Complex multivariate testing problems are frequently encountered in many scientific disciplines, such as engineering, medicine and the social sciences. As a result, modern statistics needs permutation testing for complex data with low sample size and many variables, especially in observational studies. The Authors give a general overview on permutation tests with a focus on recent theoretical advances within univariate and multivariate complex permutation testing problems, this book brings the reader completely up to date with today’s current thinking. Key Features: Examines the most up-to-date methodologies of univariate and multivariate permutation testing. Includes extensive software codes in MATLAB, R and SAS, featuring worked examples, and uses real case studies from both experimental and observational studies. Includes a standalone free software NPC Test Release 10 with a graphical interface which allows practitioners from every scientific field to easily implement almost all complex testing procedures included in the book. Presents and discusses solutions to the most important and frequently encountered real problems in multivariate analyses. A supplementary website containing all of the data sets examined in the book along with ready to use software codes. Together with a wide set of application cases, the Authors present a thorough theory of permutation testing both with formal description and proofs, and analysing real case studies. Practitioners and researchers, working in different scientific fields such as engineering, biostatistics, psychology or medicine will benefit from this book.
An interactive guide to the statistical tools used to solve problems during product and process innovation End to End Data Analytics for Product Development is an accessible guide designed for practitioners in the industrial field. It offers an introduction to data analytics and the design of experiments (DoE) whilst covering the basic statistical concepts useful to an understanding of DoE. The text supports product innovation and development across a range of consumer goods and pharmaceutical organizations in order to improve the quality and speed of implementation through data analytics, statistical design and data prediction. The book reviews information on feasibility screening, formulation and packaging development, sensory tests, and more. The authors – noted experts in the field – explore relevant techniques for data analytics and present the guidelines for data interpretation. In addition, the book contains information on process development and product validation that can be optimized through data understanding, analysis and validation. The authors present an accessible, hands-on approach that uses MINITAB and JMP software. The book: • Presents a guide to innovation feasibility and formulation and process development • Contains the statistical tools used to solve challenges faced during product innovation and feasibility • Offers information on stability studies which are common especially in chemical or pharmaceutical fields • Includes a companion website which contains videos summarizing main concepts Written for undergraduate students and practitioners in industry, End to End Data Analytics for Product Development offers resources for the planning, conducting, analyzing and interpreting of controlled tests in order to develop effective products and processes.
This book considers specific inferential issues arising from the analysis of dynamic shapes with the attempt to solve the problems at hand using probability models and nonparametric tests. The models are simple to understand and interpret and provide a useful tool to describe the global dynamics of the landmark configurations. However, because of the non-Euclidean nature of shape spaces, distributions in shape spaces are not straightforward to obtain. The book explores the use of the Gaussian distribution in the configuration space, with similarity transformations integrated out. Specifically, it works with the offset-normal shape distribution as a probability model for statistical inference on a sample of a temporal sequence of landmark configurations. This enables inference for Gaussian processes from configurations onto the shape space. The book is divided in two parts, with the first three chapters covering material on the offset-normal shape distribution, and the remaining chapters covering the theory of NonParametric Combination (NPC) tests. The chapters offer a collection of applications which are bound together by the theme of this book. They refer to the analysis of data from the FG-NET (Face and Gesture Recognition Research Network) database with facial expressions. For these data, it may be desirable to provide a description of the dynamics of the expressions, or testing whether there is a difference between the dynamics of two facial expressions or testing which of the landmarks are more informative in explaining the pattern of an expression.
A novel presentation of rank and permutation tests, with accessible guidance to applications in R Nonparametric testing problems are frequently encountered in many scientific disciplines, such as engineering, medicine and the social sciences. This book summarizes traditional rank techniques and more recent developments in permutation testing as robust tools for dealing with complex data with low sample size. Key Features: Examines the most widely used methodologies of nonparametric testing. Includes extensive software codes in R featuring worked examples, and uses real case studies from both experimental and observational studies. Presents and discusses solutions to the most important and frequently encountered real problems in different fields. Features a supporting website (www.wiley.com/go/hypothesis_testing) containing all of the data sets examined in the book along with ready to use R software codes. Nonparametric Hypothesis Testing combines an up to date overview with useful practical guidance to applications in R, and will be a valuable resource for practitioners and researchers working in a wide range of scientific fields including engineering, biostatistics, psychology and medicine.
