in the last few years in the growth, doping and processing technologies of the wide bandgap semiconductors. As a result, this class of materials now holds significant promis for semiconductor electronics in a broad range of applications. The principal driver for the current revival of interest in III-V Nitrides is their potential use in high power, high temperature, high frequency and optical devices resistant to radiation damage. This book provides a wide number of optoelectronic applications of III-V nitrides and covers the entire process from growth to devices and applications making it essential reading for those working in the semiconductors or microelectronics. Broad review of optoelectronic applications of III-V nitrides
Inside the 3rd edition of this esteemed masterwork, hundreds of the most distinguished authorities from around the world provide today's best answers to every question that arises in your practice. They deliver in-depth guidance on new diagnostic approaches, operative technique, and treatment option, as well as cogent explanations of every new scientific concept and its clinical importance. With its new streamlined, more user-friendly, full-color format, this 3rd edition makes reference much faster, easier, and more versatile. More than ever, it's the source you need to efficiently and confidently overcome any clinical challenge you may face. Comprehensive, authoritative, and richly illustrated coverage of every scientific and clinical principle in ophthalmology ensures that you will always be able to find the guidance you need to diagnose and manage your patients' ocular problems and meet today's standards of care. Updates include completely new sections on "Refractive Surgery" and "Ethics and Professionalism"... an updated and expanded "Geneitcs" section... an updated "Retina" section featuring OCT imaging and new drug therapies for macular degeneration... and many other important new developments that affect your patient care. A streamlined format and a new, more user-friendly full-color design - with many at-a-glance summary tables, algorithms, boxes, diagrams, and thousands of phenomenal color illustrations - allows you to locate the assistance you need more rapidly than ever.
Poverty, inequality, and dispossession accompany economic globalization. Bringing together three international law scholars, this book addresses how international law and its regimes of trade, investment, finance, as well as human rights, are implicated in the construction of misery, and how international law is producing, reproducing, and embedding injustice and narrowing the alternatives that might really serve humanity. Adopting a pluralist approach, the authors confront the unconscionable dimensions of the global economic order, the false premises upon which they are built, and the role of international law in constituting and sustaining them. Combining insights from radical critiques, political philosophy, history, and critical development studies, the book explores the pathologies at work in international economic law today. International law must abide by the requirements of justice if it is to make a call for compliance with it, but this work claims it drastically fails do so. In a legal order structured around neoliberal ideologies rather than principles of justice, every state can and does grab what it can in the economic sphere on the basis of power and interest, legally so and under colour of law. This book examines how international law on trade and foreign investment and the law and norms on global finance has been shaped to benefit the rich and powerful at the expense of others. It studies how a set of principles, in the form of a New International Economic Order (NIEO), that could have laid the groundwork for a more inclusive international law without even disrupting its market-orientation, were nonetheless undermined. As for international human rights law, it is under the terms of global capitalism that human rights operate. Before we can understand how human rights can create more just societies, we must first expose the ways in which they reflect capitalist society and how they assist in reproducing the underlying terms of immiseration that will continue to create the need for human rights protection. This book challenges conventional justifications of economic globalization and eschews false choices. It is not about whether one is "for" or "against" international trade, foreign investment, or global finance. The issue is to resolve how, if we are to engage in trade, investment, and finance, we do so in a manner that is accountable to persons whose lives are affected by international law. The deployment of human rights for their part must be considered against the ubiquity of neoliberal globalization under law, and not merely as a discrete, benevolent response to it.
A state-of-the-art, multidisciplinary approach to cancer and aging With the majority of cancers occurring in individuals over the age of 65 against a backdrop of an expanding aging population, there is an urgent need to integrate the areas of clinical oncology and geriatric care. This timely work tackles these issues head-on, presenting a truly multidisciplinary and international perspective on cancer and aging from world-renowned experts in geriatrics, oncology, behavioral science, psychology, gerontology, and public health. Unlike other books on geriatric oncology that focus mainly on treatment, Cancer and Aging Handbook: Research and Practice examines all phases of the cancer care continuum, from prevention through evidence-based diagnosis and treatment to end-of-life care. Detailed clinical and research information helps guide readers on effective patient care as well as caregiver training, research, and intervention. Coverage includes: Epidemiology of cancer in older adults, plus the unique physical, mental, and social issues involved Strategies and guidelines for prevention, screening, and treatment of older individuals with cancer The most common cancers in the elderly, including breast, colorectal, lung, prostate, and ovarian cancer Cancer survivorship in older adults as well as the all-critical issues of palliative care and pain management Emerging topics such as caregiver and family issues, different models of care, and cost considerations An essential resource for clinicians and caregivers as well as researchers interested in this evolving field, Cancer and Aging Handbook is also useful for public health professionals and policymakers who need to formulate services and allocate resources for the growing population of older cancer patients.
