This concise handbook provides oncologists and other healthcare providers with crucial updates in the field, including an updated review of the current understanding of the biology of the HER2 pathway, an overview of HER2-testing, and evidence-based discussions of available and emerging HER2-targeted treatment options. An essential clinical text for physicians that screen and treat patients with breast cancer and require an accessible, up-to-date survey of the dynamic treatment landscape.
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in women worldwide, accounting for nearly a quarter of the total new cancer cases each year. Of these cases, approximately 15–25% overexpress HER2, a transmembrane RTK kinase that is associated with aggressive tumor growth and poor outcomes. However, in the past decade, survival rates of patients with HER-positive breast cancer have significantly improved due to increased screening, HER2 testing, and breakthrough HER2-targeted drug therapies. Handbook of HER2-Targeted Agents in Breast Cancer provides oncologists, primary care physicians, trainees and other healthcare providers with a concise, accessible, and up-to-date survey of the field, including a review of our current understanding of the biology of the HER2 pathway and the rationale for targeting it in early-stage and advanced breast cancer, an overview of HER2-testing, and evidence-based discussions of available HER2-targeted regimens in the adjuvant and metastatic settings.
This book brings to the surface the lines of experimentation and artistic renewal appearing after the exhaustion of Neorealism, mapping complex areas of interest such as the emergence of ethical concerns, the relationship between ideology and representati
What tensions characterized the relationships between cinema, European Leftists, and emerging postcolonial ideologies after World War II? In Traveling Auteurs, author Luca Caminati analyzes the work of influential Italian filmmakers Roberto Rossellini, Pier Paolo Pasolini, and Michelangelo Antonioni as they engaged politically and aesthetically with the global landscapes and politics of the Cold War period. As documentaries, the films considered in this book record specific manifestations of political sensibilities of the twentieth century. As bodies of work, they reveal that the traveling auteurs who made them were symptomatic actors in complex geopolitical networks. As cultural objects reflecting and shaping contemporaneous debates, they provoke a complex afterlife at home and abroad. In the three chapters dedicated to Rossellini in India, Pasolini in Africa and the Middle East, and Antonioni in China, Caminati pays particular attention both to the reception that these films had in the countries where they were shot and to their legacies in Italian film history. As it follows the entanglements of filmmakers, artists, and activists involved as allies or direct witnesses to momentous political change, this book sheds new light on anticolonial struggles, the reaffirmation of the Non-Aligned Movement, and the consolidation of the Chinese Communist Party.
In the late nineteenth and early twentieth centuries, the production of literary and cultural manifestoes enjoyed a veritable boom and accompanied the rise of many avant-garde movements. Legitimizing the Artist considers this phenomenon as a response to a more general crisis of legitimation that artists had been struggling with for decades. The crucial question for artists, confronted by the conservative values of the dominant bourgeoisie and the economic logic of triumphant capitalism, was how to justify their work in terms that did not reduce art to a mere commodity. In this work Luca Somigli discusses several European artistic movements – decadentism, Italian futurism, vorticism, and imagism – and argues for the centrality of the works of F.T. Marinetti in the transition from a fin de siécle decadent poetics, exemplified by the manifestoes of Anatole Baju, to a properly avant-garde project aiming at a complete renewal of the process of literary communication and the abolition of the difference between producer and consumer. It is to this challenge that the English avant-garde artists, and Ezra Pound in particular, responded with their more polemical pieces. Somigli suggests that this debate allows us to rethink the relationship between modernism and post-modernism as complementary ways of engaging the loss of an organic relationship between the artist and his social environment.
Are you looking for a lesson in language and in life? If the answer is yes, look no further. Luckily for us, Italians have gifted the globe with their many contributions in the realms of art, opera, cinema, pizza—the list is endless. Although, one area which is often overlooked is the Italian gift of the gab. The greatest gift of them all. Italians possess a bevy of phrases to get you through all of life’s phases. So, if you want to change your life, it’s simple. All you must change is your vocabulary. Living The Lingo of Linguine will provide you with some of Italy’s wisest words, expressions, and proverbs. It will strike up a conversation of cultural comparison and translate these words, not only into English but into a carefully curated way of life. You are welcomed to embrace this language of longevity. To value a vernacular which will raise your vibration. To proudly pronounce an existence of peace and positivity. And to dive into a dialogue like no other.
Soon to be an AppleTV+ series, this is the definitive account of how Enzo Ferrari became the master of motor racing, and one of the most complex, important and imposing figures in the 20th century. The book draws upon years of original research, conducted in Italy and abroad, and unveils hidden aspects of Ferrari's career - from his early days as a racer, to how he founded the Ferrari company, and even his dealings with the Italian Fascist government and Communist leaders. Learn how Ferrari pushed his drivers to the brink of disaster, revolutionised the automobile industry and overcame family and company infighting on his rise to greatness.
