This chapter offers an overview of the basic biology of phagocytes, macrophages, dendritic cells, and neutrophils and how it is affected by receptors for the Fc portion of antibodies (FcRs), particularly FcγRs. We focus on important processes such as phagocytosis and antigen presentation but it must be considered that these occur within the context of inflammation, where the complementary roles of the different phagocyte populations are clearly exposed. For this purpose, a brief description of the inflammatory response has also been included. Finally, research in innate immunity is coming to terms with the wide range of responses that can be achieved by selective engagement of pattern-recognition receptors, and we provide examples of how receptors not normally associated with responses to immunocomplexes modulate cellular activation mediated by FcRs.