India today looms large globally, where it hardly loomed at all twenty years ago. It is likely to be a key global actor throughout the twenty-first century and could well emerge soon as one of the top five global powers. Does the Elephant Dance? seeks to survey the main features of Indian foreign policy. It identifies elements of Indian history relevant to the topic; examines the role therein of domestic politics and internal and external security challenges, and of domestic and international economic factors; and in successive chapters delves into the specifics of India's policy within its South Asian neighbourhood, and with respect to China, the USA, West Asia (the Middle East), East Asia, Europe and Russia, and multilateral diplomacy. It also touches on Indian ties to Africa and Latin America and the Caribbean. India's "soft power", the role of migration in its policy, and other cross-cutting issues are analyzed, as is the role and approach of several categories of foreign policy actors in India. Substantive conclusions close out the volume, and touch, inter alia, on the absence of an organizing framework for Indian foreign policy.
The purpose of our present work is to review the fundamental studies on inhibition of soil urease activity and the applied studies on improving efficiency of urea fertilizers by inhibition of soil urease activity. The general literature on these topics covers 65 years, and the patent literature comprises a period of nearly 40 years. Studies related to inhibition of soil urease activity were performed in a great number of countries' well representing all the continents. Full texts of the papers describing these studies were published in one of 18 languages·'. The literature data reviewed are structured into 10 chapters, 81 subchapters, and 224 sections. The bibliographical list consists of 830 papers cited. ·In alphabetical order: Argentina, Armenia, Australia, Austria, Belgium, Belorussia, Brazil. Bulgaria, Canada, China, Costa Rica, Cuba. Czech RepUblic, Egypt, Estonia, France, Georgia (Gruzia), Germany, Hungary, India, Iraq, Ireland, Israel, Italy. Japan, Kazakhstan, Lithuania, Malaysia, Moldova, Netherlands, New Zealand, Pakistan, Philippines, Poland, Romania, Russia, Saudi Arabia, Slovakia, South Africa, South Korea, Spain, Sri Lanka. Sudan, Sweden, Thailand, Turkey, Ukraine, United Kingdom, United States of America. Uzbekistan .
Clinical Anesthesia, Seventh Edition covers the full spectrum of clinical options, providing insightful coverage of pharmacology, physiology, co-existing diseases, and surgical procedures. This classic book is unmatched for its clarity and depth of coverage. *This version does not support the video and update content that is included with the print edition. Key Features: • Formatted to comply with Kindle specifications for easy reading • Comprehensive and heavily illustrated • Full color throughout • Key Points begin each chapter and are labeled throughout the chapter where they are discussed at length • Key References are highlighted • Written and edited by acknowledged leaders in the field • New chapter on Anesthesia for Laparoscopic and Robotic Surgery Whether you’re brushing up on the basics, or preparing for a complicated case, the digital version will let you take the content wherever you go.
N-Sulfonated-N-Heterocycles covers the synthesis, chemistry and biological applications of these compounds, focusing on pioneering synthetic approaches, mechanistic insights and their limitations, as well as recent advances in this field. The synthesis of some of N-sulfonated N-heterocycles and their transformation to other useful cyclic and acyclic compounds are discussed, as well as their uses as useful intermediates in the preparation of polymeric and medicinal materials. This book includes detailed methods and protocols, and the focus on applications makes this resource an essential guide for all researchers in the area of organic, medicinal and polymeric synthetic study. - Reviews the use of N-sulfonated N-heterocycles as important precursors for the synthesis of biologically active compounds - Includes information on synthetically useful transformations of N-sulfonated N-heterocycles - Covers a wide synthetic methods used for an important branch of heterocycles and their biological evaluation in detail - Features over 500 schemes to illustrate different synthetic pathways and reactions of N-sulfonated N-heterocycles
With the growing age of the population, the proportion of elderly patients with diffuse coronary artery disease and severe comorbidities is increasing. The characteristics of these patients render them unsuitable for currently recognized revascularization procedures (CABG, PTCA). Therefore, there is an urgent need for new treatment modalities which could alleviate their symptoms and increase blood flow to the ischemic myocardium, while being less invasive for their fragile condition. The aim of this book is to provide an anatomical and physiological background as well as a complete review of the alternative methods of revascularization which are under development, namely transmyocardial laser revascularization, therapeutic angiogenesis and neurostimulation.