This book deals with problems related to the evaluation of customer satisfaction in very different contexts and ways. Often satisfaction about a product or service is investigated through suitable surveys which try to capture the satisfaction about several partial aspects which characterize the perceived quality of that product or service. This book presents a series of statistical techniques adopted to analyze data from real situations where customer satisfaction surveys were performed. The aim is to give a simple guide of the variety of analysis that can be performed when analyzing data from sample surveys: starting from latent variable models to heterogeneity in satisfaction and also introducing some testing methods for comparing different customers. The book also discusses the construction of composite indicators including different benchmarks of satisfaction. Finally, some rank-based procedures for analyzing survey data are also shown.
This new atlas, the fourth of a successful series, is a completely revised and updated edition of a previously published FDG PET-CT atlas. In the past few years, considerable progress has been made in the field of PET-CT imaging, and this new edition takes full account of these recent developments. Furthermore, its educational mission has been broadened: beyond serving as a straightforward guide to FDG PET-CT imaging it now encompasses the integrative use of contrast-enhanced CT and MRI. The new edition also includes non-oncological indications for FDG PET-CT. The atlas aims to help imaging practitioners to recognize physiological and benign pathological FDG uptake and illustrates in a case-based, practical manner the PET-CT appearances of all the major tumors and infectious, inflammatory, and neurodegenerative disorders. The main clinical applications are covered, and learning points and pitfalls are clearly articulated. The consistent, user-friendly format facilitates image interpretation and allows rapid review of key information needed for FDG PET-CT imaging.
Thyroid Diseases is a comprehensive reference supported by a useful selection of schematic diagrams, tables, and charts. Its basic science section supplements classic and recent reviews of the subject by discussing structural and functional aspects of the thyroid gland, including thyroid hormone action (receptor and non-receptor mediated) and the hypothalamic-pituitary-thyroid control mechanisms. The clinical aspect of the book critically reviews current diagnostic modalities and addresses the choice of specialized tests and optimal sequence of their performance. Diagnostic modalities discussed include in vitro radioisotopic and nonradioisotopic assays of thyroid hormone, TSH, thyroglobulin, calcitonin, and autoantibodies. The various techniques are evaluated to show which procedures are applicable for each condition. This book brings together information dispersed across the medical and radiological literature. It will benefit professionals in radiology, nuclear medicine, and endocrinology, as well as students in these fields.
An interactive guide to the statistical tools used to solve problems during product and process innovation End to End Data Analytics for Product Development is an accessible guide designed for practitioners in the industrial field. It offers an introduction to data analytics and the design of experiments (DoE) whilst covering the basic statistical concepts useful to an understanding of DoE. The text supports product innovation and development across a range of consumer goods and pharmaceutical organizations in order to improve the quality and speed of implementation through data analytics, statistical design and data prediction. The book reviews information on feasibility screening, formulation and packaging development, sensory tests, and more. The authors – noted experts in the field – explore relevant techniques for data analytics and present the guidelines for data interpretation. In addition, the book contains information on process development and product validation that can be optimized through data understanding, analysis and validation. The authors present an accessible, hands-on approach that uses MINITAB and JMP software. The book: • Presents a guide to innovation feasibility and formulation and process development • Contains the statistical tools used to solve challenges faced during product innovation and feasibility • Offers information on stability studies which are common especially in chemical or pharmaceutical fields • Includes a companion website which contains videos summarizing main concepts Written for undergraduate students and practitioners in industry, End to End Data Analytics for Product Development offers resources for the planning, conducting, analyzing and interpreting of controlled tests in order to develop effective products and processes.
Permutation testing for multivariate stochastic ordering and ANOVA designs is a fundamental issue in many scientific fields such as medicine, biology, pharmaceutical studies, engineering, economics, psychology, and social sciences. This book presents new advanced methods and related R codes to perform complex multivariate analyses. The prerequisites are a standard course in statistics and some background in multivariate analysis and R software.
The purpose of this book is to illustrate a new statistical approach to test allelic association and genotype-specific effects in the genetic study of diseases. There are some parametric and non-parametric methods available for this purpose. We deal with population-based association studies, but comparisons with other methods will also be drawn, analysing the advantages and disadvantages of each one, particularly with regard to power properties with small sample sizes. In this framework we will work out some nonparametric statistical permutation tests and likelihood-based tests to perform case-control analyses to study allelic association between marker, disease-gene and environmental factors. Permutation tests, in particular, will be extended to multivariate and more complex studies, where we deal with several genes and several alleles together. Furthermore, we show simulations under different assumptions on the genetic model and analyse real data sets by simply studying one locus with the permutation test.
