The last decade has seen a rapid growth in our understanding of the cognitive systems that underlie mathematical learning and performance, and an increased recognition of the importance of this topic. This book showcases international research on the most important cognitive issues that affect mathematical performance across a wide age range, from early childhood to adulthood. The book considers the foundational competencies of nonsymbolic and symbolic number processing before discussing arithmetic, conceptual understanding, individual differences and dyscalculia, algebra, number systems, reasoning and higher-level mathematics such as formal proof. Drawing on diverse methodology from behavioural experiments to brain imaging, each chapter discusses key theories and empirical findings and introduces key tasks used by researchers. The final chapter discusses challenges facing the future development of the field of mathematical cognition and reviews a set of open questions that mathematical cognition researchers should address to move the field forward. This book is ideal for undergraduate or graduate students of psychology, education, cognitive sciences, cognitive neuroscience and other academic and clinical audiences including mathematics educators and educational psychologists.
Accessible, concise, and clinically focused, Essentials of Pain Medicine, 4th Edition, by Drs. Honorio T. Benzon, Srinivasa N. Raja, Scott M. Fishman, Spencer S. Liu, and Steven P. Cohen, presents a complete, full-color overview of today's theory and practice of pain medicine and regional anesthesia. It provides practical guidance on the full range of today's pharmacologic, interventional, neuromodulative, physiotherapeutic, and psychological management options for the evaluation, treatment, and rehabilitation of persons in pain. - Covers all you need to know to stay up to date in practice and excel at examinations – everything from basic considerations through local anesthetics, nerve block techniques, acupuncture, cancer pain, and much more. - Uses a practical, quick-reference format with short, easy-to-read chapters. - Presents the management of pain for every setting where it is practiced, including the emergency room, the critical care unit, and the pain clinic. - Features hundreds of diagrams, illustrations, summary charts and tables that clarify key information and injection techniques – now in full color for the first time. - Includes the latest best management techniques, including joint injections, ultrasound-guided therapies, and new pharmacologic agents (such as topical analgesics). - Discusses recent global developments regarding opioid induced hyperalgesia, addiction and substance abuse, neuromodulation and pain management, and identification of specific targets for molecular pain. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.
From pre-operative assessment to post-operative care, Principles and Practice of Lymphedema Surgery presents authoritative guidance on surgical techniques in the treatment and management of Lymphedema. Concise and easily accessible, this highly visual reference helps deepen your understanding of each procedure and how to perform them. Step-by-step instructions and procedural videos from a team of leading authorities in the field of lymphedema and microsurgery equip you to implement the most innovative and latest surgical and non-surgical approaches and achieve optimal outcomes for all of your patients.
Originally developed to support video games, graphics processor units (GPUs) are now increasingly used for general-purpose (non-graphics) applications ranging from machine learning to mining of cryptographic currencies. GPUs can achieve improved performance and efficiency versus central processing units (CPUs) by dedicating a larger fraction of hardware resources to computation. In addition, their general-purpose programmability makes contemporary GPUs appealing to software developers in comparison to domain-specific accelerators. This book provides an introduction to those interested in studying the architecture of GPUs that support general-purpose computing. It collects together information currently only found among a wide range of disparate sources. The authors led development of the GPGPU-Sim simulator widely used in academic research on GPU architectures. The first chapter of this book describes the basic hardware structure of GPUs and provides a brief overview of their history. Chapter 2 provides a summary of GPU programming models relevant to the rest of the book. Chapter 3 explores the architecture of GPU compute cores. Chapter 4 explores the architecture of the GPU memory system. After describing the architecture of existing systems, Chapters 3 and 4 provide an overview of related research. Chapter 5 summarizes cross-cutting research impacting both the compute core and memory system. This book should provide a valuable resource for those wishing to understand the architecture of graphics processor units (GPUs) used for acceleration of general-purpose applications and to those who want to obtain an introduction to the rapidly growing body of research exploring how to improve the architecture of these GPUs.