The seventh edition of this classic text outlines the fundamental physical principles of thermal radiation, as well as analytical and numerical techniques for quantifying radiative transfer between surfaces and within participating media. The textbook includes newly expanded sections on surface properties, electromagnetic theory, scattering and absorption of particles, and near-field radiative transfer, and emphasizes the broader connections to thermodynamic principles. Sections on inverse analysis and Monte Carlo methods have been enhanced and updated to reflect current research developments, along with new material on manufacturing, renewable energy, climate change, building energy efficiency, and biomedical applications. Features: Offers full treatment of radiative transfer and radiation exchange in enclosures. Covers properties of surfaces and gaseous media, and radiative transfer equation development and solutions. Includes expanded coverage of inverse methods, electromagnetic theory, Monte Carlo methods, and scattering and absorption by particles. Features expanded coverage of near-field radiative transfer theory and applications. Discusses electromagnetic wave theory and how it is applied to thermal radiation transfer. This textbook is ideal for Professors and students involved in first-year or advanced graduate courses/modules in Radiative Heat Transfer in engineering programs. In addition, professional engineers, scientists and researchers working in heat transfer, energy engineering, aerospace and nuclear technology will find this an invaluable professional resource. Over 350 surface configuration factors are available online, many with online calculation capability. Online appendices provide information on related areas such as combustion, radiation in porous media, numerical methods, and biographies of important figures in the history of the field. A Solutions Manual is available for instructors adopting the text.
Medicinal plant cultivation has received an impetus in the recent years due to revival of interest in herbal medicines necessitating authoritative information on cultivation and utilization of this valuable flora. The book on Medicinal Plants includes information on current status of medicinal plants, their phytochemistry, quality control, good agricultural practices and good manufacturing practices in medicinal plants and information on commercially grown medicinal plants and those important in trade. Details on botany, crop improvement, crop protection, crop production, post harvest handling, chemical composition, chemical analyses and uses of commercially grown crops are also included. The book which is a systematic compilation of available information on promising 65 medicinal species helps in providing specific information on the cultivation and utilization of these crops to farmers, academicians, students and related user industries. This documented information also serves to give an insight to the major research lacunae and formulate appropriate research strategies in these crops.
This book provides multifaceted components and full practical perspectives of systems engineering and risk management in security and defense operations with a focus on infrastructure and manpower control systems, missile design, space technology, satellites, intercontinental ballistic missiles, and space security. While there are many existing selections of systems engineering and risk management textbooks, there is no existing work that connects systems engineering and risk management concepts to solidify its usability in the entire security and defense actions. With this book Dr. Anna M. Doro-on rectifies the current imbalance. She provides a comprehensive overview of systems engineering and risk management before moving to deeper practical engineering principles integrated with newly developed concepts and examples based on industry and government methodologies. The chapters also cover related points including design principles for defeating and deactivating improvised explosive devices and land mines and security measures against kinds of threats. The book is designed for systems engineers in practice, political risk professionals, managers, policy makers, engineers in other engineering fields, scientists, decision makers in industry and government and to serve as a reference work in systems engineering and risk management courses with focus on security and defense operations.
Networks are ubiquitous in science and have become a focal point for discussion in everyday life. Formal statistical models for the analysis of network data have emerged as a major topic of interest in diverse areas of study, and most of these involve a form of graphical representation. Probability models on graphs date back to 1959. Along with empirical studies in social psychology and sociology from the 1960s, these early works generated an active network community and a substantial literature in the 1970s. This effort moved into the statistical literature in the late 1970s and 1980s, and the past decade has seen a burgeoning network literature in statistical physics and computer science. The growth of the World Wide Web and the emergence of online networking communities such as Facebook, MySpace, and LinkedIn, and a host of more specialized professional network communities has intensified interest in the study of networks and network data. Our goal in this review is to provide the reader with an entry point to this burgeoning literature. We begin with an overview of the historical development of statistical network modeling and then we introduce a number of examples that have been studied in the network literature. Our subsequent discussion focuses on a number of prominent static and dynamic network models and their interconnections. We emphasize formal model descriptions, and pay special attention to the interpretation of parameters and their estimation. We end with a description of some open problems and challenges for machine learning and statistics.