The book presents statistical methods and models that can usefully support the ev- uation of educational services and quality of products. The contributions collected in this book summarize the work of several researchers from the universities of Bologna, Firenze, Napoli and Padova. The contributions are written with a cons- tent notation and a uni?ed view, and concern methodological advances developed mostly with reference to speci?c problems of evaluation using real data sets. The evaluation of educational services, as well as the analysis of judgements and preferences, poses severe methodological challenges because of the presence of one or more of the following aspects: the observational (non experimental) nature of the context, which is associated with the well-known problems of selection bias and presence of nuisance factors; the hierarchical structure of the data, that entails c- related observations and consideration of effects at different levels of the hierarchy and their interactions (multilevel analysis); the multivariate and qualitative nature of the dependent variable, that requires the use of ad hoc statistical methodologies; the presence of non observable factors, e. g. the satisfaction, calling for the use of latent variables models; the simultaneous presence of components of pleasure and components of uncertainty in the explication of the judgments, that asks for the speci?cation and estimation of mixture models. The ?rst part of the book deals with latent variable models.
This book deals with problems related to the evaluation of customer satisfaction in very different contexts and ways. Often satisfaction about a product or service is investigated through suitable surveys which try to capture the satisfaction about several partial aspects which characterize the perceived quality of that product or service. This book presents a series of statistical techniques adopted to analyze data from real situations where customer satisfaction surveys were performed. The aim is to give a simple guide of the variety of analysis that can be performed when analyzing data from sample surveys: starting from latent variable models to heterogeneity in satisfaction and also introducing some testing methods for comparing different customers. The book also discusses the construction of composite indicators including different benchmarks of satisfaction. Finally, some rank-based procedures for analyzing survey data are also shown.
This book covers some biostatistical methods and several case studies useful to interpret and analyze dental research in the areas of orofacial pain and temporomandibular disorders. It will guide practitioners in these fields who would like to interpret research findings or find examples on the design of clinical investigations. After an introduction dealing with the basic issues, the central sections of the textbook are dedicated to the different types of investigations in sight of specific goals researchers may have. The final section contains a recent approach based on nonparametric permutation tests which can be adopted in many practical situations. The field of orofacial pain and temporomandibular disorders is emerging as one of the most critical areas of clinical research in dentistry. Due to the complexity of clinical pictures, the multifactorial etiology, and the importance of psychosocial factors in all aspects of the TMD practice, clinicians often find it hard to appraise their modus operandi, and researchers must constantly increase their knowledge in epidemiology and medical statistics. Indeed, proper methodological designs are fundamental to reaching high levels of internal and external validity of findings in this specific area.
Complex multivariate testing problems are frequently encountered in many scientific disciplines, such as engineering, medicine and the social sciences. As a result, modern statistics needs permutation testing for complex data with low sample size and many variables, especially in observational studies. The Authors give a general overview on permutation tests with a focus on recent theoretical advances within univariate and multivariate complex permutation testing problems, this book brings the reader completely up to date with today’s current thinking. Key Features: Examines the most up-to-date methodologies of univariate and multivariate permutation testing. Includes extensive software codes in MATLAB, R and SAS, featuring worked examples, and uses real case studies from both experimental and observational studies. Includes a standalone free software NPC Test Release 10 with a graphical interface which allows practitioners from every scientific field to easily implement almost all complex testing procedures included in the book. Presents and discusses solutions to the most important and frequently encountered real problems in multivariate analyses. A supplementary website containing all of the data sets examined in the book along with ready to use software codes. Together with a wide set of application cases, the Authors present a thorough theory of permutation testing both with formal description and proofs, and analysing real case studies. Practitioners and researchers, working in different scientific fields such as engineering, biostatistics, psychology or medicine will benefit from this book.
Statistical shape analysis is a geometrical analysis from a set of shapes in which statistics are measured to describe geometrical properties from similar shapes or different groups, for instance, the difference between male and female Gorilla skull shapes, normal and pathological bone shapes, etc. Some of the important aspects of shape analysis are to obtain a measure of distance between shapes, to estimate average shapes from a (possibly random) sample and to estimate shape variability in a sample[1]. One of the main methods used is principal component analysis. Specific applications of shape analysis may be found in archaeology, architecture, biology, geography, geology, agriculture, genetics, medical imaging, security applications such as face recognition, entertainment industry (movies, games), computer-aided design and manufacturing. This is a proposal for a new Brief on statistical shape analysis and the various new parametric and non-parametric methods utilized to facilitate shape analysis.
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