This book provides a detailed overview of the latest developments in the rapidly evolving specialty of Neuro-Oncology arranged in approximately 500 questions arranged in multiple-choice and matching formats. It features insight into the latest World Health Organization classification of central nervous system tumors and molecular genetics with information on how to apply a range of intraoperative adjuncts. Guidance on the latest therapeutic techniques such as stem-cell and immunotherapy in clinical practice is also discussed. To assist the reader in developing a deep understanding of the topics, the questions in all chapters are accompanied by relevant explanations to reinforce the key points covered. Neuro-Oncology Explained Through Multiple Choice Questions is a practical and up-to-date resource on how to diagnose, treat and manage a variety of disorders related to neuro-oncology. Its clear, easy-to-follow format and recognition of critical concepts make it an important resource for neurosurgical and oncology trainees preparing for certification examinations and the more experienced practitioners seeking an overview of the latest developments within the field. Additional questions via app: Download the Springer Nature Flashcards app for free and use exclusive additional material to test your knowledge.
Ultrasmall Radio Frequency and Micro-wave Microelectromechanical systems (RF MEMs), such as switches, varactors, and phase shifters, exhibit nearly zero power consumption or loss. For this reason, they are being developed intensively by corporations worldwide for use in telecommunications equipment. This book acquaints readers with the basics of RF MEMs and describes how to design practical circuits and devices with them. The author, an acknowledged expert in the field, presents a range of real-world applications and shares many valuable tricks of the trade.
This proceedings volume contains selected and peer-reviewed original oral and poster contributions to be presented at the 5th International Symposium on Nanoporous Materials, Vancouver, Canada, May 25-28, 2008. It presents recent scientific advances in the area of nanoporous materials, especially those with ordered pores of sizes between 1 and 50 nm, their synthesis, characterization and applications in adsorption, catalysis, bio-related processes, environmental cleanup and nanotechnology. A unique feature of this volume is the wide variety of nanoporous materials covered, ranging from ordered silica nanostructures, silicas with incorporated organic and inorganic species, ordered nanoporous carbons and polymers, metal organic frameworks, nanostructured catalysts to nanoporous films, membranes and monoliths. This proceedings volume reflects the current trends and advances in the field of nanomaterials, which will certainly continue to attract the attention of materials scientists around the globe. It will therefore be a valuable reference for materials scientists, chemists and physicists working in academia, national and industrial laboratories.
Diabetes mellitus is a chronic disease of absolute or relative insulin deficiency or resistance characterised by disturbances in carbohydrate, protein and fat metabolism. It is estimated that between 5-10 per cent of the population suffer from this disease. This syndrome is a contributing factor in a large percentage of deaths from heart attacks and strokes as well as renal failure and vascular disease. About 90 per cent of the cases of diabetes mellitus fall into Type 2 where obesity plays a major role. Research in the field is wide-spread ranging from causes to treatment. This book brings together leading research from throughout the world.
This work is concerned with the design of PID controllers, calculation of set point weighting parameter and identification of transfer function models for unstable systems with time delay and without or with a zero.
This book offers both a practical as well a theoretical approach to Solvent Microextraction (SME) and will help analytical chemists to evaluate SME for a given sample preparation. Introductory chapters overview a comparison of SME with other sample preparation methods, a summary of the technical aspects, and a detailed theoretical treatment of SME. The book then describes the practical aspects of the technique, with detailed “how to” chapters devoted to the preparation and analysis of atmospheric, solid and liquid environmental, clinical and industrial samples. This text will serve as both a handy laboratory desk-reference and an indispensible instructional tool.
Organometallic chemistry is an interdisciplinary science which continues to grow at a rapid pace. Although there is continued interest in synthetic and structural studies the last decade has seen a growing interest in the potential of organometallic chemistry to provide answers to problems in catalysis, synthetic organic chemistry and also in the development of new materials. This Specialist Periodical Report aims to reflect these current interests, reviewing progress in theoretical organometallic chemistry, main group chemistry, the lanthanides and all aspects of transition metal chemistry. Volume 31 covers literature published during 2001. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.