In recent years, the use of bioconjugation as strategy for development of more specific and directed drugs has been widely researched. Tetrapyrrolic macrocycles are one of the most common families of organic compounds applied in medicinal chemistry, specifically for diagnosis and therapy. For optimization of their efficiency as therapeutic molecules, it is relevant to promote their linking to biomolecules capable of targeting altered cells. This work brings a new dimension to the literature by combining structural modification of biomolecules and polymers with pyrrole-based compounds. It will be of great interest to academicians, industrialists, and undergraduate and graduate students of chemistry, biosciences, and pharmacy since, as apart from the theoretical aspects, it discusses experimental components. Features: Discusses methods for protein modification Useful for academicians, industrialists and undergraduate and graduated students of chemistry, biosciences, and pharmacy Explains the synthesis of pyrrole-based molecules
Healing Plants of Nigeria: Ethnomedicine and Therapeutic Applications offers comprehensive information on the use of herbal medicines in West Africa. Combining an evidence-based, ethnobotanical perspective with a pharmacological and pharmaceutical approach to phytomedicine, the book bridges the gap between the study of herbal plants’ pharmacological properties and active compounds for the development of clinical drugs and community-oriented approaches, emphasising local use. It demonstrates how the framework of African traditional medicine can be preserved in a contemporary clinical context. The book outlines the history and beliefs surrounding the traditional use of herbs by the local population alongside their application in contemporary phytotherapy in Nigeria and West Africa. It features a critical assessment of the scientific rationale behind the use of these plants in ethnomedicine and offers a composite catalogue of phytotherapeutic and wellness agents, detailing the safety profile, efficacy, and scientific integrity of plants used to treat diseases and optimise health. Features: An ethnobotanical survey containing over 200 full-colour photographs of Nigerian and West African plants. A unique combination of ethnobotany and pharmacognosy, bridging the divide between pharmaceutical and community-oriented approaches to herbal medicine research. Contextual discussion of the therapeutic potential of Nigerian herbal medicine. Offers a template which can be used to separate the superstitious aspects of ethnomedicine from culturally inherited deposits of knowledge. A handbook for herbal and natural medicine practitioners, the book is aimed at African thinkers, scientists, healthcare providers and students of pharmacology and ethnomedicine.
Tap into the gold standard on central nervous system infections: Infections of the Central Nervous System, 4e is now fully revised and updated to accommodate the wealth of new CNS information discovered over the past decade. More than 90 leading experts contribute chapters, providing comprehensive, up-to-date information. With a broad scope and thorough detail, the text addresses pathogenesis, clinical manifestations, diagnosis, and therapy of various CNS infections and related conditions. Features: Every chapter has been extensively revised and updated, nearly half with new author teams NEW chapter on acute encephalitis NEW clinical information on treatment of tuberculosis, non-tubercular mycobacterial infections, brain abscess, and Lyme disease NEW color design and color images Numerous diagrams, figures, tables, illustrations and photographs demonstrate the content Evidence-based references
Histone deacetylase inhibitors (HDI) have been largely known for their ability to induce cell cycle arrest and apoptosis of tumor cells, effects that have translated into clinically significant antitumor activity against certain malignancies. In addition, there is now increasing evidence that HDIs are also endowed with immunoregulatory properties. Interestingly, while some reports have highlighted the anti-inflammatory effects of these compounds, others have shown pro-inflammatory effects triggered by HDIs in in vitro and in vivo studies. Known targets for HDIs are histone deacetylases (HDACs), enzymes that are recruited to gene promoters where they regulate transcription through histone modifications. Some HDACs, however, can also deacetylate nonhistone proteins, indicating that the role of HDACs in cell biology goes beyond their initial described effects on histones and encompasses now more complex regulatory functions. This complexity, along with the fact that most of the HDI currently in use are pan-HDI (multiple HDAC targets), might explain the divergent immunoregulatory effects of these compounds. Given this conundrum, in this chapter we have summarized the current understanding of the expression/function of specific HDACs in immune cells, knowledge that is providing important insights into their role in immunobiology and also paving the way for the development of more selective and potentially less toxic epigenetic-based approaches to effectively harness antitumor immune responses.