FROM THE BESTSELLING AUTHOR OF MESSI AND RONALDO. Tipped for greatness from an early age, it's easy to think that every moment of Neymar's life has been played out under the glare of a spotlight. But did you know that Real Madrid were just €60,000 away from signing him in 2006? Or that a phone call from Pelé stopped Neymar leaving Santos for Chelsea in 2010? Or that his move to Paris Saint-Germain in 2017 caused tension with his new teammates? Find out about all this and more in Luca Caioli's tirelessly researched biography, featuring exclusive interviews with those who know him best, including friends, family, coaches and teammates. Includes all the action from the 2018/19 season.
Lionel Messi is a mesmerising talent who has continued to astound the world of football ever since assuming his role at the heart of a star-studded Barcelona side in 2004. Overcoming a career-threatening growth hormone deficiency, he has won almost everything there is to win, including an unprecedented four FIFA Ballons d'Or. Luca Caioli draws on numerous exclusive testimonies to tell Messi's story, including his parents and extended family, his coaches, those who have played alongside him and even Messi himself. Messi is a revealing portrait of football's most unassuming superstar, updated to include the dramatic 2013/14 season and the 2014 FIFA World Cup in which his match-winning performances finally began to win over his harshest critics – his fellow countrymen.
Cold hands clamped around my neck. From the corner of my eye, something clicked and glinted, like a knife. Sure as hell was not going to find out. The hands became an arm. I sank my teeth into the skin. He let go. I made for the door, did not look back. My chest burned as my legs scaled the wall. The dead taste of blood in my mouth made me gag.
This book is the fourth of four dealing with bioclimatic design and construction by focusing on the most basic and polyvalent of modern environmental systems: the bioclimatic greenhouse, the "Swiss-army chainsaw" of architecture. More specifically, this fourth volume focuses on architectural integration, environmental prediction and how to simulate and structurally size a bioclimatic wooden greenhouse. In more general terms, it helps us to consider how to design and build the structure of bioclimatic, low-energy architecture, with low environmental impact. This multi-volume book covers both free-standing greenhouses that can naturally heat and cool themselves, and lean-to greenhouses that support the natural heating and cooling of buildings; this includes both agricultural greenhouses and greenhouses suited to host people. As a result, it is a trans-disciplinary work deriving its areas of concern from a broad range of study areas, spanning from environmental, to constructional, to structural, drawing the clarity of the approach from the fact that the topics are presented by a single author with a single voice and a designer's mindset. To achieve this, the book adopts a composite set of explanatory strategies and communication registers – including extensive support by 3D construction drawings and examples – and presents not only stateof-the-art solutions, but also experimental ones.
This compact but exhaustive textbook, now in its significantly revised and expanded second edition, provides an essential introduction to the field quantization of light and matter with applications to atomic physics and strongly correlated systems. Following an initial review of the origins of special relativity and quantum mechanics, individual chapters are devoted to the second quantization of the electromagnetic field and the consequences of light field quantization for the description of electromagnetic transitions. The spin of the electron is then analyzed, with particular attention to its derivation from the Dirac equation. Subsequent topics include the effects of external electric and magnetic fields on the atomic spectra and the properties of systems composed of many interacting identical particles. The book also provides a detailed explanation of the second quantization of the non-relativistic matter field, i.e., the Schrödinger field, which offers a powerful tool for the investigation of many-body problems, and of atomic quantum optics and entanglement. Finally, two new chapters introduce the finite-temperature functional integration of bosonic and fermionic fields for the study of macroscopic quantum phenomena: superfluidity and superconductivity. Several solved problems are included at the end of each chapter, helping readers put into practice all that they have learned.
The European experience suggests that the efforts made to achieve an efficient trade-off between monetary policy and prudential supervision ultimately failed. The severity of the global crisis have pushed central banks to explore innovative tools—within or beyond their statutory constraints—capable of restoring the smooth functioning of the financial cycle, including setting macroprudential policy instruments in the regulatory toolkit. But macroprudential and monetary policies, by sharing multiple transmission channels, may interact—and conflict—with each other. Such conflicts may represent not only an economic challenge in the pursuit of price and financial stability, but also a legal uncertainty characterizing the regulatory developments of the EU macroprudential and monetary frameworks. In analyzing the “legal interaction” between the two frameworks in the EU, this book seeks to provide evidence of the inconsistencies associated with the structural separation of macroprudential and monetary frameworks, shedding light upon the legal instruments that could reconcile any potential policy inconsistency.