The seventh edition of this classic text outlines the fundamental physical principles of thermal radiation, as well as analytical and numerical techniques for quantifying radiative transfer between surfaces and within participating media. The textbook includes newly expanded sections on surface properties, electromagnetic theory, scattering and absorption of particles, and near-field radiative transfer, and emphasizes the broader connections to thermodynamic principles. Sections on inverse analysis and Monte Carlo methods have been enhanced and updated to reflect current research developments, along with new material on manufacturing, renewable energy, climate change, building energy efficiency, and biomedical applications. Features: Offers full treatment of radiative transfer and radiation exchange in enclosures. Covers properties of surfaces and gaseous media, and radiative transfer equation development and solutions. Includes expanded coverage of inverse methods, electromagnetic theory, Monte Carlo methods, and scattering and absorption by particles. Features expanded coverage of near-field radiative transfer theory and applications. Discusses electromagnetic wave theory and how it is applied to thermal radiation transfer. This textbook is ideal for Professors and students involved in first-year or advanced graduate courses/modules in Radiative Heat Transfer in engineering programs. In addition, professional engineers, scientists and researchers working in heat transfer, energy engineering, aerospace and nuclear technology will find this an invaluable professional resource. Over 350 surface configuration factors are available online, many with online calculation capability. Online appendices provide information on related areas such as combustion, radiation in porous media, numerical methods, and biographies of important figures in the history of the field. A Solutions Manual is available for instructors adopting the text.
Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. This exhaustively comprehensive edition of the classic Bonica’s Management of Pain, first published 65 years ago, expertly combines the scientific underpinnings of pain with clinical management. Completely revised, it discusses a wide variety of pain conditions—including neuropathic pain, pain due to cancer, and acute pain situations—for adults as well as children. An international group of the foremost experts provides comprehensive, current, clinically oriented coverage of the entire field. The contributors describe contemporary clinical practice and summarize the evidence that guides clinical practice.
Coppell has produced a wealth of personalities that could have leapt from the pages of a novel. The town's early days brought John and Sarah Stringfellow, who helped found the town's oldest church, and Josiah and John Record, a father-and-son duo who were victims of lynching. The coming of the Cottonbelt Railroad created the mystery of town namesake George Coppell. The town was home to farmers like domino-loving Buren Ledbetter and sharecropper W.A. Ottinger. It had its own "Floyd the Barber" (Floyd Harwell), as well as Jo Jackson, the librarian known to most as the "Bird Lady of Coppell." The town has produced a wealth of heroes like Carroll Kirkland, who was killed in World War II, and Jacob Schick, a decorated veteran of the Iraq War. It is also a town that has turned tragedy into triumph through stories like Todd and Tara Storch, who transformed the pain of their daughter Taylor's death into the life-giving charity Taylor's Gift. Together their stories tell the story of Coppell, a place that at its heart will always be a small town.
Advances in nanofabrication, characterization tools, and the drive to commercialize nanotechnology products have contributed to the significant increase in research on inorganic nanowires (INWs). Yet few if any books provide the necessary comprehensive and coherent account of this important evolution. Presenting essential information on both popular and emerging varieties, Inorganic Nanowires: Applications, Properties, and Characterization addresses the growth, characterization, and properties of nanowires. Author Meyyappan is the director and senior scientist at Ames Center for Nanotechnology and a renowned leader in nanoscience and technology, and Sunkara is also a major contributor to nanowire literature. Their cutting-edge work is the basis for much of the current understanding in the area of nanowires, and this book offers an in-depth overview of various types of nanowires, including semiconducting, metallic, and oxide varieties. It also includes extensive coverage of applications that use INWs and those with great potential in electronics, optoelectronics, field emission, thermoelectric devices, and sensors. This invaluable reference: Traces the evolution of nanotechnology and classifies nanomaterials Describes nanowires and their potential applications to illustrate connectivity and continuity Discusses growth techniques, at both laboratory and commercial scales Evaluates the most important aspects of classical thermodynamics associated with the nucleation and growth of nanowires Details the development of silicon, germanium, gallium arsenide, and other materials in the form of nanowires used in electronics applications Explores the physical, electronic and other properties of nanowires The explosion of nanotechnology research activities for various applications is due in large part to the advances in the growth of nanowires. Continued development of novel nanostructured materials is essential to the success of so many economic sectors, ranging from computing and communications to transportation and medicine. This volume discusses how and why nanowires are ideal candidates to replace bulk and thin film materials. It covers the principles behind device operation and then adds a detailed assessment of nanowire fabrication, performance results, and future prospects and challenges, making this book a valuable resource for scientists and engineers in just about any field. Co-author Meyya Meyyappan will receive the Pioneer Award in Nanotechnology from the IEEE Nanotechnology Council at the IEEE Nano Conference in Portland, Oregon in August, 2011
Still the most widely used comprehensive resource in orthopaedic surgery, Campbell's Operative Orthopaedics is an essential reference for trainees, a trusted clinical tool for practitioners, and the gold standard for worldwide orthopaedic practice. Unparalleled in scope and depth, this 14th Edition contains updated diagnostic images, practical guidance on when and how to perform every procedure, and rapid access to data in preparation for surgical cases or patient evaluation. Drs. Frederick M. Azar and James H. Beaty, along with other expert contributors from the world-renowned Campbell Clinic, have collaborated diligently to ensure that this 4-volume text remains a valuable resource in your practice, helping you achieve optimal outcomes with every patient. - Features evidence-based surgical coverage throughout to aid in making informed clinical choices for each patient. - Covers multiple procedures for all body regions to provide comprehensive coverage. - Keeps you up to date with even more high-quality procedural videos, a new chapter on biologics in orthopaedics, and expanded and updated content on hip arthroscopy, patellofemoral arthritis and more. - Follows a standard template for every chapter that features highlighted procedural steps, high-quality illustrations for clear visual guidance, and bulleted text. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices
Since its first edition in 1975, this extraordinary textbook has helped shape the way biochemistry is taught, offering exceptionally clear writing, innovative graphics, coverage of the latest research techniques and advances, and a signature emphasis on physiological and medical relevance. Those defining features are at the heart of this edition.