This Text Is An Attempt To Reconstruct The Bhakti Movement From The 8Th Century Tamil Nadu To The 16Th Century Punjab, In Its Totality, As A Connected Organic Phenomenon And As Perhaps The Earliest Indian Voice Of Deconstructive Modern Thought.
Natural Dyes : Scope and challenges is a comprehensive, thoroughly scientific, single source reference book on natural dye stuffs and dyeing. This book provides a detailed chemistry of all the available natural dyes and also of the food colors. Analytical methods including extraction, identification and estimation of the chemical components of these dyes, which will help in the production of quality dyes, are discussed. The applications of these dyes in pharmaceuticals, herbal cosmetics, paints and paintings also are explained. The challenges lying ahead due to the greater demand resulted from the ever-increasing acceptance and demand of these dyes and their solutions are discussed. Substitute sources, new chromophores, bioactivities including antioxidant potential and antimicrobial properties of the plant-derived dyes also are dovetailed. This book will serve as a reference book for students, teachers and workers of Textile dyeing, Textile chemistry, Clothing and textiles, Plant Sciences, Pharmacy and Fine Arts. It will also of great use for NGOs and farmers who would be interested in value-addition of their trees, commercial manufacturers of natural dyes and even to a layman interested in natural colors. D. Rathi
Surface Modification by Solid State Processing describes friction-based surfacing techniques for surface modification to improve resistance to corrosion and wear, also changing surface chemistry. Surface conditions are increasingly demanding in industrial applications and surface modification can reduce manufacturing and maintenance costs, leading to improved component performance, reliability and lifetime. Friction-based technologies are promising solid state processing technologies, particularly for light alloys, in the manufacturing of composite surface and functionally graded materials This title is divided into five chapters, and after an introduction the book covers friction surfacing; friction stir processing; surface reinforcements of light alloys; and characterization techniques based on eddy currents. - Describes friction-based surfacing techniques for surface modification to improve resistance to corrosion and wear, and change surface chemistry - Emphasizes industrial applications - Describes existing and emerging techniques
Chitosan, a natural based polymer obtained by alkaline deacetylation of chitin, is non-toxic, biocompatible, and biodegradable. These properties make chitosan a good candidate for the development of conventional and novel drug delivery systems. Recently, there has been a growing interest in the chemical modification of chitosan in order to improve its solubility and widen its applications. Chemical modification of chitosan is useful for the association of bioactive molecules to the polymer and controlling the drug release profile. Chemical modification will introduce desired properties and enlarge the field of the potential applications of chitosan with the choice of various types of side chains. In this monograph, recent studies on the various types of chitosan microspheres are discussed from the viewpoint of drug delivery applications. Moreover, different types of chitosan derivatives developed as controlled drug delivery carriers and their preparation methods are discussed in detail. The modifications discussed here include amphiphilic chitosan derivatives, N-(aminoalkyl) chitosan, carboxymethyl chitosan, thiolated chitosans, phosphorylated chitosan, etc. Special emphasis has been given to the development of chitosan-based polyelectrolyte complexes, graft copolymerized chitosan and chitosan-based stimuli-responsive hydrogels as drug delivery carriers. The reviewed studies lead to the conclusion that chitosan derivatives are promising materials for the controlled delivery of various types of therapeutic agents.
This volume is a scholarly reference to published research results on the neurobiology and neuroanatomy of depression and the association of depression with disorders of the central nervous system. The book reviews and discusses aspects of recent research on the underlying mechanisms of depression, including neurotransmitter dysregulation, hypothal
During the early 1930s, when I was a graduate student and later a post-doctoral researcher at the National Research Council for the University of Wisconsin at Madison, we had the opportunity to get acquainted with many graduate students from China who were sent to the University for training in modern basic sciences as well as social sciences. The University of Wisconsin continues to graduate a large number of Chinese students. Economic conditions in the 1930s were very precarious for the United States and other parts of the world. Many of us students grew closer together because we were living on similarly tight budgets. As a matter of fact, we subleased a part of our apartment in Madison to some Chinese graduate students. This was a very nice opportunity for us to learn about the scientific and cultural back ground of our Chinese friends. Many of them came from the interior of China and had had very little opportunity to become acquainted with people from a western culture. Living with these students was a very pleasant and educational experience which gave us a good pic ture of the cultural life and educational system of China at that time--an intimate picture that one normally would not see without travelling in that country.
