A comprehensive review of all the vascular proliferations involving the skin and subcutaneous tissue, including recently described disease entities. Superbly illustrated with both clinical and histopathologic photographs, the book moves from a proposed new system of classification and nomenclature for vascular neoplasms, to a full discussion of benign and malignant proliferations, including hamartomas, benign neoplasms, malignant neoplasms, and several related newly reported diseases. The authors describe in-depth the clinical and morphologic aspects of each entity and detail their clinicopathologic correlation, differential diagnosis, prognosis, and therapy.
Don’t skim the surface of diagnosis; gain in-depth, full-color insight with Cutaneous Soft Tissue Tumors. This succinct, yet meaningful, field guide deconstructs all presentations in one easy-to-read and comprehensive text. With over 2,000 color images right at your fingertips, you’ll examine magnified, panoramic, and architectural views of each proliferation, fostering maximum understanding. Add Cutaneous Soft Tissue Tumors to your bookshelf and you’ll master the essential skill of histopathological diagnosis to deliver the best courses of treatment for your patients.
Studies of the trade between the Atlantic World and Asia during the sixteenth and seventeenth centuries typically focus on the exchanges between Atlantic European countries – especially Portugal, the Netherlands and England – and Asia across the Cape route. In The Atlantic World and the Manila Galleons. Circulation, Market, and Consumption of Asian Goods in the Spanish Empire, 1565-1650, José L. Gasch-Tomás offers a new approach to understanding the connections between the Atlantic World and Asia. By drawing attention to the trans-Pacific trade between the Americas and the Philippines, the re-exportation of Asian goods from New Spain to Castile, and the consumption of Chinese silk, Chinese porcelain and Japanese furnishings in New Spain and Seville, this book discloses how New Spanish cities and elites were main components of the spread of taste for Asian goods in the Spanish Empire. This book reveals how New Spanish family and commercial networks channelled the market formation of Asian goods in the Atlantic World around 1600.
During the year between July 1588, when the Spanish Armada set sail from Spain and July 1589, when the survivors of the English counterpart of this fleet, the little-known English Armada, reached port in England, two of history's worst naval catastrophes took place. A great deal of attention has been dedicated to the former and precious little to the latter. This book presents a full-scale account of an event which has been neglected for more than four centuries. It reconstructs the military operations day by day for the first time, taking apart the established notion that, with the defeat of the Spanish Armada, England achieved maritime supremacy and the decay of Spain began. This book clearly and in a rigorously documented fashion shows how the defeat of the English Armada counterbalanced that of the Spanish, frustrating England's intention of seizing Philip II's American empire and changing the tide of the war.
The definitive account of transpacific Asian movement through the Spanish empire—from Manila to Acapulco and beyond—and its implications for the history of race and colonization in the Americas. Between 1565 and 1815, the so-called Manila galleons enjoyed a near-complete monopoly on transpacific trade between Spain’s Asian and American colonies. Sailing from the Philippines to Mexico and back, these Spanish trading ships also facilitated the earliest migrations and displacements of Asian peoples to the Americas. Hailing from Gujarat, Nagasaki, and many places in between, both free and enslaved Asians boarded the galleons and made the treacherous transpacific journey each year. Once in Mexico, they became “chinos” within the New Spanish caste system. Diego Javier Luis chronicles this first sustained wave of Asian mobility to the early Americas. Uncovering how and why Asian peoples crossed the Pacific, he sheds new light on the daily lives of those who disembarked at Acapulco. There, the term “chino” officially racialized diverse ethnolinguistic populations into a single caste, vulnerable to New Spanish policies of colonial control. Yet Asians resisted these strictures, often by forging new connections across ethnic groups. Social adaptation and cultural convergence, Luis argues, defined Asian experiences in the Spanish Americas from the colonial invasions of the sixteenth century to the first cries for Mexican independence in the nineteenth. The First Asians in the Americas speaks to an important era in the construction of race, vividly unfolding what it meant to be “chino” in the early modern Spanish empire. In so doing, it demonstrates the significance of colonial Latin America to Asian diasporic history and reveals the fundamental role of transpacific connections to the development of colonial societies in the Americas.