This issue of Critical Care Clinics will focus on Severe Acute Respiratory DIstress Syndrome and dealing with it in the ICU. Topics will include: Challenges and Successes in ARDS Research;Mechanical ventilation with Lung Protective Strategies: What works?; Gene therapy for ALI/ARDS;High Frequency Oscillatory Ventilation in ALI/ARDS;Prone positioning therapy in ARDS;Recovery and Long-term outcome in ARDS; and Experimental models and emergeing hypotheses for ALI and ARDS
This book discusses single-channel, device-to-device communication in the Internet of Things (IoT) at the signal encoding level and introduces a new family of encoding techniques that result in significant simplifications of the communication circuitry. These simplifications translate into lower power consumption, smaller form factors, and dynamic data rates that are tolerant to clock discrepancies between transmitter and receiver. Readers will be introduced to signal encoding that uses edge-coded signaling, based on the coding of binary data as counts of transmitted pulses. The authors fully explore the far-reaching implications of these novel signal-encoding techniques and illustrate how their usage can help minimize the need for complex circuitries for either clock and data recovery or duty-cycle correction. They also provide a detailed description of a complete ecosystem of hardware and firmware built around edge-code signaling. The ecosystem comprises an application-specific processor, automatic protocol configuration, power and data rate management, cryptographic primitives, and automatic failure recovery modes. The innovative IoT communication link and its associated ecosystem are fully in line with the standard IoT requirements on power, footprint, security, robustness, and reliability.
Obtain the best outcomes from the latest techniques with help from a "who's who" of orthopaedic trauma experts! In print and online, you'll find the in-depth knowledge you need to manage any type of traumatic injury in adults. Major updates keep you up to speed on current trends such as the management of osteoporotic and fragility fractures, locked plating technology, post-traumatic reconstruction, biology of fracture repair, biomechanics of fractures and fixation, disaster management, occupational hazards of radiation and blood-borne infection, effective use of orthotics, and more. A DVD of operative video clips shows you how to perform 25 key procedures step by step. A new, full-color page layout makes it easier to locate the answers you need quickly. And now, for the first time, you can access the complete contents online, for enhanced ease and speed of reference! Complete, absolutely current coverage of relevant anatomy and biomechanics, mechanisms of injury, diagnostic approaches, treatment options, and associated complications equips you to confidently approach every form of traumatic injury. Enhanced and updated coverage keeps you current on the latest knowledge, procedures, and trends - including post-traumatic reconstruction, management of osteoporotic and fragility fractures, locked plating systems, mini incision techniques, biology of fracture repair, biomechanics of fractures and fixation, disaster management, occupational hazards of radiation and blood-borne infection, effective use of orthotics, and much more. More than six hours of operative videos on DVD demonstrate 25 of the very latest and most challenging techniques in real time, including minimally invasive vertebral disc resection, vertebroplasty, and lumbar decompression and stabilization. Online access allows you to rapidly search the complete contents from any computer. New editor Christian Kretek contributes additional international expertise to further enhance the already exceptional editorial lineup. An all-new, more user-friendly full-color text design enables you to find answers more quickly, and more efficiently review the key steps of each operative technique. More than 2,400 high-quality line drawings, diagnostic images, and full-color clinical photos show you exactly what to look for and how to proceed.