The Art of Objects explores the experimental encounter of arts and industry in Italy at the turn of the 20th century, tracing the origins of the Italian culture of design in the social and aesthetic construction of the age's most iconic industrial objects.
FROM THE BESTSELLING AUTHOR OF RONALDO AND NEYMAR. Prolific, cool-headed and unerringly consistent, Lionel Messi is one of the most revered footballers in history. But did you know that his transfer to Barcelona was first agreed on a paper napkin? Or that an x-ray of his hand was to thank for identifying his growth hormone deficiency? And do you know why he refused to collect his first ever Champions League winner's medal? Find out all this and more in Luca Caioli's classic portrait of a footballing icon, featuring exclusive interviews with those who know him best and even Messi himself.
This book is the first of four dealing with bioclimatic design and construction by focusing on the most basic and polyvalent of modern environmental systems: the bioclimatic greenhouse, the “Swiss-army chainsaw” of architecture. More specifically, this first volume focuses on preliminary bioclimatic design of greenhouses, laying down fundamental principles that are also likely to be invaluable in designing, in more general terms, bioclimatic and low-energy architecture, with low environmental impact. This multi-volume book covers both free-standing greenhouses that can naturally heat and cool themselves, and lean-to greenhouses that support the natural heating and cooling of buildings; this includes both agricultural greenhouses and greenhouses suited to host people. As a result, it is a trans-disciplinary work deriving its areas of concern from a broad range of study areas, spanning from environmental, to constructional, to structural, drawing the clarity of the approach from the fact that the topics are presented by a single author with a single voice and a designer’s mindset. To achieve this, the book adopts a composite set of explanatory strategies and communication registers – including extensive support by 3D construction drawings and examples – and presents not only stateof-the-art solutions, but also experimental ones.
Marx and Singularity by Luca Basso attempts to understand the development of Marx’s thought, from the early writings to the Grundrisse, as a search for individual realisation. Drawing upon the concept of singularity in contemporary French theory, and problematising its relation to Marx’s vocabulary, this book challenges organicist interpretations of Marx’s early work. The productivity of the notion of singularity is argued to be based on the fact that it allows us to highlight the element of individual realisation, stressing at the same time its distance from the modern conception of individuality. The “correlate” of singularity is the reciprocity, moving and unstable, between the “individual” and the “collective”, which occurs in class struggles. Updated and revised edition of Socialità e isolamento: la singolarità in Marx published by Carocci in 2008.
From Fidel Castro to Qassem Soleimani, the US government has been involved in an array of assassinations and assassination attempts against foreign leaders and officials. The President's Kill List reveals how the US government has relied on a variety of methods, from the use of poison to the delivery of sniper rifles, and from employing hitmen to simply laying the groundwork for local actors to do the deed themselves. It shows not only how policymakers decided on assassination but also the level of Presidential control over these decisions. Tracing the history of the US government's approach to assassination, the book analyses the evolution of assassination policies and, for the first time, reveals how successive administrations - through private justifications and public legitimations - ensured assassination remained an available tool.
Digital marketing encompasses more than eight branches. In the service industry managers must learn how to compensate for the intangibility that characterises digital technologies. This book explains most of the theories and the techniques necessary to avoid typical mistakes and to promote online hotels, restaurants, local tourism development offices, wellness centres, gyms and other clubs. You will learn how to: • improve the position in the Search Engine with SEO techniques • manage paid promotions such as Display Campaigns and Google Ads • use social media, such as TikTok and Facebook • create Content for your channels • sell services with Online Travel Agencies and other distributors • implement Internet of Things in the service’s operations • automate the management with Artificial Intelligence • understand the potential of Augmented and Virtual Reality • analyse your guests’ interests • answer positive or negative Reviews • design a brand Voice and Personality • get closer to your audience • lead Influencers and Opinion Leaders
From a young age, Neymar was identified as a future great of world soccer. Since his move to Barcelona in 2013 he has progressed at an unstoppable rate, not simply coping but thriving under the pressure of expectation. Having established himself as a vital prong alongside Messi and Suarez in Barcelona's attack, 2015/16 saw him vying to take the starring role. His performances made his a serious contender for the Ballon d'Or, an award long-dominated by the unfaltering Messi and Ronaldo. It now seems only a matter of time before he adds the accolade to his ever-growing trophy collection. Fully updated and drawing on exclusive interviews with those who have known and worked with him, Neymar paints a compelling picture of the life and career of a global icon.