The Latest Applications For Cellmechanism Research in Drug Discovery Designed to connect research on cell mechanisms with the drug discovery process, Therapeutic Targets: Modulation, Inhibition, and Activation introduces readers to a range of new concepts and novel approaches to drug screening and therapeutic drug targeting to help inform future avenues of drug research. Highly topical, this accessible edited volume features chapters contributed by respected experts from around the globe. The book helps postgraduate students and professional scientists working in academia and industry understand the molecular mechanisms of pharmacology, current pharmacological knowledge, and future perspectives in drug discovery, focusing on important biochemical protein targets and drug targeting strategies for specific diseases. Examining the pharmacology of therapeutically undefined targets and their potential applications, it includes chapters on traditional therapeutic targets, including enzymes (phosphodiesterases and proteases), ion channels, and G protein-coupled receptors, as well as more recently identified avenues of exploration, such as lipids, nuclear receptors, gene promoters, and more. Since different diseases require different targeting techniques, the book also includes dedicated chapters on strategies for investigating Alzheimer's, diabetes, pain, and inflammation treatments. Concluding with a cross-sectional look at new approaches in drug screening, Therapeutic Targets is an invaluable resource for understanding where the next generation of drugs are likely to emerge.
Introducción a las Psicoterapias Psicodinámicas, Experienciales, Sistémicas, Constructivistas e Integradoras recoge los contenidos teóricos del segundo cuatrimestre de la asignatura Introducción a los Tratamientos Psicodinámicos, Experienciales, Sistémicos, Constructivistas e Integradores, materia opcional de la especialidad de Psicología Clínica del grado en Psicología ofrecido por la UNED. En consecuencia, el libro ha sido elaborado con las pautas metodológicas habituales en los textos básicos de esta universidad, ya que su objetivo no es otro que proporcionar a sus alumnos una formación significativa y rigurosa en los temas que aborda. Por ello, este libro constituye un expositor, contextualizado y crítico, de contenidos que la producción editorial presenta habitualmente de manera desmembrada. En definitiva, este libro constituye un manual para obtener una visión de conjunto de los ámbitos psicoterapéuticos ajenos a la intervención cognitivo-conductual.VÁLIDO A PARTIR CURSO 23/24.
Does a bilingual person have two separate lexicons and two separate grammatical systems? Or should the bilingual linguistic competence be regarded as an integrated system? This book explores this issue, which is central to current debate in the study of bilingualism, and argues for an integrated hypothesis: the linguistic competence of an individual is a single cognitive faculty, and the bilingual mind should not be regarded as fundamentally different from the monolingual one. This conclusion is backed up with a variety of empirical data, in particular code-switching, drawn from a variety of bilingual pairs. The book introduces key notions in minimalism and distributed morphology, making them accessible to readers with different scholarly foci. This book is of interest to those working in linguistics and psycholinguistics, especially bilingualism, code-switching, and the lexicon.
Social entrepreneurship and social innovation both seek to improve the world through social change. Whereas social entrepreneurship revolves around the business side of change, social innovation focuses on the processes through which that change is generated. This textbook provides a comprehensive analysis of both topics, covering all the characteristics and elements of social innovation and social entrepreneurship, from a conceptual and practical perspective. The book has four sections: 1) Basics and concepts of Social Innovation and Social Entrepreneurship; 2) Business models and generation of value in social enterprises; 3) Social innovation within traditional companies, and 4) Definition and alignment of the impact of social innovation and entrepreneurship. Students and any practitioners that want to know about social innovation or social entrepreneurship will be exposed to contemporary topics in the field as well as a variety of cases and tools for its development. With its learning objectives, reflective questions, the definition of key concepts, and exercises, this book is the definitive text for advanced undergraduate and graduate courses in social innovation and social entrepreneurship.