Written by world-renowned experts in both CT angiography and MR angiography, this landmark work is the first comprehensive text on vascular imaging using CT and MR. It provides a balanced view of the capabilities of these modalities and practical guidelines for obtaining and interpreting images. More than 2,200 illustrations complement the text. Chapters co-authored by CT and MR authorities cover imaging of all coronary and non-coronary arteries and veins. Each chapter details indications, imaging strategies, normal and variant anatomy, diseases, surgical management, and pitfalls. The authors compare the utility of CT and MR in specific clinical situations and discuss the role of conventional angiography and ultrasound where appropriate.
N-Sulfonated-N-Heterocycles covers the synthesis, chemistry and biological applications of these compounds, focusing on pioneering synthetic approaches, mechanistic insights and their limitations, as well as recent advances in this field. The synthesis of some of N-sulfonated N-heterocycles and their transformation to other useful cyclic and acyclic compounds are discussed, as well as their uses as useful intermediates in the preparation of polymeric and medicinal materials. This book includes detailed methods and protocols, and the focus on applications makes this resource an essential guide for all researchers in the area of organic, medicinal and polymeric synthetic study. - Reviews the use of N-sulfonated N-heterocycles as important precursors for the synthesis of biologically active compounds - Includes information on synthetically useful transformations of N-sulfonated N-heterocycles - Covers a wide synthetic methods used for an important branch of heterocycles and their biological evaluation in detail - Features over 500 schemes to illustrate different synthetic pathways and reactions of N-sulfonated N-heterocycles
Thermal Degradation of Polymeric Materials, Second Edition offers a wealth of information for polymer researchers and processors who require a thorough understanding of the implications of thermal degradation on materials and product performance. Sections cover thermal degradation mechanisms and kinetics, as well as various techniques, such as thermogravimetry in combination with mass spectroscopy and infrared spectrometry to investigate thermal decomposition routes. Other chapters focus on polymers and copolymers, including polyolefins, styrene polymers, polyvinyl chloride, polyamides, polyurethanes, polyesters, polyacrylates, natural polymers, inorganic polymers, high temperature-resistant and conducting polymers, blends, organic-inorganic hybrid materials, nanocomposites, and biocomposites. Finally, other key considerations such as recycling of polymers by thermal degradation, thermal degradation during processing, and modelling, are discussed in detail. - Explains mechanisms of polymer degradation, making it possible to understand and predict material behavior at elevated temperatures - Offers systematic coverage of each polymer group that is supported by data detailed explanations and critical analysis - Investigates thermal decomposition routes in new materials, such as organic-inorganic hybrid materials and polymer nanocomposites
**Selected for Doody's Core Titles® 2024 with "Essential Purchase" designation in Veterinary Medicine** Focus on the "how" and "why" of medical/surgical conditions — the critical issues that lead to successful outcomes for your patients — with Veterinary Surgery: Small Animal, Second Edition. This two-volume full-color resource offers an authoritative, comprehensive review of disease processes, a thorough evaluation of basic clinical science information, and in-depth discussion of advanced surgeries. With an updated Expert Consult website you can access anytime and detailed coverage of surgical procedures, it is the definitive reference for surgical specialists, practicing veterinarians, and residents. - Expert Consult website offers access to the entire text online, plus references linked to original abstracts on PubMed. - Comprehensive coverage includes surgical biology, surgical methods and perioperative care, neurosurgery, and orthopedics in Volume One, and all soft tissue surgery organized by body system in Volume Two. - Extensive references to published studies available on Expert Consult show the factual basis for the material. - Strong blend of clinical and basic science information facilitates a clear understanding of clinical issues surrounding operative situations. - Highly recognized contributing authors create chapters from their own experience and knowledge base, providing the most authoritative, current information available. - Coverage of anatomy, physiology, and pathophysiology in chapters on specific organs includes information critical to operative procedures and patient management. - In-depth chapters on anesthesia, surgical oncology, tumors of the spine, and musculoskeletal neoplasia provide valuable resources for practicing surgeons, especially in the area of cancer treatment. - Preoperative considerations and surgical implications for surgical procedures help surgeons make decisions about treatment approaches. - NEW and UPDATED! Expert Consult website with print text plus complete online access to the book's contents, so you can use it anytime — anywhere. - EXPANDED! Coverage of interventional radiology techniques in Volume Two (soft tissue volume) to provide cutting-edge information on contemporary imaging modalities that gain access to different structures of the patient's body for diagnostic and therapeutic reasons. - NEW and UPDATED! Expanded coverage of coaptation devices and small animal prosthetics clearly explains how they are used in a variety of clinical situations. - EXPANDED! Principles of minimally invasive plate treatment added to Volume One (orthopedic volume) to show how these advancements maximize healing and protect the patient while meeting the surgeon's goals in using fracture fixation.