Mario Balotelli has a reputation like no other in football. Since exploding on to the scene at Inter Milan in 2007, he has won league titles in both Italy and England, moving between Europe's elite clubs. Yet for all his undoubted talent, he is better known for his off-field antics – not least his infamous run-ins with both the police and Manchester's firefighters. Once described by José Mourinho as 'unmanageable', match-winning performances at the highest level have continued to convince clubs such as AC Milan and Liverpool to give him a chance. With exclusive access to friends, teammates and coaches, acclaimed football biographer Luca Caioli talks to the people best placed to explain the mystery that is Mario Balotelli.
This book aims to understand the European political debate about contentious issues, framed in terms of religious values by religious and/or secular actors in 21st century. It specifically focuses on the Italian case, which, due to its peculiar history and contemporary political landscape, is a paradigmatic case for the study of the relationships between religion and politics. In recent years, a number of controversies related to religious issues have characterised the European public debate at both the EU and the national level. The ‘affaire du foulard’ in France, the referendum on abortion in Portugal, the recognition of same-sex marriages in many Western European States, the debate over bioethics and the regulation of euthanasia are only a few examples of contentious issues involving religion. This book aims to shed light on the interrelation between these different debates, as well as their broader meaning, through the analysis of the paradigmatic case of Italy. Italy summarizes and sometimes exasperates wider European trends, both because of the peculiar role traditionally played by the Vatican in Italian politics and for the rise, since the 1990s, of new political entrepreneurs eager to exploit ethical and civilizational issues. This work will be of great interest to scholars and students of a number of fields within the disciplines of political science, sociology and law, and will be useful for courses on religion and politics, political parties, social movements and civil society.
In Marx and the Common, Luca Basso provides a detailed reconstruction of the late Marx's connection of the collective dimension of communism and the element of individual realisation. Through an original analysis of a vast range of Marx's writings - from Capital to his political texts and scientific notes - the author brings out an articulated historical-theoretical landscape in which the notion of 'individual' is intertwined with the ideas of 'class', 'society' and 'community'. Rooting his analysis in the revolutionary power of the workers' 'acting in common', Basso brings to the fore an anthropological dynamic in Marx, irreducible to either liberal individualism or any kind of organicist approach.
Cristiano Ronaldo is known throughout the world for his devastating ability and his carefully crafted image. A two-time Ballon d’Or winner with his own fashion label, he is every inch the modern superstar, but behind the glamour lies one of the most dedicated athletes the sport has ever known. Luca Caioli, author of the bestselling Messi, tells the inside story of the Real Madrid star whose determination has driven him to the very top of his game, featuring insights from those who know him best: coaches, teammates, girlfriends and even the man himself. Updated to include all the action from his hugely successful 2013/14 campaign, Ronaldo offers a unique behind-the-scenes look at one of football’s all-time greats.
A travers le regard attentif et curieux d'un infatigable voyageur, des rencontres, des anecdotes et des coïncidences fortuites dévoilent le monde folk européen dans toute sa beauté et son authenticité. Un monde fait de musique et de musiciens, de danses et de danseurs, d'instruments et de luthiers, de festivals et de joie. Mais il est également constitué d'un patrimoine culturel et de valeurs que la sagesse centenaire des traditions a confié à un Homme moderne, toujours plus éloigné de la communauté, de la nature et de lui-même. Au temps d'Internet, du progrès technologique et de la mondialisation, parler de traditions, de proverbes, de dialectes, d'instruments anciens et de danses populaires peut sembler anachronique. Le message renfermé dans ces pages vous fera réfléchir sur le caractère actuel de ces langages populaires et sur la façon dont ils peuvent guider l'Homme vers un chemin conscient.
Following on from the successful book "Natural Born CAADesigners: Young American Architects", this book takes a look at the most recent architectonic developments in the Mediterranean countries, where architects have up to now been strongly influenced by the archaeologically significant environment and their classical architectural inheritance. How do young architects in Italy, France, Spain and Greece react to the new digital age? The electronic tools give them the chance to free themselves from the burden of tradition, to explore fascinating opportunities in their architecture. This book provides a colourful and concise overview of their work, using previously unpublished material. The team IAN+ was formed in 1997 in Rome by Carmelo Baglivo, Luca Galofaro and Stefania Manna. Maria Luisa Palumbo works at the McLuhan Programm in Culture and Technology.
Strength, speed and dedication: Cristiano Ronaldo is known throughout the world as a colossus of the modern game. But did you know that he underwent laser heart surgery aged just fifteen to enable him to continue playing the game he loved? Or that Nacional, his first professional club, donated twenty balls and two sets of kits to his youth team in order to sign him? Or how he came to be known as abelhinha -'little bee'- a name he would later pass on to his Yorkshire Terrier? Find out all this and more in Luca Caioli's biography of the global superstar, featuring exclusive insights from those who know him best and even the man himself.
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