The existence of interactions between different but overlapping legal systems has always presented challenges to black letter law. This is particularly true of the relationship between international law and domestic law and the relationship between federal law and the laws of individual federation members. Moreover some organisations have created their own supranational constitutional systems: the United Nations Charter is the best known, and is often referred to as the 'World Constitution', but the European Court of Justice in Luxembourg views the European Treaties as a 'Constitutional Charter' for Europe, while the European Court of Human Rights has defined the European Convention on Human Rights as a constitutional instrument of 'European public order'. It is in the dynamic relationship between domestic constitutional laws, EU law, the ECHR and the UN Charter that the most persistent difficulties arise. In this context 'interordinal instability' not only provokes strong academic interest, but also affects what has been called 'governance' or 'global government' and undermines both legal certainty and individual fundamental rights. Different solutions - constitutionalist and pluralist - have been explored, but none of them has received global acceptance. In this book Luis Gordillo analyses the interordinal instabilities which arise at the European level, focusing on three main strands of case law and their implications: Solange, Bosphorus and Kadi. To solve the difficulties caused by this instability Gordillo proposes a form of soft constitutionalism, which he calls 'interordinal constitutionalism', as a means to bring order and stability to global legal governance. The original Spanish thesis on which this book is based was awarded the Nicolás Pérez Serrano Prize by the Centro de Estudios Políticos y Constitucionales, for the best dissertation in constitutional law 2009-2010.
Audiovisual translation is the fastest growing strand within translation studies. This book addresses the need for more robust theoretical frameworks to investigate emerging text- types, address new methodological challenges (including the compilation, analysis and reproduction of audiovisual data), and understand new discourse communities bound together by the production and consumption of audiovisual texts. In this clear, user- friendly book, Luis Pérez-González introduces and explores the field, presenting and critiquing key concepts, research models and methodological approaches. Features include: • introductory overviews at the beginning of each chapter, outlining aims and relevant connections with other chapters • breakout boxes showcasing key concepts, research case studies or other relevant links to the wider field of translation studies • examples of audiovisual texts in a range of languages with back translation support when required • summaries reinforcing key issues dealt with in each chapter • follow- up questions for further study • core references and suggestions for further reading. • additional online resources on an extensive companion website This will be an essential text for all students studying audiovisual or screen translation at postgraduate or advanced undergraduate level and key reading for all researchers working in the area.
This book provides some regional aspects considered by manufacturing firms in their decisions to gain competitiveness and have effects on the performance of their supply chains (SC). Some of the main aspects considered are: government's policies, fixed costs, the availability and quality of infrastructure services. This book also discusses the risks for the SC; based on a perception approach, some aspects studied are: demand, suppliers and production processes and how these are related to other elements of the SC. The authors use structural modeling to analyze the evaluation of some manufacturing practices and their impact on customer service satisfaction, agility and flexibility of the SC. The context of this study is immersed in the Mexican manufacturing industry of exportation, also known as maquiladora industry of Ciudad Juarez, México. This borderland is among the top 10 manufacturing Mexican cities. World class industries are located in this region and have been recognized around the world for their competitiveness and high performance. Therefore, the methods and results exposed in this book may be valuable and useful for readers and researchers of the SC worldwide.
This superbly illustrated book is the most comprehensive available guide to adnexal neoplasms of the skin. More than 70 entities are described in individual chapters that follow a uniform structure: historical review, clinical features, histopathology, histogenesis, immunohistochemistry, molecular anomalies, and treatment. Readers will find state of the art knowledge on all aspects, including the cytogenetic and chromosomal abnormalities associated with each neoplasm. Without exception, the illustrations are high-quality, full-color, original digital pictures. The histopathology images are taken from perfectly cut and stained sections and the immunohistochemistry illustrations are of an unrivalled quality among textbooks of dermatology and dermatopathology. A complete list of references from original description to the present day is also supplied for each neoplasm. Cutaneous adnexal neoplasms are a large and heterogeneous group of benign and malignant lesions. This book will assist the reader in early and correct recognition, which is essential for appropriate choice of treatment and prognostic assessment.
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