This outline of Korea’s civilisation is a cultural history that examines the ways the Korean people over the past two millennia understood the world and viewed their place in society. In the traditional era, the interaction between several broad religious and philosophical traditions and social institutions, state interests and, at times, external pressures, provides the framework of the story. In the modern era, the chief concern is with the rapid and momentous cultural changes that have occurred over the past one and a half centuries in the idea and spread of education, the rise in influence of students, the development of mass culture, the redefinition of gender, and the continuing importance of religion.
This book presents a tutorial review of van der Pol model, a universal oscillator model for the analysis of modern RC−oscillators in weak and strong nonlinear regimes. A detailed analysis of the injection locking in van der Pol oscillators is also presented. The relation between the van der Pol parameters and several circuit implementations in CMOS nanotechnology is given, showing that this theory is very useful in the optimization of oscillator key parameters, such as: frequency, amplitude and phase relationship. The authors discuss three different examples: active coupling RC−oscillators, capacitive coupling RC−oscillators, and two-integrator oscillator working in the sinusoidal regime. · Provides a detailed tutorial on the van der Pol oscillator model, which can be the basis for the analysis of modern RC−oscillators in weak and strong nonlinear regimes; · Demonstrations the relationship between the van der Pol parameters and several circuit implementations in CMOS nanotechnology, showing that this theory is a powerful tool in the optimization of key oscillator parameters; · Provides three circuit prototypes implemented in modern CMOS nanotechnology in the GHz range, with applications in low area, low power, low cost, wireless sensor network (WSN) applications (e.g. IoT, BLE).
In recent years, nanocomposites have captured and held the attention and imagination of scientists and engineers alike. Based on the simple premise that by using a wide range of building blocks with dimensions in the nanosize region, it is possible to design and create new materials with unprecedented flexibility and improvements in their physical properties. This book contains the essence of this emerging technology, the underlying science and motivation behind the design of these structures and the future, particularly from the perspective of applications. It is intended to be a reference handbook for future scientists and hence carries the basic science and the fundamental engineering principles that lead to the fabrication and property evaluation of nanocomposite materials in different areas of materials science and technology.
The Latest Applications For Cellmechanism Research in Drug Discovery Designed to connect research on cell mechanisms with the drug discovery process, Therapeutic Targets: Modulation, Inhibition, and Activation introduces readers to a range of new concepts and novel approaches to drug screening and therapeutic drug targeting to help inform future avenues of drug research. Highly topical, this accessible edited volume features chapters contributed by respected experts from around the globe. The book helps postgraduate students and professional scientists working in academia and industry understand the molecular mechanisms of pharmacology, current pharmacological knowledge, and future perspectives in drug discovery, focusing on important biochemical protein targets and drug targeting strategies for specific diseases. Examining the pharmacology of therapeutically undefined targets and their potential applications, it includes chapters on traditional therapeutic targets, including enzymes (phosphodiesterases and proteases), ion channels, and G protein-coupled receptors, as well as more recently identified avenues of exploration, such as lipids, nuclear receptors, gene promoters, and more. Since different diseases require different targeting techniques, the book also includes dedicated chapters on strategies for investigating Alzheimer's, diabetes, pain, and inflammation treatments. Concluding with a cross-sectional look at new approaches in drug screening, Therapeutic Targets is an invaluable resource for understanding where the next generation of drugs are likely to emerge.