This highly topical book comes at a time when the two-way relationship between humankind and the environment is moving inexorably to the top of the agenda. It covers both sides of this delicate balancing act, explaining how various natural processes influence humanity, including its economic activities and engineering structures, while also illuminating the ways in which human activity puts pressure on the natural environment. Chapters analyze a varied selection of phenomena that directly affect people’s lives, from geological processes such as earthquakes and tsunamis to cosmic events such as magnetic storms. The author moves on to consider the effect we have on nature, ranging from the impact of heavy industry to the environmental consequences of sport and recreational pastimes. Complete with maps, photographs and detailed case studies, this book provides a comprehensive overview of the biggest issue we face as a species—the way we relate to the natural world around us. This book includes more than 100 maps showing the global distribution of different natural processes/human activities and more that 450 photographs from many countries and all oceans. It will provide a valuable resource for both graduate students and researchers in many fields of knowledge. Sergey Govorushko is a chief research scholar at the Pacific Geographical Institute, Russian Academy of Sciences. He is also Professor at the Far Eastern Federal University (Vladivostok). Sergey Govorushko received his PhD from the Institute of Geography, Russian Academy of Sciences. His research activities focus on the interaction between humanity and the environment, including the impact of nature on humanity; the impact of humanity on the environment; and assessment of the interaction (environmental impact assessment, environmental audit, etc.). He has authored eight and co-authored seven monographs.
This book focuses on the nature and properties of soils of Hindu Kush-Himalayas and their management for agricultural land use. It discusses all aspects of climatic variations and potential of resources in the Himalayan region including examples from Afghanistan, Bangladesh, Bhutan, China (Tibet), India, Myanmar, Nepal and Pakistan. Chapters cover the geology of the parent material of native soils, soils microbes, flora and fauna. Soil classification has been given in detail to better understand the nature of soils for judicious management strategies. The authors present land use practices and suggestions for changes in land use to benefit from the full potential of the soils in this region. Their ultimate aim is to find ways of feeding the ever-increasing population and raising the standard of life for the people living in the Himalayan mountain region.
Bioactive Natural Products covers all the aspects of bioactive natural product research from ethnobotanical investigations to modern, technologically assisted isolation and structural determination of active compounds. An internationally selected group of experts share their knowledge of a wide range of bioactivities and chemical compound classes. Topics in the chapters describing the modern application of detection, isolation, and structural determination techniques are strongly supported by chapters detailing and reviewing research involving various classes of bioactivity. Research areas include the immunomodulatory, antiviral, cytotoxic, anti-inflammatory, and insect behavior classes of bioactivity. Extensive referencing throughout the text is helpful to those readers not familiar with this subject and serves as a critical review for more experienced researchers. The book is also excellent for upper division or post-graduate courses.
Extracorporeal circulation has become firmly established as an invaluable and routine adjunct to cardiac and vascular surgery. Since its introduction in 1953, the technique has evolved rapidly with advancing technology leading to improvements in and simplification of the equipment involved. Developments in the understanding and application of basic science have also had a huge impact as our understanding of the complex anatomy, biochemistry, pharmacology and pathophysiology of the heart continues to grow. It is these advances in both technology and science that form the basis of this fourth edition of Techniques in Extracorporeal Cirulation. The book continues to provide a comprehensive overview of the field, covering both established techniques for those new to the field of extracorporeal circulation, and current and future developments. It attempts to answer some of the innumerable practical problems associated with the routine use of artificial circulation and oxygenation, and hopes to stimulate thought and debate among its readers regarding more complex or controversial issues. Topics new to the fourth edition include robotic surgery and off-pump surgery, while other chapters have been thoroughly revised and updated to take into account developments and changes in the field. With its multidisciplinary approach, the book will remain an essential reference for all health care professionals working in the cardiac surgical operating room, in particular cardiothoracic surgeons, anaesthetists and perfusionists.
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