Current research lays emphasis on exploring natural products for use in nutraceuticals and pharmaceuticals to overcome various side effects of synthetic drugs. Fungi occupy an eminent position among natural sources of food and medicinal importance since ancient times. Many fungal species have been eaten as food and used in folk medicine for the treatment of many human ailments as mentioned in traditional medical literature. However, scanty information is available pertaining to the nutraceutical and pharmaceutical importance of fungi which merits an extensive review. This book spotlights the use value macrofungi in human health. Macrofungi with health benefitting properties largely belong to Basidiomycota followed by Ascomycota growing indoor (cultivated) and outdoor (wild). We endeavoured to throw light on the benefits of macrofungal taxa in relation to their food and medicinal significance in human life. We provided knowledge pertaining to the ethnomycological significance of macrofungi with respect to their uses as food and medicine by the people inhabiting different parts of the world. This book highlights the nutritional composition and bioactive compounds present in macrofungi. We also focused on the pharmacological activities of macrofungi contributing towards their medicinal value against several human disorders. We cited many commercially available nutraceutical and pharmaceutical products of macrofungal origin. This work will hopefully serve as a basic reference for general public, mycologists, researches and industry men, interested in consumption, research and marketing of macrofungi.
Olive Mill Waste: Recent Advances for Sustainable Management addresses today's most relevant topics in olive oil industry sustainable management. Emphasizing recent advisable practices, the book explores the potential of reutilizing OMW to power the mill itself, the reuse of OMW as soil amendment, aerobic biological treatment of OMW and compost production, the case study of OMW within the biorefinery concept, the recovery of bioactive compounds from OMW, and their applications in food products and cosmetics. Recent research efforts have concluded that the successful management of OMW focuses on three main routes: (a) reuse of water, (b) reuse of polyphenols, and (c) reuse of nutrients. Following this consideration, the book covers sustainable practices in the olive oil industry, revealing opportunities for reutilizing the water of OMW within the process or as s soil amendment. At the same time, it explores all the possibilities of recovering polyphenols and reutilizing them in target products, such as foods and cosmetics. In addition, the book presents successful cases of industrial OMW valorization through real world experiences. - Covers the most recent advances in the field of olive mill waste management following sustainability principles - Fills the gap of transfer knowledge between academia and industry - Explores the advantages, disadvantages and real potential of processes and products in the market
Nanoporous Materials III contains the invited lectures and peer-reviewed oral and poster contributions to be presented at the 3rd Conference on Nanoporous Materials, which will be hosted in Ottawa, Canada, June 2002. The work covers complementary approaches to and recent advances in the field of nanostructured materials with pore sizes larger than 1nm, such as periodic mesoporous molecular sieves M41S and FSM16 and related materials including clays, carbon molecular sieves, colloidal crystal templated organic and inorganic materials, porous polymers and sol gels. The broad range of topics covered in relation to the synthesis and characterization of ordered mesoporous materials are of great importance for advanced adsorption, catalytic and separation processes as well as the development of nanotechnology. The contents of this title are based on topics to be discussed by invited lecturers, which deal with periodic mesoporous organosilicas, stability and catalytic activity of aluminosilicate mesostructures, electron microscopy studies of ordered materials, imprinted polymers and highly porous metal-organic frameworks. The other contributions deal with tailoring the surface and structural properties of nanoporous materials, giving a detailed characterization as well as demonstrating their usefulness for advanced adsorption and catalytic applications.
The Guest Editors have assembled international experts in rheumatology to present an update to pediatricians. The basics are covered, including an article on the principles of inflammation in the child and one on the approach to the child with joint inflammation. From there, specifics are presented in the following articles: Laboratory Testing in Rheumatology; Rheumatologic Emergencies in newborns, children and adolescents; Juvenile Idiopathic Arthritis; Macrophage Activation Syndrome; Systemic Lupus Erythematosus; Idiopathic Inflammatory Myopathies in Childhood; Scleroderma; Vasculitis; Kawasaki disease; Autoinflammatory diseases; Approach to the patient with non-inflammatory musculoskeletal pain; and Immune deficiency diseases with rheumatic manifestations.
Engage diverse learners in your classroom with culturally responsive instruction! This second edition includes new or expanded coverage of Latino students, ELLs, immigrant students, race, and racial identity, and new coverage of standards-based, culturally responsive lesson planning and instruction, differentiated instruction, RTI, and the Common Core State Standards. Bonnie Davis helps all educators: Tailor instruction to their unique student population Reflect on their cultures and how this shapes their views of the world Cultivate a deeper understanding of race and racism in the U.S. Create culturally responsive instruction Understand how culture affects learning
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